CN1382479A - External-applied Chinese medicine for treating hypertension and its preparing process - Google Patents
External-applied Chinese medicine for treating hypertension and its preparing process Download PDFInfo
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- CN1382479A CN1382479A CN 02114586 CN02114586A CN1382479A CN 1382479 A CN1382479 A CN 1382479A CN 02114586 CN02114586 CN 02114586 CN 02114586 A CN02114586 A CN 02114586A CN 1382479 A CN1382479 A CN 1382479A
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- radix salviae
- herba apocyni
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- salviae miltiorrhizae
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Abstract
An externally-applied Chinese medicine for treating hypertension is prepared from 6 raw materials including uncaria stem with hooks, red sage root, prunella spike, borned, etc. Its preparing process is also disclosed. Its advantages are high curative effect and no toxic by-effect.
Description
Affiliated technical field:
The present invention relates to a kind ofly bring into play the external Chinese medicine that drug effect is treated, be specifically related to hypertensive external Chinese medicine of a kind of treatment and preparation technology thereof by skin absorbs.
Background technology:
Hypertension is a kind of worldwide commonly encountered diseases, the medicine that has been widely used at present has with calcium ion antagonist nitrendipine, diuretic, beta-blocker, calcium antagonist, Angiotensin-Converting inhibition etc., but these medicines are to be plinth very with the single medicine treatment basically, its shortcoming is: the medicine amount effect curve is low flat, body produces counter regulation after the medicine blood pressure lowering, activates and water-sodium retention with the RAS system as sympathetic, can reduce even offset antihypertensive effect.The Chinese medicine and western medicine that begins to adopt from the nineties is better than single medicine therapeutic effect in conjunction with the drug combination effect, as the compound blood pressure reducing capsule, Ramulus Uncariae Cum Uncis hypertension pill, compound Herba Apocyni veneti (Folium Apocyni Veneti) hypertension pill, Radix Salviae Miltiorrhizae drop pill, Spica Prunellae chiang ya wan, the blood pressure lowering that have appeared on the market the at present electuary etc. that nourishes blood, but these medicines all are oral formulations, taking medicine all has certain influence to hepatic and renal function when afterwards digestive tract being had stimulation and drug metabolism, so therapeutic effect is also undesirable.Though and pure Chinese medicine antihypertensive formulation also has development, because the improper effect of compatibility of drugs is not good enough, therefore the preparation method imperfection yet there are no the pure Chinese medicine antihypertensive formulation into patient's approval simultaneously.
Summary of the invention:
One of purpose of the present invention provides the hypertensive external Chinese medicine of a kind of treatment, and the prior art antihypertensive effect is undesirable, price is higher to overcome, the shortcoming of toxic side effect, and two of purpose provides a kind of preparation technology who treats hypertensive external Chinese medicine.
For achieving the above object, technical solution of the present invention is:
The hypertensive external Chinese medicine of a kind of treatment, its special character is: its composition of raw materials (weight ratio) is as follows
Ramulus Uncariae Cum Uncis 180～220 Radix Salviae Miltiorrhizaes 135～165 Herba Apocyni venetis 135～165
Spica Prunellae 90～110 Borneolum Syntheticums 4.5～5.5 azones 4.5～5.5
The preferred version of above-mentioned raw materials prescription (weight ratio) is:
Ramulus Uncariae Cum Uncis 200 Radix Salviae Miltiorrhizaes 150 Herba Apocyni venetis 150
Spica Prunellae 100 Borneolum Syntheticums 5 azones 5
The preparation technology of the hypertensive external Chinese medicine of above-mentioned treatment, its special character is, comprises the steps one, get the raw materials ready successively: press composition of raw materials (weight ratio) and prepare Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Herba Apocyni veneti, Spica Prunellae, Borneolum Syntheticum and azone; Two, the Radix Salviae Miltiorrhizae got ready, Herba Apocyni veneti are cleaned, oven dry, coarse pulverization be placed in the container with lid, add 80% alcohol reflux 2 times, the solvent multiple is respectively 10 times, 8 times, and the time was followed successively by 2 hours, 1 hour, and merging filtrate is made Radix Salviae Miltiorrhizae then, the Herba Apocyni veneti alcohol extract is standby; Three, Radix Salviae Miltiorrhizae, Herba Apocyni veneti medicinal residues and Ramulus Uncariae Cum Uncis, the Spica Prunellae got ready are decocted with water 2 times, each 60 minutes, amount of water is respectively 8 times, 7 times, the filtration of removing slag is evaporated to 1.05～1.10/60 ℃ of relative densities, adds ethanol to pure content and reaches 60%, mix, leave standstill filtration in 24 hours, add " Radix Salviae Miltiorrhizae, Herba Apocyni veneti alcohol extract " and mix, reclaiming ethanol, to be evaporated to relative density be 1.05～1.10/60 ℃ fluid extract; Four, get quantitative flow extractum and add Borneolum Syntheticum, the azone of getting ready, mix, last adding distil water filters to aequum.
In above-mentioned the 4th step, Borneolum Syntheticum is earlier with a small amount of ethanol dissolving.
Theoretical foundation of the present invention is: hypertension is a kind of common syndrome based on the systemic arterial blood pressure rising, and clinical symptoms with headache, dizzy for seeing more.From the theory of Chinese medical science analysis, suppressing the hyperactive liver and subsiding YANG, tranquilizing by nourishing the heart are answered in treatment, dredge channels and activating collaterals, activating blood circulation to dissipate blood stasis.From the doctor trained in Western medicine theory analysis, treatment should be regulated neuroendocrine function, with blood vessel dilating, reduction peripheral vascular resistance, microcirculation improvement, thereby reaches the purpose that brings high blood pressure down.Hatred is according to above-mentioned Chinese and western medicine theory, and it is monarch that the present invention has taked with the Ramulus Uncariae Cum Uncis, and Herba Apocyni veneti, Spica Prunellae are minister, and Radix Salviae Miltiorrhizae, Borneolum Syntheticum are assistant, and being equipped with azone is the attached principles of formulating prescriptions.
Compared with prior art, advantage of the present invention is as follows:
1, antihypertensive effect is remarkable: the present invention is without digestive tract, avoided the influence of PH, food and Digestive system to drug effect, trade name of the present invention is drafted and is " flat safe adjust blood pressure liquid ", through clinical observation, employing at random, singly blind, parallel, controlled trial (matched group is that nifedipine is oral) proves, the blood pressure lowering width of cloth shelf of this product is greater than nifedipine level (P＜0.01), and the energy microcirculation improvement, and certain effect for reducing fat is arranged, especially be fit to the gerontal patient and use;
2, instant effect: this product is through clinical observation, and generally speaking, 30 minutes begin to work behind the coating, and bleeding from anus pressed off beginning decline in one hour, after 3-4 hour, shrinks pressure energy decline 20-40mm/Hg, diastolic pressure decline 4-8mm/Hg;
3, have no side effect, do not influence digestive tract and hepatic and renal function: owing to be external, therefore medicine is without digestive tract, having reduced stimulates gastrointestinal, walk around the first pass effect of liver simultaneously, alleviated burden of liver, do not influenced renal blood flow and glomerular filtration amount, harmless to hepatic and renal function, the peak valley phenomenon of blood substance concentration when conventional administration not occurring;
4, easy to use, no pain: external is smeared, Transdermal absorption, according to the state of an illness, every day, medication was 1-2 time, after blood pressure is reduced to normal level, can reduce consumption and number of times, or the next day with once getting final product;
5, cheap, be fit to China's actual conditions;
6, preparation technology is simple.
Description of drawings:
Accompanying drawing is preparation technology's flow chart of the present invention.
The specific embodiment:
Following embodiment all is described with preparation 1000ml product.
Embodiment 1: this example is a most preferred embodiment,
Composition of raw materials (weight ratio): Ramulus Uncariae Cum Uncis 200g, Radix Salviae Miltiorrhizae 150g, Herba Apocyni veneti 150g, Spica Prunellae 100g, Borneolum Syntheticum 5g, azone 5g;
Preparation technology: referring to accompanying drawing, one, get the raw materials ready: press composition of raw materials (weight ratio) and prepare Ramulus Uncariae Cum Uncis 200g, Radix Salviae Miltiorrhizae 150g, Herba Apocyni veneti 150g, Spica Prunellae 100g, Borneolum Syntheticum 5g, azone 5g; Two, Radix Salviae Miltiorrhizae, Herba Apocyni veneti are cleaned, oven dry, coarse pulverization be placed in the container with lid, add 80% alcohol reflux 2 times, the solvent multiple is respectively 10 times, 8 times of raw materials used weight, time was followed successively by 2 hours, 1 hour, and the filtrate that merges twice is then made Radix Salviae Miltiorrhizae, the Herba Apocyni veneti alcohol extract is standby; Three, Radix Salviae Miltiorrhizae, Herba Apocyni veneti medicinal residues and Ramulus Uncariae Cum Uncis, Spica Prunellae are decocted with water 2 times, each 60 minutes amount of water are respectively 8 times, 7 times of raw materials used weight, the filtration of removing slag, be evaporated to 1.05～1.10/60 ℃ of relative densities, add ethanol to pure content and reach 60%, mix, leave standstill filtration in 24 hours, add " Radix Salviae Miltiorrhizae, Herba Apocyni veneti alcohol extract " and mix, reclaiming ethanol, to be evaporated to relative density be 1.05～1.10/60 ℃ fluid extract; Four, get fluid extract 100g adding and mix with alcohol-soluble Borneolum Syntheticum 5g, azone 5ml, last adding distil water filters to 1000ml, and the bottling vanning is put in storage.
Embodiment 2:
Composition of raw materials (weight ratio): Ramulus Uncariae Cum Uncis 180g, Radix Salviae Miltiorrhizae 165g, Herba Apocyni veneti 165g, Spica Prunellae 90g, Borneolum Syntheticum 5.5g, azone 4.5g.
Preparation technology is with embodiment 1.
Embodiment 3:
Composition of raw materials (weight ratio): Ramulus Uncariae Cum Uncis 220g, Radix Salviae Miltiorrhizae 135g, Herba Apocyni veneti 135g, Spica Prunellae 110g, Borneolum Syntheticum 4.5g, azone 5.5g.
Borneolum Syntheticum promptly mixed with fluid extract without the ethanol dissolving during preparation technology the 4th went on foot; All the other steps are with embodiment 1.
The present invention is suitable for the crowd: hypertension, high blood viscosity.
Using method of the present invention: being coated with outward, is the center with Quchi, the tsusanli acupoint every day 1～2 time, and application area is not less than 20 square centimeters, as has a dizzy spell then to add and be coated with temple, and the patient can regulate consumption and number of times according to the monitoring of blood pressure situation.The condition of this product stock is: lucifuge, the shady and cool airtight preservation in place.
Main production equipments of the present invention is a common equipment: comprise boiler, Chinese medicine extraction pot, ethanol reclaimer, filter, filling machine and sealing machine.
Claims (4)
1, the hypertensive external Chinese medicine of a kind of treatment, it is characterized in that: its composition of raw materials (weight ratio) is as follows
Ramulus Uncariae Cum Uncis 180～220 Radix Salviae Miltiorrhizaes 135～165 Herba Apocyni venetis 135～165
Spica Prunellae 90～110 Borneolum Syntheticums 4.5～5.5 azones 4.5～5.5
2, the hypertensive external Chinese medicine of a kind of treatment as claimed in claim 1, it is characterized in that: described composition of raw materials (weight ratio) is as follows
Ramulus Uncariae Cum Uncis 200 Radix Salviae Miltiorrhizaes 150 Herba Apocyni venetis 150
Spica Prunellae 100 Borneolum Syntheticums 5 azones 5
3, a kind of preparation technology who treats hypertensive external Chinese medicine as claimed in claim 1 is characterized in that: comprise the steps one, get the raw materials ready successively: press composition of raw materials (weight ratio) and prepare Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Herba Apocyni veneti, Spica Prunellae, Borneolum Syntheticum and azone; Two, the Radix Salviae Miltiorrhizae got ready, Herba Apocyni veneti are cleaned, oven dry, coarse pulverization be placed in the container with lid, add 80% alcohol reflux 2 times, the solvent multiple is respectively 10 times, 8 times, and the time was followed successively by 2 hours, 1 hour, and merging filtrate is made Radix Salviae Miltiorrhizae then, the Herba Apocyni veneti alcohol extract is standby; Three, Radix Salviae Miltiorrhizae, Herba Apocyni veneti medicinal residues and Ramulus Uncariae Cum Uncis, the Spica Prunellae got ready are decocted with water 2 times, each 60 minutes, amount of water is respectively 8 times, 7 times, the filtration of removing slag is evaporated to 1.05～1.10/60 ℃ of relative densities, adds ethanol to pure content and reaches 60%, mix, leave standstill filtration in 24 hours, add " Radix Salviae Miltiorrhizae, Herba Apocyni veneti alcohol extract " and mix, reclaiming ethanol, to be evaporated to relative density be 1.05～1.10/60 ℃ fluid extract; Four, get quantitative flow extractum and add Borneolum Syntheticum, the azone of getting ready, mix, last adding distil water filters to aequum.
4, a kind of preparation technology who treats hypertensive external Chinese medicine as claimed in claim 3 is characterized in that: in described the 4th step, Borneolum Syntheticum is earlier with a small amount of ethanol dissolving.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021145865A CN1195537C (en) | 2002-05-21 | 2002-05-21 | External-applied Chinese medicine for treating hypertension and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021145865A CN1195537C (en) | 2002-05-21 | 2002-05-21 | External-applied Chinese medicine for treating hypertension and its preparing process |
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| Publication Number | Publication Date |
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| CN1382479A true CN1382479A (en) | 2002-12-04 |
| CN1195537C CN1195537C (en) | 2005-04-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021145865A Expired - Fee Related CN1195537C (en) | 2002-05-21 | 2002-05-21 | External-applied Chinese medicine for treating hypertension and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173422A (en) * | 2013-05-28 | 2014-12-03 | 广西玉林宏江能源科技有限公司 | Special effect antihypertensive wetly-applied medicinal towel used for Yongquan acupoint of human feet |
| CN115068541A (en) * | 2022-03-18 | 2022-09-20 | 黑龙江中医药大学 | A topical Chinese medicinal balm containing aromatic essential oil with blood pressure lowering effect |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618124B (en) * | 2009-08-10 | 2010-11-03 | 沈阳亿灵医药科技有限公司 | Kendir pressure-reducing sticking agent and preparation method thereof |
-
2002
- 2002-05-21 CN CNB021145865A patent/CN1195537C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173422A (en) * | 2013-05-28 | 2014-12-03 | 广西玉林宏江能源科技有限公司 | Special effect antihypertensive wetly-applied medicinal towel used for Yongquan acupoint of human feet |
| CN115068541A (en) * | 2022-03-18 | 2022-09-20 | 黑龙江中医药大学 | A topical Chinese medicinal balm containing aromatic essential oil with blood pressure lowering effect |
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| Publication number | Publication date |
|---|---|
| CN1195537C (en) | 2005-04-06 |
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