CN1347728A - Chinese medicine prepn for treating rheumatic osteoarthropathy - Google Patents
Chinese medicine prepn for treating rheumatic osteoarthropathy Download PDFInfo
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Abstract
The Chinese medicine preparation includes the active components of 13 kinds of Chinese medicinal materials including Chinese peashrub root, giant knotweed rhizome, notoperygium root, honeysuckle, cortex acanthopanacis radicis, etc. It may be prepared in tonic wine, granule, mixture and other oral dosage form. It hs the functions of diminishing inflammation, stopping pain, regulating immunity, protecting bone, promoting blood supply inside bone and promoting bone formation. Clinical application shows that the medicine preparation has high curative effect, mild medicine effect and no toxic side effect and may be taken for long period.
Description
Technical field
The present invention addresses Chinese patent medicine, especially about a kind of Chinese medicine preparation for the treatment of rheumatic osteoarthropathy.Be applied to treat the osteoarthrosis rheumatism, comprise symptoms such as sour distending pain that osteoarthritis (bone matrix hyperplasia OA), osteoporosis (OS), rheumatoid arthritis (RA) etc. cause is swollen.
Background technology
Bone matrix hyperplasia, osteoporosis, these three diseases of rheumatoid arthritis all belong to the rheumatism system.Clinical manifestation has identical symptom---the articular muscle swelling and pain, and the deadlock in morning that weight is different all is a chronic disease, pain is heavier when acute attack, and joint synovial bursa hydrops can take place.But the cause of disease of these three diseases and different in kind, the order of severity are also different.
These three sick traditional Chinese medical science all belong to arthromyodynia, arthralgia aggravated by cold, severe and migratory arthralgia category.Be because rheumatism is gone into network, through BI-syndrome involved the blood vessels resistance, stagnation of QI-blood.It is a deficiency of both the liver and kidney.Then muscles and bones is loose withers softly for liver governing tendons, kidney governing bones, deficiency of both the liver and kidney, and rheumatism is gone into then arthralgia of network, and it is stiff that blood vessels numbness hinders then swelling.On China's traditional Chinese medical science ancient book arthromyodynia there is argumentation than system.
The inventor was engaged in rheumatismal clinical research for a long time since 1963.Various types of arthritis all there is rich experience.Especially joint disease such as rheumatoid arthritis, osteoarthritis, osteoporosis adopt traditional Chinese medical herbal treatment all to obtain better curative effect.
1, osteoarthritis claims bone matrix hyperplasia again, is the commonly encountered diseases of middle-aged and elderly people, how to be caused by strain, the cold moist institute that stimulates.Often occur in the hyperosteogeny (title bony spur among the people) at positions such as cervical vertebra, lumbar vertebra, knee joint, finger.Its hyperosteogeny of cervical vertebra the person claim cervical spondylosis, and various clinical manifestations are arranged.Lumbar vertebra hyperosteogeny often has aching pain in waist and back and sciatica.Knee joint hyperosteogeny usually merges bursitis, synovial bursa hydrops.The finger hyperosteogeny has stiff and lesser tubercle formation in the morning of short time, claims Hai Bodeng (Heberden) tuberosity.
2, osteoporosis also is the commonly encountered diseases of middle-aged and elderly people.Especially middle aged and aged women is many.Be because the endocrine level descends, decrease in estrogen particularly, disorder of calcium metabolism and the bone marrow matter calcium deficiency that causes and form osteoporosis.The whole body articular muscle symptom of aching is arranged.Normal and hyperosteogeny takes place simultaneously.
3, rheumatoid arthritis is a wherein the heaviest disease, is to be caused by the disorderly institute of autoimmune function.The women has morbidity more than male, the aged,middle aged person and young man's each age group.It is main invading medium and small joint, joint swelling and pain, arthroedema, the stiff time in morning is long, more than 2 hours by one day, erythrocyte sedimentation rate speedup, the rheumatoid factor positive, a few patients antinuclear antibody positive.Osteoporosis is arranged, the change of arthrostenosis.Bone destruction, joint deformity, amyotrophy can take place and the maimed person in serious symptom and end-stage patients.
Method to these three sick western medical treatments all is to use nonsteroidal anti inflammatory analgesic (NSAID), as diclofenac, ibuprofen, mobic etc. kind more than 10 is arranged.At once the analgesic effect of these medicines is fine, generally can keep many times of half a day.But the disease controlling effect is relatively poor, and the time has been grown drug resistance, and toxicities such as stomachache, hepatic and renal function injure are arranged.
Osteoporosis is popular method of replenishing the calcium at present, because calcium tablet is difficult to absorb and poor effect, may provide raw material for calculi in vivo.The women takes the method for Western medicine estrogen sheet, and side effect is bigger, has increased the chance of cancer, thereby is difficult to promote.
The bone matrix hyperplasia doctor trained in Western medicine generally adopts the method for symptomatic treatment and physical therapy.The method that patient often selects acupuncture, massages and takes traditional Chinese medicine.Disorderly the people of clothes health product is also a lot.
These two breaths of lying up are warming and an amount of movable, and the tendency of spontaneous remission is often arranged.
The method of rheumatoid arthritis western medical treatment is to adopt immunosuppressant such as methotrexate (MTX) or azathioprine (AZP) and the same usefulness of anti-inflammation analgesic (NSAID), and short term efficacy is good, can make patient partly alleviate or alleviate fully.But these medicine life-time service can produce drug resistance, and toxic and side effects is a lot, and after decrement or the drug withdrawal, the state of an illness again can be repeatedly.Its late result is relatively poor.
The Chinese patent medicine aspect had had tiger bone-papaya wine, Feng in the past property medicated wine, DAHUOLUO DAN, medicine for osteodynia due to pathogenic wind-dampness etc., all superseded.Many Chinese patent medicine listings were arranged in recent years, arthromyodynia was all had certain curative effect.These medicines all are the treatment rules that meets traditional Chinese medical science dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain.Modern mechanism has the effect of anti-inflammatory analgetic, antiallergic action.But these medicines are not set about from the depths, and to protection sclerotin and inhibition immunity, anti-angiogenic scorching aspect still lacks research.The medicated wine property of medicine that has is hotter, and Chang Butai is fit to the damp and hot heavier region characteristic in north and south, the Changjiang river.
It all is the immunosuppressant of Chinese medicine that Glucosidorum Tripterygll Totorum and Tripterygium Hypoglaucum Hutch Tablet (Radix Tripterygii Wilfordii and Tripterygium hypoglaucum are equal congeners) are still arranged in addition, and rheumatoid arthritis is had certain curative effect.But toxicity is very big, and amenorrhea, leukopenia, the infringement of conscience kidney function of nervous system etc. are arranged.The state of an illness can be bounced after the drug withdrawal.
Summary of the invention
The present invention provides a kind of good effect, safety, and the property of medicine is gentle, and heat symptom-complex, sympotoms caused by cold factors etc. all is fit to, and can take for a long time, can treat the Chinese medicine preparation of various rheumatic osteoarthropathies.
The chronic phase of bone matrix hyperplasia, osteoporosis, these three diseases of rheumatoid arthritis all has deficiency of both the liver and kidney, rheumatism to go into network, the resistance of blood vessels numbness is its common characteristic.According to secular clinical experience, the prescription that proposes this Chinese medicine preparation has the effect of liver-kidney tonifying, expelling wind and activating blood circulation.And name and be three soup of Shen Shi rheumatism.Be applicable to the chronic phase of these three diseases, the back extremities joint person of aching is arranged.
Three steamed dumpings of Chinese medicine preparation Shen Shi rheumatism of the present invention contain the active ingredient of following 13 kinds of Chinese medicine medical materials: Radix Caraganae Sinicae 5-10 part, polygoni cuspidati,radix 5-10 part, downy rosemyrtle root 5-10 part, Rhizoma Et Radix Notopterygii 5-10 part, Caulis Lonicerae 5-10 part, Cortex Acanthopancis 2-4 part, Ramulus Sambuci Williamsii 5-10 part, Radix Dipsaci 2-4 part, Cortex Eucommiae 2-4 part, Fructus Psoraleae 2-4 part, Radix Rehmanniae 2-4 part, Pericarpium Citri Reticulatae 1-3 part and Radix Glycyrrhizae 1-3 part.Chinese medicine activity of drug ingredients composition and pharmaceutical carrier are pressed arbitrary proportion and are formed, and wherein active ingredient accounts for weight ratio and can be 0.1-99.9%, and pharmaceutical carrier accounts for weight ratio can be 99.9-0.1%.Pharmaceutical carrier is wine, dextrin, starch, sucrose or other common carrier.
The present invention treats 13 kinds of Chinese medicine active ingredients that the rheumatic osteoarthropathy Chinese medicine preparation comprises, because suitable cooperation produces good synergism, makes this Chinese medicine preparation that better curative effect be arranged, and the therapeutical effect of these components is as described below:
1, Radix Caraganae Sinicae, polygoni cuspidati,radix, downy rosemyrtle root three medical instruments have expelling wind and activating blood circulation, removing obstruction in the collateral to relieve pain effect.Be applicable to various arthralgia such as OA, OS, RA.
Radix Caraganae Sinicae: sweet in flavor and warm in property, QI invigorating promoting blood circulation and stopping pain effect is arranged, traditional treatment has a delicate constitution, and rheumatism is gone into network, and muscles and bones is ached.Contain compositions such as alkaloid, plant sterol, lactone coumarin, have the elimination arthritis.Suppress immunity, reduce the effect of blood viscosity, anticoagulant etc.There is not side reaction.
Downy rosemyrtle root: sweet flat, expelling wind and removing dampness, removing obstruction in the collateral to relieve pain effect are arranged.Prescription,local is used for the treatment of arthritis and hepatitis.Our clinical experience and Radix Caraganae Sinicae are with treating rheumatoid arthritis, osteoarthritis, cervical spondylosis, lumbago and skelalgia etc.There is not side reaction.
Polygoni cuspidati,radix: bitter cold has expelling wind and removing dampness, heat clearing and blood circulation promoting effect.Contain multiple anthraquinone analog compound, stilbene analog derivative, phenoloid.Has many-sided effect such as blood vessel dilating, anticoagulation, heart tonifying, the liver protecting, immunosuppressant.
2, Caulis Lonicerae, Rhizoma Et Radix Notopterygii, Cortex Acanthopancis three medicines all have the dispelling wind and removing obstruction in the collateral effect.Wherein Rhizoma Et Radix Notopterygii has anti-inflammatory analgetic, skin expansion blood vessel, the effect of diaphoresis antipyretic.Caulis Lonicerae has immunosuppressive action and diastole muscle spasm and analgesic effect is arranged.Cortex Acanthopancis has anti-inflammatory analgetic and heart tonifying vasodilative effect.
3, Ramulus Sambuci Williamsii, Radix Dipsaci are the medicines commonly used for the treatment of trauma fracture, have the promoting blood circulation and promoting skeleton formation effect.Two medicines all have protection and promote sclerotin new life according to the study, improve osteoporotic effect.
Ramulus Sambuci Williamsii: sweet flat, dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain effect are arranged.Tradition is used for rheumatalgia, traumatic injury.Has the sclerotin of promotion new life, the effect of accelerating union of bone fracture.And analgesic effect is arranged and suppress vascular permeability, and the detumescence effect is arranged.We can treat the osteoarthrosis rheumatism by clinical experience, can protect sclerotin and reducing swelling and alleviating pain.
Radix Dipsaci: bitter temperature has invigorating the liver and kidney, strengthening bone and muscle, promoting blood circulation effect.Tradition is used for diseases such as the weak fracture of soreness of waist and knee joint.Contain compositions such as alkaloid.Pharmacology has analgesia, promotes tissue newborn, and the protection sclerotin promotes the effect of bone tissue growth.Our clinical osteoarthrosis rheumatism that is used for the treatment of can improve sore waist and aching in the waist and the back, can protect sclerotin, and it is loose to be difficult for decalcification.
4, the Cortex Eucommiae, Fructus Psoraleae, Radix Dipsaci, the Radix Rehmanniae all have invigorating the liver and kidney, qualcomm meridian effect.This four medicine all is the medicine commonly used of treatment soreness of waist lumbago.The Cortex Eucommiae, Fructus Psoraleae are the suffer from a deficiency of the kidney principal agents of the soreness of waist of the blue or green pretty young woman's pill for curing of ancient prescription.Comparatively suitable to osteoporosis, hyperosteogeny.
Fructus Psoraleae can promote estrogen secretion, and the Radix Rehmanniae can promote adrenal cortex function, and two medicines can both improve the hormone in vivo level.The Radix Rehmanniae still has anti-angiogenic inflammation and regulates the effect of immunologic function, and four medicines together not only can treatment of arthritis, and can strong body constitution.Patient's whole body situation is improved.
5, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are harmonizing drug, to improve taste and protection appetite, patient can be taken for a long time.
The present invention treats the rheumatic osteoarthropathy Chinese medicine preparation can operate the peroral dosage form that is prepared into medicated wine, granule, pill, tablet, mixture or ampere-type routinely, its preparation method for example:
1, medicated wine
The medicated wine processing technique: the consumption one material medicated wine with a people is example, by the prepared slices of Chinese crude drugs total amount of three soup formulas of above-mentioned Shen Shi rheumatism 250～300 grams is arranged approximately, cleans, and airing is put into 50 degree Chinese liquor, 2000 grams, soaks about 20 days, leaches wine liquid.Medical material is put into Chinese liquor 1000-1500 gram again, flooded about 30 days, take out wine liquid, twice medicated wine is merged, filter, in the bottle of packing into.
2, mixture
After by three soup formula weighings of above-mentioned Shen Shi rheumatism each component medical material being mixed, soaked 2～12 hours, boil and boiled state 2 hours, extracting juice with little fire maintenance.Medicinal residues added water boil 2 hours again, and extracting juice merges twice medicine juice, concentrates, and adds antiseptic, stir evenly, mixture.
3, granule
By three soup formula weighings of above-mentioned Shen Shi rheumatism each component, after the medical material mixing, decoct with water 2 times, remove medicinal residues, to boil liquid and merge after-filtration, it is 1.08g/cm that filtrate is concentrated to medicinal liquid density
3, add the ethanol postprecipitation, get supernatant, reclaim ethanol and concentrated, add and left standstill 8 hours after water stirs, get supernatant concentration and become half extractum.Adding excipient again---Sugarless type is with starch or dextrin; Sugared type sucrose is arranged, and heating makes the sugar dissolving a little.Mix the dough shape, cool, make graininess, the granule of 20 order sizes is got in screening, and is dry again.In temperature 60-80 ℃, to dry 2～3 hours, moisture content is 7%, again granulate.With the finished product branch pouch of packing into, promptly get the bagged granules electuary.
OA, SA, these three diseases of RA though character is different, have common characteristic (1) that the symptom of joint muscular soreness is all arranged; (2) degenerative change of B﹠J is all arranged; (3) going down of endocrine function all arranged.Therefore, in treatment, there is common characteristic (1) all will remove swelling and pain---the anti-inflammatory analgetic of articular muscle; (2) all to protect and improve sclerotin; (3) all need to improve endocrine hormone level in the body.
The present invention treats the pharmacological action of the Chinese medicine preparation of rheumatic osteoarthropathy: all medicines such as (1) Radix Caraganae Sinicae, polygoni cuspidati,radix, downy rosemyrtle root, Rhizoma Et Radix Notopterygii, Caulis Lonicerae, Cortex Acanthopancis, Ramulus Sambuci Williamsii, Radix Dipsaci all have anti-inflammatory analgesic action in various degree.(2) Ramulus Sambuci Williamsii, Radix Dipsaci have the protection sclerotin, promote sclerotin new life's effect.(3) Fructus Psoraleae, the Radix Rehmanniae, Radix Glycyrrhizae can promote endocrine function, improve the effect of adrenocortical hormone or serum estrogen level, thereby can regulate the calcium metabolism function in protection endocrine and the sclerotin.To preventing and treating osteoporosis and calcium deficiency plays positive role.(4) Radix Caraganae Sinicae, Caulis Lonicerae, polygoni cuspidati,radix, the Radix Rehmanniae all have certain immunosuppressant, immunoregulation effect, thereby rheumatoid arthritis is had therapeutic effect.(5) polygoni cuspidati,radix, the Radix Rehmanniae still have blood vessel dilating, anticoagulant, anticoagulation, suppress the effect of the promoting blood circulation and detumescence of vascular permeability.(6) the most of medicine in the prescription all has strong effect as the Radix Rehmanniae, Radix Dipsaci, the Cortex Eucommiae, Fructus Psoraleae, Radix Caraganae Sinicae, Cortex Acanthopancis, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae etc., comprises heart tonifying, protects the liver, leukocyte increasing, raising endocrine level, antioxidation etc.Therefore this Chinese medicine preparation not only can treatment of arthritis, and can strong body constitution, promotes health.
The Chinese medicine preparation that the present invention treats rheumatic osteoarthropathy all has curative effect preferably through for many years clinical practice to rheumatoid arthritis, osteoporosis, bone matrix hyperplasia, and effective percentage reaches 85-90%.
The early stage rheumatoid arthritis people of 14 examples are arranged, the multiple arthralgia of extremity, hands, refer to, arthralgia such as wrist, knee joint are obvious.About stiff half a day in morning, but sclerotin does not destroy not distortion as yet.Through more than a year with medicated wine of the present invention treatment, wherein 12 routine whole body joints and both hands not bitterly, pneumonedema, not stiff, do not have distortion, no atrophy, effective percentage is 85.7%, indexs such as erythrocyte sedimentation rate, rheumatoid factor, third reactive protein all drop to normally.Clinical complete remission.
With medicated wine treatment middle-aged and elderly people hyperosteogeny of the present invention or companion's osteoporosis, the back aching pain in should and back that causes, lower limb knee joint soreness swelling, symptoms such as arm numbness of hand pain amount to 120 examples, and wherein 102 examples are alleviated and taken a turn for the better.Effective percentage is 85.0%.
To the early stage rheumatoid arthritis active stage patient of 30 examples, extremities joint swells and ache, and morning, stiff a whole morning was to a whole day.Rheumatoid factor (RF) total positives, erythrocyte sedimentation rate (ESR, normal value 0-20mm/h) 30～130mm/h does not wait, average out to 82mm/h, third reactive protein (CRP, normal value is 2-6mg%) is 6～34mg%, orosomucoid (MPT, normal value 2-4mg%) is 4.5～25.5mg%.Through mixture treatment of the present invention 1～6 month, produce effects 17 examples were 56.7%, and effective 10 examples are 33.3%, and total effective rate is 90.0%.
Articular muscle is ached and the change of B﹠J because these three diseases all have.All be based on anti-inflammatory analgetic at the Chinese patent medicine that uses at present; Doctor trained in Western medicine adopts outside the anti-inflammatory analgetic, also uses the bigger immunosuppressant of toxicity, and advocates curative effect and the uncertain absorption of replenishing the calcium and increasing calcium.
And this Chinese medicine preparation not only has the anti-inflammatory analgetic effect, and unusual part and advantage still have (1) can protect sclerotin, and its approach is by improving the balance that the hormone in vivo level is regulated calcium, and promotes the blood supply in the sclerotin, promotes sclerotin new life.(2) Chinese medicine preparation has immunoregulation effect, can suppress humoral immunization, and not influence cellular immunization.(3) 13 kinds of active ingredient of Chinese herbs comprising of Chinese medicine preparation because suitable cooperation produces good synergism, have good effect, and the property of medicine is gentle, and heat symptom-complex, sympotoms caused by cold factors etc. all is fit to, and does not have toxicity, and safety can be taken for a long time.
To further illustrate the present invention by following examples, but not limit content of the present invention.
Concrete enforcement is vertical
Three soup medicated wine of embodiment 1 Shen Shi rheumatism---the manufacturing of joy wine
Take by weighing 0.3 kilogram in 3 kilograms of medical material Radix Caraganae Sinicaes, 3 kilograms of polygoni cuspidati,radixs, 3 kilograms of downy rosemyrtle roots, 3 kilograms of Caulis Loniceraes, 3 kilograms of Rhizoma Et Radix Notopterygiis, 3 kilograms of Ramulus Sambuci Williamsii, 1.2 kilograms of Radix Dipsaci, 1.2 kilograms of the Cortexs Eucommiae, 1.2 kilograms in the Radix Rehmanniae, 1.2 kilograms of Fructus Psoraleaes, 1.2 kilograms of Cortex Acanthopanciss, 0.6 kilogram of Pericarpium Citri Reticulatae and Radix Glycyrrhizae, add up to 24.9 kilograms.Clean, airing is put into 200 kilograms of 50 degree Chinese liquor, soaks about 20 days, leaches wine liquid.Medical material is put into 100 kilograms of Chinese liquor again, flooded about 30 days, take out wine liquid, twice medicated wine is merged.Filter, packing, 200～500 milliliters every bottle, the concentration of wine is 50 degree.Perhaps add the syrup dilution, the concentration of wine is controlled at about 15～20 degree.Sweet taste is degree of being with agreeable to the taste.Packing, 500～1000 milliliters every bottle.
Instructions about how to take medicine: (1) undiluted medicated wine: every day 2-3 time, each one little handleless cup (about 30-50 milliliter), middle tuxedo oneself dilutes with beverage.(2) medicated wine that dilutes with syrup: every day 2～3 times, each about 50～100 milliliters.Take during dining.
The manufacturing of three soup mixture of embodiment 2 Shen Shi rheumatism
Take by weighing 1.8 kilograms of medical material Radix Caraganae Sinicaes, 2.1 kilograms of polygoni cuspidati,radixs, 2.4 kilograms of downy rosemyrtle roots, 1.8 kilograms of Rhizoma Et Radix Notopterygiis, 2.4 kilograms of Caulis Loniceraes, 0.9 kilogram of Cortex Acanthopancis, 2.1 kilograms of Ramulus Sambuci Williamsii, 0.9 kilogram in 0.9 kilogram of Radix Dipsaci, 0.9 kilogram of the Cortex Eucommiae, 0.9 kilogram of Fructus Psoraleae, 0.9 kilogram in the Radix Rehmanniae, 0.9 kilogram of Pericarpium Citri Reticulatae and Radix Glycyrrhizae add up to 19.8 kilograms, after the medical material mixing, soaked 6 hours, and boiled and keep boiling state 2 hours, extracting juice with little fire.Medicinal residues added water boil 2 hours again, and extracting juice merges twice medicine juice, concentrated.Add preservative sodium benzoate, addition 1% stirs evenly, mixture, contain crude drug 140g in per 100 milliliters of mixture.Divide the bottle of packing into, 500 milliliters every bottle.
Taking method: every day 3 times, each 30-60 milliliter.
The manufacturing of three decoction particles agent of embodiment 3 Shen Shi rheumatism
Press embodiment 1 described prescription weighing each component, 24.9 kilograms of total amounts.After the medical material mixing, add about 80 kilograms and 50 kilograms in water, decoct 2 times, remove medicinal residues, to boil liquid and merge after-filtration, it is 1.08g/cm that filtrate is concentrated to medicinal liquid density
3, add 5 kilograms of postprecipitations of ethanol, get supernatant, reclaim ethanol, left standstill after the stirring 8 hours, get supernatant concentration and become half extractum, heavily about 4 kilograms.Adding excipient again---Sugarless type is with 0.2 kilogram in starch or dextrin; 0.2 kilogram of sucrose of sugared type is arranged, and heating makes the sugar dissolving a little.Mix the dough shape, cool, make graininess in granulator, the granule of 20 order sizes is got in screening, and is dry again.Dried 2～3 hours in temperature 60-80 ℃, moisture content is 7%.Granulate again, 1.8 kilograms of finished products, with the finished product branch pouch of packing into, every bag 3 gram promptly gets the bagged granules electuary.Every gram finished product is equivalent to crude drug 13.8 grams.
Taking method: every day 3 times, each 3-6 gram, the boiled water impulsive motion is taken.
Embodiment 4 treatment cases
One female patient, 16 years old, it was surplus to suffer from rheumatoid arthritis 1 year, and extremities joint swells and ache, and the two wrist duplexs of both hands swell and ache obviously, bend and stretch limitedly, and two knee joints have obvious hydrops, point the distortion that slants.With medicated wine of the present invention treatment, the concentration of wine is 50 degree, and every day 2 times, each one little handleless cup (about 30 milliliters) dilutes with boiled water during clothes, crosses clothes with dish during middle dinner.Extremities joint swells and ache and obviously alleviates after three months, and about six months, two knee joint hydrops are eliminated.Treat about 3 years clinical complete remission altogether.Normal life, work, marriage, fertility.The limb muscle of atrophy in the past regrows gradually, and finger still has the distortion that slants, but pneumonedema is not stiff.Rheumatoid factor negative, erythrocyte sedimentation rate 5mm/h.
Embodiment 5 treatment cases
One male patient, 18 years old.Extremities joint pain 1 year is surplus, and finger near-end articulations digitorum manus and the 2nd, 3 metacarpophalangeal joints swelling are obvious, and both hands can not be held stiff all day, night sharp ache, the obvious swelling of left elbow joint can not be stretched, right swelling and pain in knee has obvious hydrops, erythrocyte sedimentation rate 122mm/h.Take the medicated wine of 50 degree Chinese liquor, every day 2 times, each one little handleless cup (about 30 milliliters) is with the boiled water dilution, crosses clothes with dish during middle dinner.Swelling and ache after 3 months obviously alleviates, take 1 year after, swell and ache and disappear fully.Erythrocyte sedimentation rate is reduced to 25mm/h.Take altogether 3 years surplus, the state of an illness is alleviated fully.After marrying and working, because tired disease relapse, it is surplus half a year to take medicated wine again, and state of an illness control was alleviated after 1 year.Outpatient service is followed up a case by regular visits to, and is healthy, stable disease, and ache sometimes slightly in the joint.The muscle of atrophy in the past recovers, and regrows rheumatoid factor negative.
Embodiment 6 treatment cases
One female patient, 38 years old.Extremities joint pain is surplus half a year, and the morning, both hands were stiff, 6 near-end articulations digitorum manus, 4 metacarpophalangeal joints mild swellings.There is not distortion.Erythrocyte sedimentation rate 52mm/h, the rheumatoid factor positive, ANA feminine gender, third reactive protein (CRP) 12.5mg%, orosomucoid (MPT) 7.5mg%.Rheumatoid arthritis is suffered from diagnosis.Take the medicated wine of 50 degree Chinese liquor, every day 2 times, each about 30～50 milliliters (a little handleless cup) taken during middle dinner, and diluted with laughable, and pickles are crossed clothes.About half a year, swell and ache and alleviate fully approximately.Erythrocyte sedimentation rate drops to 15mm/h, and RF, CRP, MPT all transfer feminine gender to, obeyed about 1 year, the joint not bitterly, pneumonedema, not stiff, do not have distortion, a no atrophy.Normal life, work.Overcast and rainy still have ache.Sometimes obey some medicated wine.
Embodiment 7 treatment cases
One female patient, 68 years old.The nineteen ninety-five first visit.Suffered from the extremities joint pain more than 10 year.Both hands increase thick swelling gradually in this year, and the stiff time is more and more longer, right above-knee go downstairs more and more difficult.The swelling of both hands finger is seen in inspection, the swelling of 6 near-end articulations digitorum manus, and both hands the 2nd, 3,4 have five metacarpophalangeal joints and type joint swelling.Digital tip has the Hai Bodeng tuberosity, both hands and two knee joint film making, and carpal joint is narrow, and carpal bone, metacarpal bone, phalanges are all seen osteoporosis, all bone osteoporosises of knee joint, the tibia end has hyperosteogeny, soft tissue swelling.B ultrasonic shows that right knee joint has a large amount of hydrops, thickness 24mm, the rheumatoid factor positive, erythrocyte sedimentation rate 85mm/h, CRP18mg%.Diagnosis: (1) rheumatoid arthritis (2) osteoarthritis.Give the medicated wine treatment of clothes 50 degree Chinese liquor, every day 2 times, each one little handleless cup (about 30-50 milliliter) dilutes with boiled water during middle dinner, crosses clothes with dish.Three months posterior joints swell and ache and alleviate, and right knee joint hydrops is reduced to 15mm, but still will obey analgesic such as diclofenac every night.Continue to take medicated wine, analgesic is decrement and stopping using gradually, and about about 1 year, arthralgia was alleviated substantially, and right knee joint hydrops absorbs fully.After the drug withdrawal, show effect again once March calendar year 2001, gives the clothes medicated wine again, state of an illness basic controlling.
Embodiment 8 treatment cases
One female patient, 30 years old, first visit in March, 1999.Suffer from extremities joint and swelled and ache 5 months, check finger, wrist, toe, swollen ankles, the both hands a whole morning is stiff, erythrocyte sedimentation rate 120mm/h, the RF positive, CRP16mg%, MPT12.5mg%, ANA feminine gender, IgG22.4g/L.The X demonstration of making film: two wrist both hands are osteoporosis a little, and the joint space does not have change.Clinical diagnosis: rheumatoid arthritis, active stage.Take the mixture treatment, every day 3 times, each 60 milliliters, when evening, the pain influence was slept, the clothes Voltaren.After one week, pain relief, the tablet for alleviating pain of stopping using.Swell and ache after one month and obviously alleviate.Treated about half a year front and back, and the state of an illness is alleviated substantially.Both hands and extremity pneumonedema are not stiff bitterly, do not have distortion.Every laboratory indexes is all normal or near normal range.Follow up a case by regular visits to stable curative effect so far.
Embodiment 9 treatment cases
One female patient, 56 years old.Suffer from whole body joint aches, lumbago about half a year, the inspection joint does not have swelling, and digital tip is seen three of little hard tubercles.Erythrocyte sedimentation rate, RF, CRP, the equal feminine gender of MPT, ANA and normal range.Both hands and lumbar X film making show osteoporosis and hyperosteogeny.Diagnosis osteoporosis, bone matrix hyperplasia.With the treatment of three decoction particles electuaries of Shen Shi rheumatism, every day 3 times, each 6 grams take after mixing it with hot water, one week posterior joint pain lumbago all see and alleviate.Substantially alleviate after one month.Continued later on to take three months, to consolidate curative effect.Outpatient service is followed up a case by regular visits to, and tells overcast and rainyly to ache sometimes, and is more stable in general at ordinary times.
Claims (2)
1. Chinese medicine preparation for the treatment of rheumatic osteoarthropathy, it is characterized in that described Chinese medicine preparation comprises the active ingredient of following 13 kinds of Chinese medicine medical materials: Radix Caraganae Sinicae 5-10 part, polygoni cuspidati,radix 5-10 part, downy rosemyrtle root 5-10 part, Rhizoma Et Radix Notopterygii 5-10 part, Caulis Lonicerae 5-10 part, Cortex Acanthopancis 2-4 part, Ramulus Sambuci Williamsii 5-10 part, Radix Dipsaci 2-4 part, Cortex Eucommiae 2-4 part, Fructus Psoraleae 2-4 part, Radix Rehmanniae 2-4 part, Pericarpium Citri Reticulatae 1-3 part and Radix Glycyrrhizae 1-3 part, Chinese medicine activity of drug ingredients composition and pharmaceutical carrier are pressed arbitrary proportion and are formed, and wherein to account for weight ratio be 0.1-99.9% to active ingredient, it is 99.9-0.1% that pharmaceutical carrier accounts for weight ratio, and pharmaceutical carrier is a wine, dextrin, starch, sucrose or other common carrier.
2. the Chinese medicine preparation of treatment rheumatic osteoarthropathy as claimed in claim 1 is characterized in that described Chinese medicine preparation can prepare medicated wine, granule, pill, mixture or ampere-type peroral dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011319321A CN1136005C (en) | 2001-10-16 | 2001-10-16 | Chinese medicine prepn for treating rheumatic osteoarthropathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011319321A CN1136005C (en) | 2001-10-16 | 2001-10-16 | Chinese medicine prepn for treating rheumatic osteoarthropathy |
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| Publication Number | Publication Date |
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| CN1347728A true CN1347728A (en) | 2002-05-08 |
| CN1136005C CN1136005C (en) | 2004-01-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB011319321A Expired - Fee Related CN1136005C (en) | 2001-10-16 | 2001-10-16 | Chinese medicine prepn for treating rheumatic osteoarthropathy |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101507758B (en) * | 2009-03-23 | 2012-08-01 | 丁丽华 | Traditional Chinese medicine combination |
| CN102813874A (en) * | 2012-07-27 | 2012-12-12 | 上海市中医医院 | Traditional Chinese medicine composition for treating rheumatoid arthritis |
| CN106266247A (en) * | 2016-11-14 | 2017-01-04 | 钱建荣 | A kind of compositions being applicable to treat lumbago |
| CN106723633A (en) * | 2016-11-18 | 2017-05-31 | 安徽省天和鞋服有限责任公司 | A kind of Health care cloth shoes with alleviation rheumatalgia pain function and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100393353C (en) * | 2005-09-01 | 2008-06-11 | 任翠兰 | Medicated wine |
-
2001
- 2001-10-16 CN CNB011319321A patent/CN1136005C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101507758B (en) * | 2009-03-23 | 2012-08-01 | 丁丽华 | Traditional Chinese medicine combination |
| CN102813874A (en) * | 2012-07-27 | 2012-12-12 | 上海市中医医院 | Traditional Chinese medicine composition for treating rheumatoid arthritis |
| CN106266247A (en) * | 2016-11-14 | 2017-01-04 | 钱建荣 | A kind of compositions being applicable to treat lumbago |
| CN106723633A (en) * | 2016-11-18 | 2017-05-31 | 安徽省天和鞋服有限责任公司 | A kind of Health care cloth shoes with alleviation rheumatalgia pain function and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1136005C (en) | 2004-01-28 |
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