CN1279930C - Applicaton of chinese angelica-root for preparing medicine for treating hypertension disease - Google Patents
Applicaton of chinese angelica-root for preparing medicine for treating hypertension disease Download PDFInfo
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- CN1279930C CN1279930C CN 03109735 CN03109735A CN1279930C CN 1279930 C CN1279930 C CN 1279930C CN 03109735 CN03109735 CN 03109735 CN 03109735 A CN03109735 A CN 03109735A CN 1279930 C CN1279930 C CN 1279930C
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Abstract
The present invention discloses a preparation method for a Chinese medicinal angelica preparation. In the present invention, the angelica preparation is prepared into an oral preparation by that: angelica is processed; the volatile oil is removed; the angelica is treated through procedures of extraction, concentration, ethanol deposition and filtration, and a filter solution is obtained; then the filter solution is concentrated. The preparation method can be applied to the process of preparing medicines for curing hypertension.
Description
Technical field the present invention relates to the preparation method of Radix Angelicae Sinensis, mainly relates to treat the preparation method of hypertension disease medicament.
Background technology has the effect of invigorating blood circulation, enriching blood when being classified as traditional Chinese crude drug, is used for blood deficiency, Blood stasis clinically more, is usually used in gynaecopathia, and is applied in multiple compound preparation and the decoction, and its preparation has danggui extract, danggui liujin gao.Radix Angelicae Sinensis there is no the hypertensive curative effect of medication of treatment with the angelica sinensis preparations of traditional concocting method and preparation process preparation.Adopt the angelica sinensis preparations of this technology preparation, have the hypertensive effect of treatment.
Summary of the invention the objective of the invention is to change traditional Radix Angelicae Sinensis to be concocted and formulation method, prepares a kind of medicine that can be used for treating hypertension.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions:
Angelica sinensis preparations is prepared from by Radix Angelicae Sinensis medical material and other adjuvants.Can handle through 100～120 ℃ of baking 1～2h before wherein the Radix Angelicae Sinensis medical material feeds intake; Prepare the intermediate products concentrated solution earlier, preparation process is:
(1) Radix Angelicae Sinensis 1000 grams add 8～12 times of water gagings and decocted 1-2 hour, filter.Add 6～10 times of decoctings again the 2nd time and boil 0.5～1.5h, collecting decoction.Filter, get filtrate;
(2) after filtrate 1 concentrates, add ethanol and make and contain the alcohol amount and reach 40%～70%, leave standstill 24～48h, filter, filtrate 2.
(3) filtrate 2 is reclaimed ethanol to nothing alcohol flavor, and the simmer down to concentrated solution.
This concentrated solution can be that to contain the crude drug amount be that 0.8～1.2g/ml or relative density are 1.05～1.10 concentrated solution.
Get concentrated solution and can prepare oral liquid with conventional method.Method gets oral liquid for adding antiseptic, correctives, accent pH value are 5.5-7.0.
The sprayable powder that is dried to of this concentrated solution, powder useful formulations conventional method prepares oral preparation of Chinese traditional medicinal such as granule, capsule, tablet.
Adopt the angelica sinensis preparations of this prepared, oral liquid formulations once carried out pharmacological evaluation and clinical verification, had the hypertensive effect of treatment.Other dosage form is not because of having substantial process reform with oral liquid formulations, so active ingredient is not suffered a loss, effect should be suitable with oral liquid formulation.
The specific embodiment
1, a plurality of factors that preparation method described in the technical scheme is related to are tested, with as the detailed elaboration of the technical program.
Time during table 1 Radix Angelicae Sinensis medicinal material processing and temperature are to the influence of volatile oil
| Temperature | Drying time | Result's (volatile oil check) |
| 100℃ 105℃ 115℃ | 2 1 1 | No volatile oil does not have volatile oil and does not have volatile oil, and part is sent out burnt |
The preparation of the decocting number of times that table 2 is different
| Number of times | Time (h) | Paste-forming rate |
| 1 2 3 | 2 2 2 | 13.6％ 14.8％ 15.2％ |
The preparation of different time and amount of water during table 3 secondary decocting
| The water yield for the first time | Time | The water yield for the second time | Time | Paste-forming rate (%) |
| 8 8 8 10 10 10 12 12 12 | 1 1.5 2 1 1.5 2 1 1.5 2 | 6 8 10 8 6 10 10 6 8 | 1 1.5 2 2 1 1.5 1.5 2 1 | 14.6 14.8 15.2 13.6 14.3 16.2 16.3 17.1 17.3 |
The asynchronous selection of table 4 alcohol precipitation concentration
| Adding ethanol makes to containing the alcohol amount | Result behind the precipitate with ethanol |
| 36％ 55％ 70％ | Precipitate slowlyer, be difficult for to filter the 24h precipitation, easily filter the 24h precipitation, easily filter |
The amount of table 5 concentrated solution and the relation of character
| Contain crude drug amount (g/ml) | Density | Character |
| 0.8 1.0 1.2 | 1.06 1.08 1.09 | Rarer, supernatant liquid is rarer, supernatant liquid is than thick liquid (can be used for spray drying) |
2, the application of Radix Angelicae Sinensis in preparation
Get the concentrated solution of 1.0g/ml, select different correctivess for use, different antiseptic are prepared oral liquid, and the result all meets the preparation requirement.
| PH value | Stevioside | Essence | Potassium sorbate | The result |
| 6.8 5.9 6.5 | 0.1％ 0.2％ - | - - 0.1％ | 0.1％ 0.1％ 0.2％ | Character character up to specification character up to specification is up to specification |
The embodiment of preparation solid preparation:
1.2g/ml concentrated solution 10kg spray drying is got the 600g powder.
The 1. powder 400g sucrose 600g that write out a prescription make granule.
The 2 powder 100g that write out a prescription directly overlap capsule, capsule.
Prescription 3 is got the granule in the prescription 1, and the cover capsule gets capsule.
Prescription 4 is got the granule 500g in the prescription 1, adds the 10g magnesium stearate, and tabletting gets tablet.
3, the Clinical results (Xiyuan, Beijing hospital) of the health arteries and veins heart oral liquid made of Radix Angelicae Sinensis (name temporarily):
Health arteries and veins heart oral liquid is served as reasons when the pure Chinese medicinal preparation of the treatment hypertension that is classified as main component, this research is double blinding dual analog, randomized controlled trial, holds concurrently blood stasis type as observing pattern of syndrome with syndrome of hyperactivity of yang due to yin deficiency, observes 80 examples altogether, double-blind treatment group 40 examples wherein, double blind control group 40 examples.Double-blind treatment group blood pressure lowering total effective rate is 75.00% as a result, and obvious effective rate is 32.50%, and the tcm syndrome total effective rate is 82.50%, and obvious effective rate is 37.50%, and double blind control group blood pressure lowering total effective rate is 90.00%, and apparent rate is 37.50%.The tcm syndrome total effective rate is 82.50%, and apparent rate is 37.50%.
After the treatment of health arteries and veins heart oral liquid treatment group, experimenter's blood pressure has more significantly decline, and the integration of systolic pressure is 168.43 ± 14.62 before the treatment, be 145.98 ± 12.11 after the treatment, difference is 22.45 ± 14.80, learns by statistics and handles, and statistical significance (P＜0.01) is arranged; The integration of diastolic pressure is 101.45 ± 6.32 before the treatment, is 90.18 ± 8.43 after the treatment, and difference is 11.28 ± 7.99, learns by statistics and handles, and statistical significance (P＜0.01) is arranged.
After the pained stator treatment of control group, experimenter's blood pressure has more significantly decline, and the integration of diastolic pressure is 164.13 ± 14.97 before the treatment, be 138.00 ± 14.19 after the treatment, difference is 26.13 ± 16.74, learns by statistics and handles, and statistical significance (P＜0.01) is arranged; The integration of systolic pressure is 99.20 ± 6.47 before the treatment, is 88.85 ± 9.37 after the treatment, and difference is 10.35 ± 8.47, learns by statistics and handles, and statistical significance (P＜0.01) is arranged.
On onset time, the average onset time of health arteries and veins heart oral liquid group is 2.43 ± 1.41 days, and pained stator group is 1.85 ± 0.76 days, learns by statistics and handles, statistical significance (P＜0.01) is arranged, and the average onset time of promptly pained stator group is shorter than health arteries and veins heart oral liquid group.
Claims (7)
1, the preparation method of the hypertensive angelica sinensis preparations of treatment is characterized in that: said preparation by Radix Angelicae Sinensis simply medical material and other adjuvants forms, wherein the Radix Angelicae Sinensis medical material dries by the fire processing in 1～2 hour through 100～120 ℃; Concrete preparation method is:
(1) Radix Angelicae Sinensis decocts with water 2-3 time, collecting decoction: filter, get filtrate 1;
(2) after filtrate 1 concentrates, add ethanol and make and contain the alcohol amount and reach 40%～70%, leave standstill 24～48h, filter, filtrate 2;
(3) filtrate 2 is reclaimed ethanol to there not being the alcohol flavor, and concentrate concentrated solution.
2, according to the preparation method of the hypertensive angelica sinensis preparations of the described treatment of claim 1, it is characterized in that: the method that decocts with water described in the step (1) is: 8～12 times of water gagings decocted 1～2 hour, filtered; Add 6～10 times of decoctings again the 2nd time and boil 0.5～1.5h.
3, according to the preparation method of the hypertensive angelica sinensis preparations of the described treatment of claim 1, it is characterized in that: the concentrated solution described in the step (3) is that 0.8～1.2g/ml or relative density are 1.05～1.10 for containing the crude drug amount.
4, according to the preparation method of the hypertensive angelica sinensis preparations of the described treatment of claim 1, it is characterized in that: the concentrated solution described in the step (3), with flavoring agent and antiseptic, regulating pH value is 5.5～7.0; Fine straining, fill, sterilization gets oral liquid.
5, according to the preparation method of the hypertensive angelica sinensis preparations of the described treatment of claim 1, it is characterized in that: the concentrated solution described in the step (3), spray drying gets powder.
6, according to the preparation method of the hypertensive angelica sinensis preparations of the described treatment of claim 1, it is characterized in that: use conventional method the concentrated solution that obtains is prepared into granule, capsule or tablet.
7, the angelica sinensis preparations for preparing as any described method among the claim 1-6 is used for the treatment of high blood pressure disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03109735 CN1279930C (en) | 2003-04-14 | 2003-04-14 | Applicaton of chinese angelica-root for preparing medicine for treating hypertension disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03109735 CN1279930C (en) | 2003-04-14 | 2003-04-14 | Applicaton of chinese angelica-root for preparing medicine for treating hypertension disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1537547A CN1537547A (en) | 2004-10-20 |
| CN1279930C true CN1279930C (en) | 2006-10-18 |
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| CN 03109735 Expired - Fee Related CN1279930C (en) | 2003-04-14 | 2003-04-14 | Applicaton of chinese angelica-root for preparing medicine for treating hypertension disease |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674835A (en) * | 2019-03-07 | 2019-04-26 | 美霖佳生物医学科技(苏州)有限公司 | Angelica sinensis preparations, preparation method and applications with strengthen immunity |
| CN116173084A (en) * | 2022-11-28 | 2023-05-30 | 中国中医科学院医学实验中心 | Application of single angelica formula granule as vasodilation microvascular drug |
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