CN1824066A - Medicine and food dual purpose Chinese and western medicine combined product for preventing myopia and its manufacturing method - Google Patents
Medicine and food dual purpose Chinese and western medicine combined product for preventing myopia and its manufacturing method Download PDFInfo
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Abstract
A medical product used as both medicine and food for preventing and treating the myopia caused by combination of Chinese medicine with Western medicine is prepared from composite medicine, vitamins and trace elements. Its preparing process is also disclosed.
Description
The eyes are the windows of the mind, occupy first of the face, everybody thirsts for having a pair of healthy eye and good vision, but whole world nearly half people suffers from variety classes and ophthalmic in various degree, wherein more than 4,000 ten thousand people are blind, as not adopting an effective measure, the crowd who encroached on by ophthalmic will be doubled and redoubled, ophthalmic will threaten everyone.Therefore, prevention of blindness, effectively controlling ophthalmic infringement, is one of human challenge that faces in 21 century.China of new century need a large amount of high-quality talents, body and mind especially eye health be the basis, but China youngsters and children student's physical health situation is troubling at present, the vision health problem is outstanding especially.Show that according to national students in middle and primary schools' myopic eye preventing and treating work sampling monitoring result in 1999 national pupil's poor eyesight rate is 18.57%, rate of myopia is 13.35%; Junior school student's poor eyesight rate is 45.04%, and rate of myopia is 37.44%; High school student's poor eyesight rate is 67.29%, and rate of myopia is 61.5%; How effectively to reduce the rate of myopia of youngsters and children, the control ophthalmic stops the development trend of bad vision in youngsters and children and all groups to the infringement of vision, becomes the problem that the whole society generally is concerned about.What " Sight first China Act " was that Ministry of Public Health and China Disabled Federation etc. carry out both at home and abroad hand in hand is the large-scale international cooperative project of main task and target with prevention and health care and curing cataract, has obtained remarkable achievement since the execution.This project is implemented the policy of putting prevention first from start to finish, with outreach eye care and prevention of blindness knowledge, improves eye care consciousness, as the important content of this action; The Ministry of Education, Ministry of Public Health, SARFT(The State Administration of Radio and Television), the Central Committee of the Communist Young League and China Disabled Persons' Federation's joint signature file in 2000, the education of disease prevention and health protection activity of " cherishing our eyes " of national teenager is carried out in decision in " Sight first China Act ".
In recent years, improvement because of the living condition, many children even comprise that a large amount of adults have the custom of monophagia, as have a sweet tooth and rich food dish, do not eat vegetable or edible variety and amount very little, and various vegetables are above-mentioned nutrient substance main sources, so that the nutrient substance that even if the long-term above-mentioned not monophagia of famine also very easily lacks in the body, and these nutrient substance are very important to improving whole body premunition level and ability, must influence eye health and vision level and progressively increase the weight of the state of an illness, the fact is also as this, just be enough to make us startling as above-mentioned national students in middle and primary schools' myopic eye preventing and treating work sampling monitoring result, this also does not comprise adult data! What change is exactly " custom " and the well-known people of being are the most difficult, the Chinese idiom maxim that this just has " rivers and mountains easily changes, nature difficulty move " is therefore look to changing deviation food habit by all crowds especially child comprehensively and is reached balanced nutritious purpose of preventing and treating ophthalmic and vision care huge, its probability of difficulty, feasibility and operability are obviously all unrealistic undoubtedly.
The present invention is exactly for solving this difficult problem and giving that above-mentioned Sight first China Act activity provides more, the Chinese and western medical that designs of operability and embodiment is in conjunction with pre-myopia prevention medicine-food two-purpose goods and manufacture method widely, product does not have crowd restriction, to pre-myopia prevention, improve eyes and the vision health situation has the practical value of particular importance and positive now and far-reaching significance.Be to strengthen the understanding of the present invention, the main scientific and technological principle and the innovation that below continue to introduce the present invention and foundation thereof are advantage.
Reasonably nutrient substance not only promotes teenager health normal growth to grow and to improve premunition such as booster immunization proteic synthetic etc., also is the Fundamentals of safeguarding eye health, prevention and the various oculopathy of treatment simultaneously, complements each other between them, promotes mutually.Nutritional imbalance, deficiency or superfluous, body interior all can go wrong.For ophthalmics such as pre-myopia preventions, promulgated by the ministries or commissions of the Central Government and GB2760 of following health and GB14880 officinal food dual purpose product and function become more important and outstanding, spy further are described below one by one:
Chinese medicine food aspect: Radix Glycyrrhizae sweet in the mouth cold nature, can eliminating fire and detoxication and relax the bias of various medicines.Fructus Gardeniae bitter in the mouth cold in nature, heat clearing away also make heat from urine discharge thus effect rapidly, cooling blood for hemostasis, control the jaundice disease of conjunctival congestion and swelling pain, pyretic toxicity carbuncle, whole body jaundice, and the impaired disease of this main just hepato-biliary function that makes eye bright, involve the eyes function to some extent naturally.Semen Cassiae cold nature, suppressing the hyperactive liver and subsiding YANG, clearing away heat to improve acuity of vision, liver opening at eye, liver heat removing are apt to and can be made eye bright, so be to control oculopathy key medicines such as two blurred visions are dark, blurred vision, conjunctival congestion photophobia.Flos Chrysanthemi sweet in the mouth, detoxifcation, suppressing the hyperactive liver make eye bright and move back corneal nebula.Wisdom is nourished heart, strengthens in sweet flat, the spleen reinforcing of Arillus Longan, controls palpitation and restlessness and the hypomnesis that heart spleen blood deficiency causes and people's intelligence is strengthened.The sweet temperature of Fructus Lycii, grow kidney and replenishing marrow, nourishing the liver to improve visual acuity goes wind, cloudy emerging sun to rise, it can yin nourishing, can supporing yangly be maximum characteristics and advantage again, so can control the prosperous disease such as have a dizzy spell of deficiency of the kidney yin, liver-yang.The Semen Phaseoli sweet in the mouth is acid flat, heat-clearing and toxic substances removing, diuretic detumescent, the red swelling of the skin that the Zhi Fanyin pyretic toxicity the causes diseases such as hepato-biliary function damage such as (comprising eyes), carbuncle sore tumefacting virus, jaundice of having a pain, the another name Semen Phaseoli of the non-jequirity of these product, the two acts on complete difference and the latter is poisonous should not take orally, must distinguish clear, can not use with.The Herba Menthae acrid in the mouth is cool in nature, refresh oneself's wind heat, controls the conjunctival congestion headache.Cold in nature, the liver heat removing removing heat from blood that makes eye bright of Folium Mori sweet-bitter flavor controls that conjunctival congestion is dizzy, the lung moistening removing heat from blood.Milk powder sweet in the mouth saltiness is flat, nourishing YIN Yiyang, please that face makes eye bright, vigorate qi and replenish the blood, controls the red and swollen puckery pain of binocular, makes eye bright, and curative effect is very good.Herba Portulacae acid is cold, heat-clearing and toxic substances removing, controls the blurring of vision that pyretic toxicity causes or gives birth to the nebula film and swell and ache.Folium Camelliae sinensis bitter in the mouth cold nature, resolving heat and reducing pathogenic fire are controlled diseases such as the vertigo, mental weariness.And above these just myopia be long-term excess eye-using, vision over loading and extremely tired, add all diseases due to the bad and accumulation of nutrition and environment such as light, reading habit etc.
Western modern medicine food aspect: vitamin A can be prevented and treated nyctalopia, conjunctival xerosis and keratomalacia: nyctalopia is exactly in night or the dark phenomenon of locating cannot see thing.Nyctalopia has two types, and a kind of is that the people of congenital night blindness, most of congenital night blindnesses is just blind after 40-50 year, and this nyctalopia does not also have effective Therapeutic Method at present.Another kind is the acquired night blindness of vitamin A deficiency.The people is at the dark place or see thing night, what lean on is rod cell on the retina, because containing, rod cell inside experiences material---the rhodopsin that the low light level stimulates, and one of primary raw material of synthetic rhodopsin is a vitamin A, so be understood that, if be deficient in vitamin in the diet A or gastrointestinal tract can not absorb vitamin A, cause rod cell not synthesize or synthetic rhodopsin not enough and cause nyctalopia, if in time replenish intravital vitamin A, acquired night blindness just can very fast healing; Vitamin A is to keep all epithelial tissue to perfect necessary nutrient substance, during shortage, epithelium drying, hypertrophy and keratinization are wherein influenced remarkable with the epithelium of eye etc.Because epithelial tissue is unsound, the ability of body opposing microbiological attack reduces, and catches easily; Because the lachrymal gland epithelium is unsound, secretion stops, so easily produce xerophthalmia; So vitamin A claims antixerophthalmic vitamin again.The symptom of xerophthalmia is cornea and conjunctival xerosis, inflammation, even keratomalacia and boring a hole.β-Hu square-bottomed bamboo basket Bu Su not only can change into vitamin A, again do not have the toxicity of VA and can accumulate in vivo and to the people harmless (as accumulate too much also only show skin slightly yellowing that is all, need only short-term stop using and can recover the former colour of skin rapidly), so the present invention is with its alternative part of V A, and when lacking, VA transforms rapidly with compensation VA, so tool regulate supplies double effects automatically.The bone in children abnormal development of vitamin D deficiency can cause narrow, the exophthalmos of a frame, causes ametropia.Vitamin B
1Lack and cause conjunctiva and corneal epithelium infringement causing xerophthalmia, retrobulbar neuritis, optic atrophy.Vitamin B
2Lack and to cause eyes many places inflammation such as keratitis (blood vessel hyperplasia, muddiness, fester), conjunctivitis, iritis, optic neuritis, scleral injection, even crystalline lens and vitreous opacity occur.Vitamin PP (nicotinic acid is that nicotinic acid and niacin amide are nicotiamide) lacks and causes neural malnutrition and neuritis, makes optic atrophy.Hypovitaminosis C cause intercellular substance such as collagen protein synthetic generation obstacle, wound appears and ulcer is difficult for healing; Capillary permeability increases, cause vitamin C deficiency such as subcutaneous, mucosa, hemorrhage of muscle, so can bring out eyeball and the accessory organs of eye official is hemorrhage, as serious consequences such as subretinal choroidal hemorrhage will cause losing one's sight, also can influence the healing of eye inflammation, macular hole etc.(it is a lot of that nucleic acid contains chromium for mineral calcium (bone strengthening) and trace element chromium, nucleic acid lacks and causes growth inhibited, chromium deficiency also causes insulin active low, concurrent hyperglycemia and the glycosuria on an empty stomach of comprising, because of energy shortage makes premunition that various ophthalmics lowly easily take place and looks disease, comprising also wherein that the direct harm of hyperglycemia such as retinal degeneration etc. are serious reduces vision and blinding pathological changes and is on the rise and extensively, especially old people Geng Yi lacks chromium, should pay much attention to especially) lack wall of eyeball elasticity is weakened, eye frame and optical fundus framework deformation and eye (looking) axle is elongated myopia takes place, and can not increase atrophy because of retina and choroid, be elongated, distortion, attenuation, finally cause retina to be pulled open and split formation macular hole (stating as follows), or choroidal rupture is hemorrhage cause losing one's sight (seeing above-mentioned), not only cause and deepen true myopia, vitreous opacity and liquefaction are shunk and cause also being pulled open and split and form macular hole by its retina that involves, grievous injury patient central vision dwindles as looking thing, distortion, even central vision complete obiteration, make many occupations that must rely on central vision and work as drive (because of central light loss can't be seen traffic signal, or because of image replacement or covering around the center image quilt, central vision is seen be in fact peripheral image be false center image and very easily lead to serious traffic safety accident), read and (seriously dwindle distortion, even cannot see any literal or the image of being watched attentively at all, all the other are identical with above-mentioned driving situation) etc. can't carry out at all, the vitreous humor of liquefaction that What is more leaks under the disruptive retina and constantly and enlarges, cause retina part even come off fully, as give treatment to untimely then blinding fully.Trace element-selenium is the same with vitamin C to be activated plurality of enzymes and enzyme system and is beneficial to element and vitamin Bs such as calcium (as the acidity of VC), chromium
1And vitamin B
2With the absorbing and bring into play effect, and strengthen effect mutually, of vitamin PP etc. as vitamin B
1Lack and cause vitamin B
2Output, increase, make the vitamin B in the in-vivo tissue in the urine
2Descend, vitimin supplement PP has prevented again because of vitimin supplement B
1The shortage of aggravation vitamin PP, thus make vitamin B group dosage keep balance etc., the improvement of vision is all had very great help mutually, so the helpfulness degree of association is very high.
Product of the present invention is made up of legal dietotherapeutic compound Chinese medicine 3-10 part, compound vitamin 1-3 part, compound microelement 0.01-0.1 part, calcium preparation 1-3 part; Wherein:
Compound Chinese medicine is made of in right amount Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part and milk powder;
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part are formed;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Compound calcium preparation is made up of calcium gluconate 3-5 part and calcium citrate 3-5 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
The manufacture method of product of the present invention is as follows:
The preparation of compound Chinese medicine:
A. decoction pieces type Chinese crude drug Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli (fragmentation) 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part are on the waiting list in the choosing of raw material Chinese medicine, join in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;
Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;
C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;
D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;
E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the medicinal residues that discard behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed are the acyclic dirts of agricultural soil high-quality fertilizer of returning crop stocks to the field, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;
F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;
G. the preparation of compound Chinese medicine is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, add Chinese medicine extraction liquid, be the solution dry matter content that concentration promotes and is 35-40% by milk powder 3-5 part and lactose 1-3 part part by weight, be spray dried into water content and get the compound Chinese medicine raw material below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Compacting (lactose and all very easily compression moulding of milk powder) becomes Any shape such as the sheet, grain, ball of 0.2-0.4 gram to get product, as food, nutriment, health product and medicine, advises oral every day 2-3 time, 0.4-0.8 restrains at every turn, need not the branch of crowd and dosage.
The preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
The preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
The preparation of product of the present invention: in sterilizing room, get compound Chinese medicine 1-3 part, compound vitamin 1-3 part, compound microelement 0.01-0.1 part, calcium preparation 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
Embodiment:
1, drinks 0.5 part of sheet type Chinese crude drug Radix Glycyrrhizae, 1.5 parts of Fructus Gardeniaes, 3 parts of Semen Cassiaes, 3 parts of Flos Chrysanthemis, 1.5 parts of Arillus Longans, 2 parts of Fructus Lyciis, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
2, drink 1.5 parts of sheet type Chinese crude drug Radix Glycyrrhizae, 10 parts of Semen Cassiaes, 4 parts of Fructus Lyciis, 5 parts of Flos Chrysanthemis, 3 parts of Semen Phaseolis (fragmentation), 0.5 part of Herba Menthae, 1 part on Folium Mori, 1 part of Herba Portulacae, 1 part of Folium Camelliae sinensis, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
3, drink 1 part of sheet type Chinese crude drug Radix Glycyrrhizae, 5 parts of Semen Cassiaes, 3 parts of Fructus Lyciis, 10 parts of Flos Chrysanthemis, 2 parts on Folium Mori, 3 parts of Herba Portulacaes, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
4, in sterilizing room, get 1 part of compound Chinese medicine, 1 part of compound vitamin, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
5, in sterilizing room, get 2 parts of compound Chinese medicines, 1 part of compound vitamin, 0.01 part of compound microelement, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
6, in sterilizing room, get 3 parts of compound Chinese medicines, 2 parts of compound vitamines, 0.03 part of compound microelement, 3 parts of calcium preparation, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
Supplementary copy inventive principle and advantage are as follows:
1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high; And form particularly favourite " acid is sour-sweet sweet " the popular taste products of children and easily being accepted of most crowds jointly with the acescency of the low sweet taste of lactose and calcium gluconate and calcium citrate, so service face and service group are the most extensive, its society and economic benefit are also just apparent naturally, and these also are the great novelty and the practicality of the legal approval of Patent Law.
2; the property of medicine of Chinese prescription medical material is with flat; cool; it is main and cold with flat rubber belting being slightly cold; also take into account simultaneously and liver (gallbladder); relevant other organ of order after one's own heart; lung; spleen; the protection of the function of kidney and coordination; make drug effect and function more comprehensive and mark; this double controlling; realized that Chinese medicine property of medicine general inclination is in gentle and promote the high boundary of drug effect mutually; potential side effect such as bringing " exceeding the proper limits in righting a wrong " impairment of YANG functional activities of the body fluid even new disease (traditional Chinese medical science is all understood this class situation in case occur often being difficult to control) have promptly been avoided controlling because of calentura is cold; especially can regulate simultaneously and of the application of Yin Yang balancing strength with the medicine of removing bias of medicine; thereby make the moon; sun balance of force and mutual regulating power all can reach balance and gentle; all kinds of diseases and ailments are spontaneous recovery; and because of the legal dietotherapeutic of all medical materials; effect certainly and do not have a toxic and side effects; be suitable for any crowd and serve wide, these just the present invention to the imbody of the wide main advantages of Chinese medicine adaptive surface.
3, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, and the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer has been opened up out Chinese medicine and debated disease and execute tool body content and range of application.
4, all medical materials all are conventional varieties and have no side effect, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.
5, innovate organic and inorganic mixed solvent and extract at room temperature and reclaim organic solvent and recycle molten and water-soluble substances and energy-conservation joint (cooling) water of Extraction oil with being beneficial to synchronously high-quality and high recovery rate, again with inorganic solvent and room temperature and high temperature combined extractive technique, scheme and technology, ensured extraction overall process asepticize, can carry substantially many to the greatest extent be insoluble in water or be insoluble in oil material and significantly improve drug effect and extract quality and content, and extraction ratio height, with short production cycle, energy-saving and water-saving, product cost is low, do not have (organic solvent) and pollute, its serial comprehensive advantage is traditional decocting and single with organic solvent or water or some other is because of expensive, highly difficult, the product of receiving single (fact proved and the generally acknowledged both at home and abroad compound composition extract of Chinese medicine than single composition extract good effect, this was exactly the essence and the inherent feature place of Chinese medicine originally and was determined by it), recovery rate low and short-term even long duration are difficult to that so-called modern Chinese medicine extractive technique that penetration and promotion uses is difficult to mention in the same breath.
6, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, because adopt lactose to replace the starch of easily digesting and assimilating and dextrin is made adsorbent and filler can significantly slow down the medicine slow release speed and avoid taking a very Peter Pans historic difficult problem beyond affordability of traditional decocting Chinese medicine amount, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.
Test method, data and presentation of results and prompting:
Disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, experimenter's voluntary participation.Product of the present invention because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and please understand allow keeping in Patent Law about situation: different sexes, age 12-17 the year totally 80 of teenager experimenters, it is 4 groups that 20 people are divided into for one group.Two groups of visions normal (more than 1.0), wherein one group near-sighted with compound Chinese medicine product of the present invention and usage and dosage control, another organizes not medication and compares; Two groups of visions undesired (1.0 below) in addition, wherein one group simultaneously with Chinese medicine and western medicine product of the present invention and usage and dosage prevent and treat near-sighted, another organizes not medication and compares; Test period be from the new term begins one week of back before have a holiday or vacation January so that observation and avoid reviewing examination and influence to alleviate the fulminant pseudomyopia with the extreme stage of eye.Test number and time on test reach 4 first quarter moons, tool statistical significance so suitable representativeness and credibility are arranged.The result is as follows: no matter myopia whether when the experimenter begins to test, only there are 5 people to find visual deterioration but none routine fall surpasses 0.2 with two test group personnel of product of the present invention, 15 people's vision no changes are arranged, 20 people's eyesight improvings are arranged, go up not down, and increasing degree reaches 0.1-0.3 and do not wait; No matter whether myopia when the matched group experimenter began to test, find that visual deterioration 32 people and 23 people decrease by 0.2-0.3, only 8 people's vision no changes, none eyesight improving, the person of going up not down arranged.
Prompting: over-burden and myopia takes place by the age and the objective reality fact of the general trend that more and more becomes younger and more and more huger near-sighted crowd's ratio according to China's adolescents with learning, it is (no matter true with regard to having proved absolutely product control myopia of the present invention not descend as vision after 12 years old, pseudomyopia, can prevent or alleviate its intensification to true myopia, principle is seen below and is stated) effectively, the explanation product of the present invention control myopia that goes up not down especially easily develops into true myopia and to deepen the pseudomyopia of true myopia degree effective equally, and increasing degree (illustrate that pseudomyopia is able to effective alleviation) and number explanation to prevent and treat near-sighted effect remarkable.
Claims (3)
1, Chinese and western medical is made up of dietotherapeutic compound Chinese medicine 3-10 part, compound vitamin 1-3 part, compound microelement 0.01-0.1 part, calcium preparation 1-3 part in conjunction with pre-myopia prevention medicine-food two-purpose goods; Wherein:
Compound Chinese medicine is made of in right amount Radix Glycyrrhizae 0.5-1.5 part, Semen Cassiae 3-10 part, Fructus Lycii 2-4 part, Flos Chrysanthemi 3-10 part, Fructus Gardeniae 0-3 part, Arillus Longan 0-3 part, Semen Phaseoli 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part and milk powder;
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part are formed;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Compound calcium preparation is made up of calcium gluconate 3-5 part and calcium citrate 3-5 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
2, Chinese and western medical is as follows in conjunction with the manufacture method of pre-myopia prevention medicine-food two-purpose goods:
A. the preparation of compound Chinese medicine:
A. decoction pieces type Chinese crude drug Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli (fragmentation) 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part are on the waiting list in the choosing of raw material Chinese medicine, join in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;
Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;
C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;
D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;
E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the medicinal residues that discard behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed are the acyclic dirts of agricultural soil high-quality fertilizer of returning crop stocks to the field, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;
F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;
G. the preparation of compound Chinese medicine is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, add Chinese medicine extraction liquid, be the solution dry matter content that concentration promotes and is 35-40% by milk powder 3-5 part and lactose 1-3 part part by weight, be spray dried into water content and get the compound Chinese medicine raw material below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Compacting (lactose and all very easily compression moulding of milk powder) becomes Any shape such as the sheet, grain, ball of 0.2-0.4 gram to get product, as food, nutriment, health product and medicine, advises oral every day 2-3 time, 0.4-0.8 restrains at every turn, need not the branch of crowd and dosage.
B. the preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
C. the preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
D. the preparation of the pre-myopia prevention medicine-food two-purpose goods of Chinese and western medical combination: in sterilizing room, get compound Chinese medicine 1-3 part, compound vitamin 1-3 part, compound microelement 0.01-0.1 part, calcium preparation 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
3, the purposes of the pre-myopia prevention medicine-food two-purpose goods of Chinese and western medical combination: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510136568 CN100536880C (en) | 2005-12-29 | 2005-12-29 | Application for combination for preparing food dual purpose Chinese and western medicine combined product for preventing myopia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510136568 CN100536880C (en) | 2005-12-29 | 2005-12-29 | Application for combination for preparing food dual purpose Chinese and western medicine combined product for preventing myopia |
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| CN100536880C CN100536880C (en) | 2009-09-09 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100384456C (en) * | 2005-12-29 | 2008-04-30 | 颜怀伟 | Medicine and food dual purpose product for preventing pseudomyopia and true myopia and its manufacturing method |
| CN1824064B (en) * | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of composition in preparing nutrients with edible and medicinal function for treating pseudomyopia |
| CN1824052B (en) * | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of composition in preparing product for preventing pseudomyopia and true myopia |
| CN1824057B (en) * | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of Chinese and western medicine combined composition for preparing product with edible and medicine function for treating nightblindness |
| CN1824025B (en) * | 2005-12-29 | 2010-06-23 | 颜怀伟 | Applicaiton of a Chinese-western medicine combined composition for preparing medicine and frod dual purpose nutrient for preventing frue myopia |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075878A (en) | 1992-02-29 | 1993-09-08 | 南京医学院第一附属医院 | Nutritious liquid for eyesight |
| CN1824063B (en) | 2005-12-29 | 2010-12-29 | 颜怀伟 | Medicine and food dual purpose Chinese and western medicine combined product for preventing and trecting pseudomyopia |
| CN1824064B (en) | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of composition in preparing nutrients with edible and medicinal function for treating pseudomyopia |
| CN1824052B (en) | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of composition in preparing product for preventing pseudomyopia and true myopia |
| CN1824025B (en) | 2005-12-29 | 2010-06-23 | 颜怀伟 | Applicaiton of a Chinese-western medicine combined composition for preparing medicine and frod dual purpose nutrient for preventing frue myopia |
| CN1824061B (en) | 2005-12-29 | 2010-12-08 | 颜怀伟 | Application of a combination for preparing medicine and food dual purpose nutrient for preventing true myopia |
| CN1824057B (en) | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of Chinese and western medicine combined composition for preparing product with edible and medicine function for treating nightblindness |
| CN100546610C (en) | 2005-12-29 | 2009-10-07 | 颜怀伟 | Pre-myopia prevention medicine-food two-purpose product and manufacture method |
| CN100384456C (en) | 2005-12-29 | 2008-04-30 | 颜怀伟 | Medicine and food dual purpose product for preventing pseudomyopia and true myopia and its manufacturing method |
| CN1824059B (en) | 2005-12-29 | 2010-11-10 | 颜怀伟 | Use of nutritive product for preventing and treating nightblindness |
-
2005
- 2005-12-29 CN CN 200510136568 patent/CN100536880C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384456C (en) * | 2005-12-29 | 2008-04-30 | 颜怀伟 | Medicine and food dual purpose product for preventing pseudomyopia and true myopia and its manufacturing method |
| CN1824064B (en) * | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of composition in preparing nutrients with edible and medicinal function for treating pseudomyopia |
| CN1824052B (en) * | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of composition in preparing product for preventing pseudomyopia and true myopia |
| CN1824057B (en) * | 2005-12-29 | 2010-06-09 | 颜怀伟 | Use of Chinese and western medicine combined composition for preparing product with edible and medicine function for treating nightblindness |
| CN1824025B (en) * | 2005-12-29 | 2010-06-23 | 颜怀伟 | Applicaiton of a Chinese-western medicine combined composition for preparing medicine and frod dual purpose nutrient for preventing frue myopia |
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| Publication number | Publication date |
|---|---|
| CN100536880C (en) | 2009-09-09 |
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Address after: No. two, section 17, West Ring Road, Chengdu, Sichuan Patentee after: Yan Huaiwei Address before: Jili Industrial Zone, national hi tech Zone, Chancheng District, Foshan, Guangdong Patentee before: Yan Huaiwei |
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