CN1352593A - Method for forming latex or polymer membrane, including multiple discrete layers - Google Patents
Method for forming latex or polymer membrane, including multiple discrete layers Download PDFInfo
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- CN1352593A CN1352593A CN 97182484 CN97182484A CN1352593A CN 1352593 A CN1352593 A CN 1352593A CN 97182484 CN97182484 CN 97182484 CN 97182484 A CN97182484 A CN 97182484A CN 1352593 A CN1352593 A CN 1352593A
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Abstract
Single and multiple layer membranes such as gloves and condoms include one or more deactivating barrier layers and/or indicating layers to indicate to a user membrane breach or the presence of a harmful substance in blood or body fluids. A membrane may include one or more permeable or semiipermeable layers to disperse contained substances such as lubricants, biocides, spermicides, or indicators outwardly, and may also include permeable or semipermeable layers to allow transmission of body fluids or other environmental fluids inwardly into contact with an indicating or treating substance. An intermediate layer of a multi-layer membrane may include a substance to wipe, cleanse, sterilize, or otherwise treat a piercing needle. A membrane may include a sealing or coating to entrap indicators or other agents such as biocides therein. A method of making membranes such as gloves results in adouble glove having discrete inner or outer layers joined only in a cuff region. Admixing of gentian violet with latex prior to membrane formation provides biocidal properties, anti-aging effects prolonging shelf-life and tear resistance, and reduces allergic reactions in latex-allergic users.
Description
Technical field
The present invention relates to from the film that comprises that latex, polyurethanes, polyethylene, rubber and other polymer and elastomeric material form.
Background technology
The application of known this film comprises dam, the tooth of nasal tube, nose stomach tube, kidney branch road, eye and brain branch road, dental in operation and latex examination gloves, sheath, pessary, dressing, sheath, slippers, overshoes, sterilization band, conduit, pipe, curtain, the mouth of pipe, suction inlet, baby nipple, the stomach spoil positive frame, subclavian vein and artery tributaries and colostomy bag.Typically, this film contact human or animal's skin or other tissue in the use.
In recent years, need to improve this film more,, prevent the propagation of virus (as hepatitis and HIV) and other pathogen and hazardous medium so that better protection to be provided.
Disclosure of the Invention
The invention discloses several embodiments, wherein provide and had better prevention virus or other harmful pathogen propagation, and can keep the not infected film of article of pin and other penetrable thing film, the invention also discloses the structure of one or more markers, to find and to show that film rupture and virus, other pathogen and harmful chemical exist.
In one aspect of the invention, the film of sandwich construction comprises one deck or a plurality of internal layer, it is as the storage storehouse of medicine or preparation (as biocide, lubricant or indicator), it can pass skin one or more infiltrations or semi permeable, so that utility arrives outside the film in the storage storehouse, or the outside propagation that prevents to store the storehouse material, and allow external substance by, pass through film to small part.As a kind of replacement, can use and a kind ofly when breaking or be punctured, transmit medicine or preparation, and possess the non-permeable formation basically of this material At All Other Times penetrability.
According to another aspect of the present invention, the film of sandwich construction comprises one or more internal layers, it serves as the storage storehouse of medicine or reagent (as biocide, lubricant or indicator), its can with pass that the outer field material of one or more films contacts or engage in other mode, its can with originally at the substance reaction of film outside, indicate it to exist or respond it and exist in other mode.That this multilayer film can be used for selecting to the film surface by inner material or medicine or controlled flows, and provides antibiotic, sterilization or other to kill or make the deactivated function of infective agent, microorganism, virus or bacterium.
According to another aspect of the present invention, multilayer film provides the position that is used to indicate a kind of material, as based on the reaction of dna probe (as Chiron ' s " branched DNA probe ", Hoffman-LaRoche ' s " polymerase chain reaction " technology), conventional color change indicator reaction, drop reaction detects the Ph reaction and detects chemical substance, virus or the reaction of other pathogen.This multilayer film comprises one or more permeable or semi permeable layers, allows detected material to move inward by one deck or more skin, contacts with indication material or system.One or more layers can be impermeable, move to another side to prevent indicator or storage library material.
In another aspect of the present invention, the indicator that detects chemical substance, virus or other pathogen mixes with membrane material, or mixes with one deck of multilayer film, or coats the skin of monofilm or multilayer film.
Another aspect of the present invention relates to the structure of the indicator of indicating film rupture.Can pass through color change, shade changes (for example darker or more shallow), temperature change, and sense of touch changes (for example hard or tight), and indication is provided.The reaction of moisture that indicator such as cobalt chloride can pass through and exist, the indication film rupture.
In another aspect of the present invention, the permeable or semi permeable film of sandwich construction comprises one deck or more internal layer, and it is as the storage storehouse of material or reagent (as biocide, lubricant, hydrogel or indicator).Material or reagent can be by outer (one or more layers), and the material of storing the storehouse like this can arrive the outside of film.
In another aspect of the present invention, one deck or more permeable or semi permeable rete allow material to move to predetermined direction.For example, virus or other pathogen can move inward, and contact with indicator or biocide.In addition, perhaps biocide, lubricant, spermatocide, anticorrisive agent or indicator can outwards move.
In another aspect of the present invention, one or more layers film comprises and being positioned at or the indicator of outer surface, be positioned at existing of the outer virus of film or other deleterious material with detection, and/or also indicate deleterious material, or the part or all of film that passes.
Another aspect of the present invention is included in liquid or the gel that improves sense of touch is provided between the multilayer film.
During another aspect of the present invention relates to when film forms or forms, in film-forming material or the microfibre on surface or the dispersion of fiber (as Kevlar), to increase film strength and penetration resistance.
In one aspect of the invention, film comprises a kind of indicator, and when harmful substance existed, it provided identifiable reaction rapidly, with the warning user.The example of indicator comprises the dna probe as the special virus existence of detection of Chiron or Hoffman-LaRoche development, or conventional color change indicator technologies, as the phenolphthalein reaction, or the Ph indicator material, chromophore, or the dyestuff that when detected material exists, changes.
In one aspect of the invention, by capillary or capillarity, single or multiple lift film effect is by one deck or more rete transportation.Film or one deck or more multi-layeredly can also constitute optionally film of size are with the virus of restricted passage or the size of microorganism.What in addition, perhaps one deck or more rete can be for chemo-selectives.For example, can use this class film that uses in filtration and the purge process.
In another aspect of the present invention, the film that comprises permeable or semi permeable skin or internal layer comprises encapsulation process or coating so that indicator or biocide are retained in wherein.
The present invention also comprises indicator is dispersed in the whole film, or is limited in film surface or inner certain a bit or a certain zone, as on the surface of certain point or banded regions or inner.Indicator can or form the back in film forms and add film.
In another aspect of the present invention, the function of the pin treated substance in film one deck or more internal layer is a cleaning, coating, and wiping, scraping purifies, and sterilization reduces infringement, or otherwise handles pin or other puncture thing.
Another aspect of the present invention discloses the method for preparing multilayer film, and as gloves or sheath, wherein this multilayer is added into one or more predetermined zones, as only in the mouth of pipe or top area.
In another aspect of the present invention, a kind of method that will mix in conjunction with the protein (as gentian violet) and the wet latex of biocide before film forms increases film-strength and/or reduces or eliminates the allergy influence of latex allergy or sensitive individual.
In another aspect of the present invention, the sticking patch of back viscosity comprises and puncture pin or the conduit disinfectant or the cleanser that contact wherein.
Brief description of the drawings
Fig. 1 has described the plane according to the double gloves of method preparation of the present invention.
Fig. 2 is a sectional view, illustrates the double gloves of Fig. 1, is included in the biocide in the intermediate reservoir that forms between the internal layer of gloves and the skin.
Fig. 3 is a plane, and the double gloves that illustrates according to method preparation of the present invention has index strip, and it has the detection zone of separation, the different pathogen or other harmful substance or the chemical substance that exist in the environment with indication gloves user.
Fig. 4 is a sectional view, illustrates an example according to multilayer film of the present invention.
Implement best mode pin processing layer of the present invention
Pin, hollow with solid, and other sharp-pointed article such as conduit, scalpel, line or bone chip are for the infectiousness relevant with them problem that to be health care pay close attention to from duty person and other personnel.When pin took out from their packing, they were normally aseptic, but when they pass through people's health, may be contaminated, when they took out in the patient's body that infects, they were by serious pollution.
Health care worker and corpsman,hospital are usually in use poked by pin or other sharp object with the use back is unexpected.
According to the present invention, (as gloves) add a kind of material in multilayer film, with cleaning, and coating, wiping, scraping purifies, and sterilization reduces infringement, or handles pin or other puncture thing in other mode.
Film from liquid emulsion, solvent cast films, liquid polymers or other composite or elastomer formation can pass through dip forming, use fluid bed or spraying liquid material formation on formed body.After one deck or the more multi-layered deposition, comprise that the intermediate layer with handling property material is deposited., form one deck or more outer, handle or solidify film according to routine techniques thereafter.
The polymer that uses in the film according to the present invention preparation comprises prepolymer, and promptly low-molecular-weight polymer, and polymer precursor are dissolved in prepolymer and polymer precursor in the solvent, liquid monomer and be dissolved in liquid monomer in the solvent.Concrete example comprises low-molecular weight polymer, as silicon rubber (dimethyl silicone polymer: the HO-(Si-(CH of 2-200
3)
2-O-)
n-H); Polymer precursor such as low molecular weight diols, for example HO-((CH
2)
4-O-)
18)-H and low-molecular-weight vulcabond, for example OCN-C
6H
6-CH
2-C
6H
6-NCO, its polymerization when mixing forms polyurethanes.The example of the solvent of low-molecular weight polymer comprises dimethylbenzene and n-hexane.The solvent that polymer precursor is fit to comprises dimethyl formamide and dimethyl sulfoxide (DMSO).The example of liquid monomer comprises the alpha-alkyl cyanoacrylate, and wherein alkyl group can be-methyl ,-ethyl ,-propyl group etc.The example of the solvent of liquid monomer comprises dimethyl formamide.In the description of this paper, term prepolymer, polymer and polymer precursor comprise the mixture of one or more prepolymers, polymer or polymer precursor.
In one embodiment of the invention, pin or sharp object processing layer comprise the urethane of gelatinous coating such as gluey denseness, half-mature one-tenth latex, gel, polymer, adhesive, MS has or does not have the internal layer of biocide, anticorrisive agent or the bactericide conduct of mixing.
When pin or other object pierced through film, treated substance tended to cling it, is coated with it, purifies it, or made any harmful substance deactivation that may adhere to wherein in other mode.The mechanism that pin or sharp object are handled mechanics comprises chemistry and mechanical two aspects.For example, layer preferably includes enantiopathy substance effective biocides or anticorrisive agent.In addition, layer also has the function of removing blood and other body fluid from pass pin wherein.Perhaps, can be separately or be used in combination and can physics move or the trickle friction material of quality on the pin is coated in scraping.
The example that adds the processing chemical substance of biocide in the pin processing layer comprises the mixture of polyoxyethylene and polyoxyethylene and glycerine.In forming latex film, first emulsion layer is by dipping or spraying or other routine techniques deposition.Biocide is as aldrich mixture, by the mixture multiviscosisty of polyoxyethylene and glycerine.Then the mixture after the multiviscosisty is applied on the emulsion layer, makes its drying to a certain degree, then with one or more layers emulsion layer coating.
The pin processing layer can also comprise adhesive and filmogen, and it can form sheath or other film on the surface of pin or other sharp object and the surface of its lip-deep nuisance.
One or more layers pin processing layer can also comprise cleaning agent or other material, and the surface tension properties that it can change harmful substance on the pin is physically removed layer thereafter, hold, sterilization, or reduce the infringement of nuisance, or more be not easy to infect or the human or animal of polluted membrane another side.
Aforesaid method can be used separately or be used in combination, and it can be contained in same one deck of multilayer film or in the different layers.They can contain coagulating agent or not contain coagulating agent, can use latex and artificial latex or interchangeable polymer or elastomer substitute.Pin is handled sticking patch
Describe below that pin is handled sticking patch and after use or be used to assist the method for sterile needle or other sharp object in using.
In one embodiment, back has the sticking patch of adhesive or disk and can be attached to pin and prepare the zone that penetrates.This disk can be similar to flattening or that flatten, vitamin E bead, pierces through before piercing through skin.This disk comprises antiseptic, anticorrisive agent and purification composition, and it contacts with pin before piercing through skin and leaving skin.This disk can be transparent, determines vein or other position, target area to assist a physician.Equally, adhesive can only be distributed in the periphery of disk, and it just can not be brought in the perforation like this.
The back of sticking patch can comprise and is suitable for the antiseptic or the anticorrisive agent that contact with the skin of patient or animal.
The structure of this disk can be knitting ground or constructing generation elimination effect when passing the disk extraction then of passing before allowing pin or syringe to enter.Sticking patch preferably includes antiseptic or antiseptic solution.
Biocide that contains in two embodiments or listerine can be gelatinous and/or thickness, to help pin coating or seal it in the process of extracting health or sticking patch out.
Sticking patch can also or adhere to the insertion of conduit and neostomy article and is used in combination, and can use with the catheter combination of adhering to for a long time, to suppress the growth and/or the propagation of pathogen.
Suitable sticking patch adhesive, as U.S. Patent No. 5,234,957 are proposed, and its content is incorporated herein by reference, comprise the acrylic acid polymer of partial esterification, include but are not limited to and the crosslinked acrylic acid polymer of polyolefin polyethers (polyalkenyl polyether), as from B.F.Goodrich, Cincinnati, commodity Carbopol934, the 934P by name that Ohio buys by commercial sources, 940 and 941 product.Other adhesive comprises natural or synthetic polysaccharide, as cellulose derivative, as methylcellulose, cellulose acetate, carboxymethyl cellulose, hydroxyethylcellulose etc.Other adhesive that is fit to is a pectin, the mixture of sulfuric acid sucrose and aluminium hydroxide, hydrophily polysaccharide gum, as the natural plants effluent, comprise karaya, ghatti gum, bassora gum, xanthans, jaraya gum etc., and seed glue are as guar gum, locust bean gum, psillium seed gums etc.
The suitable biocide that is used for film of the present invention comprises phenol, acridine dye, gentian violet (crystal violet), chlohexidine (chlorhexadine), Triclosan, Nonoxynol 9, gluconate (Gluconate), dextran sulfate, benzalkonium, betadyne, merbromin, silver salt, and orchid-green marine algae extract, except what list above, also comprise other suitable biocide of enumerating after preceding this description of claim.Indicator and multilayer film
In most of operations, physician or surgeon do not know whether the patient suffers from the transmissible disease of being carried by bloodborne pathogens.Particularly at operating room and emergency room, when doctor and patient's blood or body fluid contact, on their gloves indicator is arranged, can warn to have harmful, infectious or potential fatal pathogen in their liquid or the blood, be very useful.
The film (including, but are not limited to gloves and sheath) that the present invention includes repeatedly dipping or solvent formation provides indicating mechanism.The invention discloses warning user film rupture, and the indicator of warning material dangerous in user's blood and other body fluid.
As U.S. Patent No. 4,935,260 is disclosed, but the storage of the liquid in film storehouse can comprise coloured, fluorescence or reactive material, when film rupture, damage or multilated, can serve as indicator.The present invention includes by color change or outward appearance or other physical form and provide visible indication for the user of film rupture.
To the indicative variation of material in the internal layer of multilayer film, can pass through the existence of air, moisture, body fluid, harmful substance, the change of electroactive, surface tension or local pressure and causing.When the physical integrity around indicator elment is exposed to external substance or film sexually revises, the indication mechanism reaction.Causing inner layer material Ph to change owing to being exposed to the outer material of film, is another indication mechanism.
Comprise as indication material according to other the suitable indicator that uses in the film of the present invention based on the dna probe reaction, as Chiron ' s " branched DNA probe ", Hoffman-La Roche ' s " polymerase chain reaction " technology, or be used to detect the conventional color change indicator reaction of chemical substance, virus or other pathogen.Multilayer film can comprise one deck or more permeable or semi permeable layers, moves inward by each or an a plurality of skin to allow detected material, contacts with indication material or system.Viral indicator that other is fit to and indicating means are in United States Patent(USP) Nos. 4,879,211; 4,942,122; 5,039,604; 5,093,230; 5,108,891; 5,149,623; 5,156,949; 5,208,321; 5,235,039; 5,260,189; Open in 5,268,265, each is disclosed in this paper and is incorporated by reference in this text and examines.
A kind of method that is used to prepare the film that comprises the film rupture color indicator is as described below.
1. use conventional dipping, spraying or other thin layer forming technique, use elastomeric material, as latex, solvent cast films, liquid polymers, or elastomer, or polymer film form initial film.Second tunic forms by routine techniques as coating or dipping (can comprise or not comprise coagulating agent), comprising a kind of indication material, as dyestuff, crystal, reactant, developer or coagulation.
2. the selection of pigment or indicator should make its obvious change that is provided at outward appearance, sensation (hardness, texture, denseness) or temperature, and is damaged with indication user film.
3. form one deck or how other elastomeric film layer then, comprise indicant at least partially.
The present invention also comprises the multi-layer film structure of indicator, with existing of pathogen in detection and indication blood or other body fluid.
Externally rete is selected, and makes its material to comprising in the storage storehouse that forms between rete, or with material, microorganism or the pathogen of detected its existence, is impermeable, permeable or permselective.Comprise the multiple material in the storage storehouse that except between rete, forms, this material can be applied in after film forms on the interior or outer surface of film, perhaps not that multiple material is included in the bank that forms between rete, but after film forms, be applied on the interior or outer surface of film.
According to multilayer film of the present invention, except or replace indicator, can also comprise the one or more storage storehouses that are positioned between adjacent rete, and contain one or more materials, form agent as lubricant, biocide, spermatocide, anticorrisive agent, gel, hydrogel, MS, cleanser, surfactant, cleaning agent, grinding agent, coating agent, wiping agent, fiber, sense of touch improver and thin slice, thereby these materials are located substantially between the adjacent layer.In this multilayer film one or more layers can be permeable or semi permeable, moves with the orientation that allows the following stated: (1) storage storehouse material moves outside film, or (2) external substance passes through film at least partially.
According to an example 50 of multilayer film of the present invention as shown in Figure 4.For example, film 50 can comprise sheath.Impermeable internal layer 52 can form from latex or polymeric material.Biocide and/or spermatocide (as nonoxynol 9) are filled storage storehouse 54 at least in part, and this bank is formed between internal layer 52 and the middle impermeable barrier 56, and it also can comprise latex or polymeric material.Lubricant is filled in storage storehouse 58, and it forms between intermediate layer 56 and permeable outer 60, its control the aperture of lubricant by permeable layer 60 through the time discharge.Permeable layer 60 can comprise the film with aperture, and it can open aperture when stretching under pressure, allows the lubricant in storage storehouse 58 to pass through.
If internal layer 52 breaks, even break simultaneously in intermediate layer 56, seminal fluid biocide/spermatocide also initial and in the storage storehouse 54 contacts.Equally, if break in intermediate layer 56, even internal layer 52 breaks simultaneously, vaginal secretion biocide/spermatocide also initial and in the storage storehouse 54 contacts.
According to introducing of the present invention or form the internal layer of multilayer film or one or more intermediate layer or outer field method comprise dip forming method and other technology, as the spraying coating, thin slice forms technology, the fluid bed deposition, gas deposition, discharge depositing, vacuum moulding machine, centrifugal coating, and extrusion modling.Can use molding technology, as rotational molding, or the molding technology of the use plus or minus die face of other type.
Can also comprise latex, elastomer or polymer or synthetic film according to film of the present invention or rete, wherein film or rete are coated with desired substance, form agent as biocide, lubricant, indicator, spermatocide, anticorrisive agent, gel, hydrogel, MS, cleanser, surfactant, cleaning agent, grinding agent, coating agent, wiping agent, fiber, sense of touch improver and thin slice, carry out surface treatment then to contain the material of coating.The example of these surface treatment methods comprises with chemicals (as chlorine or bromine) to be handled, with sealant (as silicone or acrylic compounds material) coating, heat treatment method is handled by being exposed under the low temperature as fusing or polishing, mechanical processing method such as rotation, extrusion, ultrasonic or radio frequency heating.Every kind of common purpose of situation is that desired substance is retained on internal layer, intermediate layer or the outer field surface securely.
The surface of a side of multilayer film can be designed to impermeable, and that the material of opposite side can be designed to is permeable or permselective.
Indicator can provide on the inner surface of single or multiple lift film or outer surface, thereby makes it can be exposed to the antibody of pathogen or nuisance or nuisance.
Fig. 3 illustrates an example according to gloves 20 of the present invention, comprising the internal layer 14 that connects together in cuff district 16 and outer 12.With the outer surface of gloves 30 in conjunction with or be included in regional 32,34 and 36 the indicator that separates with the index strip 30 that other mode links to each other, be used to the user to detect and indicate pathogen in the user environment or the existence of other nuisance or chemicals.For example indicator strip can show the existence of strep (zone 32), retrovirus (zone 34) and staphylococcus (zone 36).
If film comprises the glow discharge that is selected from down group and handles polymer film, as polyethylene, tetrafluoroethene PE (TFE/PE), PET (PET), TFE/PET, polytetrafluoroethylene (PTFE), the PET (HMDS/PET) that PET (E/PET) that ethene glow discharge is handled and HMDO glow discharge are handled, indicant more effectively tunicle keep.
The indicator that comprises in the multilayer film preferably produces the reaction that can differentiate, with existing of the warning potential nuisance of user.
Indicator can have specificity to the material and the microorganism of any amount, comprises virus (comprising HIV), bacterium, saccharomycete, unwanted and harmful chemicals etc.
Concrete viral indicator can comprise as reacting (as Chiron ' s " branched DNA probe " based on dna probe, Hoffman-La Roche ' s " polymerase chain reaction " technology) indicator, the composition of P-24 antigenic reagent box, Abbot Lab goods or GP-120 mixed product.
The other example of indicator comprises conventional color change indicator reaction, and wherein detected material (pathogen, chemicals or other material) can move by adventitia, arrives indicator system.Similarly, some in these indicator can be mixed with the material of one deck in film or the multilayer film, or coats the skin of film or multilayer film.
For example, HIV and hepatitis type B virus belong to retrovirus family.Can indicate the indicator that antigen exists in HIV or its blood is P-24 antigenic reagent box and Abbot Lab goods or GP-120 mixed product.In addition, by with the common material of virus family, as the reaction of the capsid of virus family, can select other test indication retrovirus or the existence of slow virus.Indicator can also be indicated the antibody of those harmful substances in the body fluid (as blood, seminal fluid or vaginal secretion).Need particularly point out, may indicate a special material, rather than gang's harmful substance.Some indicator can for, but be not limited to the family or the group of synthetic peptide and antigenic surface decision base.Trigger through skin
When using gloves, when having, defective detected by different infiltration detector means, and some are the changes that utilize material or material surface electrical property or type.If the user does not change his gloves and removes defective gloves or be enclosed within its outside with the another gloves, is otiose.
The invention discloses the gloves that multilayer film constitutes, chemicals are contained in its place that is right after hand, and the user is protected in releases that can be triggered of these chemicals in gloves, takes adequate measures up to him or she.
The technology type that is applied to film is similar to existing through skin sticking patch technology.This technology is used in nicotine sticking patch and hormone release sticking patch.By the change of surface electrical character or breaking of complete film, they can provide and continue to discharge or specificity release.Through the example of skin sticking patch in United States Patent(USP) Nos. 4,286,592; 4,627,429; 4,839,174; 4,921,475; 4,978,531; 5,008,110; 5,087,240; 5,163,899; 5,164,189; 5,230,896; 5,234,957; 5,262,165; 5,273,756; With 5,286,490; Open in 5,290,561; Each is disclosed in this paper and is incorporated by reference in this text and examines.
The multilayer gloves preferably contain the storage storehouse of anticorrisive agent/disinfectant, and when electrical property changed or exist the gloves film of degradation under moisture or other film integrality to suffer damage, it was by discharging through dermal system.The duplicature impregnation forming method
In many application, the use of duplicature can provide better protection.For example, at present accept the surgeon in the practice or other health care practitioner wears two both hands covers, an outside that is enclosed within another is to provide the maximum protection of avoiding infection.In fact, some studies show that and wear the generation that two both hands covers can reduce infection simultaneously.
This double membrane structure also produces the space as the storage storehouse, particularly when the layer of film during in the connection of cuff or top region.This storage storehouse can be used to comprise many materials, comprises that biocide, pin handle material, sense of touch and improve liquid or gel, lubricant, spermatocide, hydrogel, indicator and scale, disk or other and be used to the material that stops pin and other sharp object to penetrate.
Hydrogel can be in U.S. Patent No. 4,499, disclosed type in 154, and disclosed full text is quoted as a reference at this paper.The function of hydrogel can make rete separately for absorbing biocide, and can play the effect of coagulating agent or lubricant.
The example of lubricant comprises water-soluble non-cytotoxic chemical compound within the scope of the present invention, its introducing sodium or potassium are with the chemical bond of change and carbonate, acetate, bicarbonate, acetate trihydrate and citrate dihydrate, as U.S. Patent No. 4,143, disclosed in 423, disclosed full text is quoted as a reference at this paper.Other lubricant that is fit to comprises U.S. Patent No. 5,073, the microballoon of describing in 365, and disclosed full text is quoted as a reference at this paper.
In the preparation method of repeatedly flooding, may form double gloves or other duplicature.Emgloves or sheath can be used the conventional preparation of impregnation forming method, wherein the mould that is shaped are immersed the drum of liquid emulsion.The method for preparing double-deck latex film according to the present invention comprises the steps:
1. cleaning die.
2. heating mould 8 minutes under the 210-220 degrees Fahrenheit.
3. immerse coagulation solution such as CaCO
3Add ethanol and add NO
3, (or calcium carbonate adds ethanol and adds nitric acid
Salt).
4. kept 2-3 minute.
5. immerse in the latex of not maturation.
6. kept 2-3 minute.
7. with cold running water leaching 15 minutes ... kept 2 minutes.
8. preparation encircles roller.
9. in the baking oven dry 6 minutes.
10. immerse in the 1.5% gentian violet distilled water solution and (can replace with other at different solutions
In biocide or chemicals, or the optional biocide of getting rid of immerses step, because of
For might not using biocide in double gloves or other film).
11. it is dry in the baking oven.
12. kept 5 minutes.
13. immerse 20% or the calcium nitrate coagulating agent of higher concentration in.
14. immerse in the latex of not maturation.
15. kept 8 minutes.
16. drying is 30 minutes in the baking oven, by the heating film maturation, is dried to final type.
17. grind and from mould, peel off duplicature into powder.
This method prepares gloves or sheath, all is to connect at its cuff or top.Fig. 1 illustrates the example according to the double gloves of the present invention's preparation, is connected at cuff district ring roller 16 with internal layer 14 comprising separated outer layer 12.Can see easily that double gloves 10 of the present invention is compared with the individual layer gloves that separate, and has the remarkable advantage that is easy to dress.Space between the two membranes can be used a step or a plurality of step of other adding different material and be constructed, the material that adds comprises, but be not limited to, gel, biocide, chemicals, silicone, in and chemicals, buffering chemicals, spermatocide, lubricant, sense of touch improver and scale, disk or other be used to the material that stops pin and other sharp object to penetrate.For example, as shown in Figure 2, can fill with biocide at the internal layer 14 of gloves and the storage storehouse 15 of outer 12 formation, as gentian violet.
Should be appreciated that this double membrane structure can also be by the preparation of said method and biocide composition, by before immersing coagulating agent, immersing in the biocide, or biocide or chemicals are mixed with coagulating agent.
Important step comprises in the said method:
(a) deposition first emulsion layer in mould;
(b) be used as effective material processed first emulsion layer of latex coagulating agent;
(c) deposition second emulsion layer on first emulsion layer in mould is used and effectively to be prevented the
One and the coagulating agent of second layer fusion; With
(d) solidify or first and second layers of maturations.
Preferred especially ground floor near not using coagulating agent around top or the cuff district, such first and second floor form the storage storehouse in the fusion of cuff district in other zone.Before ground floor uses coagulating agent, a kind of material can be deposited on ground floor in the mould above, this material is selected from biocide, indicator, spermatocide, anticorrisive agent, gel, hydrogel, MS, cleanser, surfactant, cleaning agent, grinding agent, scale, disk and other material, coating agent, wiping agent, fiber, sense of touch improver and thin slice that is used to stop pin and other sharp object to penetrate and forms agent, and this material is substantially between first emulsion layer and second emulsion layer like this.This intermediate material can also mix with coagulating agent to be used.
In another embodiment of the method for preparing double-deck latex film according to the present invention,,, in a conventional manner, at first immerse in the coagulating agent thin pulp being warming up to about 70 ℃ gloves mould or mould as " double gloves ".This coating in baking oven 80 ℃ dry 5 minutes down.Then mould is immersed in the latex compounds, its name for 38% solid that obtains from General Latex and Clemical Corporation is called vulcanized latex 1-N-4402, keeps about 5 seconds.Then that deposit is partly following dry about 1 minute at 80 ℃.With about 3 minutes of latex deposit leaching in warm water, 100 ℃ were descended dry 5 minutes in baking oven, until latex deposit bone dry then.
Be coated with the zinc stearate water emulsion release agent of about 3-5% solid,, be applied to first emulsion layer in the mould, except the zone in cuff or the marginal zone 1-2 inch by spraying or dipping.Then the zinc stearate coating was descended dry approximately 3-5 minute at about 100 ℃, in first emulsion coating, used the coagulating agent that does not contain powder.Then this coagulating agent coating was descended dry about 5 minutes at about 80 ℃, then mould is immersed in the latex compounds once more, regulate impregnating speed so that second tunic of homogeneous to be provided.Then second layer membrane portions ground was descended dry about 1 minute at about 80 ℃, leaching is about 3 minutes in warm water.Then with second tunic 125 ℃ of following maturations 20 minutes.Use the coating of corn starch powder, then gloves are peeled off from mould.
The gloves that obtain have two separating layers, and except the zone of cuff or edge 1-2 inch, this zone is made up of monofilm.
Release agent can use after secondary condenses coating, perhaps is added in the secondary coagulating agent, uses simultaneously with it.
Can use many different potential release agents, comprise: zinc stearate and other stearate, hydrogel composition, powder such as calcium carbonate, cornstarch, microballoon, wax emulsion such as paraffin and crystallite, the silicon emulsion, the high concentration gentian violet, silicone oil, acrylic acid composition for separating, the separation maturation of emulsion layer, the chlorination of ground floor emulsion layer before the second layer is used.
According to the prescription of the specific latex, release agent and the coagulating agent that use, consider impregnating speed, the formation of the second layer requires pliability.For example, (do not use the release agent coating) in the cuff district and can use different impregnating speeds, and/or the second layer can twice dipping in body region with body region, can single impregnation in the cuff district.Special formulation according to using can also change temperature, speed and retention time.
Another example for preparing the method for multilayer latex film according to the present invention comprises the steps:
1. cleaning die.
2. 65 ℃ of following heating moulds 8 minutes.
3. in the immersion latex, rotary die simultaneously.
4. 65 ℃ of following heating moulds 3 minutes.
5. cooling.
6. immerse in the latex of not maturation, simultaneously rotary die.
7. 65 ℃ of following heating moulds 3 minutes.
8. immerse Cal-Dip solution (the stearate compound of Rubichem Inc.), every 22.6gms
In isopropyl alcohol use 37.4gms Cal-Dip (can water replace alcohol).
9. 65 ℃ of following heating moulds 1 minute.
10. in the immersion latex, rotary die simultaneously.
11. 65 ℃ of following maturations 10 minutes.
12. water leaching 3 minutes.
13. dry, grind into powder and stripping film from mould.
Release of using among the present invention that is fit to or antitack agent (detacking agent) comprise calcium stearate, zinc stearate and the ammonium stearate as layer release agent.In addition, in moulding, can carry out the chlorination in telolemma or intermediate layer, as releasing agent.
A kind of method that forms the polymerization multilayer film according to the present invention comprises the steps:
(a) deposition is selected from liquid polymers and the material that is dissolved in the polymer in the solvent in mould
Material forms ground floor;
(b) handle ground floor with surfactant;
(c) in mould on the ground floor deposition be selected from liquid polymers and be dissolved in poly-in the solvent
The material of compound forms the second layer, and wherein surfactant effectively prevents first He
The fusion of the second layer; With
(d) solidify or first and second layers of maturations.
In preparing the method for latex film, in the intermediate layer of first and second interlayers or storage storehouse, can contain many materials.The example of surfactant comprises known making film emulsification or make its unsettled ionic surfactant.In this application, the term polymer comprises the synthetic material based on water.
Think and also might use other technology preparation to have the latex of multilayer separation or the film of polymeric layer.For example,, can change mould/mould and/or latex or polymer groove, leaching tank, baking oven, and/or the temperature around the chamber in the different phase of process.For example, before using the separating layer that the second layer forms telolemma, can cool off first latex or polymeric layer.In addition, can use sound wave, ultrasonic wave or temperature vibration, come diffusion barrier or make the separation of film easier.Can also use the energy exposure of different frequency in the electromagnetic spectrum.
In the situation of latex and polymer or synthetic film, by selecting to use and/or change the prescription of release agent, coagulating agent or surfactant, first and second layers can fuse or separate selectively.For example first and second layers can be as palm, the back of the hand face, dactylus, finger tip in gloves are selected the zone, fuse or link together.For example, the multilayer film of sheath can be selected top and/or zone line.Two-layer mode by the fusion multilayer film forms the closed chamber of separation, can also produce the influence of bubble or bubble.May contain different solids, liquids and gases such as lubricant, sealant, biocide, indicator, spermatocide, anticorrisive agent, gel, hydrogel, MS, cleanser, surfactant, cleaning agent, grinding agent, coating agent, wiping agent, fiber, sense of touch improver and scale, disk or other in these chambers and be used to the material that stops pin and other sharp object to penetrate.For example, may contain liquid or gas in the chamber so that cushioning effect to be provided.Perhaps, may contain the material that combines with the chamber rent in the chamber, so that indicative function to be provided.Can also select many materials, its combination is to provide color change, fuel factor, disinfectant or biocide, sclerosis, softening or change sense of touch.
Also may be by changing the chemical property of latex or polymer, the chemical property of release agent, surfactant or coagulating agent, maturation time and temperature, impregnating speed, retention time and by other method such as chlorination, change separation or degree of fusion between the layer of multilayer film.Separate or the degree of fusion scope can be separated to fully between the layer begin between the layer to stick together, through great efforts can strip off between.
Perhaps form in latex with a plurality of separating layers, the synthetic or polymer film in dipping or spraying, above-described technology can also and conventional thin slice formation and extrusion method be used in combination, to prepare multiple other multilayer film.For example, the pipe of multilayer medical science or other type can be used extrusion method formation.In dipping or spraying formation technology, form and the different layers of the multilayer film that extruding technology forms by thin slice, can select to be connected in regional or to fuse together at zone of selecting and separation or discrete other.This multilayer film is applied to utensil, wherein needs to add to prevent the safety measure of breaking, for example in colostomy bag.
The single latex of multilayer film or the texture of polymeric layer or other character may be different.For example, mould may be different inclinations and/or rotation when forming different layers, to provide intensity better film.Perhaps, when different static or magnetic field application, can use different layers.Further, different layers can be formed by different materials, as latex, polymer and synthetic, and might adopt diverse ways to handle, as adopt conventional emulsion layer chlorination to handle.Add biocide in the polyurethanes film
The glow discharge treatment technology can be used for improving the selection and the retention properties of film polymer group.
Biocide can more effectively be selected by certain polymer film and keep.This film can be selected from glow discharge and handle polymer film family, as polyethylene, the PE (TFE/PE) that tetrafluoroethene glow discharge is handled, PET (PET), TFE/PET, polytetrafluoroethylene (PTFE), the PET (HMDS/PET) that PET (E/PET) that ethene glow discharge is handled and HMDO glow discharge are handled, or any polymer film that other adopts the glow discharge method to handle.Biocide can be directly used in the film that glow discharge is handled.The film that obtains may be had a few harder, but very firm, so film will satisfy many application.
Perhaps, biocide can be used as the gas chamber of packing into, by producing glow discharge or RF discharge so that deposition directly deposits.
In addition, biocide can be introduced polymer surfaces and/or inside in film forms, and can obtain the character of sterilizing like this.This can by routinely with other by dipping, casting, spray-painting, vacuum moulding machine, by depositions such as fluid bed, centrifugal rotations layer dipping or mix and finish.External coating can form by same technology, to contain biocide and to obtain the required minimizing of breaking.
Coating in the scope of the invention comprises spermatocide such as N-9 and the one or more organopolysiloxane compounds that can be used for latex film, and as U.S. Patent No. 5,304, disclosed in 375, disclosed full text is quoted as a reference at this paper.Adopt the clear coat of waterborne compositions that rubber membrane can be provided, wherein said composition contains good emulsion binder, emulsifying agent, inorganic fluorochemical and thickener, as U.S. Patent No. 5,182, described in 142, disclosed full text is quoted as a reference at this paper.The cellulosic coating material comprises by emulsification and to be contained water-soluble pore creating material by the synthetic latex that the stable cellulosic polymer of surfactant forms, and can also use plasticizer, as U.S. Patent No. 5, described in 126,146, disclosed full text is quoted as a reference at this paper.Add biocide in porous and the imporosity polyurethanes film
This can be undertaken by four kinds of methods that describe below.Except last a kind of biocide that all needs, at room temperature has low vapour pressure (less than-0.013 crust).In all cases, the solvent that contacts with biocide can not react with biocide, changes the biocide chemical property, can irreversibly destroy the antibiotic and antiviral activity of biocide like this.
(1) the holding back of biocide in the hole of porous membrane.
A. in forming, introduces film biocide
This film can be used following steps and form, (1) with polymerization completely polyurethanes be dissolved in the appropriate solvent, or (2) be dissolved in the polyester-urethane prepolymer of molecular weight 1000-3000 in the solvent, subsequently with crosslinked or maturation agent sulfuration or the maturation that add in the solution.In both cases, solvent must be the solvent that biocide and polyurethanes all can dissolve.
Be used for the type (polyethers, polyester or polyester-polyamide) that this purpose solvent depends on polyurethanes and the type of biocide.Some solvents to be selected such as following table are listed.
Table 1: their solubility parameter dissolution with solvents parameter (cals/cc) of solvent agent to be selected
1/2The medium glycol monoethyl ether ester of the medium ethylene glycol monoethyl ether ester of the medium diethyl ketone of the strong butanone of the strong m-cresols of hydrogen bonding dimethyl formamide (DMF) 12.1 medium dimethylacetylamides (DMF), 10.8 medium oxolane (THF) 9.1 medium dimethyl sulfoxide (DMSO)s (DMS), 12 medium Isosorbide-5-Nitrae dioxane 10 medium phenol the last 10.2 formic acid 12.1 strength sulfuric acids 9.3 8.8 10.5 11.4 is medium
Also attempt to use water-soluble polymer within the scope of the invention.
Also can use the mixture of these solvents between mutually, and and have the solubility parameter scope at 8-24 (cals/cc)
1/2Mixture with medium or strong hydrogen-bonded non-solvent.
At first biocide is dissolved in this solvent or the solvent mixture, to form near saturated solution, then and polyurethanes in being dissolved in identical or approximate solvent and carbamate prepolymer mixing.In solution, contain under the situation of polyester-urethane prepolymer, in polymer, add maturation agent (be generally and have 2 or more multi-functional acid amides or alcohol), before film is about to casting, add biocide solution.The blend films that obtains is used the method for patent (United States Patent(USP) Nos. 4,813,966 and 4,704, the 130) description of Gilding and is cast, and disclosed full text is quoted as a reference at this paper, and carries out following modification.
Cast membrane is immersed precipitated liquid, immerse solvent extraction liquid subsequently, biocide has the trend that flows in the solution from rubber.Two kinds of methods can reduce this once missing, and (1) precipitation or extract are saturated with biocide, or (solubility parameter is less than-9 (cals/cc) to use low polar liquid in (2) precipitation or the extract
1/2, weak hydrogen bonding).Because most of biocides are strong polarity, they tend to be retained in the medium or strong polarity environment of polyurethanes, rather than are extracted and enter in the liquid.
After subsequent drying and the annealing, remove remaining solvent, biocide physically is retained in the hole of film.
B. film forms the back and introduces biocide
Porous polyurethanes film can carry out swelling with the solvent of the saturated table 1 of biocide or the mixture of solvent mixture or these solvents and non-solvent.In the situation of linear polyurethane, must adjust the ratio of non-solvent, the soft segment of solvent mixture swelling carbamate (polyethers segment) like this, but can dissolve polymer.In swelling, solvent/sweller carries biocide and enters hole by polymer architecture.
Film is taken out from biocide solution, the dry and annealing with film, this is to remove sweller, and biocide is retained in hole and the polymeric matrix.
(2) biocide is in the absorption of bore area, and this method is used for porous membrane.
The program that employing is identical with 1A and 1B, the extraction from rubber except solvent or sweller, (solubility parameter is less than 9 (cals/cc) by finishing in the non-solvent liquid that film is immersed low polarity mostly
1/2, weak hydrogen bonding).In this case, non-solvent liquid is saturated without biocide, and therefore just very possible biocide is adsorbed on the surface (and being retained in the matrix of rubber) of polarity polyurethanes hole.Non-adsorptivity biocide molecule immerses in the non-solvent in the hole, and the adsorptivity biocide is stayed pore surface.Any solvent or dissolvent residual can be removed by dry and annealing in the film.
(3) precipitation of biocide in rubber matrix, this method are used for the amino first of imporosity
The acid esters film.
The program that employing is identical with 1A and 1B, the method that does not adopt the patent of Gilding to describe except the method that is used to prepare the hole.On the contrary, film only is to cast from solution, adopts the program that forms film usually: dipping, coating, spraying, rotation etc.Under the situation of preformed film, can strengthen the diffusion of sweller along two stretching with biocide by improving rubber membrane.
The extraction of solvent/sweller is finished by dry and annealing.In (1), can use the saturated non-solvent liquid of biocide, but preferably carry out drying.Since in the rubber solvent/sweller concentration reduce, biocide will be precipitated out, and forms phase separation region in rubber matrix.
(4) functional group of biocide and polyurethanes chain chemistry combination, this method is used for
Porous and imporosity film.
The advantage that polyurethanes has carbamate and urea to connect with relative active chain.Only by 1: 1 isocyanates of stoichiometric ratio: amido or isocyanates: slightly the departing from of-OH base, can make easily the end of the chain or branch point have too much amido ,-rubber of OH base or isocyanic acid alkali.
The biocide molecule can be chemically bound on these groups then.After this combination is finished, cause some molecule no longer to have biocidal activity, this point is extremely important.
These association reactions can carry out (1) before film forms, and when polyurethanes or carbamate prepolymer are in solvent (adding crosslinked subsequently or the maturation agent), or (2) are after film forms.
Under first kind of situation, the biocide association reaction will carry out in solution with polyurethanes.Under second kind of situation, carry out in the swelling net of biocide association reaction with rubber.In both of these case, solvent or sweller must keep inertia in association reaction.
After the reaction, solvent or sweller are removed according to the method for describing in (1) or (3) part.Even the biocide chemical bond to the polyurethanes chain, also can be separated in rubber matrix, carry out but use more than the method better method of describing in (3) part.
By using synthetic, can not necessarily must use solvent or sweller based on water.
(5) sealing on film surface.
For top all methods, carry out final coating, the surface of diaphragm seal to prevent the loss of biocide in using or storing, is very important.Can go in the polyurethane ester solution of low viscosity (low % solid) by final impregnating, or, carry out this coating by approaching the plasma or the vapor deposition of elastomeric polymer film.The mixing of gentian violet and latex
According to one aspect of the present invention, gentian violet and liquid emulsion mix by dipping or spray technique before film forms.Can use very wide variable concentrations, but the aldrich mixture of preferred weight ratio 1.5%.The applicant finds that except the thing characteristic of killing livestock, the gentian violet of adding exceeds unexpected result by mixing two of generations.Protein molecular combination in gentian violet and the latex, this can produce two benefits.The first, this can produce anti-aging or antioxidation, and this can prolong storage life, improves tear resistance.The second, it can reduce the allergic reaction of latex allergy or sensitive users.Can use other combined with protein biocide, replace gentian violet or and gentian violet be used in combination.Microfibre is reinforced
Present invention resides in the preparation process, by adding the microfibre reinforced membrane.Microfibre such as aromatic polyamides, aramid fiber, fibrous glass, natural fiber, nylon and graphite, before application, use in or use after, can directly mix with latex or polymeric film material.These fiber reinforced can application with the one deck or the more multi-layered combination of monofilm or multilayer film.Fiber reinforced can also passing through adds one deck or more preformed lamella in multilayer film, reach fiber reinforced.
Can also be by adding monofilament (being similar to setline) at one or more layers, or by around one or more layers or middlely twine monofilament in predetermined mode, reinforce.
Can also use cataphracted particle and sequin, to improve film strength and penetration resistance.Can be one deck of single or multiple lift film or more multi-layered, add or handle these fish scales or disk.These fish scales or disk can also have magnetic, can locate in predetermined mode by using electromagnetic field in film forms like this.The present inventor thinks that it is CTFA cosmetic composition dictionary that the catalogue that is suitable for biocide of the present invention is selected from title, the third edition, 1982, The Cosmetic. publishes Toiletry and Fragrance Association, Inc., Washington D.C. HC BLUE NO.1
N
4, N
4-Bls (2-hydroxyethyl)-N
1-methyl-2-nitro-p-phenylenediamine (PPD) HC BLUE NO.2
N
1, N
4, N
4-(2-hydroxyethyl)-2-nitro-p-phenylenediamine (PPD) HC BLUE NO.3 Cibalan Blue FBLHC BLUE NO.4HC BLUE NO.5HC BROWN NO.1 Capracyl Brown 2RHC ORANGENO.1
2-nitro-4-hydroxy diphenylamine HC RED NO.1
4-amino-2-nitrodiphenylamine HC RED NO.3
N
1-(2-hydroxyethyl)-2-nitro-p-phenylenediamine (PPD) HC RED NO.6HC YELLOW NO.2
N-(2-hydroxyethyl)-2-nitroaniline HC YELLOW NO.3
N
1-three (hydroxymethyls)-methyl-4-nitro-o-phenylenediamine HC YELLOW NO.5
N
1-(2-hydroxyethyl)-4-nitro-o-phenylenediamine NONOXYNOL-2
Polyoxyethylene (2) nonylplenyl ether NONOXYNOL-4,64: 1 yellow 73 quinoline quinolinium terpenes terpineol reducing dye xanthene acid blacks 58 of yellow 13 pigments of yellow 12 pigments of yellow 3 pigments of yellow 1 pigment of purple 19 pigments of color red 112 pigments of-8NONOXYNOL-9 IODINENONOXYNOL-12 IODINE color red 57 color red 63: 1 color red of 57: 1 color red
Irgalan Grey B1. acid black 1 07
Lanamid Black B1. acid black 1 31
Nigrosine acid blue 9 ammonium salt acid blue 62 acid browns 46 acid browns 48 acid dyes acid fuchsin ACID GREEN 25 acid orange 7 acid oranges 24 acid reds 33 acid red 35 acid reds 51 acid reds 52 acid red 87 acid red 92 acid reds 95 acid violets 43 Indian yellows 1 quinoline yellow acid yellow 23 Indian yellow 73 Indian yellows 73 sodium salt D﹠amp; C BLUE NO.1 aluminium color lake
Light blue color lake D﹠amp; The blue NO.2 aluminium of C color lake
Acid Blue 74, Indigetine 1A, indigo carmine D﹠amp; C BLUE NO.4
Acid blue 9 (ammonium salt) D﹠amp; C BLUE NO.6
Indigo D﹠amp; C BROWN1
Resorcin brown, Capracyl BrownD﹠amp; C GREEN NO.3 aluminium color lake eats green 3D﹠amp; C GREEN NO.5
ACID GREEN 25 D﹠amp; C GREEN NO.6
Solvent green 3 D﹠amp; C GREEN NO.S
The green 7D﹠amp of solvent; C ORANGE NO.4
Acid orange 7 D﹠amp; C ORANGE NO.5
Acid orange 11. solvent red 72. dibromo fluorescein D﹠amp; C ORANGE NO.5. aluminium color lake
Dawn Orange.Manchu Orange.D﹠amp; C ORANGE NO.5. zirconium color lake
Petite Orange.Dawn Orange. acid red 26.Ponceau R.D﹠amp; C ORANGE NO.10
Solvent 73.Dilodofluorescein.D﹠amp; C ORANGE NO.10 aluminium color lake
Solvent red 73. erythrosine G.D﹠amp; C ORANGE NO.11D﹠amp; C ORANGE NO.17D﹠amp; C ORANGE NO.17 color lake D﹠amp; C RED NO.2 aluminium color lake D﹠amp; C RED NO.3 aluminium color lake D﹠amp; C RED NO.4 aluminium color lake D﹠amp; C RED NO.6
Lithol rubine BD﹠amp; C RED NO.6 aluminium color lake D﹠amp; C RED NO.6 barium color lake D﹠amp; C RED NO.7 calcium color lake D﹠amp; C RED NO.7 zirconium color lake D﹠amp; C RED NO.8D﹠amp; C RED NO.8 barium color lake D﹠amp; C RED NO.8 sodium color lake D﹠amp; C RED NO.9D﹠amp; C RED NO.9 barium color lake D﹠amp; C RED NO.9 zirconium strontium color lake 5D﹠amp; C RED NO.10D﹠amp; C RED NO.17D﹠amp; C RED NO.19
Rhodamine toner B. magenta D﹠amp; C RED NO.19 barium color lake
Rhodamine toner B. magenta D﹠amp; C RED NO.19 zirconium color lake D﹠amp; C RED NO.21D﹠amp; C RED NO.21 aluminium color lake D﹠amp; C RED NO.21 zirconium color lake D﹠amp; The red YSD﹠amp of C RED NO.22 dawn; C RED NO.27D﹠amp; C RED NO.27 aluminium color lake
Terabromo Terachloro fluorescein color lake D﹠amp; C RED NO.27 barium color lake D﹠amp; C RED NO.27 zirconium color lake D﹠amp; C RED NO.28
Phloxin BD﹠amp; C RED NO.30D﹠amp; C RED NO.30 aluminium color lake D﹠amp; C RED NO.30 calcium color lake D﹠amp; C RED NO.31D﹠amp; C RED NO.31 calcium color lake D﹠amp; C RED NO.33D﹠amp; C RED NO.34D﹠amp; C RED NO.34 calcium color lake D﹠amp; C RED NO.36D﹠amp; C RED NO.36 barium color lake D﹠amp; C RED NO.36 color lake
Chlorinated Para Lake.Tange OrangeD﹠amp; C RED NO.36 zirconium color lake D﹠amp; C RED NO.37
Rhodamine toner B stearate D﹠amp; C RED NO.37 calcium color lake
Rhodamine toner B stearate solvent D﹠amp; C RED NO.39D﹠amp; C RED NO.40D﹠amp; C YELLOW NO.5 aluminium color lake D﹠amp; C YELLOW NO.5 zirconium color lake D﹠amp; C YELLOW NO.6 aluminium color lake D﹠amp; C YELLOW NO.7D﹠amp; C YELLOW NO.8
Uranine, sodium fluorescein, naphthol yellow S D﹠amp; C YELLOW NO.10D﹠amp; C YELLOW NO.10 aluminium color lake D﹠amp; C YELLOW NO.11EXT.D﹠amp; C VIOLET NO.2EXT.D﹠amp; C YELLOW NO.7EXT.D﹠amp; C YELLOW NO.7 aluminium color lake FD﹠amp; C RED NO.20FD﹠amp; C RED NO.22FD﹠amp; C RED NO.40FD﹠amp; C YELLOW NO.5FD﹠amp; C YELLOW NO.5 aluminium look is decided FD﹠amp; C YELLOW NO.6FD﹠amp; C YELLOW NO.6 aluminium color lake solvent red 48 solvent red 49s: 1 solvent red, 72 solvent red, 73 solvent violet, 13 solvent yellows, 13 tartrazines are selected from " federal register (Federal Register) ", 43 the volume on January 26th, 4, Friday antibacterial soap:
Cloflucarban
Para-chloro-mein-xylenof
Povidone-iodine is combined into thing
1.5% phenol or water/alcoholic solution still less
Triclocarbon
The Triclosan personnel health nurses hand cleanser
Benzalkonium chloride
The Benzene Chloride first and second oxygen ammoniums
Clofluearban
Hexylesorinal
The iodine that the phosphate of alkyl-aryloxy polyethylene glycol mixes
The methyl chloride benzene first and second oxygen ammoniums
Nonylphenoxy gathers (ethyleneoxy) ethanol-iodine
Para-chloro-meta-xylenol
The polyvinylpyrrolidone Surgidine
1.5% phenol or water/alcoholic solution still less
The poloxamer Surgidine
Tricloearban
Goods before the Undecoylium chloride-iodine complex patient operation
Benzalkonium chloride
The Benzene Chloride first and second oxygen ammoniums
Hexyl resorcin
The iodine that the phosphate of alkyl-aryloxy polyethylene glycol mixes
The methyl chloride benzene first and second oxygen ammoniums
Nonylphenoxy gathers (ethyleneoxy) ethanol-iodine
Para-chloro-meta-xylenol
1.5% phenol or water/alcoholic solution still less
The poloxamer Surgidine
The polyvinylpyrrolidone Surgidine
The agent of Undecoylium chloride-iodine complex skin sterilization
Benzalkonium chloride
The Benzene Chloride first and second oxygen ammoniums
Hexyl resorcin
The iodine that the phosphate of alkyl-aryloxy polyethylene glycol mixes
Tincture of iodine agent
The methyl chloride benzene first and second oxygen ammoniums
Nonylphenoxy gathers (ethyleneoxy) ethanol-iodine
Para-chloro-meta-xylenol
1.5% phenol or water/alcoholic solution still less
The poloxamer Surgidine
The polyvinylpyrrolidone Surgidine
Triclosan
Triple dye
Undecoylium chloride-iodine complex skin wound cleaning agent
Cloflucarban
The iodine that the phosphate of alkyl-aryloxy polyethylene glycol mixes
Tincture of iodine agent
Nonylphenoxy gathers (ethyleneoxy) ethanol-iodine
Para-chloro-meta-xylenol
1.5% phenol or water/alcoholic solution still less
The poloxamer Surgidine
The polyvinylpyrrolidone Surgidine
Triclosan
Triple dye
Uhdecoylium chloride-iodine complex skin wound protective agent
Benzalkonium chloride
The Benzene Chloride first and second oxygen ammoniums
Hexyl resorcin
The iodine that the phosphate of alkyl-aryloxy polyethylene glycol mixes
Tincture of iodine agent
The methyl chloride benzene first and second oxygen ammoniums
Nonylphenoxy gathers (ethyleneoxy) ethanol iodine
Para-chloro-meta-xylenol
Claims (29)
1. method that is used to prepare the multilayer latex film that comprises two separating layers at least may further comprise the steps:
(a) deposition first emulsion layer on mould;
(b) at least a portion of described ground floor is handled with release agent;
(c) with at least a portion of described ground floor with can be effectively as the material of latex coagulating agent
Handle;
(d) deposition second latex at least a portion of the ground floor described in the described mould
The layer, described release agent can effectively prevent basically described first and second layers in institute
State at least a portion fusion of film; With
(e) solidify or described first and second layers of maturation.
2. the method for claim 1 also is included in step (d) is handled at least a portion of described first emulsion layer before with biocide step.
3. the method for claim 2, wherein said biocide and the mixing of described coagulating agent.
4. the method for claim 2, wherein said biocide and the mixing of described antitack agent.
5. the method for claim 2, wherein said biocide comprises gentian violet.
6. the method for claim 2, wherein said biocide comprises nonoxynol 9.
7. the method for claim 2, wherein said biocide comprises chlorhexidine.
8. the method for claim 2, the described release agent of deposition in step (b) wherein, the described ground floor surrounding extension area contact of getting along well, described like this first and second layers fuse together in described zone.
9. the method for claim 8, wherein said film comprises gloves.
10. the method for claim 8, wherein said film comprises sheath.
11. the process of claim 1 wherein that described film comprises gloves.
12. the process of claim 1 wherein that described film comprises sheath.
13. the method for claim 1, also be included in step (d) before at least a portion of the ground floor described in the described mould deposited material step, wherein said material is selected from lubricant, sealant, biocide, indicator, spermatocide, anticorrisive agent, gel, hydrogel, MS, cleanser, surfactant, cleaning agent, grinding agent, coating agent, wiping agent, fiber, sense of touch improver; Scale, disk and other material and thin slice that is used to stop pin and other sharp object to penetrate form agent, thereby described material is located substantially between described first emulsion layer and described second emulsion layer.
14. the method for claim 1 further is included in the step of at least one extra layer of deposition at least a portion of the described second layer.
15. the process of claim 1 wherein that described release agent comprises zinc stearate.
16. a method that is used to prepare the multilayer latex film that comprises two separating layers at least may further comprise the steps:
(a) deposition is selected from liquid polymers and the material that is dissolved in the polymer in the solvent on mould
Material forms ground floor;
(b) at least a portion of described ground floor is handled with surfactant;
(c) at least a portion of the ground floor described in the described mould deposition to be selected from liquid poly-
Compound and the material that is dissolved in the polymer in the solvent form the second layer, described table
Surface-active agent can effectively prevent described first and second layers of at least a portion basically
Fusion; With
(d) solidify or described first and second layers of maturation.
17. the method for claim 16 also is included in step (c) is handled at least a portion of described ground floor before with biocide step.
18. the method for claim 17, wherein said biocide and described surfactant mix.
19. the method for claim 17, wherein said biocide comprises gentian violet.
20. the method for claim 17, wherein said biocide comprises nonoxynol 9.
21. the method for claim 17, wherein said biocide comprises chlorhexidine.
22. the method for claim 16, the described surfactant of deposition in step (b) wherein, the described ground floor surrounding extension area contact of getting along well, described like this first and second layers fuse together in described zone.
23. the method for claim 16, wherein said film comprises gloves.
24. the method for claim 16, wherein said film comprises sheath.
25. the method for claim 17, wherein said film comprises gloves.
26. the method for claim 17, wherein said film comprises sheath.
27. the method for claim 16, also be included in step (c) before at least a portion of the ground floor described in the described mould deposited material step, wherein said material is selected from lubricant, sealant, biocide, indicator, spermatocide, anticorrisive agent, gel, hydrogel, MS, cleanser, surfactant, cleaning agent, grinding agent, scale, disk and other are used to the material that stops pin and other sharp object to penetrate, coating agent, wiping agent, fiber, the sense of touch improver, form agent with thin slice, thereby described material is located substantially between described first emulsion layer and described second emulsion layer.
28. the method for claim 16 further is included in the step of at least one extra layer of deposition at least a portion of the described second layer.
29. a method that is used to prepare the multilayer latex film that comprises two separating layers at least may further comprise the steps:
(a) deposition first emulsion layer on mould;
(b) at least a portion of described ground floor is handled with release agent;
(c) deposition second latex at least a portion of the ground floor described in the described mould
The layer, described release agent can effectively prevent basically described first and second layers in institute
State at least a portion of film and fuse; With
(d) solidify or described first and second layers of maturation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97182484 CN1352593A (en) | 1997-10-20 | 1997-10-20 | Method for forming latex or polymer membrane, including multiple discrete layers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97182484 CN1352593A (en) | 1997-10-20 | 1997-10-20 | Method for forming latex or polymer membrane, including multiple discrete layers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1352593A true CN1352593A (en) | 2002-06-05 |
Family
ID=5178531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97182484 Pending CN1352593A (en) | 1997-10-20 | 1997-10-20 | Method for forming latex or polymer membrane, including multiple discrete layers |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1352593A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006108333A1 (en) * | 2005-04-15 | 2006-10-19 | Zhengming Zhou | Antiallergic production of latex or pvc and method for forming the same |
| CN103549687A (en) * | 2013-11-11 | 2014-02-05 | 镇江苏惠乳胶制品有限公司 | Rubber gloves with corrosion resisting function and preparation method thereof |
| CN104669653A (en) * | 2015-02-06 | 2015-06-03 | 上海名邦橡胶制品有限公司 | Rapid permeation method of lubricating oil of condoms |
| CN105073420A (en) * | 2013-03-12 | 2015-11-18 | 安塞尔有限公司 | Breach or contamination indicating article |
| CN105358618A (en) * | 2013-07-10 | 2016-02-24 | Ttk防护设备有限公司 | A binary process for manufacture of dipped latex products |
| CN106103494A (en) * | 2014-06-13 | 2016-11-09 | Ttk防护设备有限公司 | Do not use animal derived thing method manufacturing latex dipping product and products thereof |
| CN110251737A (en) * | 2019-08-06 | 2019-09-20 | 湖南优感觉生物科技有限公司 | A kind of latex prophylactic being added to sodium hyaluronate |
| CN111358095A (en) * | 2020-04-28 | 2020-07-03 | 河北泰能鸿森医疗科技有限公司 | Disposable butyronitrile gloves and preparation method thereof |
| CN111358094A (en) * | 2020-04-28 | 2020-07-03 | 河北泰能鸿森医疗科技有限公司 | Disposable butyronitrile gloves with sweat accumulation preventing function and preparation method thereof |
| CN112568528A (en) * | 2020-12-09 | 2021-03-30 | 广州市俊达手套有限公司 | Sweat-absorbing and moisture-proof breathable latex glove and preparation method thereof |
-
1997
- 1997-10-20 CN CN 97182484 patent/CN1352593A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008532717A (en) * | 2005-04-15 | 2008-08-21 | 政明 周 | Antiallergic latex or PVC product and method for producing the same |
| WO2006108333A1 (en) * | 2005-04-15 | 2006-10-19 | Zhengming Zhou | Antiallergic production of latex or pvc and method for forming the same |
| CN105073420A (en) * | 2013-03-12 | 2015-11-18 | 安塞尔有限公司 | Breach or contamination indicating article |
| US9579532B2 (en) | 2013-03-12 | 2017-02-28 | Ansell Limited | Breach or contamination indicating article |
| CN105358618B (en) * | 2013-07-10 | 2017-04-26 | Ttk防护设备有限公司 | A binary process for manufacture of dipped latex products |
| CN105358618A (en) * | 2013-07-10 | 2016-02-24 | Ttk防护设备有限公司 | A binary process for manufacture of dipped latex products |
| CN103549687A (en) * | 2013-11-11 | 2014-02-05 | 镇江苏惠乳胶制品有限公司 | Rubber gloves with corrosion resisting function and preparation method thereof |
| CN106103494A (en) * | 2014-06-13 | 2016-11-09 | Ttk防护设备有限公司 | Do not use animal derived thing method manufacturing latex dipping product and products thereof |
| CN104669653A (en) * | 2015-02-06 | 2015-06-03 | 上海名邦橡胶制品有限公司 | Rapid permeation method of lubricating oil of condoms |
| CN110251737A (en) * | 2019-08-06 | 2019-09-20 | 湖南优感觉生物科技有限公司 | A kind of latex prophylactic being added to sodium hyaluronate |
| CN111358095A (en) * | 2020-04-28 | 2020-07-03 | 河北泰能鸿森医疗科技有限公司 | Disposable butyronitrile gloves and preparation method thereof |
| CN111358094A (en) * | 2020-04-28 | 2020-07-03 | 河北泰能鸿森医疗科技有限公司 | Disposable butyronitrile gloves with sweat accumulation preventing function and preparation method thereof |
| CN112568528A (en) * | 2020-12-09 | 2021-03-30 | 广州市俊达手套有限公司 | Sweat-absorbing and moisture-proof breathable latex glove and preparation method thereof |
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