CN1363355A - Process for preparing hypolipemic giant knotweed rhizome tablet - Google Patents
Process for preparing hypolipemic giant knotweed rhizome tablet Download PDFInfo
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- CN1363355A CN1363355A CN 01107014 CN01107014A CN1363355A CN 1363355 A CN1363355 A CN 1363355A CN 01107014 CN01107014 CN 01107014 CN 01107014 A CN01107014 A CN 01107014A CN 1363355 A CN1363355 A CN 1363355A
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- hypolipemic
- giant knotweed
- knotweed rhizome
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Abstract
A process for preparing hypolipemic Huzhang tablet includes such steps as mixing powdered giant knotweed rhizome extract with powdered lectose in Wt ratio of 20:1, mixing with 93-96% alcohol, ganulating by 0.9-mm sieve, drying, mixing with carboxymethyl starch sodium and magnesium stearate, tabletting, preparing coating slurry from alcohol, water and hydroxypropyl methylcellulose, spraying coating, and cooling.
Description
What the present invention relates to is the preparation method of hypolipemic giant knotweed rhizome tablet.
Giant knotweed rhizome tablet is that the extract Rhizoma Polygoni Cuspidati extract powder with the natural medicinal plant Rhizoma Polygoni Cuspidati is the medicine of feedstock production, has the function of cholesterol reducing and triglyceride and is used to the treatment of hyperlipidemia.Its preparation method is promptly also to granulate and tabletting with suitable auxiliary materials and mixing after the pulverizing of Rhizoma Polygoni Cuspidati dry extract is sieved at present.Its weak point is that the Rhizoma Polygoni Cuspidati tablet for preparing with the method is easy to the moisture absorption.
Given this, the purpose of this invention is to provide a kind of improved method for preparing hypolipemic giant knotweed rhizome tablet, reducing its viscosity and moisture absorption, and make technological operation simpler, loss is few, reduces cost.
The preparation method of hypolipemic giant knotweed rhizome tablet of the present invention is, with Rhizoma Polygoni Cuspidati extract powder and two kinds of raw material mix homogeneously of Powdered lactose, the ethanol of adding 93%～96% was made soft material and is 0.9 millimeter sieve series grain by the aperture by weight 20: 1 amounts; Be heated to≤60 ℃ ventilation condition under after the drying, by the aperture be 0.9～1.0 millimeter sieve carry out granulate and with the carboxymethyl starch sodium and the film-making of magnesium stearate mix homogeneously of pharmacy allowance, be used in alcohol then: water volume ratio be in 70～90: 30～10 the solution concentration be 6%～9% be the pharmaceutical purpose syrup of filmogen with the hydroxypropyl emthylcellulose, by the amount of label weight 2%～10% with spray pattern to be heated to≤40 ℃ tablet surface whitewashes after film coating handles, be cooled to room temperature, overall process is all carried out in confined conditions.It can be the powder of 0.175 mm sieve by the aperture that wherein said Powdered lactose is preferably.When the film coating processing was whitewashed on the tablet surface, according to the difference of used coating powder kind, the consumption of stomach dissolution type coating powder generally can be 2%～3% of plate core weight's amount, and the consumption of enteric solubility coating powder generally can be 5%～10% of plate core weight's amount.
In said method, can also be further with it Rhizoma Polygoni Cuspidati extract powder in raw materials used by following method preparation, so that made tablet can have even more ideal physical and chemical index: the medicinal Rhizoma Polygoni Cuspidati raw material gradation after will pulverizing decocts with water after-filtration, filtrate merges that to be condensed into proportion be standing sedimentation processing behind 1.20～1.25 and 95% the ethanol mix homogeneously, get then clear liquid remove ethanol and be concentrated into proportion be 1.05 after, spray drying prepares under～90 ℃ of temperature.Wherein, so that in this processing procedure with 95% ethanol mix homogeneously after the standing sedimentation processing time be 24 hours for well.
In above-mentioned preparation method method of the present invention, during preparation Rhizoma Polygoni Cuspidati dry extract behind water extraction the ethanol of reuse 95% carry out sedimentation and handle, can remove the composition of the big moisture-sensitive of viscosity such as a large amount of polysaccharide, tannin; Behind tabletting, make Cotton seeds in the tablet appearance again, and all operating process is all carried out in confined conditions, therefore compare with the traditional preparation process method, in preparation process, reduce the viscosity of material and simplified technological operation, the also corresponding reduction of loss and cost, the hygroscopicity of resulting Rhizoma Polygoni Cuspidati tablet product also greatly reduce.
Below by concrete example foregoing of the present invention is described in further detail, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is confined to following example.
The preparation of Rhizoma Polygoni Cuspidati dry extract: drying is not had the medicinal Rhizoma Polygoni Cuspidati raw material powder that goes mouldy be broken into coarse powder, weigh in the rearmounted extraction pot, decoct with water twice, each 1 hour, sieve with 0.175 millimeter in aperture (～80 order) filters, after merging filtrate, routine are evaporated to proportion (95 ℃～100 ℃)～1.05, add the 95% ethanol back standing sedimentation 24 hours that stirs.Filter, after getting supernatant and reclaiming ethanol and be concentrated into proportion～1.05, in control inlet temperature～145 ℃, leaving air temp～100 ℃, making vapo(u)rizing temperature is to carry out spray drying under～90 ℃ the condition, it is standby to make the Rhizoma Polygoni Cuspidati dry extract.Its use amount can be used by used Rhizoma Polygoni Cuspidati material quantity conversion back of when preparation during pharmacy.
The preparation of giant knotweed rhizome tablet: 20: 1 amounts are with above-mentioned Rhizoma Polygoni Cuspidati dry extract and two kinds of raw material mix homogeneously of Powdered lactose by weight, after the ethanol of adding 95% is made soft material, pass through the sieve series grain of aperture～0.9 millimeter (18 order) again, be heated to≤dry under 60 ℃ the ventilation condition, again by the aperture be 0.9～1.0 millimeter (16～18 order) the sieve granulate and with pharmacy in the carboxymethyl starch sodium and the magnesium stearate mix homogeneously of allowance, be pressed into plain sheet.Be used in alcohol then: water volume ratio be in 70～90: 30～10 the solution concentration be 6%～9% be the conventional pharmaceutical purpose syrup of filmogen with the hydroxypropyl methyl fiber rope, handle preheating the film coating of whitewashing to the plain sheet surface of≤40 ℃ above-mentioned compacting with spray pattern.According to the difference of used coating powder kind, the consumption of stomach dissolution type coating powder generally can be 2%～3% of plate core weight's amount, and the consumption of enteric solubility coating powder generally can be 5%～10% of plate core weight's amount.The whitewashing film coating is handled postcooling to room temperature.Overall process is all carried out in confined conditions.
Claims (6)
1. the preparation method of hypolipemic giant knotweed rhizome tablet, it is characterized in that by weight 20: 1 amount Rhizoma Polygoni Cuspidati extract powder and two kinds of raw material mix homogeneously of Powdered lactose, add that 93%～96% ethanol is made soft material and be 0.9 millimeter sieve series grain by the aperture, be heated to≤60 ℃ ventilation condition under after the drying, by the aperture be 0.9～1.0 millimeter the sieve granulate and with the carboxymethyl starch sodium and the film-making of magnesium stearate mix homogeneously of pharmacy allowance, be used in alcohol then: water volume ratio be in 70～90: 30～10 the solution concentration be 6%～9% be the pharmaceutical purpose syrup of filmogen with the hydroxypropyl emthylcellulose, by the coating powder consumption be label weight 2%～10% amount with spray pattern to be heated to≤40 ℃ tablet surface whitewashes after film coating handles, be cooled to room temperature, overall process is all carried out in confined conditions.
2. hypolipemic giant knotweed rhizome tablet preparation method as claimed in claim 1 is characterized in that said Powdered lactose is can be the powder of 0.175 mm sieve by the aperture.
3. hypolipemic giant knotweed rhizome tablet preparation method as claimed in claim 1 is characterized in that said film coating being whitewashed when handling in the tablet surface, and the consumption of stomach dissolution type coating powder is 2%～3% of a label weight.
4. hypolipemic giant knotweed rhizome tablet preparation method as claimed in claim 1 is characterized in that said film coating being whitewashed when handling in the tablet surface, and the consumption of enteric solubility coating powder is 5%～10% of a label weight.
5. as the described hypolipemic giant knotweed rhizome tablet preparation method of one of claim 1 to 4, it is characterized in that the Rhizoma Polygoni Cuspidati extract powder in the said raw material decocts with water after-filtration for the medicinal Rhizoma Polygoni Cuspidati raw material gradation after will pulverizing, filtrate merges and is condensed into proportion is 1.20～1.25, again with 95% ethanol mix homogeneously after standing sedimentation handle, get then clear liquid remove ethanol and be concentrated into proportion be 1.05 after, spray drying prepares under～90 ℃ of temperature.
6. hypolipemic giant knotweed rhizome tablet preparation method as claimed in claim 5 is characterized in that the standing sedimentation time behind said and 95% the ethanol mix homogeneously is 24 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01107014 CN1363355A (en) | 2001-01-08 | 2001-01-08 | Process for preparing hypolipemic giant knotweed rhizome tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01107014 CN1363355A (en) | 2001-01-08 | 2001-01-08 | Process for preparing hypolipemic giant knotweed rhizome tablet |
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| Publication Number | Publication Date |
|---|---|
| CN1363355A true CN1363355A (en) | 2002-08-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01107014 Pending CN1363355A (en) | 2001-01-08 | 2001-01-08 | Process for preparing hypolipemic giant knotweed rhizome tablet |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596211B (en) * | 2009-12-29 | 2015-06-24 | 韩国韩医学研究院 | Compositions and functional foods for treating and preventing obesity using polygonum cuspidatum butanol fraction and ethyl acetate fraction |
-
2001
- 2001-01-08 CN CN 01107014 patent/CN1363355A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596211B (en) * | 2009-12-29 | 2015-06-24 | 韩国韩医学研究院 | Compositions and functional foods for treating and preventing obesity using polygonum cuspidatum butanol fraction and ethyl acetate fraction |
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| C06 | Publication | ||
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| AD01 | Patent right deemed abandoned | ||
| C20 | Patent right or utility model deemed to be abandoned or is abandoned |