CN117100935A - Cell real-time monitoring device for myocardial ischemia reperfusion injury assessment - Google Patents
Cell real-time monitoring device for myocardial ischemia reperfusion injury assessment Download PDFInfo
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- 206010063837 Reperfusion injury Diseases 0.000 title claims abstract description 40
- 208000031225 myocardial ischemia Diseases 0.000 title claims abstract description 38
- 238000012806 monitoring device Methods 0.000 title claims abstract description 35
- 238000011282 treatment Methods 0.000 claims abstract description 65
- 239000008280 blood Substances 0.000 claims abstract description 55
- 210000004369 blood Anatomy 0.000 claims abstract description 54
- 238000012544 monitoring process Methods 0.000 claims abstract description 35
- 230000017531 blood circulation Effects 0.000 claims abstract description 14
- 238000011156 evaluation Methods 0.000 claims description 53
- 238000012545 processing Methods 0.000 claims description 19
- 230000000694 effects Effects 0.000 claims description 8
- 230000002107 myocardial effect Effects 0.000 claims description 8
- 239000007789 gas Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000001301 oxygen Substances 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 238000004088 simulation Methods 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 230000010354 integration Effects 0.000 claims description 4
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims description 3
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- 230000036772 blood pressure Effects 0.000 claims description 2
- 230000000747 cardiac effect Effects 0.000 claims description 2
- 238000013480 data collection Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000005265 energy consumption Methods 0.000 claims description 2
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- 238000013152 interventional procedure Methods 0.000 claims description 2
- 230000002503 metabolic effect Effects 0.000 claims description 2
- 230000009525 mild injury Effects 0.000 claims description 2
- 230000009526 moderate injury Effects 0.000 claims description 2
- 238000011160 research Methods 0.000 claims description 2
- 230000009528 severe injury Effects 0.000 claims description 2
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- 238000011269 treatment regimen Methods 0.000 claims 2
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- 210000004027 cell Anatomy 0.000 description 14
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- 208000028867 ischemia Diseases 0.000 description 4
- 230000010410 reperfusion Effects 0.000 description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3623—Means for actively controlling temperature of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/369—Temperature treatment
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- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a cell real-time monitoring device for myocardial ischemia reperfusion injury assessment, which comprises a monitoring device and a blood circulation device, wherein a monitoring system is arranged in the monitoring device, the blood circulation device comprises a blood monitoring instrument, a heart-lung machine, an oxygenator, a temperature changer, a filter and a console, the monitoring device comprises a biosensor, a data converter and a display screen, the blood circulation device is embedded in the blood monitoring instrument to monitor circulating venous blood in real time, collect various data about the blood, project the data to the display screen to display, and utilize an internal monitoring system to assess whether myocardial ischemia reperfusion injury occurs or not, assess the extent and range of the injury, and generate a treatment scheme for a doctor to refer, which is very important for determining subsequent treatment measures and predicting prognosis of a patient, and the doctor can also adjust the treatment scheme to ensure the effectiveness and safety of treatment.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a cell real-time monitoring device for myocardial ischemia reperfusion injury assessment.
Background
There is much evidence that ischemia alone is not sufficient to cause damage to the body tissue, but rather damage occurs when blood supply is suddenly restored (i.e., reperfusion) after a period of ischemia. Reperfusion injury after ischemia occurs in traumatic shock, surgery, organ transplantation, burns, frostbite, and thrombosis. Microvascular and parenchymal organ damage caused by ischemia tissue reperfusion is mainly caused by reactive oxygen species, which has been demonstrated in a variety of organs. Myocardial ischemia injury is caused by myocardial cell necrosis or temporary function impairment due to myocardial hypoxia and nutrient deficiency, and complete right bundle branch block may be caused by multi-part conduction block lower wall myocardial infarction. Whereas ischemia reperfusion injury is due to oxygen in blood HbO2 reacting with dissolved substances of damaged or necrotic cardiomyocytes to form oxygen radicals which have an damaging effect on part of the myocardium.
Therefore, it is necessary to evaluate and monitor the ischemia reperfusion injury after myocardial ischemia reperfusion, the evaluation can determine whether the myocardial ischemia reperfusion injury occurs, and the extent and scope of the injury can be evaluated, which is important for determining subsequent treatment measures and predicting prognosis of patients, and doctors can adjust the treatment scheme to ensure the effectiveness and safety of the treatment.
Disclosure of Invention
The invention aims to solve the technical requirements and provides a cell real-time monitoring device for myocardial ischemia reperfusion injury assessment.
The technical scheme of the invention is realized as follows:
the cell real-time monitoring device for myocardial ischemia reperfusion injury assessment comprises a monitoring device and a blood circulation device, wherein a monitoring system is arranged in the monitoring device, the blood circulation device comprises a blood monitoring instrument, a heart-lung machine, an oxygenator, a temperature changer, a filter and an operating platform, the heart-lung machine is provided with an output end, a blood input end and a gas input end, the output end is connected with the filter through the output end, the output end of the blood monitoring instrument is connected with the blood input end of the heart-lung machine, the output end of the filter is connected with the oxygenator, the output end of the oxygenator is connected with the temperature changer, the output end of the temperature changer is connected with the blood input end of the heart-lung machine, the temperature changer and the filter are respectively connected with the blood monitoring instrument, the heart-lung machine, the oxygenator, the temperature changer and the filter, and the monitoring device is embedded in the blood monitoring instrument;
the monitoring device comprises a biosensor, a data converter and a display screen, wherein the biosensor is connected with the data converter, and the data converter is connected with the display screen.
The aim and the technical problems of the invention can be further realized by adopting the following technical measures.
The monitoring system comprises a sensor data processing module, an evaluation module and a treatment scheme generating module, wherein the input end of the sensor data processing module is connected with the biological sensor, the output end of the sensor data processing module is respectively connected with the data converter and the evaluation module, the input end of the evaluation module is respectively connected with the blood monitoring instrument and the biological sensor, the output end of the evaluation module is connected with the treatment scheme generating module, and the output end of the treatment scheme generating module is connected with the display screen;
further, the sensor data processing module comprises a data collecting unit and a data integrating unit;
further, the evaluation module comprises an evaluation index defining unit, a blood evaluation unit and a cell evaluation unit;
further, the treatment plan generation module comprises a treatment plan database, an evaluation result conversion unit and a treatment plan simulation unit.
The invention has the beneficial effects that:
according to the invention, the blood circulation venous blood is monitored in real time by embedding the monitoring device in the blood monitoring instrument, various data about the blood are collected and projected to the display screen for display, whether myocardial ischemia reperfusion injury occurs can be diagnosed by utilizing the built-in monitoring system to evaluate, the degree and the range of the injury can be evaluated, and meanwhile, a treatment scheme can be generated for a doctor to refer, so that the method is very important for determining follow-up treatment measures and predicting prognosis of a patient, and the doctor can also adjust the treatment scheme to ensure the effectiveness and the safety of treatment.
Drawings
FIG. 1 is a device diagram of a cell real-time monitoring device for myocardial ischemia reperfusion injury assessment according to the present invention;
FIG. 2 is a schematic diagram of the operation of the sensor data processing module of the monitoring system of the present invention;
FIG. 3 is a schematic diagram of the operation of the monitoring system evaluation module of the present invention;
fig. 4 is a schematic diagram of the operation of the treatment plan generation module of the monitoring system of the present invention.
1-a blood circulation flow device; 2-blood monitoring apparatus; 3-heart-lung machine; a 4-oxygenator; 5-a temperature changer;
6-a filter; 7-a console; 8-monitoring means; 9-a biosensor; 10-a data converter; 11-display screen.
Detailed Description
In order to make the objects, features and advantages of the present invention more obvious and understandable, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is apparent that the embodiments described below are only some embodiments of the present invention, not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
As shown in fig. 1, a cell real-time monitoring device for myocardial ischemia reperfusion injury assessment comprises a monitoring device 8 and a blood circulation device 1, wherein the monitoring device 8 is internally provided with a monitoring system, the blood circulation device 1 comprises a blood monitoring instrument 2, a heart-lung machine 3, an oxygenator 4, a temperature changer 5, a filter 6 and a console 7, the heart-lung machine 3 is provided with an output end, a blood input end and a gas input end, the blood input end of the heart-lung machine 3 is connected with the filter 6 through the output end, the gas input end is connected with a proper blood vessel, the gas input end is connected with a gas source to provide oxygen and other needed gases, the filter 6 is arranged at the blood input end of the heart-lung machine 3 and is used for removing solid particles and impurities in blood, the output end of the blood monitoring instrument 2 is connected with the blood input end of the heart-lung machine 3, the output end of the filter 6 is connected with the oxygenator 4, the output end of the oxygenator 4 is connected with the temperature changer 5, the output end of the temperature changer 5 is connected with the blood input end of the heart-lung machine 3, the input end of the temperature changer 5 is connected to the output end of the oxygenator 4, the temperature of blood is regulated through the temperature changer 5, the output end of the temperature changer 5 is connected to the loop input end of the heart-lung machine 3, the temperature regulated blood is reintroduced into circulation, the operating table 7 is respectively connected with the blood monitoring instrument 2, the heart-lung machine 3, the oxygenator 4, the temperature changer 5 and the filter 6, the operating table 7 operates all devices, the monitoring device 8 is embedded in the blood monitoring instrument 2, and the blood monitoring instrument 2 is used for monitoring vital signs and blood indexes of patients;
the monitoring device 8 comprises a biosensor 9, a data converter 10 and a display screen 11, wherein the biosensor 9 is connected with the data converter 10, and the data converter 10 is connected with the display screen 11.
Example two
As shown in fig. 2-4, a cell real-time monitoring device for myocardial ischemia reperfusion injury assessment comprises a monitoring device 8 and a blood circulation device 1, wherein a monitoring system is arranged in the monitoring device 8;
the monitoring system comprises a sensor data processing module, an evaluation module and a treatment scheme generating module, wherein the input end of the sensor data processing module is connected with the biological sensor 9, the output end of the sensor data processing module is respectively connected with the data converter 10 and the evaluation module, the input end of the evaluation module is respectively connected with the blood monitoring instrument 2 and the biological sensor 9, the output end of the evaluation module is connected with the treatment scheme generating module, and the output end of the treatment scheme generating module is connected with the display screen 11;
further, the sensor data processing module comprises a data collecting unit and a data integrating unit;
the data collection unit is connected with the biological sensor 9, receives analog signals or digital signals output by the sensor, samples and converts the signals output by the sensor, converts the signals into digital signals, calibrates the collected data to ensure the accuracy and reliability of the data, caches and stores the collected data, and transmits the data to the data integration unit, so that the subsequent processing and analysis are facilitated.
The data integration unit is responsible for processing and analyzing the acquired data to extract relevant parameters and indexes related to myocardial ischemia reperfusion injury evaluation, filtering and denoising the acquired data, removing noise interference, improving data quality, extracting characteristic parameters and indexes related to myocardial ischemia reperfusion injury from the data, and transmitting the characteristic parameters and indexes to the evaluation module.
Further, the evaluation module comprises an evaluation index defining unit, a blood evaluation unit and a cell evaluation unit;
the evaluation index limiting unit is used for setting an index and a parameter range for evaluating myocardial ischemia reperfusion injury, and a doctor or a researcher can set specific evaluation indexes such as electrocardio activity, blood substance concentration and the like and a corresponding normal range according to clinical requirements and research requirements; the blood evaluation unit analyzes the collected blood parameters such as blood oxygen saturation, hemoglobin level and acid-base balance, and evaluates the severity of myocardial ischemia reperfusion injury by analyzing hemodynamic parameters such as cardiac output, blood pressure, blood flow speed and the like;
the cell evaluation unit analyzes indexes such as metabolic activity, energy consumption condition and the like of cells by analyzing the concentration of substances with a large relation with myocardial cells in blood, so as to evaluate the activity and functional state of the myocardial cells;
further, the treatment plan generation module comprises a treatment plan database, an evaluation result conversion unit and a treatment plan simulation unit;
the treatment protocol database stores various treatment protocols for myocardial ischemia reperfusion injury, including medical treatment, interventional procedures, non-medical interventions, and the like. The database records the information of the applicable conditions, the medicine dosage, the operation steps and the like of various treatment schemes;
the evaluation result conversion unit reads and converts the evaluation result according to a preset standard and a reference range, classifies the evaluation result into different treatment requirements such as mild injury, moderate injury, severe injury and the like according to the severity and type of myocardial ischemia reperfusion injury, so as to facilitate subsequent treatment, and quantifies the evaluation result into a numerical value or an index so as to be matched and compared with treatment schemes in a treatment scheme database;
the treatment plan simulation unit screens out applicable treatment plans from the treatment plan database according to the evaluation result and the specific illness state and physical condition of the patient, performs personalized adjustment and customization on the selected treatment plans according to the individual difference and the treatment requirement of the patient, simulates and evaluates the effect, safety and feasibility of different treatment plans to select the most suitable treatment plan, and displays the plan on the display screen 11 for reference of doctors.
Claims (8)
1. A cell real-time supervision device for myocardial ischemia reperfusion injury aassessment, characterized in that: the cell real-time monitoring device for myocardial ischemia reperfusion injury assessment comprises a monitoring device (8) and a blood circulation device (1), wherein a monitoring system is arranged in the monitoring device (8), the blood circulation device (1) comprises a blood monitoring instrument (2), a heart-lung machine (3), an oxygenator (4), a temperature changer (5), a filter (6) and a console (7), and the monitoring device (8) is embedded in the blood monitoring instrument (2);
the monitoring device (8) comprises a biosensor (9), a data converter (10) and a display screen (11), wherein the biosensor (9) is connected with the data converter (10), and the data converter (10) is connected with the display screen (11);
the monitoring system comprises a sensor data processing module, an evaluation module and a treatment scheme generating module;
the sensor data processing module is used for receiving analog signals or digital signals output by the sensor, sampling and converting the signals output by the sensor, converting the signals into digital signal forms, calibrating the acquired data, processing and analyzing the acquired data to extract relevant parameters and indexes related to the assessment of the ischemia reperfusion injury, and transmitting the parameters and indexes to the assessment module;
the assessment module is used for setting an index and a parameter range for assessing myocardial ischemia reperfusion injury, analyzing acquired blood parameters, assessing the severity of myocardial ischemia reperfusion injury, and analyzing the concentration of substances with a larger relationship with myocardial cells in blood so as to assess the activity and the functional state of the myocardial cells;
the treatment scheme generation module stores various treatment schemes aiming at myocardial ischemia reperfusion injury, reads and converts the evaluation result according to a preset standard and a reference range, screens out applicable treatment schemes from a treatment scheme database according to the evaluation result and specific illness and physical condition of a patient, individually adjusts and customizes the selected treatment schemes according to individual differences and treatment requirements of the patient, and simulates and evaluates the effects, safety and feasibility of different treatment schemes.
2. A cell real-time monitoring device for myocardial ischemia reperfusion injury assessment according to claim 1, wherein: the heart-lung machine (3) is provided with an output end, a blood input end and a gas input end, the output end is connected with a filter (6) through the output end, the output end of a blood monitoring instrument (2) is connected with the blood input end of the heart-lung machine (3), the output end of the filter (6) is connected with an oxygenator (4), the output end of the oxygenator (4) is connected with a temperature changer (5), the output end of the temperature changer (5) is connected with the blood input end of the heart-lung machine (3), and an operating platform (7) is respectively connected with the blood monitoring instrument (2), the heart-lung machine (3), the oxygenator (4), the temperature changer (5) and the filter (6).
3. A cell real-time monitoring device for myocardial ischemia reperfusion injury assessment according to claim 1, wherein: the input end of the sensor data processing module is connected with the biosensor (9), the output end of the sensor data processing module is connected with the data converter (10) and the evaluation module respectively, the input end of the evaluation module is connected with the blood monitoring instrument (2) and the biosensor (9) respectively, the output end of the evaluation module is connected with the treatment scheme generating module, and the output end of the treatment scheme generating module is connected with the display screen (11).
4. A cell real-time monitoring device for myocardial ischemia reperfusion injury assessment according to claim 1, wherein: the sensor data processing module comprises a data collecting unit and a data integrating unit;
the data collection unit is connected with the biological sensor (9), receives an analog signal or a digital signal output by the sensor, samples and converts the signal output by the sensor, converts the signal into a digital signal form, calibrates the acquired data to ensure the accuracy and reliability of the data, caches and stores the acquired data, and transmits the acquired data to the data integration unit so as to facilitate subsequent processing and analysis;
the data integration unit is responsible for processing and analyzing the acquired data to extract relevant parameters and indexes related to myocardial ischemia reperfusion injury evaluation, filtering and denoising the acquired data, removing noise interference, improving data quality, extracting characteristic parameters and indexes related to myocardial ischemia reperfusion injury from the data, and transmitting the characteristic parameters and indexes to the evaluation module.
5. A cell real-time monitoring device for myocardial ischemia reperfusion injury assessment according to claim 1, wherein: the evaluation module comprises an evaluation index limiting unit, a blood evaluation unit and a cell evaluation unit;
the cell evaluation unit analyzes indexes such as metabolic activity, energy consumption condition and the like of cells by analyzing the concentration of substances which are in great connection with myocardial cells in blood, so as to evaluate the activity and functional state of the myocardial cells.
6. A cell real-time monitoring device for myocardial ischemia reperfusion injury assessment according to claim 1, wherein: the evaluation index limiting unit is used for setting an index and a parameter range for evaluating myocardial ischemia reperfusion injury, and a doctor or a researcher can set specific evaluation indexes such as electrocardio activity, blood substance concentration and the like and a corresponding normal range according to clinical requirements and research requirements; the blood evaluation unit analyzes the collected blood parameters such as blood oxygen saturation, hemoglobin level and acid-base balance, and evaluates the severity of myocardial ischemia reperfusion injury by analyzing hemodynamic parameters such as cardiac output, blood pressure, blood flow speed and the like.
7. A cell real-time monitoring device for myocardial ischemia reperfusion injury assessment according to claim 1, wherein: the treatment scheme generation module comprises a treatment scheme database, an evaluation result conversion unit and a treatment scheme simulation unit;
the treatment regimen database stores various treatment regimens for myocardial ischemia reperfusion injury, including medical treatments, interventional procedures, non-medical interventions. The database records the applicable conditions, the medicine dosage and the operation step information of various treatment schemes.
8. The cell real-time monitoring device for myocardial ischemia reperfusion injury assessment according to claim 7, wherein: the evaluation result conversion unit interprets and converts the evaluation result according to a preset standard and a reference range, classifies the evaluation result into different treatment requirements such as mild injury, moderate injury and severe injury according to the severity and type of myocardial ischemia reperfusion injury, so as to carry out subsequent treatment, and quantizes the evaluation result into a numerical value or an index so as to match and compare with treatment schemes in a treatment scheme database;
the treatment scheme simulation unit screens out applicable treatment schemes from a treatment scheme database according to the evaluation result and the specific illness state and physical condition of a patient, performs personalized adjustment and customization on the selected treatment schemes according to the individual difference and the treatment requirement of the patient, simulates and evaluates the effects, safety and feasibility of different treatment schemes so as to select the most suitable treatment scheme, and displays the scheme on the display screen (11) for reference of doctors.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1339975A (en) * | 1999-02-12 | 2002-03-13 | 利弗布里奇医药技术有限公司 | Mobile hart-lung machine |
| US20110092951A1 (en) * | 2009-10-20 | 2011-04-21 | Vaisnys Gintaras A | Method and Apparatus for Cardiac Tissue Monitoring and Catheter-Based Perfusion for Mitigating Acute Reoxygenation Injury |
| US20160058305A1 (en) * | 2014-08-26 | 2016-03-03 | University Of Washington | Device and method for analyzing reperfusion injury |
| CN106909786A (en) * | 2017-02-26 | 2017-06-30 | 曹亮明 | A kind of intelligent blood pressure management equipment and control method |
| CN107988150A (en) * | 2017-12-01 | 2018-05-04 | 新疆医科大学第附属医院 | A kind of identification method and system of Myocytes Anoxia-reoxygenation |
| RU2760242C1 (en) * | 2021-03-01 | 2021-11-23 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации | Method for assessing myocardial damage and risk of complications development after cardiac surgery |
| CN114758726A (en) * | 2022-04-26 | 2022-07-15 | 川北医学院附属医院 | Myocardial ischemia reperfusion influence factor data detection method |
| CN115777629A (en) * | 2022-11-29 | 2023-03-14 | 普济生物科技（台州）有限公司 | Method for establishing and evaluating myocardial ischemia reperfusion model |
-
2023
- 2023-09-01 CN CN202311130121.3A patent/CN117100935A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1339975A (en) * | 1999-02-12 | 2002-03-13 | 利弗布里奇医药技术有限公司 | Mobile hart-lung machine |
| US20110092951A1 (en) * | 2009-10-20 | 2011-04-21 | Vaisnys Gintaras A | Method and Apparatus for Cardiac Tissue Monitoring and Catheter-Based Perfusion for Mitigating Acute Reoxygenation Injury |
| US20160058305A1 (en) * | 2014-08-26 | 2016-03-03 | University Of Washington | Device and method for analyzing reperfusion injury |
| CN106909786A (en) * | 2017-02-26 | 2017-06-30 | 曹亮明 | A kind of intelligent blood pressure management equipment and control method |
| CN107988150A (en) * | 2017-12-01 | 2018-05-04 | 新疆医科大学第附属医院 | A kind of identification method and system of Myocytes Anoxia-reoxygenation |
| RU2760242C1 (en) * | 2021-03-01 | 2021-11-23 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации | Method for assessing myocardial damage and risk of complications development after cardiac surgery |
| CN114758726A (en) * | 2022-04-26 | 2022-07-15 | 川北医学院附属医院 | Myocardial ischemia reperfusion influence factor data detection method |
| CN115777629A (en) * | 2022-11-29 | 2023-03-14 | 普济生物科技（台州）有限公司 | Method for establishing and evaluating myocardial ischemia reperfusion model |
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