CN1360895A - 治疗皮肤病的药物组合物 - Google Patents
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Abstract
本发明涉及一种治疗皮肤病的药物组合物,特别是治疗腋臭、脚臭、口臭的药物组合物。它是由枯矾,氯溴,氧化锌,氰尿酸所组成,在80℃干燥,并经粉碎、过筛、混合均匀、分装、密封。该药物疗程短、效果好、患者易于接受。
Description
本发明涉及一种治疗皮肤病的药物组合物，特别是治疗腋臭、脚臭、口臭的药物组合物。
对腋臭的治疗采用手术疗法，切除大汗腺，患者痛苦大，特别是存在术后复发；近年来，采用激光照射，及局部注射进行治疗，副作用大。
汗臭的原因：腋臭多与遗传有关(490例中占89.58％)[唐荣祥 腋臭的病因探讨 临床皮肤科杂志 1996.1：24]、[杨国亮皮肤病学 上海医科大学出版社 1991：678]，患者大汗腺腺体组织数量和体积均比正常人多而大，且受性内分泌影响，还与腺体分泌物受细菌或霉菌分解发放特殊臭味。
中国专利CN1098308A提供了一种具有皮肤或皮下腺体组织萎缩或坏死作用的药用注射剂，该注射剂由经过煅烧的白矾水溶液和精制的五倍子水提取物，以及医药上可接受的低分子多糖和多元醇化合物组成。
中国专利CN1134828A提供了一种治疗腋臭的药剂，由中药虎杖、白藓皮、苦参、黄莲、当归、川芎、枯矾、及东朗碱、冰片、双氧水组成。
本发明的目的在于提供一种患者易于接受，效果好，疗程短的治疗皮肤病的药物组合物。
本发明的目的是这样实现的：本发明的药物是由下列组分制成的(用量为重量份)：枯矾70-80份，氯溴4-8份，氧化锌2-6份，氰尿酸12-20份。
所述的枯矾、氧化锌、氰尿酸均由市场采购，氯溴粉为天津市华津制药厂生产。
将上述各组份制成本发明药物的生产方法是：将枯矾、氯溴粉、氧化锌和氰尿酸分别在80℃下干燥4小时，粉碎，100目过筛后，按各组分的用量称取，混合均匀，分装于铝铂塑料袋内，密封。
产品的质量标准：颜色，类白色；PH值，4.5(1％水溶液)。
动物实验及临床观察效果报告：
本发明经急性皮肤刺激实验：动物急性皮肤刺激积分均值为0；试验动物试验侧皮肤与对照侧皮肤相比未见明显刺激反应。
小鼠急性毒性试验结果：用小鼠灌胃法计算LD50为6309mg/kg
| 剂 量(mg/kg) | 剂量对数 | 动物数 | 死亡数 | 死亡数(％) | 概率单位 |
| 40005000600070008000 | 3.6003.6983.7783.8453.907 | 1010101010 | 024810 | 0204080100 | 4.164.755.526.28 |
皮肤反应观察(注：“-”表示无反应)：
| 时 间(天) | 反应红斑 水肿 坏死 | 空白对照 |
| 481224 | - - -- - -- - -- - - | ---- |
家兔皮肤刺激试验结果：每天2次的涂抹法观察24天与对照组近似无明显反应。
本发明经消化道染毒属实际无毒。
本发明药效试验结果：利用本发明2％的混悬液0.8ml与0.2ml菌液作用10min，可将金黄葡萄球菌和白色念球菌杀灭。
注：①回收数2.1×106cfu/1ml；②回收数1.8×106cfu/1ml
| 菌种 | 品名 | 浓度(％) | 不同作用时间(min)的杀菌率(％)2 10 20 |
| 金黄色葡萄球菌① | 本发明混悬液本发明混悬液本发明混悬液空白 | 2.01.00.50 | 99.99 100.00 100.0099.99 99 99 100.0099.98 99.99 98.980 |
| 白色念球菌② | 本发明混悬液本发明混悬液本发明混悬液空白 | 2.01.00.50 | 98 90 100.00 100.0098.00 99.79 99.9990.20 91.50 99.800 |
本发明经抑菌试验，在1比20水溶液对白色念珠菌、金黄色葡萄球菌作用2分钟，抑菌率达100％。
吸汗除臭试验结果：(注：“+”表示显色，“-”表示不显色)
| 品名 | 浓度 | 不同时间(min)吸汗显色反应 |
| 本发明本发明空白对照 | 210 | + ++ +++ ++ ++- - - |
本发明经五种条件的稳定性试验结果，在金属衬膜外加塑料薄膜包装袋中贮存是稳定的，有效期为二年。
| 试验项目 | 条件 | 观察时间 | 色泽变化 |
| 光照温度湿度加速试验室温观察 | 2000-4000Lux40-80℃75-92.5％40℃相对湿5％15-25℃瓶装 | 10天10天10天90天二年 | 无变化无变化无变化无变化无变化 |
临床观察报告：
| 分组 | 病例数 | 一疗程有效例数 | 二疗程有效例数 | 复发数(％) | 反应例数局部 全身 | |
| 初治组复治组 | 32014 | 30(95.6％)0 | 012(85.7％) | 14(4.4)2(14.3) | 00 | 00 |
本发明的效果：与实施手术相比，无痛苦，具有显著的皮肤止汗、除臭及抑菌作用；且治疗周期短(对没有进行过任何治疗的患者，3天即可)，疗效好；无毒、无刺激作用，价格便宜。
使用方法：每包29克，均分6等份，先将局部(腋、脚)清洗干净，或去腋毛，将一份撒于患处，轻揉2-4分钟，早晚各一次，三天为一疗程。320例中，初治一疗程有效率达95.6％，其余作二疗程，最后有2例复发，局部和全身全无反应。
对腋臭的治疗，将本发明20克均分6等份，先将腋毛剃净、洗净，再将本发明撒上，用手轻揉3-4分钟，早晚各一次，连续3天，必要时可再续用3天；对脚臭的治疗，将脚洗净后方法同上；对口臭的治疗，120溶于冷开水中，含漱一天多次。对孕妇，暂停使用。小孩应在成人指导下使用，使用过程中，如出现皮疹，即停用。
本发明具有吸水、收敛、止汗，并促使蛋白质变性，又具较强氧化和杀菌剂，防止大汗腺分泌物分解产生臭味。
实施例：
按下述配比称取原料(千克)：
枯矾70千克，氯溴4千克，氧化锌2千克，氰尿酸12千克。
所述的枯矾、氧化锌、氰尿酸均由市场采购，氯溴粉为天津市华津制药厂生产。
将上述各组份制成本发明药物的生产方法是：将枯矾、氯溴粉、氧化锌和氰尿酸分别在80℃下干燥4小时，粉碎，100目过筛后，按各组分的用量称取，混合均匀，分装于铝铂塑料袋内，密封。
Claims (1)
1一种治疗皮肤病的药物组合物，其特征在于它是由下述重量配比的原料制成的药剂，枯矾70-80份，氯溴4-8份，氧化锌2-6份，氰尿酸12-20份。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001358936A CN1170545C (zh) | 2000-12-25 | 2000-12-25 | 治疗腋臭脚臭口臭的药物组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001358936A CN1170545C (zh) | 2000-12-25 | 2000-12-25 | 治疗腋臭脚臭口臭的药物组合物 |
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| Publication Number | Publication Date |
|---|---|
| CN1360895A true CN1360895A (zh) | 2002-07-31 |
| CN1170545C CN1170545C (zh) | 2004-10-13 |
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| CNB001358936A Expired - Fee Related CN1170545C (zh) | 2000-12-25 | 2000-12-25 | 治疗腋臭脚臭口臭的药物组合物 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014179353A1 (en) | 2013-05-02 | 2014-11-06 | Karandikar Bhalchandra M | Antimicrobial compositions and methods of making the same |
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2000
- 2000-12-25 CN CNB001358936A patent/CN1170545C/zh not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014179353A1 (en) | 2013-05-02 | 2014-11-06 | Karandikar Bhalchandra M | Antimicrobial compositions and methods of making the same |
| EP2991658A4 (en) * | 2013-05-02 | 2017-01-04 | Medical Technology Research Inc. | Antimicrobial compositions and methods of making the same |
| AU2014260033B2 (en) * | 2013-05-02 | 2019-06-27 | Medical Technology Research Inc. | Antimicrobial compositions and methods of making the same |
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| Publication number | Publication date |
|---|---|
| CN1170545C (zh) | 2004-10-13 |
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