CN1403152A - Composition for keeping skin's moisture and delaying skin's senility and its prepn - Google Patents
Composition for keeping skin's moisture and delaying skin's senility and its prepn Download PDFInfo
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- CN1403152A CN1403152A CN 02123697 CN02123697A CN1403152A CN 1403152 A CN1403152 A CN 1403152A CN 02123697 CN02123697 CN 02123697 CN 02123697 A CN02123697 A CN 02123697A CN 1403152 A CN1403152 A CN 1403152A
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Abstract
The present invention relates to one kind of composition with health function and its preparation process. The present invention features that the composition has hyaluronic acid and fish protein as main components and may be produced into various forms, including capsule, tablet, granule and oral liquid. If necessary, may be added vitamin C, vitamin E, beta-carrotene, etc. Trial taking shows that the product of the present invention can raise the skin's moisture maintaining capacity obviously, maintain skin in smooth and bright state and prevent wrinkles.
Description
Technical field
The present invention relates to a kind of composition and method of making the same with health care, especially be moisture of skin, delaying decrepitude of skin health care foods or the medicine and preparation method thereof of maintenance that have of main component with hyaluronic acid and fish protein, its dosage form comprises capsule, tablet, granule and oral liquid.
Background technology
At present, raising along with people's living standard, consumer is more and more high to the requirement of quality, function and the diversification of varieties of skin care item, no longer be satisfied with and only act on that the local shallow-layer performance of skin of face is preserved moisture and the external use skin care of Nutrition, and to by in the body to the effect of external performance skin-care and beautifying, keep skin moisturizing smooth, prevent that the oral skin care item that wrinkle produces from favoring especially.Therefore, research and develop this type of oral cosmetics and skincare product, become the another new key areas of cosmetics research and development.
According to the literature: skin is divided into epidermal area, skin corium and three parts of subcutaneous tissue from outside to inside, what wherein concern skin fitness mainly is two important substance---the hyaluronic acid and the collagen protein of skin corium, the common extracellular gelatinised matrix that contains large quantity of moisture of forming is the medium of cells survival, nutrition, metabolism and mass exchange.Extracellular matrix (also claiming intercellular substance) is a kind of large quantity of moisture that contains, and has the gel liquid of certain viscosity, makes skin pliable and tough, high resilience, and competent moisture makes the smooth delicacy of skin.With advancing age, the collagen protein in the corium begins to degenerate, and slowly follows the string, and hyaluronic acid contents obviously reduces, and the cell of skin histology and the moisture of intercellular substance are reduced, and skin corium thickness reduces, and the epidermis crisp fritter that becomes is frangible, produces microgroove.This shows that the variation of hyaluronic acid and collagen protein is the key that causes skin ageing in the skin corium.
At present, the health food that has fish protein to make on the market is used for replenishing intravital collagen protein, has the effect that keeps moisture of skin; And have experimental study to show, and take hyaluronic acid by be subjected to the animal of wound to skin, can quicken skin wound healing.The invention provides a kind of is the health food or the medicine of main component with hyaluronic acid, fish protein, by replenishing intravital hyaluronic acid and fish protein simultaneously, reach from the body to the better effect of external maintenance moisture of skin.The human experimentation result shows that the present invention more singly obeys fish protein or hyaluronic acid has more significant skin moisturizing and delaying decrepitude of skin effect.
Summary of the invention
The purpose of this invention is to provide and a kind ofly can in body, have an effect the composition and method of making the same of delaying decrepitude of skin.
The main component of product of the present invention is hyaluronic acid (comprising its esters) and fish protein.
Hyaluronic acid is the macromole mucopolysaccharide that extensively exists in the body.By the multiply-connected macromole chain polysaccharide that forms that connects of disaccharidase unit weight that glucuronic acid and aminoglucose are formed, molecular weight is 5～8,000,000.Carboxyl in the hyaluronan molecule and hydroxyl can pass through a large amount of water of hydrogen bonded, therefore, have significant water retention (6 liters/gram of theoretical moisture-holding capacity).Digest and assimilate by oral, can increase the synthetic precursor substance of hyaluronic acid in the body, make hyaluronic acid synthetic quantity increase in the skin, thereby the water retention property of skin is increased.
The fish protein that extracts from abyssal fishes is rich in collagen protein---and the protein that extensively exists in a kind of body, collagen structure is quite similar in the structure of this kind protein and the human skin, is very easy to be absorbed by the body.It is reported, take (3 months) fish protein for a long time, can improve the skin quality, dermis thickness on average increases by 83.3%, and skin elasticity increases by 7%, and the hair of embrittlement also improves.And can promote that collagen is proteic synthetic in the body, increase whole skin elasticity and moisture-retaining capacity, and then make the skin surface Smooth and moist that becomes.Skin microgroove and wrinkle are reduced, and especially the skin aging that daylight is caused improves significantly.
Product of the present invention verifies that through human experiment experimental technique and result are as follows:
1 object of observation and method
1.1 study subject: 68 routine volunteers of medical fitness are the women, minimum 35 years old of age, maximum 51 years old.Use table of random number and carry out control design at random, be divided into matched group and test-meal group.The participation crowd does not take any relevant medicine, health food and does not make at duration of test and applies some make up.
1.2 experimenter's the standard of including in
The healthy person that does not have any cardiovascular and cerebrovascular vessel, liver, kidney, hemopoietic system disease and psychiatric history.Carry out the physical examination of whole body before the test-meal, comprise projects such as Chest X-rays, B ultrasonic, electrocardiogram, routine blood test, routine urinalysis, blood biochemistry, reject the failure.
1.3 test-meal method: every day 1 time, each 4, took continuously 30 days.
1.4 observational technique
1.4.1 general situation: before and after the observed and recorded test-meal, the variation at aspects such as diet, sleep, defecation, the mental status.
1.4.2 routine blood test, routine urinalysis, blood biochemistry index: the test-meal front and back are measured respectively and relatively, observing has no change.
1.4.3 skin test: the method that adopts test skin moisture, oil content and pH value
1.4.3.1 instrument: German import Skin Analyzer SH88
1.4.3.2 environment: spacious, ventilation condition is good, the inspection chamber that spatial environmentss such as temperature, humidity are stable carries out.
1.4.3.3 check point: forehead glabella.
1.4.3.4 reference standard: according to the appended standard of Skin Analyzer SH88 instrument.
Oil content: 9-27 is normal, and＜9 are low oil, and＞27 is high oil;
Moisture content: 11-20 is normal, and＜11 is hydropenia, and＞20 is sufficient moisture content;
PH value: 4.8-5.8 is normal, and＜4.8 is low value, and＞5.8 is high value.
1.4.3.5 measurand: dip in distilled water with clean cotton balls earlier and clean tested position under rest state, dry back mensuration of carrying out moisture content, oil content, pH value in 15 minutes, the front and back of test-meal test are measured work and are operated by experienced same people.2 criterions: effectively: through Instrument measuring, moisture content or oil content improve, and check has significant difference person by statistics.Invalid: moisture content or the oil content person that do not significantly improve.3 data statistic analysis
With the international SPSS10.0 of statistical software computational analysis data.Two groups are relatively, the enumeration data X 2 test, and measurement data is checked with t, and paired t-test is relatively used in front and back on the same group.4 results, 4.1 general situations: examination the trencherman change at aspect no abnormality seens such as diet, sleep, defecation, the mental status.4.2 routine blood test, blood biochemical analysis result
Main laboratory indexes relatively before and after table 1 was taken
Test-meal group observation item
T-CHOL (mg/dl) 186.32 ± 28.62 189.47 ± 24.64 triglycerides (mg/dl) 79.32 ± 34.05 83.97 ± 28.06 glutamic-pyruvic transaminase (u/l) 18.09 ± 7.09 18.47 ± 5.79 total bilirubins (mg/dl) 0.59 ± 0.15 0.72 ± 0.19 inosine (mg/dl) 0.93 ± 0.18 0.96 ± 0.14 urea nitrogen (mg/dl) 12.31 ± 1.93 13.28 ± 1.67 blood sugar (mg/dl) 89.97 ± 11.96 91.97 ± 9.44 hemoglobins (g/dl) 12.65 ± 1.58 13.01 ± 1.22 red blood cells (* 10 after observing before observing12/ l) 4.30 ± 0.29 4.45 ± 0.26 leukocyte (* 10
9/ l) 5.86 ± 1.12 6.28 ± 1.01 routine urinalysis are normal
Every index is all in normal range in the table 1.
4.3 Chest X-rays, electrocardiogram and Abdominal B type ultrasonography all belong to normal range.
4.4 skin detection result
Table 2 matched group and test-meal group skin oil content, moisture content, pH value are relatively
Oil content moisture content pH value group n
Matched group 34 16.29 ± 9.59 16.32 ± 9.43 11.76 ± 2.95 11.85 ± 3.47 4.88 ± 0.40 4.90.36 test-meal groups 34 16.24 ± 9.38 16.47 ± 8.32 11.65 ± 2.76 13.85 ± 4.11 4.90 ± 0.38 4.83 ± 0.45 after the test-meal before the test-meal after the test-meal before the test-meal after the test-meal before the test-meal
*: self compares P＜0.01 before and after the expression on the same group, #: expression test-meal group and matched group be P＜0.05 relatively
As can be seen from Table 2, the skin moisture of test-meal group increases after test-meal, significance (P＜0.05) is also arranged with comparing before the test-meal that there was a significant difference (P＜0.01) and compare difference with matched group.
5 conclusions: the volunteer with 68 routine 35-51 years of medical fitness is divided into test-meal group and blank group at random.The test-meal group was taken capsule of the present invention 30 days.The result shows: the skin moisture of test-meal group improves after test, and its moisture of skin self relatively reaches with the blank group more all has significance to improve, and shows that this product has the effect that keeps moisture of skin.Routine blood test and blood biochemistry index all do not have obvious change after experimenter's test-meal, no allergy and untoward reaction.
Product of the present invention has carried out acute toxicity test by " toxicological evaluation of food safety procedure and method ", genetic toxicity test, comprise Salmonella reversion test, mouse bone marrow cells micronucleus test, mouse sperm deformity test, mouse testis chromosomal aberration test and mice 30d feeding trial, result of the test is as follows.
After product filling stomach of the present invention gave mice, the mice of two kinds of sexes there is no obvious poisoning symptom, and animal does not have death in the 14d.Set up standard separately according to acute toxicity, this product belongs to innocuous substance.
The result of genetic toxicity tests such as the Salmonella reversion test of product of the present invention, PCEMNR micronucleus test, mouse sperm deformity test and testicular chromosome aberration test is all negative.
The result that rat 30d feeds product of the present invention shows: each experimental group animal growth is good in experimental period, indexs such as body weight, food ration, routine blood test, blood biochemistry, organ coefficient are all in normal range, and difference that there are no significant between the matched group (P＞0.05), histopathologic examination is no abnormality seen also, illustrates that this product does not have tangible toxic action to rat.
Above-mentioned experimental result shows, by oral this product, the formation of hyaluronic acid and collagen protein in the added body simultaneously, promote the hyaluronic acid of dermal layer of the skin in the body and the formation of collagen protein, significantly increase the whole skin moisture-retaining capacity, and then improving the elasticity and the gloss of skin, single clothes fish protein or hyaluronic acid have more significant skin moisturizing effect.And point out us, in a sense,, may come delaying decrepitude of skin by the maintenance skin though we can not stop skin aging.
Product of the present invention is a main component with hyaluronic acid and fish protein, and hyaluronic acid comprises its esters.As required, can add the composition that vitamin C, vitamin E, beta-carotene and Poria extract, pollen, arbutin etc. have the skin Caring function in the prescription.In product of the present invention, in same prescription, can add or add respectively a certain simultaneously or certain several mentioned component.
Composition and method of making the same of the present invention is characterized in that described preparation of compositions method is: get above-mentioned composition, by adding different adjuvants, adopt conventional production process, promptly can be made into capsule, tablet, granule or oral liquid.
The used adjuvant of capsule in the product of the present invention, tablet and granule comprises lactose, sucrose, dextrin, glucose, starch, microcrystalline Cellulose, magnesium stearate, citric acid etc.Oral liquid in the series of products of the present invention comprises solution, suspension, Emulsion and other oral fluid agent types, used adjuvant comprises antiseptic such as benzoic acid and sodium benzoate, parabens, sorbic acid etc., suspending agent such as xanthan gum, pectin, sodium alginate etc., emulsifying agent such as tween, gelatin, arabic gum etc., correctives such as syrup, citric acid etc.
The different auxiliary material that adds in each dosage form of the present invention does not influence skin Caring effect of the present invention.Therefore product of the present invention can satisfy the requirement of consumer to different dosage form.
Composition and method of making the same with maintenance moisture of skin, delaying decrepitude of skin involved in the present invention is characterized in that containing hyaluronic acid (comprising its esters) and fish protein.
Capsule of the present invention and tablet in the 100g preparation, are made up of following material and ratio range: hyaluronic acid 1～40g, fish protein 1～60g, vitamin C 0～10g, vitamin E 0～4g, beta-carotene 0～3g, arbutin 0～1g, Poria extract 0～15g, pollen 0～15g, lactose 0～20g, starch 0～20g, microcrystalline Cellulose 0～10g, magnesium stearate 0～2g.
Granule of the present invention in the 100g preparation, is made up of following material and ratio range: hyaluronic acid 1～40g, fish protein 1～60g, vitamin C 0～10g, vitamin E 0～4g, beta-carotene 0～3g, Poria extract 0～10g, arbutin 0～1g, pollen 0～15g, sucrose 0～30g, dextrin 0～30g, lactose 0～30g, glucose 0～5g, citric acid 0～2g.
Oral liquid of the present invention comprises oral liquid, Emulsion, suspension and paste etc. in 100ml, are made up of following material and ratio range: hyaluronic acid 0.01～1g, fish protein 1～30g, vitamin C 0～0.25g, vitamin E 0～0.1g, beta-carotene 0～0.1g, Poria extract 0～2g, arbutin 0～0.2g, pollen 0～3g, benzoic acid and sodium benzoate 0～0.3g, the hard esters 0～0.25g of para hydroxybenzene first, sorbic acid 0～0.2g, pectin 0～4g, sodium alginate 0～10g, arabic gum 0～15g, gelatin 0～15g, xanthan gum 0～10g, tween 0～5g, syrup 0～15g, citric acid 0～1g, all the other are distilled water.
Using method of the present invention: once a day, one time 1～4 capsules or 1～4 tablet, each 1～2 bag of granule, every bag of 1～2g, the each 20～100ml of oral liquid.
Further specify the present invention in the following embodiments, but embodiment does not limit the scope of the invention.
Embodiment 1:
Tablet of the present invention, in the 100g preparation, it is made up of following ingredients: hyaluronic acid 15g, bathypelagic fish albumen 27g, vitamin C 4g, vitamin E 2g, Poria extract 8g, lactose 25g, starch 12g, microcrystalline Cellulose 5g, magnesium stearate 2g, tablet technology is made granule routinely, tabletting, the heavy 0.25g of sheet, outsourcing light green film-coat.
Embodiment 2:
Tablet of the present invention, in the 100g preparation, it is made up of following ingredients: hyaluronic acid 35g, fish protein 35g, vitamin C 9g, vitamin E 1g, starch 15g, microcrystalline Cellulose 5g, magnesium stearate 1g, tablet technology is made granule routinely, tabletting, ballast 0.5g, the faint yellow film coating of outsourcing.
Embodiment 3:
Tablet of the present invention, in the 100g preparation, it is made up of following ingredients: hyaluronic acid 25g, fish protein 42g, beta-carotene 1g, pollen 15g, lactose 15g, magnesium stearate 1g, microcrystalline Cellulose 1g, tablet technology is made granule routinely, tabletting, the heavy 0.7g of sheet, outsourcing colorful film clothing.
Embodiment 4:
Capsule of the present invention, it is made up of following ingredients in the 100g preparation: hyaluronic acid 28g, fish protein 32g, vitamin C 10g, vitamin E 0.7g, Poria extract 10g, starch 20g, production technology is made granule routinely, divides in the hard capsule of packing into every capsules 0.25g.
Embodiment 5:
Capsule of the present invention, it is made up of following ingredients in the 100g preparation: hyaluronic acid 16g, fish protein 22g, vitamin C 5g, vitamin E 0.7g, arbutin 1g, beta-carotene 0.5g, Poria extract 15g, pollen 15g, microcrystalline Cellulose 1g, lactose 25g, production technology is made granule routinely, divides in the hard capsule of packing into every capsules 0.5g.
Embodiment 6:
Granule of the present invention, it is made up of following ingredients in the 100g preparation: hyaluronic acid 22g, fish protein 58g, vitamin C 3g, vitamin E 0.3g, Poria extract 4g, arbutin 1g, lactose 5g, glucose 5g, citric acid 0.1g, granule production technology is routinely made granule, pack, every bag of 1g.
Embodiment 7:
Granule of the present invention, in the 100g preparation, it is made up of following ingredients: hyaluronic acid 20g, fish protein 18g, beta-carotene 1g, Poria extract 10g, arbutin 0.5g, pollen 15g, lactose 15g, cane sugar powder 20g, citric acid 0.2g, the granule production technology is made granule routinely, pack, every bag of 2g.
Embodiment 8:
Oral liquid of the present invention, in the 100ml preparation, it is made up of following ingredients: hyaluronic acid 0.5g, fish protein 20g, vitamin C 0.5g, vitamin E 0.1g, sodium benzoate 0.2g, syrup 10g, all the other are distilled water, and oral liquid process is made oral liquid routinely, bottling, every bottle of 10ml.
Embodiment 9:
Suspension of the present invention, in the 100ml preparation, it is made up of following ingredients: hyaluronic acid 1g, bathypelagic fish albumen 8g, Poria extract 3g, arbutin 0.2g, sorbic acid 0.1g, tween 1g, sodium alginate 5g, xanthan gum 10g, syrup 15g, all the other are distilled water, production technology is made suspension routinely, bottling, every bottle of 20ml.
Claims (7)
1. a composition and method of making the same that keeps moisture of skin, delaying decrepitude of skin is characterized in that containing hyaluronic acid (comprising its esters) and fish protein.
2. claim 1 keeps the compositions of moisture of skin, delaying decrepitude of skin, and wherein said fish protein is the albumen that extracts from the Fish tissue.
3. claim 1 keeps the compositions of moisture of skin, delaying decrepitude of skin also can contain vitamin C, vitamin E, beta-carotene and Poria extract, arbutin and pollen.
4. claim 1 keeps the composition and method of making the same of moisture of skin, delaying decrepitude of skin, it is characterized in that described preparation of compositions method is: get above-mentioned composition, by adding different auxiliary material, production technology routinely can be made into capsule, tablet, granule or oral liquid, and wherein the adjuvant of capsule, tablet, granule comprises lactose, glucose, sucrose, starch, microcrystalline Cellulose, magnesium stearate etc.; The oral liquid adjuvant comprises xanthan gum, fruit acid, sodium alginate, syrup, citric acid, benzoic acid and sodium benzoate, para hydroxybenzene, formate ester, sorbic acid etc.
5. the compositions of claim 4 is capsule or tablet, and in the 100g preparation, it is made up of following material and ratio range: hyaluronic acid 1～40g, fish protein 1～60g, vitamin C 0～10g, vitamin E 0～4g, beta-carotene 0～3g, Poria extract 0～15g, arbutin 0～1g, pollen 0～15g, lactose 0～20g, starch 0～20g, microcrystalline Cellulose 0～10g, magnesium stearate 0～2g.Production technology is routinely made the granule of certain particle size, and tablet forming heavily is the slice, thin piece of 0.25g, the outsourcing film-coat; Or granule is encapsulated, the heavy 0.25g of every capsules.
6. compositions is a granule in the claim 4, in the 100g preparation, is made up of following material and ratio range: hyaluronic acid 1～40g, fish protein 1～60g, vitamin C 0～10g, vitamin E 0～4g, beta-carotene 0～3g, Poria extract 0～10g, arbutin 0～1g, pollen 0～15g, sucrose 0～30g, glucose 0～5g, dextrin 0～30g, lactose 0～30g, citric acid 0～2g.Production technology is made the granule of certain particle size routinely, is distributed into bag, every bag of 1g.
7. the compositions of claim 4, described oral liquid comprises oral liquid, Emulsion, suspension and paste, in the 100ml preparation, form: hyaluronic acid 0.01～1g, fish protein 0.1～30g by following material and ratio range, vitamin C 0～0.25g, vitamin E 0～0.1g, beta-carotene 0～0.1g, Poria extract 0～2g, arbutin 0～0.2g, pollen 0～3g, benzoic acid and sodium benzoate 0～0.3g, parabens 0～0.25g, sorbic acid 0～0.2g, pectin 0～4g, sodium alginate 0～10g, arabic gum 0～15g, xanthan gum 0～10g, gelatin 0～15g, tween 0～5g, syrup 0～15g, citric acid 0～1g, all the other are distilled water.Production method is made oral liquid routinely.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02123697 CN1403152A (en) | 2002-07-09 | 2002-07-09 | Composition for keeping skin's moisture and delaying skin's senility and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02123697 CN1403152A (en) | 2002-07-09 | 2002-07-09 | Composition for keeping skin's moisture and delaying skin's senility and its prepn |
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| CN1403152A true CN1403152A (en) | 2003-03-19 |
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| CN 02123697 Pending CN1403152A (en) | 2002-07-09 | 2002-07-09 | Composition for keeping skin's moisture and delaying skin's senility and its prepn |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302783C (en) * | 2004-12-24 | 2007-03-07 | 凌沛学 | Oral taking preparation for aesthetic health care and preparation method |
| CN102939106A (en) * | 2010-02-24 | 2013-02-20 | 艾瑞克有限公司 | Protein formulations |
| CN110115379A (en) * | 2018-02-06 | 2019-08-13 | 云南绿A生物工程有限公司 | Skin care compositions and its preparation method and application |
-
2002
- 2002-07-09 CN CN 02123697 patent/CN1403152A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302783C (en) * | 2004-12-24 | 2007-03-07 | 凌沛学 | Oral taking preparation for aesthetic health care and preparation method |
| CN102939106A (en) * | 2010-02-24 | 2013-02-20 | 艾瑞克有限公司 | Protein formulations |
| CN102939106B (en) * | 2010-02-24 | 2016-06-29 | 艾瑞克有限公司 | Protein formulation |
| CN110115379A (en) * | 2018-02-06 | 2019-08-13 | 云南绿A生物工程有限公司 | Skin care compositions and its preparation method and application |
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