CN1327836A - Instant particles as Chinese medicine for treating AIDS and its preparing process - Google Patents
Instant particles as Chinese medicine for treating AIDS and its preparing process Download PDFInfo
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Abstract
A Chinese medicine in the form of instant particles for suppressing HIV virus and treating AIDS is prepared from 8 Chinese-medicinal materials including voila herb, astragalus root, safflower, red sage root, etc. through decocting three of them twice and drying to obtain powder A, decocting the rest twice and drying to obtain powder B, mixing, adding dextrin and 80 % alcohol, granulating and drying.
Description
The present invention relates to Chinese medicine composition, refer in particular to and to treat Chinese medicine composition of acquired immune deficiency syndrome (AIDS) and preparation method thereof.
Acquired immune deficiency syndrome (AIDS) is that current popular is the most extensive, and the hazardness maximum is treated the most difficult disease, and it involves countries and regions, the whole world rapidly makes thousands of people ill, is threatening hundred million people's health, and case fatality rate is up to 40～60%.Therapeutic Method has three kinds: 1, Western medicine toxicity is too big, and it can momentaryly make virus subdue, but human body also is subjected to heavy damage simultaneously, therefore can not extensively promote.2, antiviral vaccine, this is a kind of good thing of putting things right once and for all, but does not still accomplish at present, is now seeking an effective inverase.3, at present do a lot of work for the research of Chinese medicine or plant amedica in countries in the world, existing with the Radix Glycyrrhizae be prescription the gram Chinese mugwort can, certain curative effect is arranged, but effect is not really desirable.
The purpose of this invention is to provide a kind of heat-clearing and toxic substances removing, strengthening vital QI to eliminate pathogenic factors strengthens immune function of human body, suppresses the Chinese medicine electuary and the method for making thereof of the treatment acquired immune deficiency syndrome (AIDS) of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) effect.
The object of the present invention is achieved like this, the medicament of being made by the following weight proportion raw material.
1～1.85 part of 2～3.71 portions of Flos Lonicerae of 1～1.85 part of Radix Astragali of Herba Violae
1～1.85 part of 1～1.85 part of Radix Salviae Miltiorrhizae of 1～1.85 part of Rhizoma Paridis of Radix Scutellariae
1～1.85 part in 1～1.85 portion of Radix Glycyrrhizae of Radix Arnebiae (Radix Lithospermi)
Preparation method: get Herba Violae, the Radix Astragali, Radix Arnebiae (Radix Lithospermi) and decoct with water secondary, add 8～10 times of amounts of water for the first time, decocted 2.0～2.5 hours, for the second time add 8～10 times of amounts of water, decocted 1～1.5 hour, filter, merging filtrate, 3.5～4.5 ℃ of cold preservations 24～30 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard ultrafiltrate, collect concentrated solution, vacuum concentration, drying, pulverizing get A dry powder.Extracting honeysuckle, Radix Scutellariae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, the Radix Glycyrrhizae five tastes decoct with water secondary in addition, add 8～10 times of amounts of water for the first time, decoct 2.0～2.5 hours, for the second time add 8～10 times of amounts of water, decocted 1～1.5 hour, filter, merging filtrate, 3.5～4.5 ℃ of cold preservations 24～30 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard concentrated solution, collect ultrafiltrate, vacuum concentration, drying, pulverizing get B dry powder.A dry powder and B dry powder merge, and the purity that adds 0.8～1.48 part dextrin and gross weight 10% is 80% alcohol granulation, drying, and granulate promptly gets brown to the brownish black granule; Little sweet, little hardship of distinguishing the flavor of.10g/ bag packing.
Check result: moisture content≤5.0%, weight differential ± 5.0%, total number of bacteria≤1000/g, enzyme bacterium sum≤1000/g must not detect escherichia coli.
Discrimination method: (1) gets this product 2g, puts in the flask 80ml that adds diethyl ether, reflux 1 hour, discard ether solution, residue is waved most ether, adds ethanol 30ml, reflux 1 hour filters the filtrate evaporate to dryness while hot, residue adds water 40ml makes dissolving, uses n-butanol extraction 3 times, each 20ml, merge n-butyl alcohol liquid, wash with water 3 times, each 20ml, put evaporate to dryness in the water-bath, residue adds methanol 5ml makes dissolving, as need testing solution.Other gets the baicalin reference substance, adds methanol and makes the solution that every 1ml contains 1mg, and product solution shines 57 pages of tests of thin layer chromatography appendix of Chinese Pharmacopoeia nineteen ninety version in contrast; Draw above-mentioned two kinds of each 2-5ul of solution, put respectively in same and contain on the silica gel plate G lamellae that 0.3% sodium carboxymethyl cellulose is a binding agent, with chloroform: methanol: formic acid is developing solvent in 15: 4: 1, takes out, and dries.In the test sample chromatograph color, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(2) need testing solution of getting under discriminating (1) item is a need testing solution.Extracting liquorice control medicinal material 1g shines medical material solution in pairs with legal system in addition.According to appendix test of thin layer chromatography Chinese Pharmacopoeia nineteen ninety-five version, draw above-mentioned two kinds of each 2-5ul of solution, put respectively on the silica gel plate G lamellae of same usefulness 1% sodium hydroxide solution preparation, with ethyl acetate: formic acid: glacial acetic acid: water is 30: 2: 2: 4 developing solvents launch, take out, dry.Spray is with 10% ethanol solution of sulfuric acid, and is clear to developing the color 105 ℃ of bakings, puts under the ultra-violet lamp 365nm and inspects.In the test sample chromatograph color, with the corresponding position of control medicinal material chromatograph on, show identical three yellow greens and bright basket color fluorescence speckle.
(3) in the chromatogram that the assay item writes down down, the test sample peak is answered consistent with the retention time at reference substance peak.
Assay: according to high effective liquid chromatography for measuring, 61 pages of appendix of Chinese Pharmacopoeia nineteen ninety version.
The system suitability test is a filler with octadecylsilane chemically bonded silica; With methanol-acetate buffer solution, get sodium acetate 2.04g, add glacial acetic acid 10.9ml and be dissolved in water and be diluted to 1000ml, transfer PH to 3.5, be mobile phase at 6.5: 93.5; The detection wavelength is 326nm, and number of theoretical plate calculates by the chlorogenic acid peak should be not less than 5000.
The preparation of reference substance solution, precision take by weighing 105 ℃ of chlorogenic acid reference substance 5mg that are dried to constant weight, put in the 100ml measuring bottle, add weight ratio methanol: water is dissolving in 1: 1 and is diluted to scale, shakes up.Precision is measured 2ml, puts in the 10ml measuring bottle, adds methanol: water be 1: 1 to scale, shake up, promptly.
The preparation of need testing solution and mensuration are got this product 0.5g, accurate claim surely, put in the tool plug triangular flask, and the accurate methanol that adds: water is 1: 1 100ml, behind the shake well, supersound process 30 minutes, centrifugal 10000 rev/mins 10 minutes, get supernatant as need testing solution.Accurate reference substance solution and each 20ul of need testing solution of drawing injects high performance liquid chromatograph respectively, measures peak area, calculates with external standard method, promptly.
This product is calculated by drying and is contained Flos Lonicerae with chlorogenic acid (C
18H
18O
9) meter, must not be less than 0.2%.
Advantage of the present invention is: acquired immune deficiency syndrome (AIDS) is that pyretic toxicity is wreaked havoc, and violates and QI and blood, and the impairment of YIN consumption is smart, the patient is dialectical, vital QI being weakened and pathogen being violent, and lung spleen conscience is with sick, in early days, warm pathogen tend to attack the upper orifices is violated lung, and is evil in Wei Zaiqi, heat-clearing and toxic substances removing is to be the task of top priority, and what is called is anxious controls its mark also, and intenseness of heat impairment of body fluid, is bitter cold simply, suitable also with sweet cold Flos Lonicerae, assistant is with the Radix Salviae Miltiorrhizae of nourshing blood and promoting blood circulation, the Radix Astragali of supplementing QI for promoting the production of body fluid, Radix Glycyrrhizae, the cloudy Tianjin of escorting the patient, make heat clearing away and do not hinder stomach, poison removes and Tianjin must be deposited, in order to avoid heresy is gone the fraud of just hindering.Heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, strengthening vital QI to eliminate pathogenic factors.Be used for " temperature poison ", " deficient ", cure mainly early, mid-term AIDSinfected patient, patient or non-evident sympton, or patients whose symptoms were less severe such as weak, heating, cough, diarrhoea, indigestion and loss of appetite, lose weight, lymphadenectasis, heat-clearing and toxic substances removing is served as theme, and is aided with removing heat from blood and promoting blood circulation, assistant is the QI invigorating poison holding with nourishing YIN and benefiting blood, both controlled its mark, multiple Gu Qiben cures the sickness to save the patient.Each 10g, every day 2～3 times, boiled water is taken after mixing it with water.This medicine reasonable recipe, dosage form and technological design are suitable.
Select for use simian acquired immunodeficiency syndrome (SAIDS) that simian immunodeficiency virus (SIV) brings out as animal model.From clinic, nosetiology, immunology, pathology, many index observed result, set up AZT (azidothymidine AZT) positive drug control group and infect not treat to organize and compare observation: the result proves the virus titer that can reduce the blood plasma PERIPHERAL BLOOD MONONUCLEAR CELL, can suppress HIV (human immunodeficiency virus) and reverse transcriptase activity.And can improve CD cell number and CD/CD ratio, promote T, bone-marrow-derived lymphocyte propagation, induce the immunoloregulation functions such as generation that disturb poison, particularly pathomorphology inspection and find to make cell-stimulating in the lymph node, promote lymphocytosis, promote the reparation of lymphocyte nuclear.Result of the test all is better than AZT treatment matched group.
Acute toxicity test proves: it is 32g/kg that this product gavages one day maximum tolerated dose to white mice, its dosage is equivalent to 200 times of the clinical consumption per day of people by weighing machine, observes seven days, does not observe toxic reaction, the all healthy existence of white mice shows that this product takes safety.
The long term toxicity test of animal proves: this product is irritated stomach to rat, dosage is 50 times of a clinical consumption per day, successive administration 6 months, through hematology, blood biochemical learn, the pathomorphology of internal organs checks that every detection index is all normal, illustrates that this product takes safety for a long time.
Effective in cure for proving the present invention to acquired immune deficiency syndrome (AIDS), exemplify treatment 52 routine HIV the infecteds' clinical observation.
One, patient: the patient selection standard is as follows:
(1) male HIV the infected of ELISA and/or Western blotting (WB);
(2) immunologic dysfunction: T
4/ T
8Ratio＜1 and T
4Cell number＜400/mm3;
(3) age is more than 7 years old;
(4) nogestational women;
(5) reach city resident or energy Lai Da city check person regularly;
(6) agree to use treatment by Chinese herbs person voluntarily.
All usefulness medicines are promptly observed the case statistics as one more than 3 months and through check person; As used two kinds of medicines and immunologic test person as a result in treatment front and back is all arranged, calculate with two examples.
Two, observational technique:
(1) before the treatment, detects for the patient makes ELISA (two kinds of test kits of Boehring, Wellcozyme), be diagnosed as HIV the infected in outpatient service; But all keep serum, wait until and make WB in case of necessity further to make a definite diagnosis.
(2) every three months uses the monoclonal antibody reagent of U.S. B-D company (Beckton-Dickinson) and fluidic cell photometric scanning instrument (FACScan) to detect after reaching treatment before treatment begins, and calculating T4/T8 ratio and T4 cell number are as the index of observing immunologic function.
(3) clinical symptoms, sign, picture of the tongue and pulse condition according to case require to do complete first visit with examining record, during first visit according to CDC classification determine patient's stadium, and distinguish the differentiation of symptoms and signs for classification of syndrome of the traditional Chinese medical science.The light and heavy degree of symptom is with significantly (+++), and general (++), slight (+), cut in and out (±), negative (-) expression, amount to into mark during statistics: (+++) be 6 minutes, (++) is 2 minutes, and (±) is 1 minute, and (-) is 0 minute; Show alleviating of patient's symptom or increase the weight of with scoring method.
(4) the body integrated status before and after the treatment is represented it with Kano Paderewski integration method (DamovskyScore).
Three, observe the dosage of medicine:
This product electuary: every day three times, each 10g/ bag, oral.
Gram Chinese mugwort can: as positive control, give various patients' dispensings at random with this product electuary.Instructions about how to take medicine: every day secondary, each 60mg (two), daily dose 120mg.
More than each medicine oral medicine be a course of treatment all with three months, no special circumstances are then taken medicine continuously, and the complication that occurs in the observation process is given the short-term anti symptom treatment of Chinese medicine and western medicine, do serology and immunology detection between the course of treatment.
Four, curative effect is judged
(1) method: according to immune state and clinical symptoms comprehensive analysis and judgement before and after the treatment, clinical symptoms shows that with scoring method it alleviates or increases the weight of, and immune state is analyzed for degree according to increase and decrease 0.2 of T4/T8 ratio and T4 cell number increase and decrease 40/mm3: two all increase or one to increase a no change be that immunologic function takes a turn for the better; Two all subtract or one to subtract a no change be that immunologic function worsens; It is no change that two increases and decreases all are no more than limit; One increases and another subtracts the person that all do not go beyond the limit in two, then based on the increase and decrease of T4 cell, judges immune functional state.
(2) criterion of therapeutical effect: be divided into recovery from illness, produce effects, effective, effective, the invalid Pyatyi of part according to the scientific research plan regulation.
Produce effects: the HIV negative antibody or the positive, immunologic function marked improvement T4/T8 ratio＞1, and T4 cell number＞400/mm3, opportunistic infection are eliminated substantially, and it is normal that symptom and sign recovers substantially.
Effectively: HIV antibody positive, immunologic function improvement T4/T8 ratio rise and surpass 0.2, and the T4 cell number rises and surpasses 40/mm3, and opportunistic infection take a turn for the better, and symptom and sign alleviates.
Part is effective: HIV antibody and immune indexes no change, but symptom and sign has marked improvement; Or immunologic function significantly improves, and symptom and sign does not have obvious changer.
Invalid: HIV infection, immune indexes, opportunistic infection and symptom and sign all do not have significant change, comprise in the therapeutic process because of immunologic function degression, the dead person of concurrent opportunistic infection.
Five, clinical observation
(1), treatment grouping:
This organizes 104 examples, and the routine number that this product electuary and Ke Ai can be observed equates that each 52 example sees Table 1
The relation table of table 1 medication and stadium classification
This product electuary gram Chinese mugwort can amount to AC 19 12 31ARC 93 12AIDS 24 37 61 and amount to 52 52 104
About the weight of each group state of an illness, i.e. disease index, can represent it with the ratio of patient's AC/AIDS number: the disease index as this product electuary is 0.79 (19/24); The gram Chinese mugwort can then be 0.32 (12/37).Obviously, this product electuary side group state of an illness is lighter, and AC is many and AIDS is few, the disease index height; Gram Chinese mugwort can disease index lower.
(2), therapeutic outcome
1. body weight change: body weight is an important objective indicator.Each treatment group patient's body weight is steady during the treatment.Except that descending in 3 months, the body weight of the death that has and the case of failing to respond to any medical treatment reaches 10%, other most patients' body weight all in lifting on the level of former body weight in 2 kilograms, in each prescription treatment group, the most weight increase 1-3 of patient AC kilogram, maximum persons that descend are in this product electuary ARC group, on average fall 7 kilograms, Ke Ai can-ARC group then increases by 3.5 kilograms.See Table 2
(kg) treatment back (kg) difference this product electuary AC 19 73.74 71.95-1.79 before the treatment of weight in patients change list side medicine stadium example number before and after table 2 treatment
ARC 9 68.11 61.11 -7.00
But AIDS 24 63.02 61.35-1.73 gram Chinese mugwort AC 12 61.88 63.63 1.75
ARC 3 78.33 81.93 3.60
AIDS 37 59.22 59.24 0.02
2. clinical symptoms: observe weak, generate heat, cough, breathe hard, the variation before and after chest pain, diarrhoea, indigestion and loss of appetite, night sweat, erythra, lymphadenectasis, 11 kinds of sings and symptomses treatments of oral erosion.For Symptomatic HIV infected patient, clothes this product electuary and Ke Ai can after, symptom has alleviating or disappears in various degree more, the Paderewski integration variation of Kano, treatment back sees Table 3.
(meansigma methods) treatment back (meansigma methods) difference this product electuary AC 19 89.63 88.42-1.21 before the treatment of Paderewski integration change list side, patient Kano medicine stadium example number before and after table 3 treatment
ARC 9 82.78 88.43 5.55
But AIDS 24 84.85 86.79 1.94 gram Chinese mugwort AC 12 92.00 92.25 0.17
ARC 3 89.00 94.00 5.00
AIDS 37 83.57 87.84 4.27 adds up to 104 84.95 89.74 3.79
As previously mentioned, the characteristics of Tanzania's hiv infected patient are that the infringement of mild symptoms and immunologic function is serious, and in table 3, the Bing Renkashi integration changes all little, the ARC that symptom is more and AIDS Bing Renkashi integration change greatly, and the patient of ARC changes between the 5.00-5.55 branch after with each prescription medicine.
3. changes in immune function:
A, T4/T8 change and the T4 cell number: show more stable in each treatment group (this product electuary and Ke Ai can) before and after each phase patient's (AC, ARC, AIDS) the T4/T8 meansigma methods treatment, but the variation of T4 cell number is then bigger, as with Ke Ai can AC and the meansigma methods treatment of ARC patient's T4 cell number after all rise and surpass 40/mm3.This explanation: T4/T8 ratio is difficult for changing; AC patient T4 cell number more easily increases; ARC patient then lifting has.See Table 4
Treatment back difference this product electuary AC 19 T4/T8 0.63 0.67 0.04 before the patient immune function change list side medicine stadium example number immune function and treating before and after table 4 treatment
T4CC 359.05 293.31 34.26 (52 example) ARC 9 T4/T8 0.60 0.74 0.14
T4CC 394.33 392.41 -1.92
AIDS 24 T4/T8 0.20 0.18 -0.02
But T4CC 101.34 117.74 16.40 gram Chinese mugwort AC 12 T4/T8 0.73 0.78 0.05
T4CC 325.53 395.44 69.91 (52 example) ARC 3 T4/T8 0.31 0.30-0.01
T4CC 371.63 530.31 158.68
AIDS 37 T4/T8 0.17 0.16 -0.01
T4CC 85.46 115.74 30.28
B, immune state assessment: treatment back patient's immune state is divided into improvement, no change, three kinds of situations of deterioration, concludes and the results are shown in Table 5.
Patient's states evaluation form side's medicine stadium improvement no change worsens total this product electuary AC 478 19 before and after table 5 treatment
ARC 4 3 2 9
But AIDS 66 12 24 gram Chinese mugwort AC 831 12
ARC 1 1 1 3
AIDS 9 20 8 37 adds up to 32 40 32 104
The treatment of this product electuary AC, ARC, AIDS patient count 52 examples, immune state improvement person 14 examples, and no change person 16 examples, both additions promptly can keep immunologic function previous level and improvement person that 30 examples are arranged through treatment, account for 57.69%.
The gram Chinese mugwort can be treated each phase patient 52 example, immune state improvement person 18 examples, and no change 24 examples add up to 42 examples can keep the immunologic function level, account for 80.77%.
4. curative effect: the treatment time of observing case was above 3 months.Do not see the person that reaches at the criterion of cure as yet, Serological testing has a routine HIV antibody to turn out cloudy.
Patient B .M., the woman, 48 years old, its sexual partner died from HIV and infects, and I look into HIV (+), and weight loss (8 kilograms), diarrhoea, heating history etc. are arranged.Recently look into the ELISA positive, no significant discomfort, T4/T8 ratio is 1.10, T4CC is 336.1/mm3, give this product electuary after three months, acute photochemical dermatitis occurs, hypopigmentation of skin and scratching where it itches, look into the ELISA feminine gender, reexamine the preceding serum of treatment, the positive and WB feminine gender of ELISA is thought of as the ELISA false positive, it is positive to look into PCR after four months, and it is still negative to look into ELISA with a blood sample.
This two medication is imitated and be the results are shown in Table 6
The table 6 liang curative effect comparison sheet treatment group that treat side example digital display effect live part enabledisable total effective rate this product electuary 52 3 (5.76%) 6 (11.53%) 18 (34.62%) 25 (48.08%) 51.92% gram Chinese mugworts can 52 1 (1.92%) 3 (5.77%) 27 (51.92%) 21 (40.38%) 59.62% totals 104 49 45 46 55.76%
More than show, this product electuary total effective rate 51.92%, but Ke Ai total effective rate 59.62%, the two is compared, (X2=0.6237, P＞0.05), and there was no significant difference, the produce effects of this product electuary and effective percentage all are higher than Ke Ai can; Gram Chinese mugwort can the part effective percentage account for 51.92%, but be higher than this product electuary (34.62%).
5. drug side effect: clothes this product electuary person 2 examples season occurs acute photochemical dermatitis (Acuteactinic dermatitis) in summer-heat.The 2 examples back tending to vomit of feeling sick of taking medicine is adhered to transference cure after the medication, menorrhagia after 1 example was taken medicine 3 months, and 1 routine skin is itched, and accounts for 11.5%, clothes gram Ai Kezhe, small number of patients dry pharynx discomfort, meter 8.7%.
(3), case fatality rate:
Observe in patient's 104 examples, be total to dead 13 examples (12.5%), clothes this product electuary and Ke Ai can, its dead person is respectively 6 examples (11.5%) and 7 examples (13.8%), and difference is little, but it should be noted that, death person all is the AIDS case, so, patient's death, mainly to belong to late period relevant with stadium.
Six, conclusion
(1), can treat the hiv infected patient of various stadium, its total effective rate is respectively 51.92% and 59.62% with this product electuary and Ke Ai.
(2), the disease index of this product electuary be higher than Ke Ai can, but total effective rate then both are approximate.
(3), in immunologic function, the T4 cell number is more sensitive, its amplitude of variation is big than other index, particularly all death persons occur in those and are lower than 200/mm3 person, this expression immune state is closely-related with prognosis.
(4), the cloudy commentaries on classics of serum antibody occurs in two groups of each 1 examples, with pcr amplification method and p24 antigen measuring, discovery is after with treatment by Chinese herbs, immune silent oscillation HIV has taken place to be infected, can not record antibody in the serum, only finding in lymphocyte nuclear has HIV-DNA to exist, and this situation only occurs in high immune level state person, and the prompting patient may be in a kind of good clinical state.
The present invention is described in detail below in conjunction with embodiment.
Embodiment 1
The Chinese medicine electuary of treatment acquired immune deficiency syndrome (AIDS), the medicament of making by the following weight proportion raw material.
1 part of 2 portions of Flos Lonicerae of 1 part of Radix Astragali of Herba Violae
1 part of 1 part of Radix Salviae Miltiorrhizae of 1 part of Rhizoma Paridis of Radix Scutellariae
1 part in 1 portion of Radix Glycyrrhizae of Radix Arnebiae (Radix Lithospermi)
Herba Violae, the Radix Astragali are monarch drug, and Flos Lonicerae, Radix Scutellariae, Rhizoma Paridis are ministerial drug, and Radix Salviae Miltiorrhizae, Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are adjuvant drug.
Preparation method: get Herba Violae, the Radix Astragali, Radix Arnebiae (Radix Lithospermi) and decoct with water secondary, add 8 times of amounts of water for the first time, decocted 2.0 hours, for the second time add 8 times of amounts of water, decocted 1 hour, filter, merging filtrate, 3.5 ℃ of cold preservations 24 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard ultrafiltrate, collect concentrated solution, vacuum concentration, drying, pulverizing get A dry powder.Extracting honeysuckle, Radix Scutellariae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, the Radix Glycyrrhizae five tastes decoct with water secondary in addition, add 8 times of amounts of water for the first time, decoct 2.0 hours, for the second time add 8 times of amounts of water, decocted 1 hour, filter, merging filtrate, 3.5 ℃ of cold preservations 24 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard concentrated solution, collect ultrafiltrate, vacuum concentration, drying, pulverizing get B dry powder.A dry powder and B dry powder merge, and the purity that adds 0.8 part dextrin and gross weight 10% is 80% alcohol granulation, drying, and granulate promptly gets brown to the brownish black granule; Little sweet, little hardship of distinguishing the flavor of.10g/ bag packing.
Embodiment 2
The Chinese medicine electuary of treatment acquired immune deficiency syndrome (AIDS), the medicament of making by the following weight proportion raw material.
1.43 parts of 2.86 portions of Flos Loniceraes of 1.43 parts of Radixs Astragali of Herba Violae
1.43 parts of 1.43 parts of Radix Salviae Miltiorrhizaes of 1.43 parts of Rhizoma Paridis of Radix Scutellariae
1.43 parts in 1.43 portions of Radix Glycyrrhizaes of Radix Arnebiae (Radix Lithospermi)
Preparation method: get Herba Violae, the Radix Astragali, Radix Arnebiae (Radix Lithospermi) and decoct with water secondary, add 10 times of amounts of water for the first time, decocted 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, filter, merging filtrate, 4 ℃ of cold preservations 28 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard ultrafiltrate, collect concentrated solution, vacuum concentration, drying, pulverizing get A dry powder.All the other five tastes of extracting honeysuckle decoct with water secondary in addition, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, filter, merging filtrate, 4 ℃ of cold preservations 26 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard concentrated solution, collect ultrafiltrate, vacuum concentration, drying, pulverizing get B dry powder.A dry powder and B dry powder merge, and the purity that adds 1.14 parts dextrin and gross weight 10% is 80% alcohol granulation, drying, and granulate promptly gets brown to the brownish black granule; Little sweet, little hardship of distinguishing the flavor of.10g/ bag packing.
Embodiment 3
The medicament of making by the following weight proportion raw material.
1.82 parts of 3.71 portions of Flos Loniceraes of 1.85 parts of Radixs Astragali of Herba Violae
1.82 parts of 1.85 parts of Radix Salviae Miltiorrhizaes of 1.84 parts of Rhizoma Paridis of Radix Scutellariae
1.83 parts in 1.85 portions of Radix Glycyrrhizaes of Radix Arnebiae (Radix Lithospermi)
Preparation method: get Herba Violae, the Radix Astragali, Radix Arnebiae (Radix Lithospermi) and decoct with water secondary, add 10 times of amounts of water for the first time, decocted 2.5 hours, for the second time add 10 times of amounts of water, decocted 1.5 hours, filter, merging filtrate, 4.5 ℃ of cold preservations 30 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard ultrafiltrate, collect concentrated solution, vacuum concentration, drying, pulverizing get A dry powder.All the other five tastes of extracting honeysuckle decoct with water secondary in addition, add 10 times of amounts of water for the first time, decoct 2.5 hours, for the second time add 10 times of amounts of water, decocted 1.5 hours, filter, merging filtrate, 4.5 ℃ of cold preservations 30 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard concentrated solution, collect ultrafiltrate, vacuum concentration, drying, pulverizing get B dry powder.A dry powder and B dry powder merge, and the purity that adds 1.48 parts dextrin and gross weight 10% is 80% alcohol granulation, drying, and granulate promptly gets brown to the brownish black granule; Little sweet, little hardship of distinguishing the flavor of.10g/ bag packing.
Claims (4)
1, the Chinese medicine electuary of treatment acquired immune deficiency syndrome (AIDS) is characterized in that: the medicament of making by the following weight proportion raw material,
1～1.85 part of 2～3.71 portions of Flos Lonicerae of 1～1.85 part of Radix Astragali of Herba Violae
1～1.85 part of 1～1.85 part of Radix Salviae Miltiorrhizae of 1～1.85 part of Rhizoma Paridis of Radix Scutellariae
1～1.85 part in 1～1.85 portion of Radix Glycyrrhizae of Radix Arnebiae (Radix Lithospermi)
2, the Chinese medicine electuary of treatment acquired immune deficiency syndrome (AIDS) according to claim 1 is characterized in that: the medicament that preferred weight proportioning raw material is made,
1.43 parts of 2.86 portions of Flos Loniceraes of 1.43 parts of Radixs Astragali of Herba Violae
1.43 parts of 1.43 parts of Radix Salviae Miltiorrhizaes of 1.43 parts of Rhizoma Paridis of Radix Scutellariae
1.43 parts in 1.43 portions of Radix Glycyrrhizaes of Radix Arnebiae (Radix Lithospermi)
3, the method for making of the Chinese medicine electuary of treatment acquired immune deficiency syndrome (AIDS) is characterized in that:
Preparation method: get Herba Violae, the Radix Astragali, Radix Arnebiae (Radix Lithospermi) and decoct with water secondary, add 8～10 times of amounts of water for the first time, decocted 2.0～2.5 hours, for the second time add 8～10 times of amounts of water, decocted 1～1.5 hour, filter, merging filtrate, 3.5～4.5 ℃ of cold preservations 24～30 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard ultrafiltrate, collect concentrated solution, vacuum concentration, drying, pulverizing get A dry powder; Extracting honeysuckle, Radix Scutellariae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, the Radix Glycyrrhizae five tastes decoct with water secondary in addition, add 8～10 times of amounts of water for the first time, decoct 2.0～2.5 hours, for the second time add 8～10 times of amounts of water, decocted 1～1.5 hour, filter, merging filtrate, 3.5～4.5 ℃ of cold preservations 24～30 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard concentrated solution, collect ultrafiltrate, vacuum concentration, drying, pulverizing get B dry powder; A dry powder and B dry powder merge, and the purity that adds 0.8～1.48 part dextrin and gross weight 10% is 80% alcohol granulation, drying, and granulate promptly gets brown to the brownish black granule.
4, the method for making of the Chinese medicine electuary of treatment acquired immune deficiency syndrome (AIDS) according to claim 3 is characterized in that:
Preparation method: get Herba Violae, the Radix Astragali, Radix Arnebiae (Radix Lithospermi) and decoct with water secondary, add 10 times of amounts of water for the first time, decocted 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, filter, merging filtrate, 4 ℃ of cold preservations 28 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard ultrafiltrate, collect concentrated solution, vacuum concentration, drying, pulverizing get A dry powder; Extracting honeysuckle, Radix Scutellariae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, the Radix Glycyrrhizae five tastes decoct with water secondary in addition, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1.5 hours, filter, merging filtrate, 4 ℃ of cold preservations 26 hours, get the supernatant paper pulp filtering, filtrate is with ultrafiltration film cutoff value 10000 purification, discard concentrated solution, collect ultrafiltrate, vacuum concentration, drying, pulverizing get B dry powder; A dry powder and B dry powder merge, and the purity that adds 1.14 parts dextrin and gross weight 10% is 80% alcohol granulation, drying, granulate, 10g/ bag packing.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011141530A CN1136889C (en) | 2001-06-27 | 2001-06-27 | Instant particles as Chinese medicine for treating AIDS and its preparing process |
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| CNB011141530A CN1136889C (en) | 2001-06-27 | 2001-06-27 | Instant particles as Chinese medicine for treating AIDS and its preparing process |
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| CN1136889C CN1136889C (en) | 2004-02-04 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784842A (en) * | 2013-06-01 | 2014-05-14 | 吕汉 | Traditional Chinese medicine preparation for assisting to treat aids (Acquired Immune Deficiency Syndrome) |
| CN103830708A (en) * | 2014-03-12 | 2014-06-04 | 徐焘 | Formula of special-effect traditional Chinese medicine for treating AIDS (acquired immune deficiency syndrome) and preparation method thereof |
| CN105770431A (en) * | 2016-05-17 | 2016-07-20 | 唐天东 | Traditional Chinese medicine composition for treating AIDS and preparation method thereof |
| CN108704064A (en) * | 2018-07-13 | 2018-10-26 | 张敬文 | A kind of Chinese medicine composition and preparation method for treating AIDS |
-
2001
- 2001-06-27 CN CNB011141530A patent/CN1136889C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784842A (en) * | 2013-06-01 | 2014-05-14 | 吕汉 | Traditional Chinese medicine preparation for assisting to treat aids (Acquired Immune Deficiency Syndrome) |
| CN103830708A (en) * | 2014-03-12 | 2014-06-04 | 徐焘 | Formula of special-effect traditional Chinese medicine for treating AIDS (acquired immune deficiency syndrome) and preparation method thereof |
| CN105770431A (en) * | 2016-05-17 | 2016-07-20 | 唐天东 | Traditional Chinese medicine composition for treating AIDS and preparation method thereof |
| CN108704064A (en) * | 2018-07-13 | 2018-10-26 | 张敬文 | A kind of Chinese medicine composition and preparation method for treating AIDS |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1136889C (en) | 2004-02-04 |
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