CN1339975A - Mobile hart-lung machine - Google Patents

Mobile hart-lung machine Download PDF

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Publication number
CN1339975A
CN1339975A CN00803674A CN00803674A CN1339975A CN 1339975 A CN1339975 A CN 1339975A CN 00803674 A CN00803674 A CN 00803674A CN 00803674 A CN00803674 A CN 00803674A CN 1339975 A CN1339975 A CN 1339975A
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China
Prior art keywords
blood
lung machine
module
heart
pump
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CN00803674A
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Chinese (zh)
Inventor
卡斯藤·基希霍夫
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LIFBRISCH MEDICAL TECHNOLOGY Co Ltd
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LIFBRISCH MEDICAL TECHNOLOGY Co Ltd
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Application filed by LIFBRISCH MEDICAL TECHNOLOGY Co Ltd filed Critical LIFBRISCH MEDICAL TECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/155—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit with treatment-fluid pumping means or components thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/247—Positive displacement blood pumps
    • A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
    • A61M60/268—Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
    • A61M60/279—Peristaltic pumps, e.g. roller pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/38—Blood oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/538—Regulation using real-time blood pump operational parameter data, e.g. motor current
    • A61M60/546—Regulation using real-time blood pump operational parameter data, e.g. motor current of blood flow, e.g. by adapting rotor speed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/847—Constructional details other than related to driving of extracorporeal blood pumps arranged in a cassette
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/849—Disposable parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/851—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/123—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/125—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters
    • A61M2205/126—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters with incorporated membrane filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/128—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated valves

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • External Artificial Organs (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention relates to a mobile heart-lung machine for maintaining the blood circulation by taking over or supporting the cardiopulmonary function. Said machine comprises at least one venous tube (5), a blood pump (8), an oxygenator (9), an arterial filter (15), an arterial tube (4) and a tubular system for circulating the blood (7), an automatic control system (24) and a self-sufficient voltage supply. The aim of the invention is to provide a heart-lung machine that is easy to handle. To this end, the elements (4, 5, 6, 7, 8, 9, 15, 18, 21) which circulate the blood, receive the biochemical and physiological signal and carry out the control commands on the one hand and the drive and automatic control elements (23, 24, 27, 28, 29, 30, 31, 32) on the other hand are arranged in two separate modules (2, 3) and can be combined to form one functional unit.

Description

Mobile hart-lung machine
The present invention relates to a kind ofly be used to keep sanguimotor heart-lung machine according to claim 1 is as described in the preamble.
In order to keep the blood circulation of human body, utilization has telescopic heart-lung machine and takes anoxybiotic venous blood away from human body, and it is delivered to oxygenator, thereby avoids or eliminate because accident or other organ failure and stop or pouring into shortage at the blood circulation that intra-operative occurs by blood pump.In the aerating machine of carrying out artificial pulmonary function, blood has been replenished oxygen and has been removed CO 2Subsequently, after cleaning in arterial blood filter, the arterial blood of oxygen enrichment is transferred back in the patients'blood blood circulation by sleeve pipe.This class heart-lung machine is used as fixing the use in hospital.For example in WO99/59654 (CARDIOVENTION), disclosed this fixed heart-lung machine.It comprises monoblock type oxygenator and pump unit in the aseptic area that is arranged on around the patient, and in the aseptic area outside and the control station that links to each other with described unit by connection cord.This control station has control device and is used for pump and the driving device of oxygenator.
DE 43 43 334 A1 have disclosed a kind of heart-lung machine of portable use.It has supporting construction, and it is provided with handle with the back side in front, and is provided with the foot of standing of downward extension.Fix for the building block that makes heart-lung machine, be provided with corresponding clamp device.With regard to this machine, the important element of function is arranged to them and can freely approaching and therefore be protected and be damaged, and can weaken the reliability in the use like this.In addition, this machine must always be carried by two people.
DE197 02 098 A1 have also disclosed a kind of mobile hart-lung machine.This heart-lung machine comprises: one is used for the loop of blood transport to tremulous pulse; One is used for extracting from vein second loop of blood; One venous blood storage container; One oxygenator; One is designed to the blood pump of roller pump; And a form is the oxygen allotter of the oxygen concentrator that links to each other with pump at driving side.This machine has a controller that is used to control the transporting velocity of oxygen concentrator and pump, also has the connector that is used for dispersive energy supply source and/or energy storage.Though this heart-lung machine also has removable use, because its size and weight, therefore this heart-lung machine can not be handled by a people usually.Because the space in ambulance is limited, so in fact can not carry this machine under the state that undergos surgery at any time in situation about coming into prompt action.Desired emergency makes long-time installation and prepares all to become shortcoming in coming into prompt action.In addition, after using each time, above-mentioned heart-lung machine must be reinstalled and clean with the program of complexity before reusing.As a result, it is impossible reusing immediately.
WO97/16213 (BAXTER) has disclosed a kind of mobile hart-lung machine, be accommodated in comprising the blood circulation element of blood pump, heat exchanger and oxygenator and attempt to be used for disposable device, and the pump motor is accommodated in the reusable driving device.The disposable device of this confession passes through from the link of the high projection of described driving device, is connected with driving device by the force closure part.Other connector is with independently driving and automaton exist.Be used for the connector that corresponding pipe is connected with this device be expose and be damaged easily or disturb, especially use moving.
Therefore, the object of the present invention is to provide and a kind ofly locating the mobile hart-lung machine of described the sort of type at the beginning, this heart-lung machine can be widely used and can reliably and easily be handled.
This purpose can be realized by the theme of claim 1.It is divided into and has the blood circulation of making, the module (" disposable module ") of the element of reception biochemistry and physiological signal and execution control signal and module (" reusable module ") with driving and Automatic Control Component, this composition allows to change for the disposable module that comprises the blood circulation element fast after using, and heart-lung machine can be used again apace like this.Consider module, the corresponding module that can use at any time and make with compact form should be set in addition.Owing in use under situation it is pressed for time, needn't carry out complicated operations and installation measure, so in use can guarantee higher functional reliability especially.Also have, the blood circulation element is combined the length of the tubulose blood circulation that can allow between the independent component in compact module very short, therefore can reduce packing volume, and this is favourable for patient just.And in order to reduce the blood damage as much as possible, the path and the characteristic that can accurately limit and design blood channel in the module provide gratifying flox condition.In this respect, can connect the parts that for example can buy, as oxygenator, centrifugal pump head, filter etc. by fixed blood tube.If necessary, can be easy to come conversion and each parts of replacing in the disposable module that is designed to box with other parts.
Dependent claims relates to the preferred embodiments of the present invention.
According to the present invention, can two modules be combined together to form a unit in simple mode, wherein can with they one be installed in another top and make they with machinery and electric means be connected to each other.Therefore, heart-lung machine is easy to handle and can be carried by a people in moving use.Can also be with centrifugal pump as blood pump.Usually use roller pump as blood pump.Because a large amount of pump elements in them, so they are heavier and need big energy in operating process.On the other hand, centrifugal pump is energy-conservation especially.In addition, they are distinguished according to the negative pressure that is produced by swabbing action.As a result, if can not guarantee sufficient supply by the independent passive backflow of blood, then inspiration is used to supply patient needed amount according to pump rate.If do not carry out patient's cannulation as yet the most rightly owing to external environment condition or arrange these pipes with failing optimization, then when they were used for emergency, this point was a particular importance.
According to the present invention, be separately positioned in the corresponding module at the pump head that blood flow is crossed and the pump driving mechanism of blood pump.Under these modules situation combined together, pump head and pump driving mechanism interconnect by coupling.Because these elements of contact with blood are set in the single disposable module that is designed to the aseptic packaging device, so can reduce the cost of the disposable module of confession and the running cost of mobile hart-lung machine.
According to a preferred embodiment of the invention, the connector between each blood circulation element comprises that flexible pipe and/or rigid pipe are to optimize and to realize the standardization hemodynamic effect and increase internal rigid.The component for circulation of extracorporeal circulating circuit is fixed in the module housing by fixing or clamp device with the pipeline that is connected them.This system is more reliable than direct-insert pipe connections, and helps the rigidity of each element in the disposable module and better fixing.
Verified, be convenient to make at least some blood circulation elements and module to form integral body, for example casting spare.If blood circulation or for example the housing of the blood circulation of other in module element be disposable integral part with module, then the latter can further reduce size and can be with integral form production.It will also be appreciated that the form that makes module shell adopt box with blood circulation element and blood circulation, the blood circulation element that can buy by fixture, for example the pump head of oxygenator, blood pump, centrifugal pump, arterial blood filter etc. are installed in this box.The parts of the special oxygenator that designed to be used heart-lung machine of the present invention in addition, pump, filter or similarly uses such as blood circulation element and their blood conduit, steam line also can be installed in this box that for example is designed to casting spare.So just, allow the integration and compacter more of disposable module.
For any time at the heart-lung machine duration of work provides optical check to blood flow, this disposable module has transparent shell.
Confirmed to receive the element preferred sensor of biochemistry and physiological signal, these pick offs especially can detect the PH numerical value of blood, the pCO of blood 2, blood pO 2, blood heat, velocity of blood flow, FiO 2, gas temperature, gas flow rate, gas pO 2, gas pCO 2, water temperature, pump rotating speed or flow to the present flow rate of pump driving mechanism.
According to the present invention, be used for detected parameters, be used to indicate purpose with as sound, optics or audible and visible alarm and the pick off that is used to handle the numerical value that is used to control purpose link to each other with automatic control system with driving.They especially can control the pump driving mechanism of blood pump automatically, and under the situation that the set point numerical value with blood flow departs from, provide sound, optics or audible and visible alarm.Like this, any possible not normal and/or variation of patient condition all is instructed to out rapidly and reliably, and can take suitable action.For the monitoring of blood flow, not with situation that blood contacts under quantitatively the flow transducer of monitoring of blood flow also can be arranged on the arterial.The pump rate of blood pump and can be controlled it by automatic control system in infinite variable speed mode or with discontinuous incremental manner preferably between 2 liters/minute and 10 liters/minute.
According to a further embodiment of the invention, can by the outside handle can closed filling and floss hole be set at the storage container that is used to receive venous blood, arterial blood filter and/or the oxygenator that is positioned at the blood pump upstream, thereby allow storage container when this heart-lung machine is started working, thoroughly and simply to be filled and to discharge.They are specially adapted to the input of priming solution or medicament (for example being used to reduce the heparin of coagulation).Storage container can be designed to bag in this case.This storage container is as buffer, so that the flowing to and flow out of the blood that compensation changes.The use of bag makes storage container to adapt with simple mode and the blood flow volume that receives respectively.
According to the present invention, on oxygenator, can be provided with temperature control equipment, for example can adopt the form of heat exchanger, this heat exchanger can be operated and blood flows through from this heat exchanger by water, so that controlled the temperature of blood on request before blood transport is returned patient body.
The effect of pre-priming solution of filling is, heart-lung machine with before patient links to each other, is emptied completely heart-lung machine and makes it remain on the state that stands ready in cycling.For this reason, blood circulation has pre-bypass strainer, and this filter is connected as the bypass between arterial and the duct of Arantius, and priming solution circulated by this bypass before it is used for patient by manipulation.In addition, under the situation that arterial filter may stop up, can keep blood circulation by the bypass that can handle from the outside.
In the improvement of inventive concept, automatic control system has and is used for the input equipment and the output device that engage in the dialogue with the user, button/control piece and/or display are especially arranged, also be useful on the program of in this heart-lung machine work process, carrying out initialization and function control, so that guarantee shirtsleeve operation control.
Self-sustaining formula supply voltage can be designed to accumulator according to the present invention, and has the indicator that is used to indicate its charged state.Therefore can survey the imminent discharge of this accumulator in time, so that take measures to provide external power source if desired.During this period, this pump can be handled with mechanical hand-crank.
This heart-lung machine preferably also has the connector that is used to connect external power source, so that accumulator can for example be charged in ambulance or situation following time of allowing to have exhausted in accumulator operates with external power source.
Below, will be described in detail the present invention according to the illustrative embodiment shown in the accompanying drawings, wherein:
Fig. 1 has shown the view that tilts to look from the top of mobile hart-lung machine of the present invention, and it has the module that separates each other.
Fig. 2 has shown the view at the heart-lung machine shown in Fig. 1, and this heart-lung machine has the module that combines;
Fig. 3 has shown the sketch map of the blood circulation element of heart-lung machine among Fig. 1;
Fig. 4 has shown the front view of heart-lung machine among Fig. 1;
Fig. 5 has shown the view shown in above the heart-lung machine shown in Fig. 1, and
Fig. 6 has shown the side view of the heart-lung machine of Fig. 1.
Comprise two independently modules 2 and 3 at the mobile hart-lung machine shown in Fig. 11.Be contained in and predetermined can make blood circulation as the element in disposable first module 2 (" disposable module "), receive biochemistry and physiological signal and carry out control command, being contained in reusable second module 3 is to drive and control element.These two modules 2 and 3 can be combined together to form a functional unit, and they are installed in the top of another module by retaining element (not shown) (with reference to Fig. 2) with a module and mechanically are connected with each other, mutual electric connection simultaneously.Under the state that combines, heart-lung machine 1 just can use after being filled priming solution at any time, and can be connected to the patients'blood circulation that is supplied to by arterial and duct of Arantius 4 and 5.
Structure and operator scheme according to the disposable module 2 of the schematic view illustrating of Fig. 3.Patient's Deoxygenated blood flow to the module 2 of the heart-lung machine 1 that the blood circulation element is housed by duct of Arantius 5.Duct of Arantius 5 links to each other with the closed storage container 6 that is used to receive venous blood in this case.And by blood circulation 7, storage container 6 by blood pump 8 be used for linking to each other with the oxygenator 9 that is used to eliminate carbon dioxide to the blood oxygenating.Gas connector 10 feeds oxygenator 9 through filter 11, and is used for linking to each other with the extraneous gas source.Therefore, can rely on portable oxygen and carbon dioxide tank or hospital in oxygenator 9, to carry out gas exchange with the oxygen supply system.Also be provided with temperature control equipment 12 on oxygenator 9, temperature control equipment is flow through in the temperature control medium loop 13 of flowing through.In order to control the temperature of blood, blood circulation 7 has the part 14 that stretches into temperature control equipment 12.The downstream of the oxygenator 9 in blood circulation 7 is provided with the arterial blood filter 15 that is used to purify the blood.Be provided with arm 16 around arterial blood filter 15, arm 16 can be handled by the outside by a valve 17, even to allow also to keep blood circulation under the possible situation that arterial blood filter 15 stops up.The arteries 4 that is used to make blood be back to patient links to each other with arterial blood filter 15.For the flow of monitoring of blood non-contactly, on arteries 4, be provided with a flow transducer 18, this pick off is used to survey blood flow and with its notice automatic control system 24.
Fig. 4 has shown the front view of the heart-lung machine 1 with disposable module 2, the reusable module 3 that this heart-lung machine has the blood circulation element and has driving and control element.Oxygenator 9 with temperature control equipment 12 is positioned at disposable module 2 bottoms.The storage container 6 that is used to hold venous blood that is designed to sack is arranged on oxygenator 9 tops on the inclination fixture 19.Blood pump 8 is positioned on the bottom of module 2 with oxygenator 9.This blood pump is designed to centrifugal pump, and has a pump head 21, and this pump head links to each other with pump driving mechanism 23 in being arranged on reusable module 3 by coupling 22.Coupling 22 is a kind of electromagnetism couplings.Arterial blood filter 15 is arranged on blood pump 8 tops, and filter links to each other with arteries 4 and is provided with the arm 16 that has valve 17 thereon.Noncontact flow transducer 18 just in time is arranged on the front, position that arteries 4 leaves module 2.These blood circulation elements are coupled to each other by the conduit of blood circulation 7.
The automatic control system 24 that has button 25 and display 26 is arranged in the reusable module 3.Button 25 and display 26 can also be designed to the touch screen formula.Except automatic control system 24, be provided with on module 3: one is used to indicate the indicator 27 of battery state of charge, be used for manually controlling the controller 28 and the engine speed indicator 29 of the rate of pumping of centrifugal pump 8, also be useful on the connector 30 that is connected with outer power voltage.Also be provided with central authorities to open/make and break pass 31 and one display lamp 32.In addition, module 3 has the accumulator (not shown) that is used for self-sustaining formula power supply.
Disposable module 2 has transparent module shell 33, drives and the reusable module 3 of control element has opaque module shell 34 and have.Handle 35 is installed in the end face of the transparent module shell 33 of disposable module 2.
Fig. 5 has shown the blood circulation element that is arranged in the disposable module 2 with plane graph.Vein blood vessel 5 links to each other with storage container 6.By blood circulation 7, storage container 6 links to each other with oxygenator 9 (not shown) through blood pump 8, and the outlet of this oxygenator feeds in the arteries 4 by arterial blood filter 15.
In Fig. 6, express heart-lung machine 1 from the side, it has the connector that is used to connect artery and vein blood vessel 4 and 5.The gas connector 10 that can also see the outlet in loop 13 in the temperature control equipment 12 and have filter 11 in addition.Unshowned is the connecting duct 36 that schematically shows out in Fig. 3, and it has the pre-bypass strainer 37 between vein blood vessel 4 and arteries 5.By opening unshowned and can cutting off pipe 4 and 5, can finish the inner loop of blood circulation element from the closure member of outside manipulation and by clamping simultaneously.In this cycling before heart-lung machine 1 is connected to patient, the blood circulation element is emptied completely by the drain valve on the storage container 6 38 and 40.For this reason, delivery pipe 39 also links to each other with oxygenator 9 with arterial blood filter 15.
The operator scheme of above-mentioned mobile hart-lung machine 1 is as follows:
At the duration of work of mobile hart-lung machine 1, Deoxygenated blood flows into storage container 6 through vein blood vessel 5.Can realize the conveying of priming solution, medicament etc. by the valve on vein blood vessel 5 and/or the storage container 6 38,40.Blood pump is sent to the oxygenator 9 to the blood delivery of supplemental oxygen from storage container 6 by centrifugal pump 8.In the gas exchange process in oxygenator 9, blood flow is through controlling the temperature control equipment 12 of blood heat.For this reason, can be with the temperature control medium of water preferably by loop 13, send in the temperature control equipment 12 from the outside.Through gas connector 10 oxygen or oxygen mixture are introduced in the oxygenator 9.In case blood has been replenished oxygen, blood is just flowed through arterial blood filter 15 so that purify, and described arterial blood filter is equipped with arm 16.If arterial blood filter 15 is plugged during operation, then can manually arm 16 be opened so that keep the patients'blood circulation.Subsequently, by arteries 4, make blood transport return patient through flow transducer 18.
Flow transducer 18 is measured the blood flow in the arteries 4, and it links to each other with the automatic control system 24 of mobile hart-lung machine 1 by being electrically interposed in contact 20 (with reference to Fig. 1).According to measured flow, automatic control system 24 control pump driving mechanisms 23.When reaching marginal value, automatic control system 24 produces corresponding sound, optics or audible and visible alarm.
Be arranged on the pick off (not shown) that also being useful in the disposable module 2 receives biochemistry or physiological signal in addition, these pick offs are used for the function of monitoring cardiorespiratory machine 1.The signal of these pick offs is sent to automatic control system 24 by the contact that is similar to plug-in type contact 20, thereby also can be integrated into together in multitap for all contacts.This just can be easier to two modules 2 and 3 are combined.Be used to carry out the element of control signal, also can be set in the disposable module 2, and can be triggered by automatic control system 24 by electric contact piece as electrodynamic valve.
In order to make patient break away from heart-lung machine 1, detect and cooperate the occupied state of heart simultaneously by the automatic control system 24 continuous rate of pumpings that reduce blood pump 8.As long as patient is in steady statue again, can close heart-lung machine 1 subsequently.After closing, the disposable module 2 that has the blood circulation element can be by loosening fasteners with plain mode, separates with the reusable module 3 of control element by having to drive, and can replace by enough aseptic disposable modules 2 newly.After closing securing member and filling priming solution, heart-lung machine 1 can be used at any time once more.
A kind of mobile hart-lung machine 1 so just is provided, this heart-lung machine comprises a disposable module 2 and a reusable module 3 according to its module type structure, this heart-lung machine can come into operation rapidly and because these two modules 2 and 3 compactedness, so can handle by a people, therefore be specially adapted to urgent use.
In hospital, fix use by adding to be used to discharge, aspirate and the stable aspirator of heart/cardioplegia processing system, this mobile hart-lung machine 1 also are applicable to, for example be used for cardiac operation.

Claims (14)

1. mobile hart-lung machine, be used for by taking over or supporting cardio-pulmonary function to keep circulation, it has at least one radicular vein blood vessel (5), a blood pump (8), an oxygenator (9), an arterial blood filter (15), one radicular arteries blood vessel (4), an and tubulose blood circulation (7), an automatic control system (24) and self-sustaining formula power supply, it is characterized in that, can make sanguimotor element (4 on the one hand, 5,6,7,8,9,15,18,21) receive biochemistry and physiological signal, and the execution control command, described on the other hand driving and Automatic Control Component (23,24,27,28,29,30,31,32) be set at two isolating modules (2,3) in and can be combined together to form a functional unit.
2. heart-lung machine according to claim 1 is characterized in that, module combined together (2,3) can be installed in a module top of another module and they and can be connected to each other with electric means with machinery and be in the same place.
3. heart-lung machine according to claim 1 and 2, it is characterized in that, the component for circulation of blood pump (8), particularly the pump head of centrifugal pump (21) is integrally formed in and has the blood circulation of making, receive the element (4 of biochemistry and physiological signal and execution control command, 5,6,7,8,9,15,18,21) in the module (2) (" disposable module "), and the pump driving mechanism (23) of described blood pump is integrally formed to have driving and Automatic Control Component (23,24,27,28,29,30,31,32) in the module (3) (" reusable module "), and when these two modules (2, they can be connected with each other by connector (22) when 3) combining.
4. according to arbitrary described heart-lung machine in the claim 1 to 3, it is characterized in that the connector between each blood circulation element comprises flexible pipe and/or rigid pipe optimizing hemodynamic effect and to achieve standardization, and can increase internal rigid.
5. according to arbitrary described heart-lung machine in the claim 1 to 4, it is characterized in that the blood circulation element of extracorporeal circulating circuit and the conduit that connects them are set up and/or are fixed in the module shell by fixing or clamp device.
6. according to arbitrary described heart-lung machine in the claim 1 to 5, it is characterized in that at least a portion blood circulation element (4,5,6,7,8,9,15,21) is integrally formed with disposable module (2), forms a kind of integral injection molding spare especially.
7. according to arbitrary described heart-lung machine in the claim 1 to 6, it is characterized in that described disposable module (2) has transparent module shell (33).
8. according to arbitrary described heart-lung machine in the claim 1 to 7, it is characterized in that the element that receives biochemistry and physiological signal is such pick off, it can survey the pCO of blood pH, blood especially 2, blood pO 2, blood heat, velocity of blood flow, FiO 2, gas temperature, gas flow rate, gas pO 2, gas pCO 2, water temperature, pump rotating speed or flow to the present flow rate of pump driving mechanism.
9. according to arbitrary described heart-lung machine in the claim of front, it is characterized in that, be used for detecting parameter, be used to indicate purpose and link to each other with automatic control system (24) with driving as sound, optics or audible and visible alarm and the pick off (18) that is used for processing controls purpose value.
10. according to arbitrary described heart-lung machine in the claim of front, it is characterized in that, can by the outside handle can closed fillings mouth and floss hole (38,40) be set at the storage container that is used to receive venous blood (6), arterial blood filter (15) and/or the oxygenator (9) that is positioned at blood pump (8) upstream.
11. according to arbitrary described heart-lung machine in the claim 1 to 10, it is characterized in that, blood circulation (7) has a bypass strainer (37), this filter is connected as the arm between vein blood vessel (5) and guiding patient's the arteries (4), and priming solution cycled through this bypass strainer before it is used for patient by manipulation.
12. according to arbitrary described heart-lung machine in the claim 1 to 11, it is characterized in that, automatic control system (24) has an input equipment and output device that is used for engaging in the dialogue with user, especially should have button/control piece (25,28) and/or display screen (26), and a program that is used for carrying out initialization and function control at heart-lung machine (1) duration of work.
13., it is characterized in that self-sustaining formula power supply comprises an accumulator and is used to indicate the indicator (27) of charged state according to arbitrary described heart-lung machine in the claim 1 to 12.
14. according to arbitrary described heart-lung machine in the claim 1 to 13, it is characterized in that, be provided with the connector (30) that is used for external power source.
CN00803674A 1999-02-12 2000-02-14 Mobile hart-lung machine Pending CN1339975A (en)

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DE19905937A DE19905937C1 (en) 1999-02-12 1999-02-12 Mobile heart-lung machine; contains blood regeneration equipment together with control system

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CN102458244A (en) * 2009-04-27 2012-05-16 罗斯彻姆医疗创新公司 Apparatus and method for monitoring degree of integration between functions of heart and lungs, and therapeutic success of resuscitative interventions
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AU3280600A (en) 2000-08-29
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UA71948C2 (en) 2005-01-17

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