CN102312807A - Liquid chromatograph and infusion pump thereof - Google Patents
Liquid chromatograph and infusion pump thereof Download PDFInfo
- Publication number
- CN102312807A CN102312807A CN2010102217645A CN201010221764A CN102312807A CN 102312807 A CN102312807 A CN 102312807A CN 2010102217645 A CN2010102217645 A CN 2010102217645A CN 201010221764 A CN201010221764 A CN 201010221764A CN 102312807 A CN102312807 A CN 102312807A
- Authority
- CN
- China
- Prior art keywords
- infusion pump
- cam
- plunger
- liquid chromatograph
- pump
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The embodiment of the invention discloses a liquid chromatograph and an infusion pump thereof. The liquid chromatograph comprises a cam, a push rod, a plunger base and a plunger rod, wherein the stroke of the cam is 2-6 millimeters; the push rod is connected with the cam; the plunger base is sleeved in the inner cavity of the push rod; the outer ring of the plunger base is sleeved with a spring; the two ends of the spring are positioned through the plunger base and a spring fixing base fixed on the pump head of the infusion pump; and the plunger rod is connected with the plunger base. In the infusion pump, the cam of which the stroke is 2-6 millimeters is adopted, so that low-pressure pulsation of a high-pressure infusion pump in a wide flow speed range is realized, high flow stability is realized, the problem of occasional liquid absorption failure of the cam with a shorter stroke is solved, and the stability and the reliability of the high-pressure infusion pump are improved.
Description
Technical field
The present invention relates to the infusion pump technical field, more particularly, relate to a kind of liquid chromatograph and infusion pump thereof.
Background technique
Liquid chromatograph is a difference of utilizing mixture distribution ratio between liquid-solid or immiscible two kinds of liquid, mixture is carried out first separation, then the instrument of Analysis and Identification.Generally partly form by high pressure pump, inlet system, temperature control system, chromatographic column, detector, signal recording system etc.High performance liquid chromatograph is widely used in Pharmaceutical Analysis, environmental monitoring, fields such as food inspection.
Short stroke liquid chromatograph high pressure pump is the solvent delivery parts of high performance liquid chromatograph.High performance liquid chromatograph is high pressure resistant to the requirement of high pressure pump, and transfusion steadily pulsation is little, and flow degree of accuracy and precision are high.High pressure pump is mainly by cam, plunger, and seal ring, parts such as pump head and control circuit are formed, and drive the plunger axis motion by the rotation of cam, accomplish suction water.The stroke of existing analytic type liquid chromatograph high pressure pump cam mainly contains 2mm, 6mm, and 8mm, four kinds of 10mm etc. adopt the plunger rod design of floating.
Stroke is lower than the liquid chromatograph infusion pump of 2mm, because its stroke is shorter, the one-way valve that causes this pump is when flow is big, and the valve ball bob is too fast, and is poorly sealed between valve ball and the valve seat, can occur the situation of not inhaling liquid in the running; The stroke of liquid chromatograph infusion pump will cause the transfusion pulsation big if surpass 6mm, and flow accuracy is low, has influenced the sensitivity of detector.
Summary of the invention
In view of this, the invention provides a kind of liquid chromatograph and infusion pump thereof, to realize the low-pressure pulsation and the high flow capacity stability of infusion pump in the broad flow rates.
For realizing above-mentioned purpose, the present invention provides following technological scheme:
A kind of liquid chromatograph infusion pump comprises:
Cam, the stroke of said cam is between 2mm and 6mm;
The push rod that links to each other with said cam;
Be set in the plunger mat in the inner chamber of said push rod, the outer ring of this plunger mat is set with spring, and the two ends of this spring are leaned on said plunger mat respectively and are fixed on the spring fixed seat location on the pump head of this infusion pump;
The plunger rod that links to each other with said plunger mat.
Preferably, in the above-mentioned liquid chromatograph infusion pump, the stroke of said cam is 4mm.
Preferably, in the above-mentioned liquid chromatograph infusion pump, this infusion pump is the plunger pump that the phase angle differs two plunger rods of double-cam driving of 180 degree, and the stroke of these two cams is respectively 4mm and 2mm.
Preferably, in the above-mentioned liquid chromatograph infusion pump, this infusion pump is the integrated pump head structure of tandem.
Preferably, in the above-mentioned liquid chromatograph infusion pump, connect the pipeline that said two plunger rods belong to pump chamber respectively and be provided with one-way valve.
Preferably, in the above-mentioned liquid chromatograph infusion pump, the packing holder of this infusion pump is floating type packing holder.
A kind of liquid chromatograph comprises infusion pump, and this infusion pump is aforesaid infusion pump.
Can find out from above-mentioned technological scheme; Infusion pump provided by the invention is through adopting the cam of stroke between the 2mm to 6mm; Realized the low-pressure pulsation of high pressure pump in the broad flow rates; High flow capacity stability has solved the shorter cam stroke problem of not imbibition once in a while, has improved the stability and the reliability of high pressure pump.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technological scheme of the prior art; To do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below; Obviously, the accompanying drawing in describing below only is some embodiments of the present invention, for those of ordinary skills; Under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
The partial structurtes schematic representation of the liquid chromatograph infusion pump that Fig. 1 provides for the embodiment of the invention;
The schematic representation of the liquid chromatograph that Fig. 2 provides for the embodiment of the invention.
Embodiment
Liquid chromatograph infusion pump provided by the invention comprises: cam, push rod, plunger mat and plunger.
Wherein, The stroke of cam is between 2mm and 6mm, and infusion pump provided by the invention is through adopting the cam of stroke between the 2mm to 6mm, and the stroke of cam is preferably 4mm; Realized the low-pressure pulsation of high pressure pump in the broad flow rates; High flow capacity stability has solved the shorter cam stroke problem of not imbibition once in a while, has improved the stability and the reliability of high pressure pump.
Push rod links to each other with cam; Rotation through cam can promote push rod and move axially; Be arranged with plunger mat in the inner chamber of push rod, the outer ring of this plunger mat is set with spring, and the two ends of this spring are leaned on plunger mat respectively and are fixed on the spring fixed seat location on the pump head of this infusion pump.Plunger rod links to each other with plunger mat, and push rod drives plunger mat and the plunger rod axis moves, thereby accomplishes suction water.
To combine the accompanying drawing in the embodiment of the invention below, the technological scheme in the embodiment of the invention is carried out clear, intactly description, obviously, described embodiment only is the present invention's part embodiment, rather than whole embodiments.Based on the embodiment among the present invention, those of ordinary skills are not making the every other embodiment who is obtained under the creative work prerequisite, all belong to the scope of the present invention's protection.
See also Fig. 1, the partial structurtes schematic representation of the liquid chromatograph infusion pump that Fig. 1 provides for the embodiment of the invention.
Wherein, 11 is main cam, and 12 is auxiliary cam, and 13 is push rod, and 14 is plunger mat, and 15 is spring, and 16 is the secondary seal circle, and 17 is plunger rod, and 18 is the primary seal circle, and 19 is packing holder.
In the present embodiment, liquid chromatograph infusion pump provided by the invention is the plunger pump that the phase angle differs two plunger rods of double-cam driving of 180 degree, comprising: main cam 11, auxiliary cam 12, push rod 13, plunger mat 14 and plunger rod 17.
Wherein, The stroke ratio of main cam 11 and auxiliary cam 12 is 2: 1; The stroke that is preferably main cam 11 is 4mm; The stroke of auxiliary cam 12 is 2mm, and double-cam provided by the invention is in order to realize the output of mobile phase pulsating movement free through the form that adopted 2: 1, and liquid chromatograph is that high pressure and pulsation are as much as possible little to the requirement of pump.
The plunger pump that comprises main cam 11 is identical with the plunger pump structure that comprises auxiliary cam 12; Include the push rod 13 that links to each other with cam; Rotation through cam can promote push rod 13 and move along its axis; Be arranged with plunger mat 14 in the inner chamber of push rod 13, the outer ring of this plunger mat 14 is set with spring 15, and the two ends of this spring 15 are leaned on plunger mat 14 respectively and are fixed on the spring fixed seat location on the pump head of this infusion pump.Plunger rod 17 links to each other with plunger mat 14, and push rod 13 drives plunger mat 14 and plunger rod 17 axis move, thereby accomplishes suction water.This infusion pump is the integrated pump head structure of tandem, has avoided the higher drawback of machining accuracy and installation requirement.Adopt the high pressure pump of this programme design to have transfusion characteristics such as steadily pulsation is little, and flow degree of accuracy and precision are high, and is durable in use.
Connect the pipeline that two plunger rods belong to pump chamber respectively and be provided with one-way valve.
The packing holder 19 of infusion pump provided by the invention is floating type packing holder.Help guaranteeing the concentricity of plunger rod, reduce wearing and tearing.
See also Fig. 2, the schematic representation of the liquid chromatograph that Fig. 2 provides for the embodiment of the invention.
Wherein, 21 is auxiliary cam, and 22 is main cam, and 23 is the subpost stopper rod, and 24 is the principal post stopper rod, and 25 is first one-way valve, and 26 is second one-way valve.
Liquid chromatograph infusion pump provided by the invention comprises infusion pump recited above, its working principle: adopting the phase angle is that 180 degree double-cam (main cam 22, auxiliary cam 21) drive two jewel roofbolt plug (principal post stopper rods 24; Subpost stopper rod 23); Second one-way valve 26 is opened when imbibition, and first one-way valve 25 is closed, and principal post stopper rod 24 is retreated; Solvent is full of the main pump chamber, and subpost stopper rod 23 advances and accomplishes the discharge opeing action in the time of the imbibition of main pump chamber; Second one-way valve 26 is closed when the discharge opeing of main pump chamber, and first one-way valve 25 is opened, and principal post stopper rod 24 advances, and half is full of the auxiliary pump chamber solvent, and second half in chromatographic column, so far accomplishes the cam of one-period through tubes rows.The stroke ratio of major-minor cam is 2: 1, when carrying out delivery solvent, carries out pressure monitoring and demonstration by upper computer software, and the control step motor speed realizes that the flow velocity in the 0.001-9.999mL/min scope is set.
Each embodiment adopts the mode of going forward one by one to describe in this specification, and what each embodiment stressed all is and other embodiments' difference that identical similar part is mutually referring to getting final product between each embodiment.
To the above-mentioned explanation of the disclosed embodiments, make related domain professional and technical personnel can realize or use the present invention.Multiple modification to these embodiments will be conspicuous concerning those skilled in the art, and defined General Principle can realize under the situation that does not break away from the spirit or scope of the present invention in other embodiments among this paper.Therefore, the present invention will can not be restricted to these embodiments shown in this paper, but will meet and principle disclosed herein and features of novelty the wideest corresponding to scope.
Claims (7)
1. a liquid chromatograph infusion pump is characterized in that, comprising:
Cam, the stroke of said cam is between 2mm and 6mm;
The push rod that links to each other with said cam;
Be set in the plunger mat in the inner chamber of said push rod, the outer ring of this plunger mat is set with spring, and the two ends of this spring are leaned on said plunger mat respectively and are fixed on the spring fixed seat location on the pump head of this infusion pump;
The plunger rod that links to each other with said plunger mat.
2. liquid chromatograph infusion pump as claimed in claim 1 is characterized in that, the stroke of said cam is 4mm.
3. liquid chromatograph infusion pump as claimed in claim 1 is characterized in that, this infusion pump is the plunger pump that the phase angle differs two plunger rods of double-cam driving of 180 degree, and the stroke of these two cams is respectively 4mm and 2mm.
4. liquid chromatograph infusion pump as claimed in claim 3 is characterized in that, this infusion pump is the integrated pump head structure of tandem.
5. liquid chromatograph infusion pump as claimed in claim 4 is characterized in that, connects the pipeline that said two plunger rods belong to pump chamber respectively and is provided with one-way valve.
6. liquid chromatograph infusion pump as claimed in claim 1 is characterized in that, the packing holder of this infusion pump is floating type packing holder.
7. a liquid chromatograph comprises infusion pump, it is characterized in that, this infusion pump is like each described infusion pump of claim 1-6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102217645A CN102312807A (en) | 2010-07-05 | 2010-07-05 | Liquid chromatograph and infusion pump thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102217645A CN102312807A (en) | 2010-07-05 | 2010-07-05 | Liquid chromatograph and infusion pump thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102312807A true CN102312807A (en) | 2012-01-11 |
Family
ID=45426277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102217645A Pending CN102312807A (en) | 2010-07-05 | 2010-07-05 | Liquid chromatograph and infusion pump thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102312807A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102155378A (en) * | 2011-03-17 | 2011-08-17 | 芜湖天乐分析仪器有限公司 | High-pressure constant current pump of liquid chromatograph |
| CN102913407A (en) * | 2012-07-29 | 2013-02-06 | 安徽皖仪科技股份有限公司 | High-pressure constant-flow pump based on two-stage suspension transmission technology |
| CN103423120A (en) * | 2013-08-21 | 2013-12-04 | 利穗科技(苏州)有限公司 | Three-plunger high-pressure pump |
| CN105065223A (en) * | 2015-08-05 | 2015-11-18 | 浙江福立分析仪器有限公司 | High-pressure plunger infusion pump and aligning method thereof |
| CN112129854A (en) * | 2020-09-18 | 2020-12-25 | 中触媒新材料股份有限公司 | Adsorption separation evaluation device based on online detection and use method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2156303Y (en) * | 1993-03-15 | 1994-02-16 | 殷参 | Plunger pump transmission device |
| EP0801982A2 (en) * | 1996-04-18 | 1997-10-22 | Walu Apparatetechnik GmbH | Plunger type burette |
| CN1393693A (en) * | 2001-06-29 | 2003-01-29 | 中国科学院大连化学物理研究所 | Low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers |
-
2010
- 2010-07-05 CN CN2010102217645A patent/CN102312807A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2156303Y (en) * | 1993-03-15 | 1994-02-16 | 殷参 | Plunger pump transmission device |
| EP0801982A2 (en) * | 1996-04-18 | 1997-10-22 | Walu Apparatetechnik GmbH | Plunger type burette |
| CN1393693A (en) * | 2001-06-29 | 2003-01-29 | 中国科学院大连化学物理研究所 | Low-pulse high-precision efficient liquid-phase chromatographic pump with dual plungers |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102155378A (en) * | 2011-03-17 | 2011-08-17 | 芜湖天乐分析仪器有限公司 | High-pressure constant current pump of liquid chromatograph |
| CN102155378B (en) * | 2011-03-17 | 2012-12-05 | 芜湖天乐分析仪器有限公司 | High-pressure constant current pump of liquid chromatograph |
| CN102913407A (en) * | 2012-07-29 | 2013-02-06 | 安徽皖仪科技股份有限公司 | High-pressure constant-flow pump based on two-stage suspension transmission technology |
| CN102913407B (en) * | 2012-07-29 | 2015-07-29 | 安徽皖仪科技股份有限公司 | A kind of high pressure constant flow pump based on two-stage suspension drive technology |
| CN103423120A (en) * | 2013-08-21 | 2013-12-04 | 利穗科技(苏州)有限公司 | Three-plunger high-pressure pump |
| CN105065223A (en) * | 2015-08-05 | 2015-11-18 | 浙江福立分析仪器有限公司 | High-pressure plunger infusion pump and aligning method thereof |
| CN112129854A (en) * | 2020-09-18 | 2020-12-25 | 中触媒新材料股份有限公司 | Adsorption separation evaluation device based on online detection and use method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102312807A (en) | Liquid chromatograph and infusion pump thereof | |
| EP0615126B1 (en) | Solvent pumping system | |
| CN101267852B (en) | Miniature pump for drug delivery | |
| CN102691637B (en) | Micropump | |
| CN102187197B (en) | Sample injection port, and auto-sampler having the port | |
| JP6114405B2 (en) | Pumps and injection valves for liquid chromatography | |
| US20110107582A1 (en) | Automated installation procedure for a disposable flow path | |
| CN106139311A (en) | A kind of drug-supplying system comprising position detection unit | |
| CN102879505B (en) | Needle adaptor and automatic sampler using the same | |
| US9897577B2 (en) | Apparatus for field-flow fractionation | |
| CN203879700U (en) | End face cam type micro-flow plunger pump driven by stepping motor | |
| JP5977429B2 (en) | Piston pump and device for supplying and measuring medical fluid by piston pump | |
| CN106104267A (en) | The seal moving with piston in high-pressure pump | |
| CN103982390B (en) | The end surface cam type single cylinder micrometeor plunger displacement pump that a kind of servomotor directly drives | |
| US20160252435A1 (en) | Solid phase extraction cartridge | |
| JP2015535608A (en) | Microfluidic interconnect | |
| JP2018091484A (en) | Microfluidic check valve and related devices and systems | |
| CN201696242U (en) | Double-plunger high-pressure infusion pump for liquid chromatograph | |
| CN106442807A (en) | Method for detecting posaconazole chiral isomers through high performance liquid chromatography | |
| CN205581064U (en) | High pressure constant current infusion set | |
| CN204469275U (en) | The full-automatic tomographic system of a kind of list/double pump | |
| Yang et al. | Recent development in capillary ion chromatography technology | |
| CN104345114B (en) | A kind of method of reverse phase separation derivatization leucine and isoleucine | |
| CN109444310A (en) | The high pressure resistant gradient valve of liquid chromatogram and liquid chromatogram feed liquor system | |
| CN202645955U (en) | A liquid chromatogram advection infusion pump |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120111 |