CN1395964A - 西蒙得木油的医药用途 - Google Patents

西蒙得木油的医药用途 Download PDF

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CN1395964A
CN1395964A CN02141299A CN02141299A CN1395964A CN 1395964 A CN1395964 A CN 1395964A CN 02141299 A CN02141299 A CN 02141299A CN 02141299 A CN02141299 A CN 02141299A CN 1395964 A CN1395964 A CN 1395964A
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simmondsia
simmondsia oil
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CN1275606C (zh
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纳比勒·萨迪克·埃尔·穆吉
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Egyptian Natural Oil Co Ltd (natoil)
South Egypt Drug Industries Co SEDICO
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Abstract

本发明涉及西蒙得木油及其提取方法，以及含有西蒙得木油的组合物及其医药用途，所述西蒙得木油的特征在于对皮肤和粘膜无刺激和无过敏作用，所述西蒙得木油具有润滑、润湿和润肤，以及抗菌、抗炎和抗氧化性质，所述西蒙得木油具有较高复原性，改善血液循环，和对角质层较高穿透性的性质。

Description

西蒙得木油的医药用途
本发明涉及西蒙得木油及其提取方法，以及含有西蒙得木油的组合物及其医药用途。
现有技术
西蒙得木油可用于发动机的润滑，并可加入化妆品制剂中。技术缺乏的问题和要点
这里不存在问题。西蒙得木油的在先应用不涉及本发明想要保护的新用途。
发明详细说明
天然西蒙得木油是从西蒙得木灌木{Simmondsia Chinensis(LINK)Schnieder}的种子中提取得到的。所述西蒙得木油由单不饱和长链脂肪酸和脂肪醇的直链酯构成，并且所述西蒙得木油平均碳链总长为42个碳原子，因此其化学分类为液体蜡。
所述西蒙得木油完全由高分子量的直链单烯酸和单烯醇形成的酯构成。
所述的不饱和酸是二十烷酸(C20)和二十二烷酸(C22)的混合物，其中含有少量棕榈油酸(C18)和油酸(C16)。所述的不饱和醇是二十烷醇和二十二烷醇的混合物，其中含有少量二十六烷醇和低分子量醇。
所述西蒙得木油是非挥发性的，并且不会发生酸败，这部分归因于其中存在的微量组分生育酚(天然抗氧剂)，主要还是因其蜡状结构(其仅含一个醇基团，因此不会发生氧化，从而不会出现酸败)。此外，研究表明西蒙得木油具有可增进在角质层中渗透作用的6项普遍因素：低粘度，高不饱和度，低皂化数，碳链长度短，卵磷脂含量低(西蒙得木油不含卵磷脂)，直链分子和支链酯。
所述西蒙得木油有助于避免皮肤早老化的两项重要因素：干燥和脂类过氧化。所述西蒙得木油可用作优异的非隔离性滋润剂，所述滋润剂可促进皮肤的弹性和柔软性。同时，所述西蒙得木油特殊的不粘腻的涂布性和光滑性可获得极富轻软光滑的使用感。
所述西蒙得木油的特征在于其中50％含量的部分是不可皂化的(三萜烯醇和植物甾醇)，而其他植物油仅含2-3％不可皂化部分，不可皂化部分用于皮肤时可促进弹性蛋白的形成，从而增进皮肤的光泽、弹性和完整性。此外，其具有皮肤保护性，抗过敏性，抗感染性，可产生细胞刺激作用，具有皮肤再生作用和抗炎作用。
经证实，所述西蒙得木油具有抗炎作用和抗微生物作用。包括金黄色酿脓葡萄球菌和绿脓假单胞菌在内的5种最常见的细菌、以及真菌白色念珠菌都不能在西蒙得木油中生长。
所述西蒙得木油的pH值平衡，并能表现出对干燥和受损皮肤的有益效果。
西蒙得木油的提取
1、西蒙得木种子的含油量为50-55％(重量)。
2、提取西蒙得木油的第一步是在从1 Ton/Inch逐渐达到35-38Ton/Inch的压力下对碎化的种子进行压榨。
3、由第一步制得占种子重量26-28％(重量)的油，其被称为第一步油，所述第一步油适用于医药应用。
4、对经压榨的种子残渣进行分离和研磨，然后在高至100Ton/Inch的压力下再次榨取，提取得到第二步油，所述第二步油可应用于化妆品或其他领域。所得到的这种油也称为第二步油。
5、所述油(第一步油和第二步油)经一定时间淘析。
6、通过4级过滤器对所述油进行过滤。然后对所得的油进行一定时间的淘析。
7、采用比第一次使用的所述4级过滤器级别更高的4级过滤器对所得的油进行再过滤，获得医用的最终油。
8、第一步所提取的油的性能比普通油优异，特别是表现在医药效果上。
新主题：
西蒙得木油可用于治疗以下疾病：
A-皮肤病：
A-1其于水杨酸共用可有效用于牛皮癣、头屑、痤疮和鳞癣病的
治疗。
A-2其与氧化锌共用可有效治疗尿布皮炎、皮疹、过敏性皮炎和念珠菌感染。
A-3昆虫叮咬的治疗。
A-4脚趾真菌感染的治疗。
A-5保护皮肤免受非传染性致敏材料如液体洗涤皂的作用。
A-6其可有效用于兽疥癣的治疗。
A-7治疗一度烧伤和阳光灼伤。
A-8在日晒过程中保护皮肤免受紫外线损伤。
A-9用于伤口的第一助剂，以及用于治疗发炎的伤口，并以促进愈合为首要目的。
A-10褥疮的治疗。
A-11其有助于治疗斑秃和rogenetica。
A-12抑制头虱。
A-13其可有效用于单纯性口疮(唇疮疹)的治疗。
A-14其可有效用于糖尿病性损伤特别是糖尿病性脚癣(diabeticfoot)的治疗。
B-西蒙得木油可用于治疗牙龈炎和牙痛：
B-1其与盐酸利多卡因共用可有效治疗周期性口疮性溃疡。
B-2其可用于牙膏这用于治疗牙龈炎和改善牙周状况。
B-3其与氧化锌共用可有效用于牙齿的暂时填充。
B-4其可有效用于作为化疗和放疗副作用的干槽症的治疗。
C-风湿痛和关节炎：
C-1治疗和缓解多发性关节炎、风湿痛、关节痛和脊椎炎。
C-2增进理疗疗效，并且除消除应力和痉挛之外还有助于身体恢复其物理机能。
D-其可有效用于外耳炎和中耳炎的治疗：
E-对眼病的治疗：
E-1其可有效用于血栓症的治疗。
F-普通外科：
F-1其可以栓剂形式有效用于急慢性肛裂和肛瘘的治疗。
F-2前列腺炎的治疗。
F-3冻伤(Hiemorroids)(二度)的治疗。
F-4早期静脉曲张的治疗。
G-妇产科：
G-1以阴道栓的形式用于阴道炎的治疗。
G-2用于缓解痛经。
G-3用于乳头裂的治疗，并能促进愈合。
应用方法：
可通过加入其他药物应用西蒙得木油。用于使新药达到更好的疗效而不产生副作用。实施例如下：
1-将含有10％西蒙得木油和0.5％盐酸利多卡因的组合物用于治疗口腔粘膜炎症和因长期使用抗生素造成的症状。
2-将含有50％西蒙得木油和2％水杨酸的组合物的软膏剂用于治疗痤疮、牛皮癣、头屑、皮脂溢(皮脂腺的异常过度分泌)和鳞癣(表皮角质层变硬并持续脱皮)。
3-将含有50％西蒙得木油和8％氧化锌的组合物用于治疗皮疹和过敏性皮炎。
4-将含有20％西蒙得木油的栓剂用于治疗肛裂。
5-将含有20％西蒙得木油的阴道栓用于治疗非传染性阴道炎。
由上述有益效果可以清楚地知道，对于各种形式和情况，西蒙得木油在治疗各种疾病时均不会对人体和环境产生任何副作用。

Claims (15)

1、一种西蒙得木油的提取方法，所述方法在从1Ton/Inch逐渐达到3538Ton/Inch的压力下，通过对西蒙得木油已碎化的种子进行压榨制得第一步油，然后残渣再经碎化，并在高至100Ton/Inch的压力下再次榨取制得第二步油，所述第一步油和第二步油经过不同级别过滤器的过滤，所述第一步油可用于在制备治疗不同疾病的药物中的应用。
2、如权利要求1所述，从西蒙得木油种子中提取的所述西蒙得木油及其衍生物包括直链单烯酸和单烯醇，所述西蒙得木油是非挥发性的，不易氧化，不易酸败，所述西蒙得木油具有低粘度、高不饱和度、低皂化值、碳链长度短，卵磷脂含量低，直链分子和支链酯的性质，对皮肤具有高渗透性。
3、如权利要求1所述，所述西蒙得木油可用作抗菌剂、皮肤保护剂、抗过敏剂、抗炎剂、抗真菌剂、皮肤创伤愈合促进剂和血液循环促进剂。
4、如权利要求1所述，所述西蒙得木油作为一种必要组分可用于在制备治疗多种皮肤病的药物中的应用。
5、如权利要求1所述，西蒙得木油作为一种必要组分可用于在制备治疗口腔粘膜炎症，和用作暂时充填物和治疗干槽症的药物中的应用。
6、如权利要求1所述，西蒙得木油作为一种必要组分可用于在制备治疗和缓解多发性关节炎、风湿痛、关节痛和脊椎炎的药物中的应用。
7、如权利要求1所述，西蒙得木油作为一种主要组分可用于在制备治疗外耳炎和中耳炎关节痛和脊椎炎的药物中的应用。
8、如权利要求1所述，西蒙得木油作为一种主要组分可用于在制备治疗血栓症的药物中的应用。
9、如权利要求1所述，西蒙得木油作为一种主要组分可用于普通外科，并用于在制备治疗急慢性肛裂和肛瘘、前列腺炎、冻伤(Hiemorroids)(二度)治疗的药物中的应用。
10、如权利要求1所述，西蒙得木油作为一种主要组分可用于在制备治疗阴道炎，以及乳头裂的药物中的应用，并能缓解痛经。
11、如权利要求1所述，一种含有10％(重量)西蒙得木油和0.5％(重量)盐酸利多卡因的组合物，所述组合物特别用于在制备治疗口腔溃疡和牙龈炎的药物中的应用，并可消除红斑，此外还能降低与这些炎症有关的Odema，这些作用基于西蒙得木油作为抗菌剂和抗炎物质的特性，此外，西蒙得木油可用作这些病症的止痛剂，西蒙得木油也用于在制备治疗牙龈炎和因长期使用抗生素而导致疾病的药物中的应用，此外所述组合物无副作用。
12、如权利要求1所述，一种含有50％(重量)西蒙得木油和2％(重量)水杨酸的制剂，所述制剂可用于在制备治疗痤疮、牛皮癣、头屑、皮脂溢(皮脂腺的异常过度分泌)和鳞癣，以及真菌感染如癣的药物中的应用，所述制剂也无副作用。
13、如权利要求1所述，一种含有20％(重量)西蒙得木油的栓剂，所述栓剂可用于在制备治疗肛裂，其可缓解疼痛强度和许多患者的并发症的药物中的应用，并可缓解吸毒患者(pills patients)的疾病，所述栓剂无副作用。
14、如权利要求1所述，一种含有50％(重量)西蒙得木油和8％(重量)氧化锌的软膏剂，所述软膏剂可用于在制备治疗皮疹、尿布皮炎、皮炎、昆虫叮咬、和乳头裂的药物中的应用，所述软膏剂不会产生副作用。
15、如权利要求1所述，一种含有20％(重量)西蒙得木油的阴道栓，所述阴道栓可用作消除(急性和复发性)阴道炎的高效材料，所述阴道栓无副作用。
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