CN1395963A - Composite medicine for disinfecting and relieving inflammation - Google Patents

Abstract

A disinfecting and anti-inflammatory composite medicine for treating gynopathy is prepared from 7 raw materials including purpleflower Elsthotzia, wild chrysanthemum flower, moronal, chlorhexidine acetate, crudium fruit, etc.. Its advantages are high disinfecting rate up to 97% within 30 min, and deodouring action.

Description

A kind of pharmaceutical composition with bactericidal antiphlogistic effect

Technical field

The present invention relates to pharmaceutical composition, particularly a kind of pharmaceutical composition with bactericidal antiphlogistic effect is applicable to various gynaecopathias and bacillary, mycotic that prevention or treatment are directly or indirectly infected.

Background technology

Along with the progress of social civilization, the quickening of rhythm of life, individual health care is more and more important.Wherein the women is as the carrier of mankind's procreation, and its reproductive health care is particularly crucial.Based on the influence to the women of female pathology characteristic and modern environment factor, its pudendum and genitals health care require more and more higher, and the easiest invasion and attack female vulva of various pathogenic microorganism and genitals.If self health consciousness is not strong, very easily infect and cause a disease, cause various inflammatories and change and multiple gynecological diseases.Therefore keep the female vulva cleaning, keep its normal physiological self-cleaning action, use certain health-care sterilized product particularly important.This for female reproduction health and orthobiosis order maintenance all have positive effect.Chinese patent CN99113318 " a kind of traditional Chinese medical science pill for the treatment of gynaecopathia " discloses a kind of traditional Chinese medical science pill, i.e. phoenix tail ball, and have following deficiency: (1), prescription medicine are more, and preparation technology is complicated, and production cost is higher; (2), phoenix tail ball ball type is sphere or column type reuse bundle drug of topical application ball, and on gauze, reserve the fag end of 6.7cm, cause leaves fag end and gauze: a, the patient can have uncomfortable sensation, b, in the surgery, fag end and gauze are foreign body, stay the focus of infection place, easily cause the disunion or the superinfection that infect; (3), the every pill of phoenix tail ball imitated 10 days, must continuously pill be placed intravaginal in 10 days, easily caused patient's discomfort.

Summary of the invention

The object of the invention easily causes patient's discomfort, easily causes infecting that disunion or superinfection and preparation technology are complicated, the higher defective of production cost for what overcome that existing medicament exists, and a kind of pharmaceutical composition with bactericidal antiphlogistic effect is provided, have sterilization, determined curative effect and reach advanced reasonably prescription lastingly.

Medicine of the present invention is a kind of compositions, and the composition of said composition is as follows by weight ratio:

Pale reddish brown fragrant 475-525 part Flos Chrysanthemi Indici 1900-2100 part

Fructus Cnidii 950-1050 part Herba Eupatorii 950-1050 part

Nystatin 1.52-1.92 part (1,000 ten thousand ^u) chlorhexidine acetate 0.7-0.9 part

0.1 part of semi-synthetic ester fat acid ester 36# 180-220 part of Borneolum Syntheticum

An amount of substrate 180-220 part of essence (U.S. refreshing)

Above-mentioned composition component preferred weight proportioning of the present invention is as follows:

Pale reddish brown fragrant 450-550 part Flos Chrysanthemi Indici 1800-2200 part

Fructus Cnidii 900-1100 part Herba Eupatorii 900-1100 part

Nystatin 1.62-1.82 part (1,000 ten thousand ^u) chlorhexidine acetate 0.74-0.84 part

0.1 part of semi-synthetic ester fat acid ester 36# 190-210 part of Borneolum Syntheticum

An amount of substrate 190-210 part of essence (U.S. refreshing)

Above-mentioned composition component optimum weight proportioning of the present invention is as follows:

2000 parts of pale reddish brown fragrant 500 parts of Flos Chrysanthemi Indicis

1000 parts of 1000 portions of Herba Eupatoriis of Fructus Cnidii

Nystatin 1.72g (1,000 ten thousand ^u) 0.8 part of chlorhexidine acetate

200 parts of 0.1 part of semi-synthetic ester fat acid ester 36# of Borneolum Syntheticum

200 parts of an amount of substrate of essence (U.S. refreshing)

This pharmaceutical composition is by pale reddish brown perfume (or spice) (Herba Moslae, HM), Flos Chrysanthemi Indici (FlosChrysanthemi Indici, FCI), Fructus Cnidii (Fructes Cnidii, FC), Herba Eupatorii (HerbaEupatorii, HE) four flavor natural plants medicament extracts and Nystatin (Nystatin), chlorhexidine acetate (Chlorohexidine), Borneolum Syntheticum (Borneolum Syntheticum) etc., and suppository base is formed.Wherein pale reddish brown perfume (or spice) and Flos Chrysanthemi Indici heat-clearing and toxic substances removing, Fructus Cnidii the kidney warming dampness, wind dispelling insecticide, Herba Eupatorii removing dampness by means of aromatics, four medicines share the effect that has repelling foulness with aromatics, detoxifies removing dampness, be the key component of this product exploitation Chinese medicine as main sterilization effect, and Nystatin, chlorhexidine acetate have the clear and definite effect of killing fungus and common pathogen, with natural drug good complementary relationship are arranged.

Aforementioned pharmaceutical compositions can be prepared into various conventional dose according to the practice of pharmacy of routine, for example: suppository, lotion etc.

Medical material is bought by Hubei Province's medical material company.

The preparation method of drug suppository of the present invention:,, get Chinese medicines such as pale reddish brown perfume (or spice), Flos Chrysanthemi Indici, Fructus Cnidii, Herba Eupatorii according to described consumption with aforementioned pharmaceutical compositions, steam distillation extracts, collect the about 5000～6000ml of fraction, separate volatile oil, also available in case of necessity extracted with diethyl ether; Take by weighing substrate 200g,, add nystatin, chlorhexidine acetate, Borneolum Syntheticum, volatile oil and an amount of essence respectively, mix,, solidify the back to suppository and take out, pack stirring suspension notes film, cooling 50～60 ℃ of fusions.

This pharmaceutical composition passes through rational formula, has the bactericidal antiphlogistic effect, sterilization, determined curative effect is lasting: in repeatedly experimentation in recent years, we contrast this pharmaceutical composition and like product through animal and clinical random packet double-blind method, learn the testing identity pharmaceutical composition by statistics and be better than other series products.This pharmaceutical composition is applicable to and prevents directly and the various gynaecopathias and bacillary, the mycotic of indirect infection.Modern pharmacology confirms that also this pharmaceutical composition reaches more than 97% staphylococcus aureus, escherichia coli, white chain pearl coccus sterilizing rate under 15-30 minute situation of effect.

Another advantage of this pharmaceutical composition is unique prescription, gynecological infection many with leucorrhoea grow in quantity, abnormal flavour is arranged, domestic multiple Amino-Cerv at present mostly is symptomatic treatment or to because of handling, and how the abnormal flavour that this type of disease causes is eliminated, then research seldom; The change of the female mental state that this type of disease is caused, do not give enough attention especially, this pharmaceutical composition not only allows user eliminate abnormal flavour but also allows user give out one delicate fragrance all over the body in bactericidal antiphlogistic, no longer includes the misgivings of heart with back user.Demonstrate fully the theory of " people-oriented for science and technology ", treatment of diseases and daily health caring are combined.

[composition] this product is made up of pale reddish brown perfume (or spice), Flos Chrysanthemi Indici, Nystatin, chlorhexidine acetate, Fructus Cnidii, Herba Eupatorii and suppository base.

The cleaning of [scope of application] vaginal mucosa is antibacterial.

After cleaning vagina before [usage and dosage] 1. sleeps every night, include medicine in vagina, each one with the forefinger that is with the colloid fingerstall; 2. when being used for generally cleaning, warm water dissolves an amount of suppository and directly cleans pudendum.

[points for attention] 1. this suppository are medicine for external use, must not be oral; 2. the anemia of pregnant woman is forbidden; 3. anaphylaxis person's forbidding is arranged; 4. must be with aseptic fingerstall during vagina medicinal, prevent germ contamination; 5. this product can be used for general cleaning, only needs warm water to dissolve the back cleaning and gets final product; 6. because of temperature is too high suppository is dissolved or during deliquescing, can after the freezing shaping of refrigerator, exercise again and use.

Deposit at [storage] shady and cool dry place below 35 ℃.

[effect duration] 12 months

The specific embodiment

Embodiment 1

Pharmaceutical composition composition weight proportioning of the present invention is as follows:

1900 parts of pale reddish brown fragrant 475 parts of Flos Chrysanthemi Indicis

950 parts of 950 portions of Herba Eupatoriis of Fructus Cnidii

Nystatin 1.62g (1,000 ten thousand ^u) 0.7 part of chlorhexidine acetate

180 parts of 0.1 part of semi-synthetic ester fat acid ester 36# of Borneolum Syntheticum

180 parts of an amount of substrate of essence (U.S. refreshing)

The preparation method of drug suppository of the present invention:,, get pale reddish brown perfume (or spice), Flos Chrysanthemi Indici, Fructus Cnidii, Herba Eupatorii Chinese medicine according to described consumption with aforementioned pharmaceutical compositions, steam distillation extracts, collect the about 5000～6000ml of fraction, separate volatile oil, also available in case of necessity extracted with diethyl ether; Take by weighing substrate,, add nystatin, chlorhexidine acetate, Borneolum Syntheticum, volatile oil and an amount of essence respectively, mix,, solidify the back to suppository and take out, pack stirring suspension notes film, cooling 50～60 ℃ of fusions.

Embodiment 2

Pharmaceutical composition composition weight proportioning of the present invention is as follows:

2100 parts of pale reddish brown fragrant 525 parts of Flos Chrysanthemi Indicis

1050 parts of 1050 portions of Herba Eupatoriis of Fructus Cnidii

Nystatin 1.82g (1,000 ten thousand ^u) 0.9 part of chlorhexidine acetate

220 parts of 0.1 part of semi-synthetic ester fat acid ester 36# of Borneolum Syntheticum

220 parts of an amount of substrate of essence (U.S. refreshing)

The preparation method of drug suppository of the present invention is identical with embodiment 1.

Embodiment 3

Pharmaceutical composition composition weight proportioning of the present invention is as follows:

2000 parts of pale reddish brown fragrant 500 parts of Flos Chrysanthemi Indicis

1000 parts of 1000 portions of Herba Eupatoriis of Fructus Cnidii

Nystatin 1.72g (1,000 ten thousand ^u) 0.8 part of chlorhexidine acetate

200 parts of 0.1 part of semi-synthetic ester fat acid ester 36# of Borneolum Syntheticum

200 parts of an amount of substrate of essence (U.S. refreshing)

The preparation method of drug suppository of the present invention is identical with embodiment 1.

This drug suppository bactericidal effect sees Table 1

Table 1 bactericidal effect

Project	Concentration	Action time (min)	Sterilizing rate (%)
				Golden yellow staphylococcus (ATCC6538)	Stock solution	????15	????≥99.90
Escherichia coli (8099)	Stock solution	????20	????≥99.90
				Candida albicans (ATCC10231)	Stock solution	????30	????≥99.90

The preparation method technical maturity of drug suppository of the present invention, wherein the natural drug extraction separation goes out effective volatile oil and nystatin and molten matrix, forms through mixing, notes film, condensation, membrane removal packing, meets the relevant regulations that national drug is produced.This drug suppository has the significant advantage that Chinese medicine and western medicine closes system at the disinfection product scope, effect rapidly, curative effect is lasting, easy to use is its distinguishing feature, its mesostroma is chosen 36 ℃--37 ℃ of semi-synthetic fatty acids that dissolve, make it under the human body normal body temperature, can discharge ingredient, be easy to ensure the quality of products and under room temperature (25 ℃ ± 5 ℃), be solid state, through the sample survey of Hubei Province Center for Disease Control (CDC), this drug suppository is safe and reliable, the anxious poison test of per os, the skin irritation test, eye irritant test, the vaginal irritation test is all negative, do not see the cumulative toxicity reaction, mutagenicity test is also negative.Its stability test meets the relevant regulations of the examination and test of products, does not see that specificity changes.This drug suppository effective component is clear and definite, and content assaying method and has been formulated the technical standard of clear and definite standard for this drug suppository accurately and reliably, and the quality control of product is reliable.

Claims (4)

1, a kind of pharmaceutical composition with bactericidal antiphlogistic effect is characterized in that the composition of said composition is by weight ratio:

Pale reddish brown fragrant 475-525 part Flos Chrysanthemi Indici 1900-2100 part

Fructus Cnidii 950-1050 part Herba Eupatorii 950-1050 part

Nystatin 1.52-1.92 part (1,000 ten thousand u) chlorhexidine acetate 0.7-0.9 part

0.1 part of semi-synthetic ester fat acid ester 36# 180-220 part of Borneolum Syntheticum

An amount of substrate 180-220 part of essence (U.S. refreshing)

2,, it is characterized in that said composition composition preferred weight proportioning is according to the described pharmaceutical composition of claim 1:

Pale reddish brown fragrant 450-550 part Flos Chrysanthemi Indici 1800-2200 part

Fructus Cnidii 900-1100 part Herba Eupatorii 900-1100 part

Nystatin 1.62-1.82 part (1,000 ten thousand u) chlorhexidine acetate 0.74-0.84 part

0.1 part of semi-synthetic ester fat acid ester 36# 190-210 part of Borneolum Syntheticum

An amount of substrate 190-210 part of essence (U.S. refreshing)

3,, it is characterized in that said composition component optimum weight proportioning is according to the described pharmaceutical composition of claim 1:

2000 parts of pale reddish brown fragrant 500 parts of Flos Chrysanthemi Indicis

1000 parts of 1000 portions of Herba Eupatoriis of Fructus Cnidii

0.8 part of Nystatin 1.72g (1,000 ten thousand u) chlorhexidine acetate

200 parts of 0.1 part of semi-synthetic ester fat acid ester 36# of Borneolum Syntheticum

200 parts of an amount of substrate of essence (U.S. refreshing)

4,, it is characterized in that this pharmaceutical composition is that practice of pharmacy is prepared into suppository or lotion according to claim 1,2 or 3 described pharmaceutical compositions.