CN1331974A - Eyesight improving medicine liquid - Google Patents
Eyesight improving medicine liquid Download PDFInfo
- Publication number
- CN1331974A CN1331974A CN 00136013 CN00136013A CN1331974A CN 1331974 A CN1331974 A CN 1331974A CN 00136013 CN00136013 CN 00136013 CN 00136013 A CN00136013 A CN 00136013A CN 1331974 A CN1331974 A CN 1331974A
- Authority
- CN
- China
- Prior art keywords
- add
- borneolum syntheticum
- alumen
- barrier
- eyes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to one kind of medicine capable of being permeated into eyeground to treat eye disease and its preparation process. The medicine is prepared with safflower, chrysanthemum, alum and borneol and through the distillated water washing, decoction, filtering, concentration, cooling, mixing with ethanol, refrigeration, mixing with "ammonia test liquid", pH regulation, mixing with Tween-80, mixing with distillated water of safflower and chrysanthemum; the crushing, sieving, mixing with distillated water, filtering, high pressure disinfection and other steps of alum and borneol; merging and bottling. It may be used to treat the pathologic change of retina and other parts in eyeground without toxic side effect.
Description
The invention belongs to medical technical field, the particularly a kind of medicine and preparation technology thereof that can penetrate into optical fundus treatment oculopathy.
TCM Ophthalmology is divided into inside and outside barrier oculopathy with oculopathy, as diseases such as keratitis, corneal nebula, conjunctivitis, sclera, irises, be that the visible person of naked eyes claims external oculopathy oculopathy, the ophthalmic illness needs to claim cataracta ophthalmopathy by the inspect by instrument person, resembles cataract, vitreous opacity, retinopathy etc.The present collyrium of selling on the market (cream), though a lot, main therapeutical effect is based on antiinflammatory basically, also has only inflammation, antibiotic effective, other effect is not good without exception.Though resemble " fog-removing medicine " treatment vitreous opacity in these medicines, cataracta ophthalmopathies such as cataract such as " catalin " treatment.Truly have basis in theory, should be effective, but not all right clinically.Not only can not treat cataracta ophthalmopathy, keep not developing, not worsening also and be unable to handle.In these medicament for the eyes, be only limited to eyeball angle conjunctiva behind the eye dripping, can not infiltrate ophthalmic, thereby not control cataracta ophthalmopathy, effect equals zero.In with drug for diminishing inflammation and antibiosis, other active drug is just seldom arranged except antibiotic.Antibiotic Drug resistance is well-known.Except that the minority Chinese medicine preparation, all the other are Western medicine.Commercially available in addition medicament for the eyes cost is too high, has increased patient's burden, and poor effect.
The object of the present invention is to provide a kind ofly by the aqueous humor barrier, can carry other hybrid medicine again and penetrate into the optical fundus jointly, can treat dispel the barrier eyesight improving liquid and the preparation technology thereof of optical fundus retina, optic disc and macular disease.
Pharmacological action of the present invention is: liver heat removing and eyesight improving, and anti-inflammation, the nebula of the dispelling Nu that disappears, puckery tear detoxifcation, the blood pressure lowering analgesia, blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis, meridians and collaterals dredging, regulation of mental activities makes eye bright.
Main component of the present invention is Alumen 4-6 part, Borneolum Syntheticum 1-2 part, for promoting blood circulation to restore menstrual flow, and stasis-dispelling and pain-killing, cooling blood for hemostasis can add Flos Carthami 1-3 part; For wind-dispelling heat-dissipating, liver heat removing and eyesight improving, eliminating inflammation and expelling toxin can add Flos Chrysanthemi 1-2 part.
Preferred version of the present invention is: 3 parts on Flos Carthami, 2 parts of Flos Chrysanthemis, 4 parts in Alumen, 1 part of Borneolum Syntheticum.
Preferred plan of the present invention is: 1.5 parts on Flos Carthami, 1.5 parts of Flos Chrysanthemis, 5.5 parts in Alumen, 1.5 parts of Borneolum Syntheticums.
Flos Carthami is an annual herb, is used as medicine with flower, also claims red Cymbidium ensifolium (L.) Sw., thorn Flos Carthami, Semen astragali sinici, Herba Astragali Sinici, and is warm in nature, nontoxic, has special fragrance, mildly bitter flavor, with spend length of a film, color is scarlet, matter is soft for good.Cure mainly promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, and blood cooling and hemostatic functions is arranged.
Flos Chrysanthemi is a feverfew, the head inflorescence of chrysanthemum, and different name is: joint China, aurin, Flos Chrysanthemi, true chrysanthemum, tame chrysanthemum, Jin Rui, Flos Chrysanthemi and medicine chrysanthemum etc.; The branch of anti-chrysanthemum, Flos Chrysanthemi, Flos Chrysanthemi and CHUJU is arranged, and we use Flos Chrysanthemi.Its property delicate fragrance is lightly seasoned, little hardship.Nature and flavor sweetness and bitterness, cold, nontoxic; Gui Jing: people's lung Liver Channel.Cure mainly: wind-dispelling heat-dissipating, liver heat removing and eyesight improving, eliminating inflammation and expelling toxin has antibacterial action to various bacteria.Ophthalmology is controlled conjunctival congestion, lacrimation, the nebula of dispelling film.
Alumen, different name is: Alumen, Alumen, Gypsum Fibrosum, Bai Jun, snow vitriol, living vitriol, Muscovitum vitriol etc., be the mineral alunite, refine the crystallization trigonal system that forms through processing.Proportion 2.6-2.8, property is crisp, and is not of uniform size for irregular crystalline solid, gets that its color is white, gloss and no-sundries, doping person use it.Composition is: KAl
3(SO
4)
2(OH)
6Its pharmacological action is: 1. various bacteria is had antibacterial action; 2. anti-trichomonas vaginitis effect; 3. astriction, external has anastalsis.Nature and flavor: sour, puckery, cold, poisonous, (" Bencao Jingshu " meaning: sour in the mouth gas is cold nontoxic.) return through: go into lung, taste, large intestine channel.Cure mainly: conjunctival congestion, corneal nebula, puckery tear, the bulbar conjunctiva polyp that disappears, control the marginal blepharitis eye.
Borneolum Syntheticum is Borneolum Syntheticum section plant, the processed goods of Borneolum Syntheticum resin.Or be the synthetic product of being processed into of Camphora Lignum Pini Nodi wet goods chemical method.Approach greatly with sheet, color is pure white, and gas is pure and fresh, and fragrant pure person is good.This liquid employee is the good merchantable brand in the composite.Composition: by the crystallization that from the resin of Borneolum Syntheticum and volatile oil, obtains, be to be close to pure dextro Borneolum Syntheticum, contain multiple ter penoids.Nature and flavor are arduous, cool, nontoxic, return through: go into the cardiopulmonary warp.Cure mainly logical all keys, the nebula of dispelling makes eye bright, conjunctival congestion film nebula.Pharmacology: pain relieving and antisepsis can be used for neuralgia or antiinflammatory.The hot perfume (or spice) of Borneolum Syntheticum is walked to scurry, and the energy priming is up.Excrete in vivo with after glucuronic acid combines.Experimental results show that: Borneolum Syntheticum can make the permeability of corneal epithelial cell increase, and the angle of penetration membrane barrier action is arranged, and promotes other medicines angle of penetration membrane barrier action simultaneously in addition.
Normal saline is excipient solution, mixes application in proportion with above-mentioned medicine.
Processing technique of the present invention is:
1. Flos Carthami
1. wash it fast with distilled water, decoct 1-10 time, each 0.5 hour～2 hours, filter, merge repeatedly filtrate;
2. filtrate is concentrated into syrupy shape, cooling, and constantly stir, slowly add 95% ethanol of 2～6 times of amounts simultaneously, fully to stir, cold preservation 5～24 hours is reclaimed ethanol evaporation to there not being vinosity;
3. add " ammonia solution ", transfer pH value 6.5～9.0, place cold preservation and spend the night, reheat removes ammonia, adds sodium chloride 0.5-0.6 part, dissolving.
4. add " tween 80 " again, the limit edged stirs, and adding distil water is 10～30 parts again, stirs evenly filtration, is orange light colour.
2. Flos Chrysanthemi
The processing technique of Flos Chrysanthemi and Flos Carthami are identical.
3. Alumen
1. Alumen is pulverized, crossed 100～140 mesh sieves;
2. add 30～50 times of dissolved in distilled water, stirred 3～20 minutes, static 1～3 hour, restir 3～20 minutes, static again 1～3 hour, restir 3～20 minutes, static again 1～3 hour;
3. use filter paper filtering 2～4 times, bottling;
4. pressed 1～2 hour sterilization for 2～4 pounds with the pressure cooker high pressure;
5. sealing cooling, standby;
4. Borneolum Syntheticum
1. the Borneolum Syntheticum porphyrize is become powder, cross 120 mesh sieves;
2. 20～30 times of amounts of adding distil water stir and fill part, after static 1 hour, fill a part stirring again, and till CL, static again cold preservation is spent the night.
3. use filter paper filtering 3～5 times,, do not add a cover with uncovered bottled;
4. with 30 watts of Burdick lamp irradiations 30～40 minutes, vibration stirred evenly, and shines 30～40 minutes again, and vibration stirs evenly again, and the irradiation vibration is 2～3 times again, reaches till the sterilization;
5. add a cover cold preservation and spend the night, standby.
Synthetic at last:
Add 10～50 parts of 0.9% normal saline after Flos Carthami, Flos Chrysanthemi, each liquid of Alumen is mixed in proportion, add Borneolum Syntheticum liquid mixing behind the mixing again, with liquid testing PH:6.5～7.8, proportion 1.005～1.030 is degree, bottles then and seals.
Indication of the present invention: cataract, glaucoma, vitreous opacity, optic atrophy, retinopathy, retinal hemorrhage, bulbar conjunctiva polyp are climbed fine, macular disease, sugar net disease, epiphora induced by wind, acute and chronic keratitis, acute and chronic conjunctivitis, myopia, hypermetropia, amblyopia, and other oculopathy of inside and outside barrier or inflammation.
Contraindication of the present invention: allergic ophthalmopathy patient forbidding.
Toxic and side effects of the present invention: the present invention does not find toxicity.Side effect is little behind the eye dripping irritation to be arranged, and can disappear after closing order number minute.Can continue a usefulness, can life-time service.
Consumption of the present invention: 6～12 times on the one, one time one, or follow the doctor's advice.
Storage life of the present invention: cold preservation can be preserved 2 years, and room temperature can be preserved half a year.
The present invention is owing to there is medicine by the aqueous humor barrier, and this medicine can carry other mixture again and infiltrate the optical fundus jointly, so can treat optical fundus retina, optic disc, macular disease, have abundant raw material, cheap, flavour of a drug are few, technology is simple, and is easy to make, the good effect that has no side effect.
Biotic experiment and clinical operating position:
Biotic experiment: once observed its eyeball and change, and do not find toxic and side effects so far, as cat, Canis familiaris L., kitten, doggie, little chicken, duckling young bird, rabbit son, white rabbit (individual) surplus in the of totally 20 grows up with multiple zoopery eye dripping, elder is month surplus continuously, every day, eye dripping was 2～3 times, few person 5 days, 1 time on the one.This lasts 2 years with zoopery, and inferior surplus in the of 1500, the beginning is used for human body, clinical.
The zoopery situation: have a doggie to just reach the moon, left eye is bitten, and has suffered from acute keratitis, through using this invention, every day 5 times, one time 1, inflammatory congestion alleviated in 3 days, the minimizing of shedding tears, and inflammation disappears after 5 days, but leave over the cornea nebula, cover whole cornea, and the situation that has expansion to prolong, use the present invention through continuing point, 2 times on the 1st, 1 time 1, corneal nebula disappears after March, recovery from illness.
Other has the congenital pupil abnormal development of a little cat, and night, pupil did not enlarge, no significant change.Through with every day of the present invention 3 times, 1 time 1, after May, pupil recovers the enlarged rounded in night, has recovered normal.
Bumped right eye when also having a doggie to rob food, shed tears later on, promptly shed tears down with the wind, enclosed frosting winter near the eyes outdoor.Through using the present invention, 2 times on the 1st, 1 time 1, recovery from illness after 10 days.
Clinical setting: nearly 20 years of clinical use this product, treat various oculopathy, comprise inside and outside barrier oculopathy, about 5000 people altogether, about 100,000/person-time, removing the allergic ophthalmopathy patient has anaphylaxis, promptly heals after the drug withdrawal, and all the other do not find other toxic and side effects.
Therapeutical effect to main oculopathy:
1. cataract
The present invention can significantly activate the function of eye proteolytic enzyme, decompose muddy protein, with degeneration and sedimentary protein is eliminated, that is to say and can fundamentally decompose the intraocular opacities material, activate metabolism, supply nutrition, improve lenticular transparency, can after treatment effect for a long time, prevent turbid matter regeneration.Can thoroughly treat cataract.Treat example surplus the cataract 200 with the present invention over 20 years, 98 eyes of 50 examples of sampling, the result is as follows: 9 eyes of 5 examples of fully recovering account for 9.2%, and 24 eyes of produce effects 12 examples account for 24.1%, and 51 eyes of effective 26 examples account for 55.4%, total effective rate 88.7%, invalid 7 examples account for 11.3%.
Matched group 30 examples, 58 eyes are with " catalin " eye dripping.
The result is as follows: recovery from illness 0, and produce effects 0,12 eyes of effective 7 examples account for 24.3%, and 46 eyes of invalid 23 examples account for 75.7%.
2, vitreous opacity
The present invention can the intravital turbid matter of powerful heat absorbing glass and vitreous opacity in inflammation exudate, vitreous hemorrhage, and can get rid of toxin, improve the eye microcirculation, nutrition ocular tissue to be increasing transparency, thereby thoroughly treats vitreous opacity.
Treat the over one hundred example of primary disease for many years, 68 eyes of 36 examples of sampling, the result is as follows: 4 eyes of 3 examples of fully recovering account for 7.0%, and 19 eyes of produce effects 10 examples account for 28.4%, and 35 eyes of effective 18 examples account for 51.3%, and 10 eyes of invalid 5 examples account for 13.3%, total effective rate: 86.7%.
33 eyes of matched group 18 examples are with " fog-removing medicine " eye dripping.
The result is as follows: recovery from illness 0, produce effects 0,2 eyes of effective 1 example, 31 eyes of invalid 17 examples, effective 0.66%, invalid 93.4%.
3, glaucoma
(1) the present invention can improve the corpus ciliare function, regulates ophthalmic blood flow volume and proteinic unusual, improves blood circulation, eliminates the ophthalmic blood stasis, improves aqueous humor and produces, and gets rid of the metabolic waste in the tissue, thereby can reduce intraocular pressure.
(2) analgesic activity
The existing analgesic activity of medicine of the present invention itself add the reduction of intraocular pressure simultaneously, so its analgesic effect is clearly.To acute congestive glaucoma, can lower intraocular pressure in two days with the present invention, complete pain relieving in three days, all state of an illness are alleviated fully, the recovery from illness of two weeks.Effective equally to chronic glaucoma, but the time is longer, needs surplus alleviation the in January.When no obvious subjective symptoms, should continue medication a period of time, can keep like this not recurring.
Treat nearly hundred examples of acute glaucoma for many years, 42 eyes of 23 examples of sampling, its result is as follows: 27 eyes of 14 examples of fully recovering, 10 eyes of produce effects 5 examples, 2 eyes of effective 1 example, 3 eyes of invalid 3 examples, effective percentage 92.7%, invalid 7.3%.
24 eyes of matched group 14 examples, general with " sieve's Shu card product ", " timolol " western medicine such as wait that eye dripping and other medicines are injected, taken orally, its result is as follows: 2 eyes of 2 examples of fully recovering, 4 eyes of produce effects 3 examples, 4 eyes of effective 2 examples, 14 eyes of invalid 7 examples, effective percentage 41.7%, inefficiency 58.3%.
4, retinopathy and optic neuritis, optic atrophy
The present invention has osmosis, can directly arrive retina by the aqueous humor barrier.Wherein there is multiple medications that the function of stocking of activation visual cell, optic nerve is all arranged,, can treats retinopathy and optic atrophy etc. so can improve retinal function.Other has diminishing inflammation, gets rid of the function of toxin, so can treat diseases such as optic neuritis, retinitis.Now that 42 eyes treatments of 22 examples in the example surplus the case 50 statistics is as follows: 8 eyes of 4 examples of fully recovering, 17 eyes of produce effects 9 examples, 11 eyes of effective 6 examples, 6 eyes of invalid 3 examples.Total effective rate 85.7%, inefficiency 14.3%.
Matched group: 16 eyes of 10 examples are various therapies such as western modern medicine, hormone, vitamin and other symptomatic treatments.The result fully recovers 0,2 eyes of produce effects 2 examples, 3 eyes of effective 2 examples, 11 eyes of invalid 6 examples, effective percentage 31.2%.
5, acute and chronic keratitis
There is multiple medicine that various bacteria is had bacteriostasis among the present invention, function of promoting blood circulation to disperse blood clots, astriction are arranged again, so can treat various inflammation ophthalmics.But but corneal inflammation not only anti-inflammation but also pain relieving simultaneously again because astriction is arranged, and can prevent the generation and the development of corneal nebula.Treat 178 eyes of various keratitis 92 examples over 20 years, statistical result is as follows: 42 eyes of 20 examples of fully recovering account for 23.4%, and 56 eyes of produce effects 30 examples account for 31.4%, and 68 eyes of effective 36 examples account for 38.8%, and 12 eyes of invalid 6 examples account for 6.4%, total effective rate 93.6%.
Matched group: 32 eyes of 20 examples, medicine are antimicrobial drug eye dripping such as " ciprofloxacins " and for oral administration, injection.The result is as follows: recovery from illness 0,8 eyes of produce effects 6 examples, 12 eyes of effective 8 examples, 12 eyes of invalid 6 examples, total effective rate 62.5%, inefficiency 47.5%.
6, acute and chronic conjunctivitis
Example surplus the acute conjunctivitis 300 is all cured basically, and about more than 94%, the nonresponder is about 6%.The chronic conjunctivitis curative effect is relatively poor, does not have cured person in 200 examples, and produce effects 25% is effective 17%, and is invalid 58%, total effective rate 42%.
7, corneal nebula
As follows to 56 the eye statistics of corneal nebula 33 examples due to a variety of causes: 8 eyes of 8 examples of fully recovering account for 14.3%, and 18 eyes of produce effects 9 examples account for 32.1%, and 20 eyes of effective 10 examples account for 35.5%, and 10 eyes of invalid 6 examples account for 18.1%, total effective rate 81.9%.
Embodiment:
Take by weighing raw material by following proportioning:
Flos Carthami 150 grams, Flos Chrysanthemi 150 grams, Alumen 550 grams, Borneolum Syntheticum 150 grams.
Preparation method is as follows:
1. Flos Carthami
1. wash it fast with distilled water, decoct 3 times, each 1 hour, filter, merge repeatedly filtrate;
2. filtrate is concentrated into syrupy shape, cooling, and constantly stir, slowly add 95% ethanol of 4 times of amounts simultaneously, fully to stir, cold preservation 12 hours is reclaimed ethanol evaporation to there not being vinosity;
3. add " ammonia solution ", transfer pH value 7.0, place cool overnight, reheat removes ammonia, adds sodium chloride 5.5 grams, dissolving.
4. add " tween 80 " again, the limit edged stirs, and adding distil water is 200 milliliters again, stirs evenly filtration, is orange light colour.
2. Flos Chrysanthemi
The processing technique of Flos Chrysanthemi and Flos Carthami are identical.
3. Alumen
1. Alumen is pulverized, crossed 120 mesh sieves;
2. add 40 times of dissolved in distilled water, stirred 10 minutes, static 2 hours, restir 10 minutes, static again 2 hours, restir 10 minutes, static again 2 hours;
3. use filter paper filtering 3 times, bottling;
4. pressed 1.5 hours sterilization for 3 pounds with the pressure cooker high pressure;
5. sealing cooling, standby;
4. Borneolum Syntheticum
1. the Borneolum Syntheticum porphyrize is become powder, cross 120 mesh sieves;
2. 25 times of amounts of adding distil water stir fully, after static 1 hour, fully stir again, and till CL, static again cold preservation is spent the night.
3. use filter paper filtering 4 times,, do not add a cover with uncovered bottled;
4. with 30 watts of Burdick lamp irradiations 30 minutes, vibration stirred evenly, and shines 30 minutes again, and vibration stirs evenly again, and the irradiation vibration is 3 times again, reaches till the sterilization;
5. add a cover cold preservation and spend the night, standby.
Synthetic at last:
Add 300 milliliters of 0.9% normal saline after Flos Carthami, Flos Chrysanthemi, each liquid of Alumen is mixed in proportion, add Borneolum Syntheticum liquid mixing behind the mixing again, with liquid testing PH:7.0, proportion 1.020 is degree, bottles then and seals, and finishes the present invention.
Claims (6)
1, a kind of barrier eyesight improving liquid of dispelling is characterized in that it is the water preparation of being made by the following weight proportion raw material:
Alumen 4-6 part, Borneolum Syntheticum 1-2 part.
2, a kind of barrier eyesight improving liquid of dispelling according to claim 1 is characterized in that it is the water preparation of being made by the following weight proportion raw material:
4-6 part, Borneolum Syntheticum 1-2 part, Flos Carthami 1-3 part.
3, a kind of barrier eyesight improving liquid of dispelling according to claim 1 is characterized in that it is the water preparation of being made by the following weight proportion raw material:
Alumen 4-6 part, Borneolum Syntheticum 1-2 part, Flos Chrysanthemi 1-2 part.
4, a kind of barrier eyesight improving liquid of dispelling according to claim 1 is characterized in that it is the water preparation of being made by the following weight proportion raw material:
Alumen 4-6 part, Borneolum Syntheticum 1-2 part, Flos Chrysanthemi 1-2 part, Flos Carthami 1-3 part.
5, a kind of barrier eyesight improving liquid of dispelling according to claim 1, wherein the weight proportion of each raw material is:
Flos Carthami 150 grams, Flos Chrysanthemi 150 grams, Alumen 550 grams, Borneolum Syntheticum 150 grams.
6, the preparation method of a kind of barrier eyesight improving liquid of dispelling according to claim 1 is characterized in that:
(1) Flos Carthami
1. wash it fast with distilled water, decoct 3 times, each 1 hour, filter, merge repeatedly filtrate;
2. filtrate is concentrated into syrupy shape, cooling, and constantly stir, slowly add 95% ethanol of 4 times of amounts simultaneously, fully to stir, cold preservation 12 hours is reclaimed ethanol evaporation to there not being vinosity;
3. add " ammonia solution ", transfer pH value 7.0, place cold preservation and spend the night, reheat removes ammonia, adds sodium chloride 5.5 grams, dissolving;
4. add " tween 80 " again, the limit edged stirs, and adding distil water is 200 milliliters again, stirs evenly filtration, is orange light colour;
(2) Flos Chrysanthemi
The processing technique of Flos Chrysanthemi and Flos Carthami are identical;
(3) Alumen
1. Alumen is pulverized, crossed 120 mesh sieves;
2. add 40 times of dissolved in distilled water, stirred 10 minutes, static 2 hours, restir 10 minutes, static again 2 hours, restir 10 minutes, static again 2 hours;
3. use filter paper filtering 3 times, bottling;
4. pressed 1.5 hours sterilization for 3 pounds with the pressure cooker high pressure;
5. sealing cooling, standby;
(4) Borneolum Syntheticum
1. the Borneolum Syntheticum porphyrize is become powder, cross 120 mesh sieves;
2. 25 times of amounts of adding distil water stir and fill part, after static 1 hour, fill a part stirring again, and till CL, static again cold preservation is spent the night;
3. use filter paper filtering 4 times,, do not add a cover with uncovered bottled;
4. with 30 watts of Burdick lamp irradiations 30 minutes, vibration stirred evenly, and shines 30 minutes again, and vibration stirs evenly again, and the irradiation vibration is 3 times again, reaches till the sterilization;
5. add a cover cold preservation and spend the night, standby;
Synthetic at last:
Add 300 milliliters of 0.9% normal saline after Flos Carthami, Flos Chrysanthemi, each liquid of Alumen is mixed in proportion, add Borneolum Syntheticum liquid mixing behind the mixing again, with liquid testing PH:7.0, proportion 1.020 is degree, bottles then and seals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136013 CN1127960C (en) | 2000-12-25 | 2000-12-25 | Eyesight improving medicine liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136013 CN1127960C (en) | 2000-12-25 | 2000-12-25 | Eyesight improving medicine liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1331974A true CN1331974A (en) | 2002-01-23 |
| CN1127960C CN1127960C (en) | 2003-11-19 |
Family
ID=4597020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00136013 Expired - Fee Related CN1127960C (en) | 2000-12-25 | 2000-12-25 | Eyesight improving medicine liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1127960C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523799A (en) * | 2015-01-31 | 2015-04-22 | 高君琳 | Externally-applied traditional Chinese medicine liquid for preventing myopia and treating early pseudomyopia and preparation method thereof |
| CN104922467A (en) * | 2015-04-10 | 2015-09-23 | 陈圣沪 | Chinese medicinal herbal eye drop for efficiently treating cataract |
| CN105920328A (en) * | 2016-06-03 | 2016-09-07 | 陈瑞 | Drops for treating keratitis |
| CN105998755A (en) * | 2016-07-22 | 2016-10-12 | 杨立建 | Mild-moxibustion medicine and mild-moxibustion apparatus for treating myopia and amblyopia |
| CN108578459A (en) * | 2018-07-26 | 2018-09-28 | 河北御本然生物科技有限公司 | A kind of champignon cream and production method for eye |
| CN108938701A (en) * | 2018-09-03 | 2018-12-07 | 安徽科技学院 | Ocular fluid and preparation method thereof is smoked in a kind of improving eyesight |
-
2000
- 2000-12-25 CN CN 00136013 patent/CN1127960C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523799A (en) * | 2015-01-31 | 2015-04-22 | 高君琳 | Externally-applied traditional Chinese medicine liquid for preventing myopia and treating early pseudomyopia and preparation method thereof |
| CN104922467A (en) * | 2015-04-10 | 2015-09-23 | 陈圣沪 | Chinese medicinal herbal eye drop for efficiently treating cataract |
| CN105920328A (en) * | 2016-06-03 | 2016-09-07 | 陈瑞 | Drops for treating keratitis |
| CN105998755A (en) * | 2016-07-22 | 2016-10-12 | 杨立建 | Mild-moxibustion medicine and mild-moxibustion apparatus for treating myopia and amblyopia |
| CN108578459A (en) * | 2018-07-26 | 2018-09-28 | 河北御本然生物科技有限公司 | A kind of champignon cream and production method for eye |
| CN108938701A (en) * | 2018-09-03 | 2018-12-07 | 安徽科技学院 | Ocular fluid and preparation method thereof is smoked in a kind of improving eyesight |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1127960C (en) | 2003-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102178784B (en) | Combination therapy used for treating visual disturbances and damages and relieving asthenopia | |
| CN102631558B (en) | Medicament for treating eye disease and preparation method of medicament | |
| CN101648018A (en) | Medicinal composition for treating ophthalmic inflammation and application thereof | |
| CN103083546B (en) | Method for processing condensed pill for regaining sight | |
| CN1127960C (en) | Eyesight improving medicine liquid | |
| CN105106318B (en) | A kind of Chinese medicine composition and preparation method thereof for treating xerophthalmia | |
| CN1824025B (en) | Applicaiton of a Chinese-western medicine combined composition for preparing medicine and frod dual purpose nutrient for preventing frue myopia | |
| CN1824063A (en) | Medicine and food dual purpose Chinese and western medicine combined product for preventing and trecting pseudomyopia and its manufacturing method | |
| CN1824067A (en) | Medicine and food dual purpose product for preventing myopia and its manufacturing method | |
| CN101647913B (en) | Traditional Chinese medicine preparation for treating senile cataract and viral keratitis | |
| CN113413415B (en) | Lanosterol eye drops and preparation method thereof | |
| CN1824052A (en) | Medicine and frod dual purpose Chinese and western medicien combined nutrient for preventing pseudomyopia and true myopia and its manufacturing method | |
| CN1824064A (en) | Medicine and food dual purpose nutrient for preventing and treating pseudomyopia and its manufacturing method | |
| CN1824066A (en) | Medicine and food dual purpose Chinese and western medicine combined product for preventing myopia and its manufacturing method | |
| CN101648015A (en) | Chinese medicinal composition for treating glaucoma and application thereof | |
| CN105769920A (en) | Pearl clear-sighted eye drops and preparation method | |
| CN103405609B (en) | Traditional Chinese medicine preparation for treating cataract | |
| CN105902686A (en) | In-situ gel eyewash containing nano-carbon crystals and preparation method thereof | |
| CN100423731C (en) | Eye brightening eye washing liquid and its preparation method | |
| CN108524448B (en) | A kind of euphadienol anti-cataract eye-drops preparations and its preparation method and application | |
| CN1544072A (en) | Chinese traditional medicine for treating senile eye diseases and its preparation | |
| CN1162454A (en) | Green bamboo liquid for fumigation of eyes and preparation thereof | |
| CN103948633A (en) | Eye drops for treating oculopathy and preparation method thereof | |
| CN101612288B (en) | Traditional Chinese medicine for treating diabetic retinopathy | |
| CN1400004A (en) | Chinese medicine preparation for curing chronic conjunctivitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |