CN1403038A - Medicated food nutrient capable of detoxicating cigarette, health cigarette and its making process - Google Patents

Medicated food nutrient capable of detoxicating cigarette, health cigarette and its making process Download PDF

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CN1403038A
CN1403038A CN02133595A CN02133595A CN1403038A CN 1403038 A CN1403038 A CN 1403038A CN 02133595 A CN02133595 A CN 02133595A CN 02133595 A CN02133595 A CN 02133595A CN 1403038 A CN1403038 A CN 1403038A
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cigarette
toxicity
dietotherapeutic
tobacco
degrading
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CN1161044C (en
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颜怀玮
易敏
颜怀璞
颜怀瑨
颜怀璋
颜怀琦
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Abstract

The medicated food nutrient is designed and prepared based on the detoxicating principle and biochemical principle in body and can reduce the harm of toxic matters produced during lighting cigarette. The medicated food nutrient consists of composite vitamins, composite trace elements and calcium agent; and may be used as food, medicine, or their additive. The health cigarette consists of the medicated food nutrient and shredded tobacco. The present invention makes it possible to reduce the harm of cigarette to active and passive smokers.

Description

Degrading toxicity of cigarette dietotherapeutic nutrient harmless cigarette and manufacture method
Technical field: the invention belongs to food, medicine and tobacco and manufacture field thereof.
Background technology:
Smoking is harmful to your health, universally acknowledged; Smoking cessation is also unrealistic by force.Although grow to even greater heights to the cry of eliminating harmfulness of smoking in countries in the world, become the world trends that gesture can not shelves, but the fact is: according to statistics, other national number of smokers of the world is about 900,000,000, add the smoker of China 300,000,000 2 thousand ten thousand, whole world number of smokers surpasses 1,200,000,000!
On May 31st, 2002 was the 16th " World No Smoking Day ".According to statistics, China has 3.2 hundred million smokers approximately at present, and being subjected to they people of smoking influence is that the involuntary smoker is then up to 700,000,000 more than.In other words, there are 55% Chinese often to live among the smog that is harmful to health approximately! The environment smoke from cigarette is classified as A level carcinogenic substance by the World Health Organization, the suffered harm of involuntary smoker and active smoker is serious equally, and bigger for the harm of many weak populations such as pregnant woman, infant: the possibility that the women suffers from the cancer of the uterus or other malignant tumour doubles, also cause easily infertile, the pregnancy period unusual, fetal abnormality or cross presenility etc.; Children Ze Yi causes feeblemindedness, brings out diseases such as meningitis, digestive system variation.The BMJ " lancet " that on April 20th, 2002 published has been delivered the scientist's of states such as Denmark and Japan investigation achievement: whether Mr. and Mrs' smoking can influence their child's sex.If smoking during preparation is born child may reduce living boy's probability.This is that scientist finds that for the first time smoking is relevant with neonate's M-F.They infer that reason may be the sperm or the easier injury that is subjected to smoking of male sex embryo of carrying Y chromosome.Smoking be we can say human body is had much more harms than benefits.
24 months-28 days August in 1997, the tenth World tobacco and healthy conference are held in Beijing, China capital.This theme of the Congress is: tobacco, the pestilence that constantly spreads.Illustrated the harmfulness of smoking to human health high level overview.President Jiang Zemin appeals in conference opening speech: the Chinese of hobby smoking will pay attention to healthy and environmental protection current " economic situation is fine, social stability " time.The extensive scholar in island says among the Secretary General of the World Health Organization: the tobacco pestilence that constantly spreads is " big fire of global village ".Appeal that " all neighbourhood " all resists this " avoidable public health disaster ".Tobacco was imported China into from the Ming Dynasty, and the harm of this World super populous nation tobacco is to allowing the startling stage of people by now.China's number of smokers total value has reached more than 300,000,000 2 thousand ten thousand people at present according to statistics.This number almost equates with the summation of number of smokers in all developed countries.Have 2.5 hundred million to be the smoker in the rural area among these 300,000,000 thickness people, this is how to allow the people bristle with anger, the huge numeral of anti-people's deep thinking.
It is not unique, but has its counterpart, in fact also not only seriously in this: the quantity of smoking population is also rising with 2% progressive increase rate every year on average, various serious diseases and death are also followed, and die from smoking as annual nearly 750,000 people of China, are to cause the maximum country of death toll because of smoking in the world.In the face of the development trend of the present smoking size of population of China and cumulative year after year thereof, it is not difficult to visualize: by 2025, now less than 20 years old Chinese teenager, will have 5000 die ten thousand deaths in the smoking diseases associated! Cigarette light harm in the smog that the back produces maximum multiple carcinogenic substance in nicotine, carbon monoxide, chloride and the tar, radio isotope, heavy metal element etc. are arranged.A tobacco leaf contains 100 milligrams of nicotines approximately.Inhale the people of half winding cigarette every day, the dosage of the radioactive element that its lung is accepted every year is equivalent to the chest x-ray perspective 300 times.As everyone knows, Smoking is harmful to your health, and smoking also endangers passive smoking crowd's health on every side.According to World Health Organization's statistics, the whole world reaches 4,000,000 more than because of the death toll that smoking causes every year.Estimation also will sharply increase in future.We know that nicotine content is not quite similar with quality of tobacco is different with processing technology in the Linear Leaf Speedwell cigarette, and general every contains the 1.5-3 milligram.What really be absorbed by the body accounts for 20%.Nicotine can damage tunica mucosa bronchiorum, causes tracheitis; Can poison brain cell, make the smoker central nervous system disease occur; Can promote the formation of cancer; Can cause blood pressure to raise, palpitating speed, even cardiac arrhythmia brings out angina pectoris, can cause stomachache and other disease of stomach.Can produce carbon monoxide 20-30 milligram during every cigarette burning.Carbon monoxide is higher 250 times than carbon dioxide with the affinity of hemoglobin.When human body sucked a large amount of carbon monoxide, carbon monoxide combined a large amount of carbon of formation and closes hemoglobin with hemoglobin, cause tissue and organ anoxic, thereby made multiple organ such as brain, heart produce damage.Tar can be attached to smoker's tracheae, bronchus and alveolar surface, produces physics, chemical stimulation, damage human respiratory organ pipe function.Tar contains multiple carcinogenic, short cancer thing.The cigarette package that burns can produce 0.24-0.28 microgram BaP, seriously brings out lung cancer.Smoker's self health care at first is to give up smoking, but smoking is as the instrument of a kind of hobby, a kind of custom, a kind of social activity, for many smoker's short-terms take leave of cigarettes still difficulty accomplish smoking in adolescents crowd especially, can't resist the temptation of cigarette on the contrary, add smoker's troop without hesitationly.So brainstrust says worriedly, in 20 years of future we will face from the challenge of tobacco relevant disease.Event actively tries every possible means to be administered, standard has become an instant international social concern, and tobacco business also suffers huge and fatal government, group and individual claim repeatly, faces extremely severe existence and destiny crisis.
Obviously, to consumer and all favourable science solution of tobacco business is development and production and sales to direct and indirect smoker's harm all very little " harmless cigarette ", obviously be consumer, tobacco manufacturer, government and various circles of society can both be generally with extensively and pleased acceptance and the thing expected.Therefore, the following tissue in the world is classified one of following nine hang-ups in the world to " harmless cigarette " as, its reason and purpose are exactly: fact proved that the effect of the administrative smoking cessation order in countries in the world is limited, " anti-smoking law " is difficult to put into effect again against the huge interests of interests in many ways especially smoker's habits and customs and psychological need and tobacco manufacturer and state tax revenue so far.
Present nearly all cigarette all is the cigarette that increases filter tip, wishes to reduce the noxious material that enters human body by the specialty fibers of filter tip or the suction-operated of activated carbon, in the hope of reaching the purpose of " harmless cigarette ".But this is difficult to accomplish: though filter tip has reduced the soakage of habituation material such as nicotine, come as if to have reduced harm outwardly to human body, actually not so, because so, the minimizing of the habituation material of smoker in will satellite, the time cycle of keeping also shortens and accelerates the frequency of smoking, thereby do not have the health-care effect of expection, increase the cigarette consumption amount on the contrary and cause bigger environmental pollution, further increase the extent of injury of " second-hand-cigarette " and increase consumer's financial burden, unique science way is the Physiology and biochemistry detoxifcation principle intrinsic according to human body, approach and material solve.
" manufacture method of drug rehabilitation health cigarette " of ZL91107211.X, with vitamin C, E, carotenoid and trace element zinc, calcium and sodium selenite etc. is raw material, be used to prevent interior vitamin of smoker's body and trace element minimizing and cause liver cancer, carcinoma of mouth, cancer of the esophagus and angiocardiopathy, smoker or involuntary smoker take the back and realize detoxifcation in the body, overcome filter-tip defective, a significant achievement of the tobacco of can yet be regarded as really.But this invention only lays particular emphasis on and solves in the cigarette combustion product the too many universality of noxious material kind and set out, and only done consideration from the common detoxifcation mode and the desired substance of liver, the BaP that endangers maximum several poisonous substances such as toxicity maximum in the cigarette combustion product is formulated special efficacy detoxifcation scheme and toxicide matter, and these are only " harmless cigarette " real urgent need and necessary key difficult problems that solve.In addition, cigarette-detoxifying being needed comprehensive fast reaction is that the system coordination of many organs and function is strengthened the property performance, provided the detoxifcation material etc. of quick conversion also to need significantly to improve.
4, summary of the invention: 4,1 goal of the invention:
The present invention is exactly to provide a kind of degrading toxicity of cigarette dietotherapeutic nutrient and harmless cigarette and manufacture method at deficiency of prior art, comprehensive utilize bio-transformation first-phase reaction, adoption of innovation fast reaction detoxifcation material and solve its source and the A wide selection of colours and designs problem, with significantly and fast raising liver, courage, enteron aisle etc. separate, the separating of toxin expelling organ, toxin expelling ability; Innovation starts and improves the comprehensive detoxifcation mechanism of uniting of liver, courage, enteron aisle, kidney and bladder; Start the bio-transformation second-phase reaction, create RE detoxifcation condition, strengthen the RE function of detoxification; Under numerous compounds that innovation produces in generally solving the cigarette combustion process and noxious material the prerequisite to human body harm problem, knowing the secondary from the primary, catch principal contradiction is that emphasis solves the crucial harm of poison of cigarette, and strengthens the detoxifcation problem of the numerous poisonous substances that solve cigarette.4,2 technical problems and solution and beneficial effect (advantage):
Untie the medicine and pharmacology principle of tobacco harm secret, lift up science and mysterious veil between tobacco and the health, not only can save the life that hundreds and thousands of ten thousand smokers slowly disappear, and can effectively contain the various illness that tobacco causes.Human to tobacco full appreciation and the struggle of the harm that brings with tobacco, relate to sociology, psychology, philosophy, medical science, pedagogy, kinematics, aesthetics, theology, historical-artistic etc.Adhere to the doctrine that everything has two aspects, accurately, science, prove tobacco with healthy equitably; Safeguard non-smoker's rights and interests; Standard juvenile healthy the civilized mode of living; Clarification a middle-aged person smoking does not have obscure understandings such as big evil; Open the mystery of the science of tobacco and health; And how to use a series of medicine and pharmacology principles, and clear up and dissolve the infringement of harmful substance health, improve the immunologic function of human body, craving for tobacco is removed on scientific and precise ground, and the radical cure pathology is contained the cigarette evil spirit.Must not " have a surplus after one's death forget to draw back one's hand, do not have at the moment road think later ", very to rethinking dawn of new hopes when having no way out and will facing the numerous difficulties that are difficult to go beyond, evening when then being! Great novelty of the present invention, marked improvement and importance are seen some from this.
1) adopt fast reaction detoxifcation material and solve its source and A wide selection of colours and designs problem, can be significantly and fast raising liver, courage, enteron aisle etc. separate, the separating of toxin expelling organ, toxin expelling ability:
For making general scientific and technical personnel better understand the present invention, be necessary the biotransformation brief introduction of liver as follows: liver is the main synthetic organ of benefit materials in the body metabolism process and main decomposition organ poisonous, harmful substance the organ that promptly detoxifies; Liver also has important excretory function, it by the secretion hepatic bile constantly with some metabolites with enter some foreign matters in the human body such as medicine, dyestuff, poisonous substance and heavy metallic salt etc. enter enteron aisle and excrete, thereby play detoxication.What be worth particularly pointing out is: some benefit materials also must be decomposed after finishing the work, otherwise understand harmful to human equally and become harmful substance, as insulin is the indispensable important benefit materials of the normal glycometabolism of human body, but just lose activity under the relevant catalysis of enzyme in liver rapidly in the effect back that plays a role, this kind process is the deactivation of hormone; Otherwise during as serious hepatopathy, insulin content increases in the blood, causes carbohydrate metabolism disturbance, and same serious harm is healthy and become harmful substance.Similarly thing is a lot, as the nosotoxic one of the main reasons of liver property brain is exactly when the serious pathology of liver, because of function of detoxification reduces, can not transform that releasing acts on amino acid by enteric bacteria and the noxious materials such as aromatic amine that produce, these materials enter in the brain with blood becomes " false neurotransmitter ", replaces and disturbs the effect of normal neurotransmitter catecholamine and cause neural mental symptom.This shows the importance of liver organ and function of detoxification thereof and the relativity of popularity and benefit materials.Obviously, finish task of the present invention, at first be that to protect liver organ, improve its vigor be liver function, could ensure and improve its detoxification ability.
The present invention adopts to transform and is used to the fast reaction detoxifcation material that detoxifies immediately and solves source and A wide selection of colours and designs problem, and can allow body reserve and conversion with " preparing for any eventuality " in advance by modes such as oral food of the present invention, medicines, thereby receive beyond thought outstanding effects such as starting and improve detoxifcation organ such as liver and function of detoxification immediately, could adapt to answer up elimination smoking, drinking produces the requirement of harm immediately to human body.
2) create RE detoxifcation condition, can receive and strengthen RE function of detoxification, startup and improve the comprehensive serial beyond thought great useful outstanding effect such as detoxifcation mechanism of uniting of liver, courage, enteron aisle, kidney and bladder:
Kidney is the useless or unnecessary material of human body and poisonous, the main excretory organs of harmful substance, and be to be carrier and solvent with water, no matter and the active of renal tubule or passive reabsorption all are selectively, promptly the heavy absorbability of different materials there is very big difference, be called selective reabsorption, the material that promptly has the water-soluble structure characteristics can relatively waltz through renal tubule and excrete with urine, material major part by renal tubule time the with fat-soluble design feature is heavily absorbed again to be difficult to excrete, and eventually the composition of urine is exactly that human body needs maybe can clear out of external material on substantially.Therefore, solving after noxious material detoxifies in liver, discharges some poisonous substance problems by courage and enteron aisle, the water-soluble problem that also must solve remaining metabolite is external to exclude by kidney smoothly, just can reach the final purpose that the present invention separates the numerous poisonous substances of cigarette.To this, application must be paid much attention to and use for reference to the relativity theoretical value of aforesaid " benefit materials ", otherwise, as these materials can not excrete rapidly, overheap in vivo, no matter it is this moment, whether itself was harmful to health, all can serious harm healthy.
Adoption of innovation of the present invention can generate simultaneously in liver and can carry out dissimilar oxidations by the multiple organic substance of catalysis, reduction reaction, so very important both can supply H, can be subjected to the nicotinic acid of the constituent of the NAD of H and NADP again, so can start the intrinsic oxidation of detoxifcation organs such as liver simultaneously, reduction, serial chain reaction such as hydrolysis, it is the first-phase reaction of bio-transformation, end-product mostly is alcohol soluble in water, phenol, amine, the product that acid is perhaps polyhydroxylated and water-soluble, pass through courage easily, enteron aisle and kidney, bladder excretes, and is enough to solve especially water-soluble structure harm of poison problem of majority.
3) further start the bio-transformation second-phase reaction, promptly various association reactions solve the crucial harm of poison of cigarette with emphasis, and strengthen the detoxifcation problem of the numerous poisonous substances that solve the smoking generation:
The present invention is above-mentioned 1) and 2) generally solve on the numerous compounds and the basis of noxious material to human body harm problem that produce in the cigarette combustion process, further start the bio-transformation second-phase reaction again, be various association reactions, solve the crucial harm of poison of cigarette with emphasis.Association reaction-hydration reaction as the great chemical carcinogen-BaP of power in cigarette combustion and other source, just can make because of hydroxyl is not water insoluble, can not excrete and endanger nucleic acid intrinsic property and function so that cause genetic material mutation and the fat-soluble BaP of canceration takes place, be converted to water-soluble, the aquation BaP that easily excretes and solve it to toxicity of human body and seriously fatal (cancer) problem, liposoluble substances such as other main poisonous substance that cigarette produces such as tar, also can be releasings such as association reaction or lower its toxicity by the bio-transformation second-phase reaction, thereby reach the purpose that emphasis solves the crucial harm of poison of cigarette, and strengthen the detoxifcation problem of the numerous poisonous substances that solve the smoking generation.
4) avoid or significantly alleviate the duality of biotransformation detoxifcation and intoxicating, biotransformation is carried out to the detoxifcation aspect all the time:
Very big change can take place in the biologically active of various materials in biotransformation, the perform toxic attenuation that has, the toxicity that has can strengthen on the contrary, so can not generally regard biotransformation as " detoxication ", detoxifcation can transform under different situations with this a pair of contradiction of intoxicating.Still the extremely toxic substance BaP that produces with cigarette combustion is an example: the interior experiment of external and body has all proved the converted product 7 of BaP, 8,9,10-tetrahydrochysene-9,10 epoxy BaP glycol can combine with 2 bit aminos of guanine base by covalent bond really and cause gene mutation and carcinogenic, and this product is exactly by above-mentioned aquation BaP oxygenation again.
Many fast reaction antioxidant vitamin A, vitamin C, vitamin E that the present invention adopts and trace elements of selenium, the zinc synergy that significantly improves oxidation resistance are enough to block these oxidation reactions fast and reach biotransformation is carried out to the detoxifcation direction all the time; Can recognize further also that thus liver of the present invention, courage, enteron aisle, kidney, the comprehensive associating of bladder are in time separated, the great novelty and the practicality of toxin expelling object space case.
5, the specific embodiment:
Degrading toxicity of cigarette dietotherapeutic nutrient of the present invention is made of jointly B B-complex, composite trace element and calcium agent.Its raw material consumption is by weight:
B B-complex 20-30 part,
Composite trace element 1-3 part,
Calcium agent 30-60 part;
Harmless cigarette of the present invention is made up of degrading toxicity of cigarette dietotherapeutic nutrient and cigarette cut tobacco.Its raw material consumption is by weight:
Degrading toxicity of cigarette dietotherapeutic nutrient product 0.5-1%, cigarette cut tobacco 99.5-99%.
The manufacture method of degrading toxicity of cigarette dietotherapeutic nutrient of the present invention and harmless cigarette is:
1) manufacturing of B B-complex:
Get retinol1 0-20 part, Cobastab 15-10 part, Cobastab 122-6 part, vitamin C 50-100 part, VD1-2 part, vitamin E2 0-50 part, nicotinic acid 10-15 part, pantothenic acid 15-30 part, porphyrize is the end in the glass mortar, airtight keep in Dark Place standby.
This used various raw material also can adopt the identical kind of other function among Pharmacopoeia of People's Republic of China version in 2000, GB2760-1996, the GB14880-94 to substitute or share, but should be above-mentioned various raw-material consumptions by its active ingredient conversion.
2) manufacturing of composite trace element:
Get sodium selenate 1-2 part, zinc lactate 20-30 part, ferrous gluconate 10-20 part, copper gluconate 5-10 part, porphyrize is the end in the glass mortar, and airtight preservation is standby.
This used various raw material also can adopt the identical kind of other function among Pharmacopoeia of People's Republic of China version in 2000, GB2760-1996, the GB14880-94 to substitute or share, but should be above-mentioned various raw-material consumptions by its active ingredient conversion.
3) manufacturing of calcium agent:
Get calcium chloride 30-60 part, grind well in the glass mortar, airtight moistureproof preservation is standby.
This used calcium agent also can adopt the identical kind of other function among Pharmacopoeia of People's Republic of China version in 2000, GB2760-1996, the GB14880-94 to substitute or share, but should be above-mentioned various raw-material consumptions by its active ingredient conversion.
4) manufacturing of degrading toxicity of cigarette dietotherapeutic nutrient:
Get B B-complex 20-30 part, composite trace element 1-3 part and calcium agent 30-60 part, porphyrize is the end in the glass mortar, by different requirement specification airtight packages, keep in Dark Place, promptly get finished product, confession is directly edible, medicinal or as food, medicine host or additive, consumption is pressed GMP-ordinary production needs.
5) manufacturing of harmless cigarette:
Degrading toxicity of cigarette dietotherapeutic nutrient is pressed the 0.1-0.5% of cigarette cut tobacco weight, and the process that adds essence by cigarette cut tobacco evenly joins in the pipe tobacco, makes finished cigarette, for sucking usefulness.
Embodiment:
1, get 30 parts of 20 parts of B B-complexes, 1 part of composite trace element and calcium agent, porphyrize is the end in the glass mortar, becomes 0.3-0.5 gram/grain specification with food-grade or pharmaceutical grade gelatins encapsulated, is used as food, medicine.
2, degrading toxicity of cigarette dietotherapeutic nutrient among the embodiment 1 is pressed 0.3% of cigarette cut tobacco weight, the process that adds essence by cigarette cut tobacco evenly joins in the pipe tobacco, makes harmless cigarette.
Understand for saving the specification length and being convenient to, the beneficial effect in aforementioned summary of the invention, concentrate the scientific and technological principle of replenishing some important beneficial effects and foundation again and briefly explain as follows:
The present invention adopts vitamin A to replace the class Hu square-bottomed bamboo basket Bu Su of ZL91107201.X, be because liver store with detoxifcation usefulness all be vitamin A, but not class Hu square-bottomed bamboo basket Bu Su, class square-bottomed bamboo basket Bu Su recklessly is stored in the adipose tissue, generally metabolism with fat, and lipometabolic characteristics be exactly the time slow, the process complexity, assemble usefulness in being difficult in short-term in a large number for urgent need, and class recklessly square-bottomed bamboo basket Bu Su to be converted into the characteristics of vitamin A similar to the fat metabolism, also very consuming time, these all be difficult to adapt to degrading toxicity of cigarette or other detoxifcation fast reaction and in short-term in consumption very big must be in advance enough requirements of using of storage preemergency, in addition, the physiology of class Hu square-bottomed bamboo basket Bu Su is tired, and only the 1/6-1/7 event consumption for vitamin A is big, colouring power is extremely strong, and someone thinks that the vitamin A of class Hu square-bottomed bamboo basket Bu Su conversion is different with the natural vitamin A role, and all outward appearance and the promptly emergent detoxification ability influence of quality to harmless cigarette is bigger for these; Adopt vitamin D be for the storage that improves calcium and free function so that more preferably be equipped with the emergency requirement service, and can prevent and treat generally serious again acalcicosis; Adopt Cobastab 1Be to change the indispensable important coenzyme of metabolism such as diphosphothiamine into because of it; Adopt Cobastab 12Be because of itself and folic acid (because of enteric microorganism can be synthesized, also be rich in the green vegetable etc., generally have no lack of so the present invention does not compensate, to simplify material composition) transport together that labile methyl group participates in the metabolism of one carbon unit in the body and the normal expression that is beneficial to the synthetic and function of extremely important benefit materials such as nucleic acid, protein, choline, phosphatide, as the opposing poisonous substance as the aforementioned BaP to the harm of gene and canceration, to help liver to shift out fatty to prevent and treat fatty liver etc.; Adopt sodium selenate to replace the sodium selenite among the ZL91107201.X to be that it is more stable, the few raw material consumption of selenium content is big, to be more conducive to its even distribution in product of the present invention, better effects if also reduces the difficulty of production technology and effectively ensures security of products of the present invention; Zinc sulfate among the employing zinc lactate replacement ZL91107201.X etc. is because its absorption is best at the soonest, lactate also is the normal energy of human body, and its weak acid performance is the vitamin C that easily lost efficacy because of oxidation Decomposition of protection and the destructive and bad mouthfeel (this is very crucial to tobacco sucking quality) of strong acid of sulfate radical-free effectively; Adopt ferrous gluconate to be because iron is the constituent of cytochrome system and catalase, peroxidase, they are to play vital series effect in the bio-transformation first-phase reaction process in biological oxidation, and human body iron deficiency often, ferrous gluconate is than the better also easily dissolving absorption of other chalybeate mouthfeel, and the metabolism of glucose acid group is easy, product is CO 2With water, simply nontoxic, and can be made for the energy and the No Assets waste; Adopt copper gluconate to be because copper is serial oxidasic constituent or active essential by it, seemingly promote the ability of separating cigarette series poisonous substance that biological oxidation is the bio-transformation first-phase reaction equally with iron phase, scarce copper also makes in the ferritin utilization of iron be obstructed, make the increase of liver concentration of iron and be prone to hemosiderosis and anaemia, all the other same ferrous gluconates; Adopting calcium chloride to replace calcium lactate etc. among the ZL91107201.X is to consider its dissolubility high (1.5ml water is with regard to solubilized 1 gram calcium chloride under the room temperature, boiling water only needs 0.7ml water especially), be very easily to absorb and the agent of rapid-action ionized calcium, and be that the edible nutrition fortifier of GB14880-94 approval is so can't restrain obstacle equally, and its pH value is very wide, from 4.5-8.5, so be again good acidity regulator and buffer, be particularly conducive to and add in the pipe tobacco in order to make harmless cigarette and to be beneficial to guaranteeing the quality of tobacco product, or good drier, can prevent the finished cigarette moisture absorption and quality descends or go mouldy, and these by chance all are a lot of difficult problems that cigarette faces, especially rainy season and southern humid area, be beneficial to prolongation value preserving phase and shelf life, this is for requiring cigarette must indicate that the cry of the term of validity grows to even greater heights even become more important today of " facing a charge in court ".

Claims (8)

1, a kind of degrading toxicity of cigarette dietotherapeutic nutrient is characterized in that being made up of jointly B B-complex, composite trace element and calcium agent.
2, degrading toxicity of cigarette dietotherapeutic nutrient is characterized in that the raw material consumption is by weight:
B B-complex 20-30 part;
Composite trace element 1-3 part;
Calcium agent 30-60 part.
3, the manufacture method of degrading toxicity of cigarette dietotherapeutic nutrient is:
3, the manufacturing of 1 B B-complex:
Get retinol1 0-20 part, Cobastab 15-10 part, Cobastab 122-6 part, vitamin C 50-100 part, VD1-2 part, vitamin E2 0-50 part, nicotinic acid 10-15 part, pantothenic acid 15-30 part, porphyrize is the end in the glass mortar, airtight keep in Dark Place standby;
When this used various raw material adopt the identical equivalent kind of other function among Pharmacopoeias of People's Republic of China version in 2000, GB2760-1996, the GB14880-94 to substitute or share, should be above-mentioned various raw-material consumptions by the conversion of equivalent kind active ingredient;
3, the manufacturing of 2 composite trace elements:
Get sodium selenate 1-2 part, zinc lactate 20-30 part, ferrous gluconate 10-20 part, copper gluconate 5-10 part, porphyrize is the end in the glass mortar, and airtight preservation is standby;
When this used various raw material adopt the identical equivalent kind of other function among Pharmacopoeias of People's Republic of China version in 2000, GB2760-1996, the GB14880-94 to substitute or share, should be above-mentioned various raw-material consumptions by the conversion of equivalent kind active ingredient;
3, the manufacturing of 3 calcium agent:
Get calcium chloride 30-60 part, grind well in the glass mortar, airtight moistureproof preservation is standby;
When this used various raw material adopt the identical equivalent kind of other function among Pharmacopoeias of People's Republic of China version in 2000, GB2760-1996, the GB14880-94 to substitute or share, should be above-mentioned various raw-material consumptions by the conversion of equivalent kind active ingredient;
3, the manufacturing of 4 degrading toxicity of cigarette dietotherapeutic nutrients:
Get B B-complex 20-30 part, composite trace element 1-3 part, calcium agent 30-60 part, porphyrize is the end in the glass mortar, by different requirement specification airtight packages, finished product, keep in Dark Place.
4, a kind of harmless cigarette is characterized in that being made up of degrading toxicity of cigarette dietotherapeutic nutrient and cigarette cut tobacco.
5, harmless cigarette is characterized in that the raw material consumption is by weight:
Degrading toxicity of cigarette dietotherapeutic nutrient product 0.5-1%, cigarette cut tobacco 99.5-99%.
6, the manufacture method of harmless cigarette is characterized in that:
Degrading toxicity of cigarette dietotherapeutic nutrient is pressed the 0.1-0.5% of cigarette cut tobacco weight, and the process that adds essence by cigarette cut tobacco evenly joins in the pipe tobacco, makes finished cigarette.
7, the purposes of degrading toxicity of cigarette dietotherapeutic nutrient is characterized in that as food, medicine; As food, medicine host or additive, consumption is pressed GMP-ordinary production needs.
8, the purposes of harmless cigarette is characterized in that as sucking food.
CNB021335958A 2002-08-09 2002-08-09 Medicated food nutrient capable of detoxicating cigarette, health cigarette and its making process Expired - Fee Related CN1161044C (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101584475A (en) * 2009-06-22 2009-11-25 常州生奥基因生物科技有限公司 Smoker nutrition health-care natural biological combination
CN102475354A (en) * 2010-11-19 2012-05-30 红塔烟草(集团)有限责任公司 Application of vitamin B3-vitamin E ester in tobacco product and tobacco product
CN102499449A (en) * 2011-11-03 2012-06-20 湖南中烟工业有限责任公司 Reconstituted tobacco capable of reducing content of nitrosamine in mainstream smoke of cigarettes, and preparation method and application method for reconstituted tobacco
CN104305223A (en) * 2014-09-29 2015-01-28 于惊涛 Nutrient supplement composition suitable for smokers

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101584475A (en) * 2009-06-22 2009-11-25 常州生奥基因生物科技有限公司 Smoker nutrition health-care natural biological combination
CN101584475B (en) * 2009-06-22 2014-01-08 常州生奥基因生物科技有限公司 Smoker nutrition health-care natural biological combination
CN102475354A (en) * 2010-11-19 2012-05-30 红塔烟草(集团)有限责任公司 Application of vitamin B3-vitamin E ester in tobacco product and tobacco product
CN102499449A (en) * 2011-11-03 2012-06-20 湖南中烟工业有限责任公司 Reconstituted tobacco capable of reducing content of nitrosamine in mainstream smoke of cigarettes, and preparation method and application method for reconstituted tobacco
CN102499449B (en) * 2011-11-03 2013-10-23 湖南中烟工业有限责任公司 Reconstituted tobacco capable of reducing content of nitrosamine in mainstream smoke of cigarettes, and preparation method and application method for reconstituted tobacco
CN104305223A (en) * 2014-09-29 2015-01-28 于惊涛 Nutrient supplement composition suitable for smokers

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