CN1401344A - Chinese medicine gel for treating cervicitis and cervical erosion, and preparing method thereof - Google Patents
Chinese medicine gel for treating cervicitis and cervical erosion, and preparing method thereof Download PDFInfo
- Publication number
- CN1401344A CN1401344A CN 01126561 CN01126561A CN1401344A CN 1401344 A CN1401344 A CN 1401344A CN 01126561 CN01126561 CN 01126561 CN 01126561 A CN01126561 A CN 01126561A CN 1401344 A CN1401344 A CN 1401344A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- cervicitis
- catechu
- gel
- cervical erosion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 206010008323 cervicitis Diseases 0.000 title claims abstract description 26
- 230000003628 erosive effect Effects 0.000 title claims abstract description 25
- 208000006374 Uterine Cervicitis Diseases 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title description 4
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 41
- 239000000284 extract Substances 0.000 claims abstract description 37
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 35
- 244000080767 Areca catechu Species 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 16
- 239000002253 acid Substances 0.000 claims abstract description 8
- 239000002798 polar solvent Substances 0.000 claims abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims description 22
- 229930013930 alkaloid Natural products 0.000 claims description 15
- 244000235603 Acacia catechu Species 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 230000004907 flux Effects 0.000 claims description 7
- 235000018553 tannin Nutrition 0.000 claims description 7
- 229920001864 tannin Polymers 0.000 claims description 7
- 239000001648 tannin Substances 0.000 claims description 7
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 claims description 6
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 6
- 235000005487 catechin Nutrition 0.000 claims description 6
- 229950001002 cianidanol Drugs 0.000 claims description 6
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims description 6
- 235000012734 epicatechin Nutrition 0.000 claims description 6
- 229920002521 macromolecule Polymers 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000013019 agitation Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 229910017604 nitric acid Inorganic materials 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- 241000219784 Sophora Species 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 description 18
- 210000001215 vagina Anatomy 0.000 description 7
- 230000009471 action Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000829 suppository Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 238000005411 Van der Waals force Methods 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000003679 cervix uteri Anatomy 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 201000003988 chronic cervicitis Diseases 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000001050 pharmacotherapy Methods 0.000 description 2
- 238000000554 physical therapy Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 239000006216 vaginal suppository Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 description 1
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001572 anti-trichomonad Effects 0.000 description 1
- 230000035587 bioadhesion Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 102000015694 estrogen receptors Human genes 0.000 description 1
- 108010038795 estrogen receptors Proteins 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229960001660 histamine phosphate Drugs 0.000 description 1
- ZHIBQGJKHVBLJJ-UHFFFAOYSA-N histamine phosphate Chemical compound OP(O)(O)=O.OP(O)(O)=O.NCCC1=CNC=N1 ZHIBQGJKHVBLJJ-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 229930014456 matrine Natural products 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229920003168 pharmaceutical polymer Polymers 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011265612A CN1167446C (en) | 2001-08-28 | 2001-08-28 | Chinese medicine gel for treating cervicitis and cervical erosion, and preparing method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011265612A CN1167446C (en) | 2001-08-28 | 2001-08-28 | Chinese medicine gel for treating cervicitis and cervical erosion, and preparing method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1401344A true CN1401344A (en) | 2003-03-12 |
CN1167446C CN1167446C (en) | 2004-09-22 |
Family
ID=4666575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB011265612A Expired - Fee Related CN1167446C (en) | 2001-08-28 | 2001-08-28 | Chinese medicine gel for treating cervicitis and cervical erosion, and preparing method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1167446C (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102526170A (en) * | 2011-12-31 | 2012-07-04 | 许学志 | Catechu extract composition for resisting tubercle bacillus, preparation method of catechu extract composition, pharmaceutical preparation containing catechu extract composition, and application of catechu extract composition |
CN104510767A (en) * | 2013-10-08 | 2015-04-15 | 广西壮族自治区花红药业股份有限公司 | Gel preparation for treating cervicitis and cervical erosion and preparation method thereof |
CN110354182A (en) * | 2019-08-12 | 2019-10-22 | 南京依美生物科技有限公司 | It is a kind of to treat gynaecology's reparation gel and preparation method thereof that cervical squamous intraepithelial turns up |
CN110433284A (en) * | 2019-08-07 | 2019-11-12 | 广东圆康再生医学科技开发有限公司 | A kind of composition that treating cervicitis, gelling agent and preparation method thereof |
-
2001
- 2001-08-28 CN CNB011265612A patent/CN1167446C/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102526170A (en) * | 2011-12-31 | 2012-07-04 | 许学志 | Catechu extract composition for resisting tubercle bacillus, preparation method of catechu extract composition, pharmaceutical preparation containing catechu extract composition, and application of catechu extract composition |
CN102526170B (en) * | 2011-12-31 | 2015-04-29 | 许学志 | Catechu extract composition for resisting tubercle bacillus, preparation method of catechu extract composition, pharmaceutical preparation containing catechu extract composition, and application of catechu extract composition |
CN104510767A (en) * | 2013-10-08 | 2015-04-15 | 广西壮族自治区花红药业股份有限公司 | Gel preparation for treating cervicitis and cervical erosion and preparation method thereof |
CN110433284A (en) * | 2019-08-07 | 2019-11-12 | 广东圆康再生医学科技开发有限公司 | A kind of composition that treating cervicitis, gelling agent and preparation method thereof |
CN110354182A (en) * | 2019-08-12 | 2019-10-22 | 南京依美生物科技有限公司 | It is a kind of to treat gynaecology's reparation gel and preparation method thereof that cervical squamous intraepithelial turns up |
Also Published As
Publication number | Publication date |
---|---|
CN1167446C (en) | 2004-09-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN113133991B (en) | Colchicine soluble microneedle patch and preparation method thereof | |
CN101297973B (en) | Highly bioadhesive and thermosensitive hydrogel, and preparation method and application thereof | |
CN101648007B (en) | Pharmaceutical composition for treating ulcus cruris and preparation method thereof | |
CN103462883B (en) | Matrine diatomic alcohol plastid temperature-sensitive gel and preparation method thereof | |
Zhou et al. | Improved efficacy of Panax notoginseng saponin loaded into BSP/alginate microspheres for the treatment of alcoholic gastric ulcers | |
CN1272038C (en) | Preparation of Chinese medicinal suppository for treating female chronic cervicitis | |
CN1742938A (en) | Lifukang medicine for vagina and preparing method thereof | |
CN101874809A (en) | Local anti-inflammatory external medicinal composition using glycerol DMSO mixed solvent | |
CN1167446C (en) | Chinese medicine gel for treating cervicitis and cervical erosion, and preparing method thereof | |
CN1903289A (en) | Gel for treating hemorrhoidal anus and rectum diseases, and its prepn. method | |
CN1562142A (en) | Chinese medicinal gels for treating vaginitis, cervicitis and cervical erosion and its preparing method | |
Li et al. | Application of traditional Chinese medicine in film drug delivery system | |
CN1781503A (en) | Ilex pubescens extract for treating angitis and its preparation | |
CN110507712B (en) | Externally applied Chinese pulsatilla root extract for treating arthritis and preparation method thereof | |
CN105147827B (en) | A kind of antibacterial medicines and preparation method thereof | |
CN1660353A (en) | Gel of Chinese traditional medicine for treating cervicitis, colpitis and preparing method | |
CN1660059A (en) | Composite liposome of vitaminaacid as well as preparation method and application | |
CN101513478B (en) | External application ointment for treating III stage angiitis | |
CN1293893C (en) | Gel of Chinese traditional medicine and preparation method | |
CN1965893A (en) | Liquid formulation for treating allergic rhinitis | |
CN103271984B (en) | Preparation method and application of sophora alopecuroides total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation | |
CN101919799B (en) | Novel sustained-release transdermal medicament delivery system | |
CN102258456A (en) | Gel containing antifungal drug and preparation method thereof | |
CN117064841A (en) | Rectal in-situ heating gel composition for treating chronic prostatitis and preparation method and application thereof | |
CN115645380A (en) | Anti-synovitis microneedle patch and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI ZHONGDA SHUGUANG MEDICAL RESEARCH DEVELO Free format text: FORMER OWNER: SHANGHAI UNIV. OF TRADITIONAL CHINESE MEDICINE Effective date: 20051111 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20051111 Address after: 200021 Shanghai city Pu Road No. 189 Shuguang Building 5 floor A block Patentee after: Shanghai University of Chinese Medicine Shuguang Medicine Research and Development Co., Ltd. Address before: 200032 No. 530, Lingling Road, Shanghai Patentee before: Shanghai University of Traditional Chinese Medicine |
|
ASS | Succession or assignment of patent right |
Owner name: HUAHONG PHARMACEUTICAL CO., LTD., GUANGXI Free format text: FORMER OWNER: SHANGHAI ZHONGDA SHUGUANG MEDICAL RESEARCH DEVELOPMENT CO., LTD. Effective date: 20060210 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20060210 Address after: 545007 No. 74 Hongguang Road, Guangxi, Liuzhou Patentee after: Guangxi Huahong Pharmaceutical LLC Address before: 200021 Shanghai city Pu Road No. 189 Shuguang Building 5 floor A block Patentee before: Shanghai University of Chinese Medicine Shuguang Medicine Research and Development Co., Ltd. |
|
C56 | Change in the name or address of the patentee |
Owner name: GUANGXI HUAHONG PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME OR ADDRESS: HUAHONG PHARMACEUTICAL CO., LTD., GUANGXI |
|
CP01 | Change in the name or title of a patent holder |
Address after: No. 74 Hongguang Road, Guangxi, Liuzhou Patentee after: Guangxi Huahong Pharmaceutical Co., Ltd. Address before: No. 74 Hongguang Road, Guangxi, Liuzhou Patentee before: Guangxi Huahong Pharmaceutical LLC |
|
DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Lu Zhou Document name: payment instructions |
|
DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Lu Zhou Document name: Notice of termination of patent right |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040922 Termination date: 20200828 |