CN1331530C - Medicinal preparation for treating stomach and intestine diseases and its preparing method - Google Patents
Medicinal preparation for treating stomach and intestine diseases and its preparing method Download PDFInfo
- Publication number
- CN1331530C CN1331530C CNB2005102005157A CN200510200515A CN1331530C CN 1331530 C CN1331530 C CN 1331530C CN B2005102005157 A CNB2005102005157 A CN B2005102005157A CN 200510200515 A CN200510200515 A CN 200510200515A CN 1331530 C CN1331530 C CN 1331530C
- Authority
- CN
- China
- Prior art keywords
- tannalbin
- granule
- aluminium silicate
- starch
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a medicinal preparation for treating gastric and intestinal diseases and a preparing method thereof. The medicinal preparation is prepared from berberine hydrochloride, chlorpheniramine maleate, thiamine nitrate, tannalbin, ethacridine lactate, aluminium silicate, starch, magnesium stearate and ethanol. The medicine of the present invention can be mainly used for treating diseases, such as dysentery, acute and chronic gastroenteritis, acute and chronic diarrhea, abnormal fermentation in intestines, etc. Compared with the prior art, the present invention has the advantages of good therapeutic effect, no toxic or side effect, safe admittance, etc.
Description
Technical field: the present invention relates to a kind of pharmaceutical preparation for the treatment of stomach, intestinal diseases and preparation method thereof, belong to technical field of medicaments.
Background technology: diarrhoea is a kind of common sympton in the digestive system disease, means defecation frequency more than at ordinary times, and feces is thin, and water content increases, and lipotrophy sometimes has the indigestion thing, or contains pus and blood.At present, a lot of treatment diarrheal medicines have appearred on the market, but most therapeutic effect is undesirable or exist bigger side effect, as furazolidone, be acknowledged as the acute and chronic diarrhoea of treatment, the good medicine of bacillary dysentery, but its side effect is bigger, can occur gastrointestinal upset after taking, feel sick, drug reactiones such as vomiting, polyneuritis, allergic rash, allergic dermatitis, allergic asthma, extremely serious toxic reaction also can take place in indivedual infants.
Summary of the invention:
The objective of the invention is to: a kind of pharmaceutical preparation for the treatment of stomach, intestinal diseases and preparation method thereof is provided, and medicine of the present invention is to acute and chronic diarrhoea, and the therapeutic effect of dysentery is good, and has no side effect, and takes safety, to solve the problem that prior art exists.
The present invention is achieved in that according to listed as parts by weight it adds suitable adjuvant for 30～60 parts by 100～150 parts of berberine hydrochloride, 1～3 part of chlorphenamine maleate, 3～7 parts of thiamine mononitrates, 200～400 parts of tannalbin, 20～50 parts of ethacridine lactate and aluminium silicate and is prepared from.Say accurately, calculate according to weight, it is prepared into capsule preparations by berberine hydrochloride 120g, chlorphenamine maleate 2g, thiamine mononitrate 5g, tannalbin 300g, ethacridine lactate 30g, aluminium silicate 43g, starch 12.5g, magnesium stearate 2.5g and ethanol 200g; Described preparation can also be prepared into except capsule: tablet, soft capsule, granule, drop pill, oral liquid or syrup.
The preparation method that the present invention treats the pharmaceutical preparation of stomach, intestinal diseases is: it is standby to take by weighing berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and starch or sucrose; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and starch or sucrose, pulverize successively, cross 40～80 mesh sieves, mixing, the ethanol of adding 70%～85% is as wetting agent, stir and made soft material in 20～40 minutes, above-mentioned soft material is made granule by 14～40 order stainless steel meshs, under 40～100 ℃, dry to the granule water content below 4%, the granule of above-mentioned oven dry is ground into fine powder, cross 40～80 mesh sieves, add magnesium stearate, mixing promptly gets the effective ingredient of medicine of the present invention, and the effective ingredient that obtains is added the adjuvant that needs, be prepared into capsule according to conventional method, tablet, granular preparation.
The preparation method that the present invention treats the pharmaceutical preparation of stomach, intestinal diseases is: take by weighing berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate, mixing, promptly get the effective ingredient of medicine of the present invention, the effective ingredient that obtains is added the adjuvant that needs, is prepared into soft capsule, drop pill, oral solutions and syrup preparation according to conventional method.
The present invention treats stomach, the capsule of intestinal diseases medicine is preparation like this: take by weighing berberine hydrochloride 120g, chlorphenamine maleate 2g, thiamine mononitrate 5g, tannalbin 300g, ethacridine lactate 30g, aluminium silicate 43g, starch 12.5g, magnesium stearate 2.5g and ethanol 200g, with berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and starch mixing, the ethanol of adding 75% is as wetting agent, stir and made soft material in 30 minutes, above-mentioned soft material is made granule by 20 order stainless steel meshs, under 80 ℃, dry to the granule water content below 4%, the granule of above-mentioned oven dry is ground into fine powder, cross 60 mesh sieves, add magnesium stearate, mixing, encapsulated, make 1000, promptly.
Berberine hydrochloride among the present invention is an antimicrobial drug, be the phellodendron bark extracting and refining and alkaloid, tool is good for the stomach, the effect of whole intestinal, antibiotic, antiinflammatory, can suppress the breeding of various disease carrying germs, Gram-positive and negative bacteria, dysentery bacterium, escherichia coli etc. there are stronger inhibitory action, especially effective to coliform enteritis and enteral abnormal fermentation.
Tannalbin and aluminium silicate are good adsorption and only hold back medicine, and thiamine mononitrate is used in time replenishing body needs when stomach, enteritis and diarrhoea take place.Simultaneously, it has the auxiliary treatment effect to dyspeptic treatment.Wherein tannalbin is formed by tannic acid and protein bound, goes into the effect that enteral can be brought into play convergence, antiinflammatory, secretion inhibitor, and does not decompose at gastric the clothes back, decomposite tannic acid to small intestinal, make protein coagulation, the astringing to arrest diarrhea effect is arranged, be used for acute gastroenteritis, non-bacterial diarrhoea.
Ethacridine lactate has the effect of treatment bloody dysentery and bacillary intestinal illness, and chlorphenamine maleate is an antihistaminic, can suppress gastrointestinal smooth muscle and shrink, thereby suppress enterokinesia.Wherein ethacridine lactate is a sterilization antiseptic, can suppress gram positive bacteria, mainly is coccus, especially streptococcus; Chlorphenamine maleate is powerful hydryllin, and is all effective with treatment to the prevention of various anaphylaxis illness.
Medicine of the present invention is mainly used in treatment of conditions such as dysentery, acute/chronic gastroenteritis, acute and chronic diarrhea, enteral abnormal fermentation, and compared with prior art, the present invention has good effect, has no side effect, and takes safe advantage.
Below be the clinical observation on the therapeutic effect of this product:
The applicant adopts this product berberine compound tannalbin capsule acute and chronic diarrhea totally 70 examples in the 6-10 month in 1998 at Hospital Attached to Guiyang Medical College's contagious department; Furazolidone treatment acute and chronic diarrhea 30 examples are in contrast, and are existing that the clinical observation material brief summary is as follows:
One, case is selected: case is selected from is in hospital and the outpatient, meets high medical college teaching material " lemology ", " internal medicine " the 4th edition diagnosis and typing standard.Inclusion criteria is as follows:
1. acute enteritis: the course of disease＜February, stomachache, diarrhoea, yellow rare watery stool, number of times＞4 time/day, the stool routine examination microscopy: WBC number＜15/HP, stool is cultivated negative.
2. acute bacillary dysentery: the course of disease＜February, stomachache, diarrhoea, mucopurulent bloody stool, tenesmus has or does not have heating.The left abdomen tenderness.The stool routine examination microscopy: WBC number＞15/HP, or pus cell is arranged, macrophage.Stool is cultivated to have or do not have and detects: dysentery bacterium.
3. chronic enteritis: the course of disease＞February, stomachache repeatedly, diarrhoea, stool character, number of times, routine examination is with acute.
Two, physical data: several 70 examples of the total example of treatment group, male's 45 examples, women's 25 examples, age 16? 8 years old, acute enteritis 45 examples wherein, acute bacterial enteritis 15 examples, chronic enteritis 10 examples.Matched group case sum 30 examples, male's 20 examples, women's 10 examples, 16～52 years old age, acute enteritis 15 examples wherein, acute bacillary dysentery 9 examples, chronic enteritis 6 examples.Two groups of acute diarrhea courses of disease all＜5 days, chronic diarrhea course of disease February～1 year.
Three, Therapeutic Method: the treatment group is with this product berberine compound tannalbin capsule 1～2 capsule, and is oral, 1～2 time/day.The course of treatment, acute 5 days, chronic 10～15 days.Matched group is with furazolidone 0.1 gram, and is oral, 3 times/day.The course of treatment, acute 7 days, chronic 10～15 days.Except that vitamin medicaments and anti symptom treatment, two groups all without other antiinflammatory, convergence, antidiarrheal during the treatment.
Four, matched group selects pharmacology by reaching two groups of medicine sources:
1. furazolidone is the furans antibiotic, and to enterobacteriaceae, the bacillary dysentery bacillus has stronger effect, has astriction simultaneously, is the good medicine of the acute and chronic diarrhoea of accepted treatment, bacillary dysentery.Furazolidone derives from Hospital Attached to Guiyang Medical College's pharmaceutical chemists and sells, specification 0.1 gram/sheet.
2. be subjected to the reagent thing: this product berberine compound tannalbin capsule derives from Guizhou-Finder Pharmaceutical Co., Ltd. and produces, specification 10 capsules/plate.
Five, lab testing: two groups of equal stool routine examinations and cultivate each once before medication and after one course of treatment of medication.
Six, observation table and recording method: formulate unified form, unified standard, the definite and efficacy determination of diagnosis is made jointly by attending doctor, chief physician, if any untoward reaction, records faithfully on the observation table.
MAIN OUTCOME MEASURES: stomachache, diarrhoea (number of times/sky, character), abdominal distention, nauseating, vomiting, heating, routine blood test.Stool routine examination, stool are cultivated, untoward reaction.
Seven, curative effect determinate standard: cultivate five indices with heating, stomachache, diarrhoea, stool routine examination, stool and determine:
1. clinical cure: in the acute case 5 days, These parameters is cloudy in 10 days changes for chronic case.
2. effective: in the acute case 10 days, These parameters is cloudy in 15 days changes for chronic case.
3. invalid: as can not to reach above-mentioned standard.
Eight, result: 70 routine patients are organized in treatment, the whole healing of acute case 60 examples, and chronic 10 examples have 6 examples to cure, and 2 examples are effective, total effective rate 97%.Matched group 30 examples, the whole healing of acute 24 examples, chronic 6 examples have 3 examples to cure, and 2 examples are effective, total effective rate 96.67%.Two groups of curative effect situations see Table 1.
Table 1 this product berberine compound tannalbin capsule for treating acute and chronic diarrhea curative effect
| The example number | The treatment group | Matched group | ||||||
| Cure (%) | Effectively (%) | Invalid (%) | The example number | Cure (%) | Effectively (%) | Invalid (%) | ||
| Acute enteritis | 45 | 45(100 ％) | 0 | 0 | 15 | 15(100 ％) | 0 | ?0 |
| Acute dysentery | 15 | 15(100 ％) | 0 | 0 | 9 | 9(100％) | 0 | ?0 |
| Chronic enteritis | 10 | 6(60％) | 2(20％) | 2(20％) | 6 | 3(50％) | 2(23％) | ?1(17％) |
The capsular acute toxicity test of this product berberine compound tannalbin:
This product berberine compound tannalbin capsule is provided lot number by Guizhou-Finder Pharmaceutical Co., Ltd.: 960812, and during experiment the capsule content is added a small amount of Tween 80 and make suspension.
Laboratory mice is provided by Third Military Medical University, the quality certification: 24301048, and its mouse oral LD50 measures, and it the results are shown in Table 2.
Kunming mouse, body weight 19～22g, experiment divides 5 groups, and 10 every group, ♂ ♀ half and half, the design of dosage geometric ratio.A gastric infusion, the filling gastric capacity is 0.3ml/10g, observes 7 days.Before the animal dead, move, close order, prostrate less, the dead did not recover after 24 hours.Try to achieve LD50=1.82g/kg by karber's method, the 95% credible 1.60～2.07g/kg that is limited to.
Table 2 berberine compound tannalbin capsule its mouse oral LD50 measurement result
| Group | Dosage (ml/mg) | Number of animals (only) | Dead animal number (only) |
| 1 | 0.50 | 10 | 0 |
| 2 | 0.90 | 10 | 3 |
| 3 | 1.62 | 10 | 6 |
| 4 | 2.916 | 10 | 7 |
| 5 | 5.249 | 10 | 10 |
This product berberine compound tannalbin capsule test of pesticide effectiveness:
This product berberine compound tannalbin capsule is produced lot number by Guizhou-Finder Pharmaceutical Co., Ltd.: 960812, and Oleum Ricini is that Tianmen, Hubei medication chemistry factory produces lot number: 891002; It is state-run Wujin, Jiangsu pharmaceutical factory product that R-1132 is called for short " sweet smell ", lot number: 910105; Laboratory mice is provided by Third Military Medical University.The quality certification: 24301048.
One, mice antidiarrheal test: earlier with 40 of no loose stool mices, body weight 24～28g, ♂ ♀ half and half, be divided into 4 groups at random, every group 10, the every Mus ig of elder generation Oleum Ricini 0.15ml/10g, after 15 minutes, the cold boiled water 0.3ml/10g of diarrhea inducing model control group ig, diarrhea " sweet smell " matched group ig " sweet smell " suspension (5mg/10ml) 0.1ml/10g: berberine compound tannalbin capsule I group ig berberine compound tannalbin capsule 5% suspension 0.1ml/10g, II group ig 2.5% suspension 0.1ml/10g, record is respectively organized mice and is done on time, soft, the loose stool number, trying to achieve different time respectively organizes Mus and does, soft, loose stool respectively accounts for the feces sum] percentage ratio, experimental result sees Table 3.The result shows that this product berberine compound tannalbin capsule has anti-diarrhea effect, but intensity is not as compound diphenoxylate.
Table 3 berberine compound tannalbin capsule is to Oleum Ricini induced mice diarrheal anti-diarrhea effect
| Feces number and percentage ratio | ||||||||||||
| Group | 2 | 4 | 6 | 8 | ||||||||
| Do | Soft | Rare | Do | Soft | Rare | Do | Soft | Rare | Do | Soft | Rare | |
| The contrast of diarrhea inducing model | 7 | 14 | 20 | 4 | 11 | 22 | 0 | 6 | 23 | 2 | 4 | 10 |
| 17.04 ％ | 34.15 ％ | 48.78 ％ | 10.81 ％ | 29.73 ％ | 59.50 ％ | 0％ | 20.69 ％ | 79.31 ％ | 12.50 ％ | 25.00 ％ | 62.50 ％ | |
| Berberine compound tannalbin capsule I | 14 | 8 | 18 | 14 | 10 | 14 | 6 | 10 | 18 | 4 | 4 | 6 |
| 35.00 ％ | 20.00 ％ | 45.00 ％ | 36.84 ％ | 26.32 ％ | 36.84 ％ | 17.65 ％ | 24.41 ％ | 52.94 ％ | 28.57 ％ | 28.57 ％ | 42.86 ％ | |
| 12 | 9 | 14 | 12 | 8 | 10 | 7 | 12 | 16 | 6 | 7 | 8 | |
| Berberine compound tannalbin capsule II | 34.29 ％ | 25.71 ％ | 40.00 ％ | 40.00 ％ | 26.67 ％ | 33.33 ％ | 20.00 ％ | 34.29 ％ | 45.71 ％ | 28.57 ％ | 33.33 ％ | 38.10 ％ |
| The fragrant ester in ground | 10 | 0 | 0 | 15 | 6 | 7 | 8 | 40 | 14 | 10 | 4 | 4 |
| 100％ | 0％ | 0％ | 53.57 ％ | 21.43 ％ | 25.00 | 30.77 ％ | 15.38 ％ | 53.85 ％ | 55.56 ％ | 22.22 ％ | 22.22 ％ | |
Two, this product berberine compound tannalbin capsule bacteriostatic test:
1, strain: Fu Shi shigella dysenteriae, enteropathogenic E.Coli (EPEL).
2, culture medium: nutrient agar.
Method and result:
(1) bacteriostatic test:
1, becomes 1: 5 with sterile purified water dilution reagent.
2, get each strain separate application inoculation nutrient agar panel after, on nutrient agar panel, punch, the aperture is 5mm.
3, will dilute reagent and be added in the hole, and put to cultivate in 37 ℃ of incubators and observed and the record result in 24 hours.
4, result: dilution berberine compound tannalbin capsule had tangible bacteriostasis (table 4) to Fu Shi shigella dysenteriae and enteropathogenic E.Coli in 1: 10
Table 4 berberine compound tannalbin capsule bacteriostatic test result
| Strain | Antibacterial circle diameter (mm) |
| The Ge Shi shigella dysenteriae | 14 |
| Enteropathogenic E.Coli | 12 |
Annotate: twice result of the test average.
(2) minimum inhibitory concentration (MIC) test:
1, with adding mixing in the nutrient agar behind sterile purified water dilution this product berberine compound tannalbin capsule, making the reagent final concentration is 1: 5,1: 10,1: 100,1: 200,1: 800,1: 1000, pour plate.
2, dilute each strain with sterile saline, make 100,000,000/ml bacterium liquid.
3, get each bacterium liquid one ring respectively with inoculating loop, be inoculated on the culture medium that contains the variable concentrations reagent, put to cultivate in 37 ℃ of incubators and observe after 24 hours and the record result.
4, result: observing bacterial growth situation on the culture medium, is the minimum inhibitory concentration (MIC) (table 5) of this medicine with the high dilution of the reagent of integral asepsis growth
Table 5 this product berberine compound tannalbin capsule minimum inhibitory concentration (MIC) result of the test
| By reagent dilution factor and bacterial growth situation | ||||||||
| Strain | 1∶5 | 1∶10 | 1∶100 | 1∶200 | 1∶400 | 1∶800 | 1∶1000 | MIC |
| The Fu Shi shigella dysenteriae | - | - | - | - | - | + | + | 1∶400 |
| Enteropathogenic E.Coli | - | - | - | + | + | + | + | 1∶100 |
Annotate :+bacteria growing arranged;-asepsis growth.
(3) minimum bactericidal concentration (MBC) test:
1, extracts the inoculated bacteria place medium agar piece of integral asepsis growth in the MIC test, be inoculated on the nutrient agar that does not contain reagent.
2, put the interior cultivation of 37 ℃ of incubators after 24 hours, observe also record result.
3, result: observing bacterial growth situation on the culture medium, is the minimum bactericidal concentration (MBC) (table 6) of this medicine with the high dilution of the reagent of integral asepsis growth
Table 6 this product berberine compound tannalbin capsule minimum bactericidal concentration (MBC) result of the test
| Strain | 1∶5 | 1∶10 | 1∶100 | 1∶200 | 1∶1000 | MBC |
| The Fu Shi shigella dysenteriae | - | + | + | + | + | 1∶5 |
| Enteropathogenic E.Coli | - | + | + | - | - | 1∶5 |
Annotate :+bacteria growing arranged;-asepsis growth.
In sum, this product berberine compound tannalbin capsule has certain anti-diarrhea effect to Oleum Ricini induced mice diarrhoea, but action intensity is not as compound diphenoxylate; This product berberine compound tannalbin capsule has tangible bacteriostasis (MIC is respectively: Fu Shi shigella dysenteriae 1: 400, enteropathogenic E.Coli 1: 100) and bactericidal action (MBC is respectively: Fu Shi shigella dysenteriae 1: 5. enteropathogenic E.Coli is 1: 5) to Fu Shi shigella dysenteriae and enteropathogenic E.Coli.
The specific embodiment:
Embodiments of the invention 1: take by weighing berberine hydrochloride 120g, chlorphenamine maleate 2g, thiamine mononitrate 5g, tannalbin 300g, ethacridine lactate 30g, aluminium silicate 43g, starch 12.5g, magnesium stearate 2.5g and ethanol 200g, with berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and starch mixing, the ethanol of adding 75% is as wetting agent, stir and made soft material in 30 minutes, above-mentioned soft material is made granule by 20 order stainless steel meshs, under 80 ℃, dry to the granule water content 3%～4%, the granule of above-mentioned oven dry is ground into fine powder, cross 60 mesh sieves, add magnesium stearate, mixing, encapsulated, make 1000, promptly get capsule of the present invention.This product content is faint yellow to yellow powder or granule, and every dress 0.5g is oral, 1～2 time on the one, is grown up each 1, children's: 8～15 years old: each 1/2 or follow the doctor's advice.
Embodiments of the invention 2: take by weighing berberine hydrochloride 100g, chlorphenamine maleate 1g, thiamine mononitrate 3g, tannalbin 200g, ethacridine lactate 20g, aluminium silicate 30g, starch 10g, magnesium stearate 1g part and ethanol 100g, standby; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and starch, mixing, the ethanol of adding 70% stirs and made soft material in 20 minutes as wetting agent, above-mentioned soft material is made granule by 14 order stainless steel meshs, under 40 ℃, dry to the granule water content below 4%, granulate adds magnesium stearate, cross 40 mesh sieves, mixing is pressed into 1000, promptly gets tablet of the present invention.
Embodiments of the invention 3: take by weighing berberine hydrochloride 150g, chlorphenamine maleate 3g, thiamine mononitrate 7g, tannalbin 400g, ethacridine lactate 50g, aluminium silicate 60g, starch 15g, magnesium stearate 5g and ethanol 300g, standby; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and starch, mixing adds tween 80 and propylene glycol, mixing by the total amount of making then, with being pressed into 1000 of soft capsules after the colloid mill grinding, promptly obtain soft capsule of the present invention.
Embodiments of the invention 4: it is standby to take by weighing berberine hydrochloride 120g, chlorphenamine maleate 2g, thiamine mononitrate 5g, tannalbin 250g, ethacridine lactate 30g, aluminium silicate 40g, starch 1.2Kg, sucrose 4Kg and ethanol 1.8Kg; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate starch 1.2Kg, sucrose 4Kg and ethanol 1.8Kg, pulverize successively, cross 60 mesh sieves, mixing, add 80% ethanol as wetting agent, stir and made soft material in 25 minutes, above-mentioned soft material is made granule by 20 order stainless steel meshs, under 60 ℃, dry to the granule water content below 4%, the granule of above-mentioned oven dry is crossed 20 mesh sieves, granulate, mixing, be distributed into 1000 bags, promptly get granule of the present invention.
Embodiments of the invention 5: take by weighing berberine hydrochloride 140g, chlorphenamine maleate 3g, thiamine mononitrate 6g, tannalbin 380g, ethacridine lactate 45g, aluminium silicate 50g are standby; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate, cross 80 mesh sieves, mixing adds vegetable oil substrate, and pill promptly gets drop pill of the present invention.
Embodiments of the invention 6: it is standby to take by weighing berberine hydrochloride 100g, chlorphenamine maleate 1g, thiamine mononitrate 3g, tannalbin 200g, ethacridine lactate 20g, aluminium silicate 30g and sucrose 2.6Kg; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and sucrose, pulverize successively, cross 80 mesh sieves, mixing adds solvent and sorbic acid, and mixing promptly gets oral liquid formulations of the present invention.
Embodiments of the invention 7: take by weighing berberine hydrochloride 150g, chlorphenamine maleate 3g, thiamine mononitrate 7g, tannalbin 400g, ethacridine lactate 50g, aluminium silicate 60g, sucrose 2.6Kg is standby; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and sucrose, pulverize successively, cross 80 mesh sieves, mixing adds glycerol then and grinds well back adding solvent, and mixing promptly gets syrup of the present invention.
Claims (3)
1. pharmaceutical preparation for the treatment of stomach, intestinal diseases, it is characterized in that: calculate according to weight, it is prepared into capsule, tablet, soft capsule, granule, drop pill, oral liquid or syrup by berberine hydrochloride 120g, chlorphenamine maleate 2g, thiamine mononitrate 5g, tannalbin 300g, ethacridine lactate 30g, aluminium silicate 43g, starch 12.5g, magnesium stearate 2.5g and ethanol 200g.
2. treat the preparation method of the pharmaceutical preparation of stomach, intestinal diseases according to claim 1, it is characterized in that: it is standby to take by weighing berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and starch or sucrose; Get berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate and aluminium silicate and starch or sucrose, pulverize successively, cross 40～80 mesh sieves, mixing, the ethanol of adding 70%～85% is as wetting agent, stir and made soft material in 20～40 minutes, above-mentioned soft material is made granule by 14～40 order stainless steel meshs, under 40～100 ℃, dry to the granule water content below 4%, the granule of above-mentioned oven dry is ground into fine powder, cross 40～80 mesh sieves, add magnesium stearate, mixing promptly gets the effective ingredient of medicine of the present invention, and the effective ingredient that obtains is added the adjuvant that needs, be prepared into according to conventional method.
3. according to the described treatment stomach of claim 2, the preparation method of the pharmaceutical preparation of intestinal diseases, it is characterized in that: take by weighing berberine hydrochloride 120g, chlorphenamine maleate 2g, thiamine mononitrate 5g, tannalbin 300g, ethacridine lactate 30g, aluminium silicate 43g, starch 12.5g, magnesium stearate 2.5g and ethanol 200g, with berberine hydrochloride, chlorphenamine maleate, thiamine mononitrate, tannalbin, ethacridine lactate, aluminium silicate and starch mixing, the ethanol of adding 75% is as wetting agent, stir and made soft material in 30 minutes, above-mentioned soft material is made granule by 20 order stainless steel meshs, under 80 ℃, dry to the granule water content below 4%, the granule of above-mentioned oven dry is ground into fine powder, cross 60 mesh sieves, add magnesium stearate, mixing, encapsulated, make 1000, promptly get capsule of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005102005157A CN1331530C (en) | 2005-09-06 | 2005-09-06 | Medicinal preparation for treating stomach and intestine diseases and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005102005157A CN1331530C (en) | 2005-09-06 | 2005-09-06 | Medicinal preparation for treating stomach and intestine diseases and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1781548A CN1781548A (en) | 2006-06-07 |
| CN1331530C true CN1331530C (en) | 2007-08-15 |
Family
ID=36772419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005102005157A Expired - Fee Related CN1331530C (en) | 2005-09-06 | 2005-09-06 | Medicinal preparation for treating stomach and intestine diseases and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1331530C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066446B (en) * | 2007-06-29 | 2013-08-07 | 王忠玉 | Chinese medicine composition for treating enteritis |
| CN111053886A (en) * | 2020-01-10 | 2020-04-24 | 河南天昊鸿发生物技术有限公司 | Traditional Chinese medicine additive for treating poultry intestinal diseases, pharmaceutical composition containing traditional Chinese medicine additive, and preparation method and application of pharmaceutical composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170581C (en) * | 2002-11-26 | 2004-10-13 | 贵州神奇制药有限公司 | Medicine for treating intestinal diseases |
-
2005
- 2005-09-06 CN CNB2005102005157A patent/CN1331530C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170581C (en) * | 2002-11-26 | 2004-10-13 | 贵州神奇制药有限公司 | Medicine for treating intestinal diseases |
Non-Patent Citations (3)
| Title |
|---|
| 腹泻与止泻药 张石革，中国药房，第12卷第8期 2001 * |
| 腹泻与止泻药 张石革，中国药房，第12卷第8期 2001;鞣酸小檗碱的制备工业改进 刘文江 等，中国医药工业杂志，第29卷第6期 1998 * |
| 鞣酸小檗碱的制备工业改进 刘文江 等，中国医药工业杂志，第29卷第6期 1998 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1781548A (en) | 2006-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1119154C (en) | Live triple bifidobacteria preparation and preparing method thereof | |
| CN100553665C (en) | A kind of Chinese medicine medicine for the treatment of pharyngolaryngitis | |
| CN106389479B (en) | Application of bacillus coagulans in preparation of preparation for preventing or treating autism | |
| CN102836367B (en) | Bacteria-resisting, inflammation-diminishing and itching-relieving traditional Chinese medicine composition and preparation method and application thereof | |
| CN106822890A (en) | A kind of pharmaceutical composition for preventing and treating diarrhea of weaned piglets and its preparation method and application | |
| CN103157095B (en) | Kidney bean phytolectin applications in preparation of human drugs and drug composition thereof | |
| CN101991640A (en) | Preparation method of mahonia fortune-containing Chinese medicinal composition and application thereof | |
| CN106309506A (en) | Probiotic composition with menstruation regulating function and application thereof | |
| CN1331530C (en) | Medicinal preparation for treating stomach and intestine diseases and its preparing method | |
| CN107752015A (en) | The composite nutrient food that a kind of all-digestive tract improves | |
| CN102614294B (en) | Compound amoxicillin suspension injection and preparation method thereof | |
| CN101804094B (en) | Medicament for killing sperms in vitro | |
| CN106421275A (en) | Traditional Chinese medicine compound preparation for treating fish sporidiosis and preparation method thereof | |
| CN1330349C (en) | Chinese medicine composition for treating urethra infection and preparing method | |
| CN102218078B (en) | Rifaximin suspension containing montmorillonite and preparation method thereof | |
| CN103461676B (en) | Feed additive comprising lysozyme, pesticide composition and application of feed additive | |
| CN103027997A (en) | Chinese herbal compound for preventing and curing onset of disease of sturgeons due to infecting aeromonas hydrophila | |
| CN111803528A (en) | Eurotium cristatum product and application thereof | |
| CN105560374A (en) | Compound preparation for treating dairy cow mammitis and preparation method thereof | |
| Pahwa et al. | Diversified beauty of Saccharomyces boulardii | |
| NL2036449B1 (en) | Use of bacillus coagulans bc198 for improving intestinal inflammatory diseases | |
| CN110150486A (en) | A kind of feed addictive for preventing and treating the intestines problems such as milking sow constipation diarrhea | |
| CN109381508A (en) | Chinese veterinary drug preparation and preparation method thereof for treating grice diarrhoea | |
| CN109125427B (en) | Penyanjing suppository and preparation method thereof | |
| CN114848756A (en) | Preparation method of medicine for treating gastroenteritis and digestive tract ulcer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070815 Termination date: 20150906 |
|
| EXPY | Termination of patent right or utility model |