CN1393693A - Low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers - Google Patents
Low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers Download PDFInfo
- Publication number
- CN1393693A CN1393693A CN 01114148 CN01114148A CN1393693A CN 1393693 A CN1393693 A CN 1393693A CN 01114148 CN01114148 CN 01114148 CN 01114148 A CN01114148 A CN 01114148A CN 1393693 A CN1393693 A CN 1393693A
- Authority
- CN
- China
- Prior art keywords
- pump
- cos
- sin
- spaced apart
- equation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Reciprocating Pumps (AREA)
Abstract
A low-pulsating high-precision dual-plunger efficient liquid chromatographic pump is composed of primary and secondary pump heads, pump body connected with the said pump heads and the push rod consisting of linkage rod and plunger rod and driven by a motor via speed variator and cam. The plunger rod is installed via the plunger core in the pump body. The linkage rod is in touch with the cam in rolling mode. Its advantages are low cost, no liquid leakage, and high flow stability.
Description
The present invention relates to liquid chromatography pump, specifically a kind of low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers.
In the prior art, high-pressure pump is one of important composition parts of high performance liquid chromatograph, stability, repeatability and the analysis precision of the direct impact analysis of high pressure pump performance.Along with efficient liquid phase chromatographic analysis in actual applications popularize and analyze the raising that requires, also more and more higher to performance demands such as the transfusion precision of high pressure liquid chromatography pump, pulsation.Liquid chromatography pump commonly used at present comprises that pneumatic amplification pump, reciprocating pump, spiral syringe pump, membrane pump etc. are several, because pneumatic amplification pump and spiral syringe pump exist flow regulation inconvenience, solvent replacement difficulty, be unfavorable for carrying out shortcoming such as gradient elution, use fewer and fewerily, mechanical reciprocating pump is with advantage being most widely used in the liquid chromatography instrument such as its stable performance, flow regulation and solvent replacement are convenient.Present mechanical reciprocating pump mainly contains two kinds, a kind of is reciprocating plunger pump, directly drive liquid by plunger, another kind is a reciprocating diaphragm pump, reciprocating plunger mechanically drives barrier film or hydraulic diaphragm, make moving phase only contact and not contact with plunger with barrier film, wherein the former uses more relatively.
The structure of reciprocating plunger pump commonly used as shown in Figure 1, by driven by motor eccentric wheel or cam rotation, the to-and-fro movement of cam driven plunger, flow to by retaining valve control, finish imbibition discharge opeing circulation a reciprocal week of cam, the liquid of output designated volume can be adjusted piston reciprocating frequence Control Flow by changing motor speed.Owing to have the imbibition process in the reciprocating motion of the pistons, cause exporting solution and have sine pulse.Adopt double plunger or multicolumn plug system can reduce the output pulse to a certain extent, duplex plunger pump cam and piston structure are referring to Fig. 2, common duplex plunger pump has two kinds of parallel and tandems, the general employing of parallel pumps two or a cam, two in parallel uses of plunger rod, cam differs 180 °, two cams replace imbibition and discharge opeing, thereby obtain exporting comparatively stably liquid stream, in order further to reduce pulse, usually 360 ° of cam curves are divided into even quicken, at the uniform velocity with even deceleration three phases, it is 90 ° that cam differs.This pump needs 4 cover retaining valves, has increased the chance of pollution and fault.Second pump head of tandem duplex plunger pump do not add retaining valve usually, need two cams, major-minor plunger infusion flow ratio is 2: 1, when the main plunger discharge opeing, wherein 50% liquid enters chromatographic system, 50% being accumulated in the secondary plunger cavity in addition, when the main plunger imbibition, the subpost plug is delivered into liquid wherein in the chromatographic system.This system has only two retaining valves, and the chance that breaks down reduces, the corresponding raising of flow accuracy, and pressure surge is also corresponding to be reduced, and it is convenient to change solvent, is suitable for gradient elution.
Though the various improvement of duplex plunger pump have reduced pulse to a great extent, can not fundamentally eliminate pulse phenomenon fully; In addition, trace is an integral type, fracture easily, and inconvenient maintenance further reduces pulse so general ram pump also needs pulse damper or real-time pressure feedback system etc., also has, adopt the pump of membrane technique, barrier film is also fracture easily often, and is prone to the liquid leakage problem, and cost is also high.Therefore, the improvement of above-mentioned every technology is the common target of present main chromatographic apparatus company in the world.
The purpose of this invention is to provide that a kind of cost is low, no liquid leakage problem, convenient for maintaining, liquid flow low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers stably.
To achieve these goals, technical scheme of the present invention is: be composed in series by the major-minor pump head, the pump housing links to each other with the major-minor pump head, structure is identical, drive push rod on the cam driven pump body by motor respectively through wheel box, the main pump head is provided with retaining valve, it is characterized in that: described push rod is trace and plunger rod split two-part structure, plunger rod is felt at ease by post and is contained in the pump housing, and an end closely contacts with trace and is connected, and the other end is to the pump head lead channel, the pump head and the pump housing are installed together by locating sleeve, described locating sleeve both sides are respectively equipped with sealing ring and gasket seal, between the pump head and the pump housing, constitute double sealing structure; Described cam rolls with the set roller of trace free end and is connected, and divides major and minor cam, has identical base radius, the main cam lift is 10, and starting point is 0 degree, and the auxiliary cam lift is 7.125, overlap with main cam at 256.6 degree point, it is 180 ° that two cams differ;
Described plunger rod is installed in the groove that the body of bolt as the pump housing puts by orienting sleeve, and suit damping stage clip on it, damping stage clip one end are fixed on body of bolt cover bottom portion of groove, and the other end links to each other with supporting pad on being located at plunger rod; Orienting sleeve is provided with the stroke groove; One purge pipe is installed between the described pump head and the pump housing,, is led to the post heart in the locating sleeve place; Described major and minor cam work curve is abideed by the speed control equation.
The present invention has following advantage:
1. the liquid levelling is steady.The present invention is by the cam structure and the working curve thereof of Theoretical Calculation design, differ is that 180 ° cam advances plunger rod under the driving of motor, finish infusion process, the major-minor cam has identical base radius, the main cam lift is 10, the auxiliary cam lift is 7.125, makes that output liquid levelling is steady in the plunger operational process, and the relative standard deviation of retention time is less than 0.00955; The present invention adopts stepper motor segmentation step control technology, has improved the low-frequency operation characteristic, has reduced pulsation phenomenon, has enlarged the infusion pump flow range, and its flow range can reach 4 more than the order of magnitude.
2. low-cost effectively buffering effect.Because the present invention has designed damping stage clip buffer technology with major-minor cam coupling (as Fig. 6-1, shown in the 6-2), prevented the backflow pulse phenomenon in each infusion process effectively, pressure buffer is satisfactory for result, obtain extremely low pulse output flow pattern, overcome traditional buffer system failure rate height, weak effect, the high deficiency of cost.
3. easy to maintenance.The present invention improves traditional trace and the plunger rod integrative-structure is the branch body structure, and it is extremely low to obtain low pulsation pole stable liquid stream and mechanical noise; High pressure sealing pad and plunger rod can more easily carry out the dismounting maintenance.
4. no liquid is revealed, long service life.The present invention adopts the two-stage Seal Design, and it is convenient that plunger rod is cleaned, and particularly when the buffer solution that uses high salt concentration is made moving phase, can wash the salt grain of crystallization from damping fluid off, prolongs plunger rod and O-ring seal life-span.
Fig. 1 is a reciprocating plunger pump structural representation in the prior art.
Fig. 2-1 is duplex plunger pump cam and a piston structure synoptic diagram in the prior art.
Fig. 2-2 is the duplex plunger pump cam vertical view among Fig. 2-1.
Fig. 3 is an one-piece construction synoptic diagram of the present invention.
Fig. 4 is Fig. 3 cam structural representation.
Fig. 5 is that the A of Fig. 4 is to figure.
Fig. 6-1 is a main pump head assembling assumption diagram among Fig. 1.
Fig. 6-2 is an auxiliary pump head assembling assumption diagram among Fig. 1.
Fig. 7 is the vertical view of Fig. 3.
Fig. 8 separates sugared biased sample liquid chromatogram for one embodiment of the invention.
Fig. 9 among second and third embodiment of the present invention by the linear gradient Test Drawing of computer program Control Flow rate of change.
Figure 10-1 among second and third embodiment of the present invention by the step gradient Test Drawing of computer program Control Flow rate of change.
Figure 10-2 is the gradient performance figure of geopressure gradient system of Japanese JASCO company 1575 type high-pressure pumps.
Below in conjunction with accompanying drawing and principle of work the present invention is described in further detail.
Embodiment 1
Separate sugared biased sample:
As Fig. 3～5,61-, 6-2, shown in 7, the present invention is by major-minor pump head 11,12 are composed in series, the pump housing 3 and major-minor pump head 11,12 link to each other, structure is identical, drive the push rod that cam 5 drives on the pump housing 3 by motor 7 respectively through wheel box 6, main pump head 11 is provided with retaining valve 14, controlling liquid flows to, described push rod is trace 4 and plunger rod 8 split two-part structure, plunger rod 8 is installed in 3 li of the pump housings by the post heart 81, one end closely contacts with trace 4 and is connected, the other end is to pump head 1 lead channel, and the pump head 1 and the pump housing 3 are installed together by locating sleeve 10, and described locating sleeve 10 both sides are respectively equipped with sealing ring 82 and gasket seal 83, in 3 of pump head 1 and the pump housings, constitute double sealing structure; Described cam 5 rolls with the set roller 9 of trace 4 free ends and is connected, divide major and minor cam 51,52, has identical base radius, main cam 51 lifts are 10, starting point is 0 degree, auxiliary cam 52 lifts are 7.125, overlap with main cam 51 at 256.6 degree point, and it is 180 ° that two cams differ;
Shown in Fig. 6-1,6-2, described plunger rod 8 is installed in as in the groove on the body of bolt cover 85 of the pump housing by orienting sleeve 86, suit damping stage clip 87 on it, damping stage clip 87 1 ends are fixed on body of bolt and overlap 85 bottom portion of groove, and the other end links to each other with supporting pad 88 on being located at plunger rod 8; Orienting sleeve 86 is provided with stroke groove 89; One purge pipe 80 is installed between the described pump head and the pump housing,, is led to the post heart 81, clean and use in locating sleeve 10 places;
Described major and minor cam 51,52 working curves are abideed by the speed control equation, and its main cam 51 speed control equations are:
1) accelerating sections equation;
(1) R (θ)=26+ (θ/18)
2... θ=0-18 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
2) at the uniform velocity the section equation:
(1) R (θ)=26+1/9 * (θ-18) ... θ=18-90 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
3) accelerating sections equation:
(1) R (θ)=35-((108-θ) ÷ 18)
2... θ=90-108 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
4) braking section equation:
(1) R (θ)=35-((θ-108) ÷ 18)
2... θ=108-126 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
5) equal braking section equation:
(1) R (θ)=34-1/9 * (θ-126) ... θ=126-198 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
6) braking section equation:
(1) R (θ)=25+ ((216-θ) ÷ 18)
2... θ=198-216 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
7) braking section equation:
(1) R (θ)=25-((θ-216) ÷ 10)
2... θ=216-221 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
8) constant speed section equation:
(1) R (θ)=24.75, wherein θ=221-355 (being spaced apart 0.5)
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
9) accelerating sections equation:
(1) R (θ)=25-((360-θ) ÷ 10)
2... θ=355-360 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
Auxiliary cam (52) speed control equation is:
1) accelerating sections equation:
(1) R (θ)=25+0.0625 * (θ/4.5)
2θ=0-4.5 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
2) average rate section equation:
(1) R (θ)=25.0625+1/36 (θ-4.5) θ=45-256.5 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
3) accelerating sections equation:
(1) R (θ)=32.125-0.0625 * ((261-θ) ÷ 4.5)
2θ=4256.5-261 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
4) braking section equation:
(1) R (θ)=32.125-0.5625 * ((θ-261) ÷ 13.5)
2θ=261-274.5 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
5) equal braking section equation:
(1) R (θ)=31.5625-1.125/13.5 * (θ-274.5) θ=274.5-346.5 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
6) accelerating sections equation:
(1) R (θ)=25+0.5625 * ((360-θ) ÷ 13.5)
2θ=346.5-360 (being spaced apart 0.5) wherein
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ).
Principle of work of the present invention is as follows:
Two cams of the present invention replace imbibition and discharge opeing, major-minor plunger infusion flow ratio is 2: 1, when the main plunger discharge opeing, 50% liquid enters chromatographic system in the main plunger chamber, 50% being accumulated in the secondary plunger cavity in addition, when the main plunger imbibition, the subpost plug is delivered into liquid wherein in the chromatographic system; Its cam 5 structures and working curve thereof, differing is that 180 ° cam 5 advances plunger rod 8 under the driving of motor 7, finishes infusion process.Major and minor cam 51,52 has identical base radius, main cam 51 lifts are 10, auxiliary cam 52 lifts are 7.125, make that output liquid levelling is steady in the plunger operational process, adopt stepper motor segmentation step control technology, improved the low-frequency operation characteristic, reduced pulsation phenomenon, enlarged the infusion pump flow range, its flow range can reach 4 more than the order of magnitude; With damping stage clip 87 buffer technologys of major and minor cam 51,52 couplings, obtain extremely low pulse output flow pattern; Traditional trace 4 and plunger rod 8 integrative-structures are the branch body structure, and it is extremely low to make it to obtain low pulsation pole stable liquid stream and mechanical noise;
As shown in table 1, among the liquid chromatography pump replica test result, carbohydrate sample feeding repeated very good, the relative standard deviation of retention time shows that less than 0.00955 the pump discharge precision is high;
High performance liquid chromatography constant current infusion pump repeatability data see Table 1.
Experiment condition:
Chromatographic column: 250 * 4.6mm, Shodex-NH
210 μ m;
Moving phase: 75/25 acetonitrile/water, 1ml/min;
Detecting device: ELSD:GAIN9 1.2BAR sample: L-pectinose, glucose, sucrose, maltose
Table 1 repeated experiment tables of data retention time (minute) L-pectinose glucose saccharose maltose
1 5.7 7.43 9.2 10.68
2 5.71 7.44 9.2 10.73
3 5.71 7.4 9.15 10.61
4 5.72 7.45 9.26 10.7
5 5.72 7.41 9.18 10.63
6 5.7 7.4 9.16 10.65
7 5.65 7.34 9.04 10.52
8 5.59 7.25 8.94 10.41
9 5.69 7.4 9.17 10.63
10 5.69 7.41 9.22 10.73
11 5.71 7.44 9.22 10.75
12 5.65 7.32 9.07 10.5
13 5.67 7.37 9.1 10.51
14 5.71 7.43 9.22 10.73 mean values, 5.69 7.39 9.15 10.63 standard variances, 0.0349 0.0536 0.0838 0.1015 relative standard deviation % 0.613 0.725 0.916 0.955
Embodiment 2～3
As shown in Figure 9, control the linear gradient Test Drawing of two playscript with stage directions invention high-pressure pump fluctuations in discharge speed among second and third embodiment of the present invention by computer program, its experiment condition:
Overall flow rate 1.0ml/min; Solvent change: A: water, B:0.5% aqueous acetone solution;
0-10min:100%A; 10-60min B changes to 100% by 0%, 60-70min 100%A;
Test findings shows that setting value and experimental result are very identical, and error is less than 3%.
Relevant comparative example:
Shown in Figure 10-1,10-2, the geopressure gradient system gradient performance of geopressure gradient of the present invention and Japanese JASCO company 1575 type high-pressure pumps is done with relatively, high-pressure pump moving phase wherein of the present invention displacement is fast, and geopressure gradient retardation time is short, the signal stabilization degree is excellent, and concentration and setting value are very identical.
Claims (5)
1. low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers, it is characterized in that: by major-minor pump head (11,12) be composed in series, the pump housing (3) and major-minor pump head (11,12) link to each other, structure is identical, drive the push rod that cam 5 drives on the pump housing (3) by motor (7) respectively through wheel box (6), main pump head (51) is provided with retaining valve, it is characterized in that: described push rod is trace (4) and plunger rod (8) split two-part structure, plunger rod (8) is installed in the pump housing (3) lining by the post heart (81), one end closely contacts with trace (4) and is connected, the other end is to pump head (1) lead channel, the pump head (1) and the pump housing (3) are installed together by locating sleeve (10), described locating sleeve (10) both sides are respectively equipped with sealing ring (82) and gasket seal (83), between the pump head (1) and the pump housing (3), constitute double sealing structure; Described cam (5) rolls with the set roller of trace (4) free end (9) and is connected, divide major and minor cam (51,52), has identical base radius, main cam (51) lift is 10, starting point is 0 degree, auxiliary cam (52) lift is 7.125, overlaps with main cam (51) at 256.6 degree point, and it is 180 ° that two cams differ.
2. according to the described low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers of claim 1, it is characterized in that: described plunger rod (8) is installed in as in the groove on the body of bolt cover (85) of the pump housing by orienting sleeve (86), suit damping stage clip (87) on it, damping stage clip (87) one ends are fixed on body of bolt cover (85) bottom portion of groove, and the other end links to each other with supporting pad (88) on being located at plunger rod (8).
3. according to claim 1 low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers, it is characterized in that: orienting sleeve (86) is provided with stroke groove (89).
4. according to claim 1 low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers, it is characterized in that: a purge pipe (80) is installed between the described pump head and the pump housing, is located, lead to the post heart (81) in locating sleeve (10).
5. according to claim 1 low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers, it is characterized in that: described major and minor cam (51,52) working curve is abideed by the speed control equation, and its main cam (51) speed control equation is:
1) accelerating sections equation;
(1) R (θ)=26+ (θ/18)
2... θ=0-18 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
2) at the uniform velocity the section equation:
(1) R (θ)=26+1/9 * (θ-18) ... θ=18-90 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
3) accelerating sections equation:
(1) R (θ)=35-((108-θ) ÷ 18)
2... θ=90-108 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
4) braking section equation:
(1) R (θ)=35-((θ-108) ÷ 18)
2... θ=108-126 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
5) equal braking section equation:
(1) R (θ)=34-1/9 * (θ-126) ... θ=126-198 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
6) braking section equation:
(1) R (θ)=25+ ((216-θ) ÷ 18)
2... θ=198-216 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
7) braking section equation:
(1) R (θ)=25-((θ-216) ÷ 10)
2... θ=216-221 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
8) constant speed section equation:
(1) R (θ)=24.75, wherein θ=221-355 is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
9) accelerating sections equation:
(1) R (θ)=25-((360-θ) ÷ 10)
2... θ=355-360 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
Auxiliary cam (52) speed control equation is:
1) accelerating sections equation:
(1) R (θ)=25+0.0625 * (θ/4.5)
2Wherein θ=0-4.5 is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
2) average rate section equation:
(1) R (θ)=25.0625+1/36 (θ-4.5) θ=4.5-256.5 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
3) accelerating sections equation:
(1) R (θ)=32.125-0.0625 * ((261-θ) ÷ 4.5)
2Wherein θ=256.5-261 is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
4) braking section equation:
(1) R (θ)=32.125-0.5625 * ((θ-261) ÷ 13.5)
2Wherein θ=261-274.5 is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
5) equal braking section equation:
(1) R (θ)=31.5625-1.125/13.5 * (θ-274.5) θ=274.5-346.5 wherein is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ)
6) accelerating sections equation:
(1) R (θ)=25+0.5625 * ((360-θ) ÷ 135)
2Wherein θ=3465-360 is spaced apart 0.5
(2) X=25-R (θ) * COS (θ), Y=R (θ) * Sin (θ).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01114148 CN1238717C (en) | 2001-06-29 | 2001-06-29 | Low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01114148 CN1238717C (en) | 2001-06-29 | 2001-06-29 | Low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1393693A true CN1393693A (en) | 2003-01-29 |
| CN1238717C CN1238717C (en) | 2006-01-25 |
Family
ID=4660821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01114148 Expired - Lifetime CN1238717C (en) | 2001-06-29 | 2001-06-29 | Low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1238717C (en) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011050586A1 (en) * | 2009-10-30 | 2011-05-05 | 北京普析通用仪器有限责任公司 | Serial-parallel liquid-phase chromatographic pump |
| CN102062072A (en) * | 2010-10-25 | 2011-05-18 | 江苏同济分析仪器有限公司 | Liquid chromatography high-pressure parallel cam pump |
| WO2011116633A1 (en) * | 2010-03-23 | 2011-09-29 | 北京普析通用仪器有限责任公司 | Liquid path distributing valve and liquid-phase chromatographic pump comprising the same |
| CN102312807A (en) * | 2010-07-05 | 2012-01-11 | 江苏天瑞仪器股份有限公司 | Liquid chromatograph and infusion pump thereof |
| CN101721839B (en) * | 2009-12-18 | 2012-06-27 | 北京创新通恒科技有限公司 | Infusion method of liquid chromatogram and dual-drive high pressure pump |
| CN102913407A (en) * | 2012-07-29 | 2013-02-06 | 安徽皖仪科技股份有限公司 | High-pressure constant-flow pump based on two-stage suspension transmission technology |
| CN102953965A (en) * | 2012-10-25 | 2013-03-06 | 安徽皖仪科技股份有限公司 | High-voltage and constant-current pump using electronic cam technique to realize constant-current liquid conveying function |
| CN102053132B (en) * | 2009-11-04 | 2013-03-27 | 北京普源精电科技有限公司 | Liquid chromatograph with plunger rod ejection pin |
| CN103221688A (en) * | 2010-11-30 | 2013-07-24 | 通用电气健康护理生物科学股份公司 | A chromatography pump |
| CN103423120A (en) * | 2013-08-21 | 2013-12-04 | 利穗科技(苏州)有限公司 | Three-plunger high-pressure pump |
| CN103590993A (en) * | 2013-11-06 | 2014-02-19 | 安徽皖仪科技股份有限公司 | Method for reducing flow fluctuations in liquid chromatograph and infusion pump device |
| CN103869030A (en) * | 2012-12-18 | 2014-06-18 | 北京普源精电科技有限公司 | Liquid chromatograph having series-connection plunger pump and control method thereof |
| CN104897822A (en) * | 2014-03-04 | 2015-09-09 | 株式会社岛津制作所 | Liquid chromatograph control system and liquid chromatograph control method |
| CN107377306A (en) * | 2017-08-18 | 2017-11-24 | 桂林航天电子有限公司 | Adjustable encapsulating controlling organization |
| CN109209811A (en) * | 2018-10-29 | 2019-01-15 | 成都格莱精密仪器有限公司 | A kind of booster-type preparative liquid chromatography infusion pump |
| CN111336078A (en) * | 2020-03-03 | 2020-06-26 | 大连依利特分析仪器有限公司 | Double-plunger liquid chromatography infusion pump, pump regulation and control method and pump system |
| CN112648163A (en) * | 2020-11-23 | 2021-04-13 | 江苏同济分析仪器有限公司 | High-pressure advection infusion pump of liquid chromatograph |
| CN113217320A (en) * | 2021-05-12 | 2021-08-06 | 陈志昌 | Hydraulic-electric intelligent numerical control crankshaft wheel plunger pump |
| CN114746752A (en) * | 2019-11-27 | 2022-07-12 | 沃特世科技公司 | Active damping gradient proportional valve |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013108918A1 (en) | 2013-08-19 | 2015-02-19 | Saint-Gobain Diamantwerkzeuge Gmbh & Co. Kg | Form dressing roll |
-
2001
- 2001-06-29 CN CN 01114148 patent/CN1238717C/en not_active Expired - Lifetime
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011050586A1 (en) * | 2009-10-30 | 2011-05-05 | 北京普析通用仪器有限责任公司 | Serial-parallel liquid-phase chromatographic pump |
| CN102052276B (en) * | 2009-10-30 | 2013-09-11 | 北京普析通用仪器有限责任公司 | Series-parallel connection liquid chromatogram pump |
| CN102053132B (en) * | 2009-11-04 | 2013-03-27 | 北京普源精电科技有限公司 | Liquid chromatograph with plunger rod ejection pin |
| CN101721839B (en) * | 2009-12-18 | 2012-06-27 | 北京创新通恒科技有限公司 | Infusion method of liquid chromatogram and dual-drive high pressure pump |
| WO2011116633A1 (en) * | 2010-03-23 | 2011-09-29 | 北京普析通用仪器有限责任公司 | Liquid path distributing valve and liquid-phase chromatographic pump comprising the same |
| CN102312807A (en) * | 2010-07-05 | 2012-01-11 | 江苏天瑞仪器股份有限公司 | Liquid chromatograph and infusion pump thereof |
| CN102062072B (en) * | 2010-10-25 | 2013-02-27 | 江苏同济分析仪器有限公司 | Liquid chromatography high-pressure parallel cam pump |
| CN102062072A (en) * | 2010-10-25 | 2011-05-18 | 江苏同济分析仪器有限公司 | Liquid chromatography high-pressure parallel cam pump |
| CN103221688A (en) * | 2010-11-30 | 2013-07-24 | 通用电气健康护理生物科学股份公司 | A chromatography pump |
| CN102913407B (en) * | 2012-07-29 | 2015-07-29 | 安徽皖仪科技股份有限公司 | A kind of high pressure constant flow pump based on two-stage suspension drive technology |
| CN102913407A (en) * | 2012-07-29 | 2013-02-06 | 安徽皖仪科技股份有限公司 | High-pressure constant-flow pump based on two-stage suspension transmission technology |
| CN102953965A (en) * | 2012-10-25 | 2013-03-06 | 安徽皖仪科技股份有限公司 | High-voltage and constant-current pump using electronic cam technique to realize constant-current liquid conveying function |
| CN103869030A (en) * | 2012-12-18 | 2014-06-18 | 北京普源精电科技有限公司 | Liquid chromatograph having series-connection plunger pump and control method thereof |
| CN103423120A (en) * | 2013-08-21 | 2013-12-04 | 利穗科技(苏州)有限公司 | Three-plunger high-pressure pump |
| CN103590993A (en) * | 2013-11-06 | 2014-02-19 | 安徽皖仪科技股份有限公司 | Method for reducing flow fluctuations in liquid chromatograph and infusion pump device |
| CN103590993B (en) * | 2013-11-06 | 2016-03-16 | 安徽皖仪科技股份有限公司 | A kind of method and pump mechanism reducing flowed fluctuation in liquid chromatograph |
| CN104897822A (en) * | 2014-03-04 | 2015-09-09 | 株式会社岛津制作所 | Liquid chromatograph control system and liquid chromatograph control method |
| CN107377306A (en) * | 2017-08-18 | 2017-11-24 | 桂林航天电子有限公司 | Adjustable encapsulating controlling organization |
| CN109209811A (en) * | 2018-10-29 | 2019-01-15 | 成都格莱精密仪器有限公司 | A kind of booster-type preparative liquid chromatography infusion pump |
| CN114746752A (en) * | 2019-11-27 | 2022-07-12 | 沃特世科技公司 | Active damping gradient proportional valve |
| US11940424B2 (en) | 2019-11-27 | 2024-03-26 | Waters Technologies Corporation | Gradient proportioning valve |
| CN111336078A (en) * | 2020-03-03 | 2020-06-26 | 大连依利特分析仪器有限公司 | Double-plunger liquid chromatography infusion pump, pump regulation and control method and pump system |
| CN112648163A (en) * | 2020-11-23 | 2021-04-13 | 江苏同济分析仪器有限公司 | High-pressure advection infusion pump of liquid chromatograph |
| CN113217320A (en) * | 2021-05-12 | 2021-08-06 | 陈志昌 | Hydraulic-electric intelligent numerical control crankshaft wheel plunger pump |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1238717C (en) | 2006-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1238717C (en) | Low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers | |
| JP5624825B2 (en) | Liquid chromatograph pump and liquid chromatograph | |
| US4310420A (en) | Mobile phase supplying method in the liquid chromatography and apparatus therefor | |
| CN1232892C (en) | Current velocity controller | |
| CN1737372A (en) | Liquid feeding system | |
| CN1895833A (en) | Laser processing head | |
| CN1840903A (en) | Piezoelectric film type fluid pump | |
| CN1721696A (en) | Multi-channel pump and its control method | |
| CN1278819C (en) | Rotary clamp | |
| CN101721839B (en) | Infusion method of liquid chromatogram and dual-drive high pressure pump | |
| CN1516784A (en) | Device for delivering fixed quantity of liquid | |
| CN1173805C (en) | Method and device for fastening screw between glass and main unit of car lamp | |
| CN1131233A (en) | Piston pump with improved hold-down mechanism | |
| CN1592819A (en) | Valve assembly of reciprocating compressor | |
| CN110051539A (en) | A kind of auxiliary device of syringe | |
| CN1159533C (en) | Air cylinder | |
| CN1320275C (en) | Micro-thin film pump with double-directional overpressure protection function and application thereof | |
| CN200943613Y (en) | Reversing valve core guiding subassembly and plunger type high pressure gas-free spraying machine | |
| CN1845779A (en) | Oxygen enricher and rotary valve | |
| JP2003293946A (en) | Series double syringe type liquid feed pump and liquid chromatograph | |
| CN1790210A (en) | Flow rate control apparatus | |
| CN216518465U (en) | High-pressure booster pump of two-way pressure boost | |
| CN2821218Y (en) | Piezoelectric film type fluid pump | |
| CN201348634Y (en) | Liquid injecting device | |
| JPS63253182A (en) | Pump device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20060125 |