CN1323600A - Compound cassia seed eye drops - Google Patents
Compound cassia seed eye drops Download PDFInfo
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- CN1323600A CN1323600A CN00110423A CN00110423A CN1323600A CN 1323600 A CN1323600 A CN 1323600A CN 00110423 A CN00110423 A CN 00110423A CN 00110423 A CN00110423 A CN 00110423A CN 1323600 A CN1323600 A CN 1323600A
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- cassia seed
- radix
- eye drops
- rhizoma
- eye
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Abstract
The invention relates to Chinese traditional medicine used to treat cataract. Its components are as follows (according to weight ratio):cassia seed (70-100), angelica (40-60), raw abalone sheel (50-80), equisetum (40-60), atractylodes rhizome (40-80), sea tangle (40-80), pipewort (40-80), tuber fleeceflower (40-80), Chinese wolfberry fruit (40-60), snake slough (2-8), burrerfly bush flower (20-60), chinese clematic (40-80), notoperygium root (40-80), white caltrop (40-80), topaz (40-80), seaweed (40-80), cicada skin (40-80).
Description
The invention belongs to field of traditional Chinese, the cataractous Chinese medicine preparation of particularly a kind of treatment.
Cataract is a kind of common senile oculopathy of ophthalmology.Both at home and abroad at present operative treatments that adopt more.This method waiting time is long, at least about 1-2, at most so the more than ten years can be ripe, during the immature phase patient's vision year by year carrying out property go down, having only cataract full maturity (crystal fully muddy) is that vision can undergo surgery when having only sensitization, and part patient is often relatively poor because of various objective and subjective reason Postoperative visual acuity, and the part especial patient belongs to taboo again, also need to insert the artificial intraocular lenses or wear the intensity convex mirror, thereby on Therapeutic Method, still have some mistaken ideas with vision enhancing.In recent years, occur some Japanese imports and home-made Western medicine eye drop on the market, in order to the treatment cataract, after the patient used, majority was thought DeGrain.
The object of the present invention is to provide a kind of all effective in curely, can make the lenticular opacity of most of cataract just and immaturity cataract patient obviously alleviate compound cassia seed eye drops without any side effects all kinds of cataract.
Technical solution of the present invention can realize according to following mode:
A kind of compound cassia seed eye drops is characterized in: contain following component (weight ratio): Semen Cassiae 70-100: Radix Angelicae Sinensis 40-60: Concha Haliotidis 50-80: Herba Equiseti Hiemalis 40-60: Rhizoma Atractylodis 40-80: Thallus Laminariae (Thallus Eckloniae) 40-80: Flos Eriocauli 40-80: Radix Polygoni Multiflori 40-80: Fructus Lycii 40-60: Periostracum Serpentis 2-8: Flos Buddlejae 20-60: Radix Clematidis 40-80: Rhizoma Et Radix Notopterygii 40-80: Fructus Atriplicis Sibiricae 40-80: Rhizoma Polygonati 40-80: Sargassum 40-80: Periostracum Cicadae 40-80.
The present invention is all effective in cure to all kinds of cataract, and the lenticular opacity of most of cataract just and immaturity cataract patient is obviously alleviated, and vision obviously strengthens, thereby, avoided the doctor trained in Western medicine operative treatment.
The test of compound cassia seed eye drops eye irritation
This test requires to carry out according to relevant " toxicity test of mucosa medication " in " new drug preclinical study guideline ".
One, purpose: observe the animal eyes contact and tried the irritant reaction situation and the recovery situation that are produced behind the thing.
Two, animal and material:
Animal: rabbit, the big ear of New Zealand is white, body weight 2-3kg, regular grade, male, female dual-purpose (206 animal housing of hospital of PLA provide)
Three, test method:
Adopt the consubstantiality own control, use 5 of rabbit, be divided into 3 groups for every group.Observe earlier before the medication and the record cornea, iris and conjunctiva situation, existing pathological changes or inflammation person, rejecting need not.To be tried thing 0.1ml then and splash in the left side eye conjunctival sac, the right side eye is given and is tried to make behind the thing the passive closed 8-10 of eyes second with normal saline in contrast.Observe to give the local response situation of being tried 6,24,48,72 hours to seven days eyes behind the thing, in accordance with regulations standards of grading corneal, iris and conjunctiva are marked respectively.Calculate mean scores, and compare with the contrast eye of same animal.
Four, result of the test and evaluation
Table 1, left side eye (being tried thing) score value X-right side eye (matched group) score value X-of tame lagophthalmos irritant reaction appraisal result (3 cell mean) time
Cornea iris conjunctiva ∑ cornea iris conjunctiva ∑ 6h 0011000 024h 0000000 048h 0000000 072h 0000000 07d 00000000 results show:
After will being tried thing and splashing into the rabbit left eye, an eye conjunctiva mild hyperaemia was arranged in 5 hours when checking, cornea, iris inspection are all normal; This conjunctival congestion recovered when checking in 24 hours.It is all normal that all the other are equipped with cornea observing time, iris, conjunctiva.Standards of grading are in accordance with regulations tried the thing mean scores less than 3.9, thus compound cassia seed eye drops, to the eye nonirritant.
Table 2, rabbit be eye irritation test reaction grade form (3 cell mean) time left side eye (being tried thing) score value X-right side eye (matched group) score value X-repeatedly
Cornea iris conjunctiva ∑ cornea iris conjunctiva ∑ 1d 0011000 02d 0000000 03d 0000000 04d 0000000 05d 0000000 06d 0000000 07d 00000000
The result shows: when being subjected to after the drug withdrawal of examination group first day, the hyperemia of an eye conjunctiva software is arranged, cornea, iris are all normal, this conjunctival congestion recovers in the time of the 2nd day, all the other each observing time, cornea, iris, conjunctiva were all normal, and each review time cornea of matched group, iris, conjunctiva are all normal, standards of grading in accordance with regulations, tried the thing mean scores less than 3.9, show compound cassia seed eye drops repeatedly medication to the eye nonirritant.
Embodiment 1: this medicament contains following component (unit: Semen Cassiae 82 Radix Angelicae Sinensis 55 Concha Haliotidiss 69 Herba Equiseties Hiemalis 55 Rhizoma Atractylodis 62 Thallus Laminariae (Thallus Eckloniae)s 69 Flos Eriocaulis 55 Radix Polygoni Multiflori 65 Fructus Lycii 55 Periostracum Serpentiss 6 Flos Buddlejaes 41 Radix Clematidis 62 Rhizoma Et Radix Notopterygiis 62 Fructus Atriplicis Sibiricaees 55 Rhizoma Polygonatis 69 Sargassums 69 Periostracum Cicadaes 69 gram).Make 1000ml preparation technology:
By above-mentioned weight, round reason, the medical material that cooks drops in the extraction pot, soaked 1 hour, heating decocts three times, and the time is respectively 2,1,1 hour, collecting decoction filters, and is concentrated into 1ml and is equivalent to about crude drug in whole 1 gram, put coldly, under agitation add ethanol, make to contain the alcohol amount and reach 60% and fully stir, leave standstill and got supernatant in 24 hours, filter, reclaim ethanol, be concentrated into and be equivalent to crude drug in whole 2 gram, put coldly, under agitation add ethanol once more, make to contain alcohol amount and reach 75%, stir evenly, leave standstill, filter, add 40%NaOH liquid, adjust pH is 8, cold preservation was left standstill 48 hours, filtered, and reclaimed ethanol, be concentrated into no ethanol flavor, add an amount of distilled water diluting, cold preservation was left standstill 24 hours, filter, add sodium chloride 8 grams, hyprolose is an amount of, ethylparaben 0.5 gram, last adding distil water is to full dose, and adjust pH is 6.5-7.5, filter to clear and bright with microporous filter membrane, sterilization, aseptic subpackaged in 5ml bottle (should give a baby a bath on the third day after its birth all over the passed examination after drying) with cobalt 60 radiation sterilizations, buckle closure, lamp inspection, the qualified back of quality inspection packing is promptly.
Embodiment 2:
This medicament contains following component (unit: Semen Cassiae 80 Radix Angelicae Sinensis 55 Concha Haliotidiss 60 Herba Equiseties Hiemalis 50 Rhizoma Atractylodis 55 Thallus Laminariae (Thallus Eckloniae)s 54 Flos Eriocaulis 57 Radix Polygoni Multiflori 60 Fructus Lycii 50 Periostracum Serpentiss 4 Flos Buddlejaes 30 Radix Clematidis 50 Rhizoma Et Radix Notopterygiis 55 Fructus Atriplicis Sibiricaees 55 Rhizoma Polygonatis 50 Sargassums 60 Periostracum Cicadaes 65 gram)
Claims (1)
1, a kind of compound cassia seed eye drops is characterized in that: contain following component (weight ratio): Semen Cassiae 70-100: Radix Angelicae Sinensis 40-60: Concha Haliotidis 50-80: Herba Equiseti Hiemalis 40-60: Rhizoma Atractylodis 40-80: Thallus Laminariae (Thallus Eckloniae) 40-80: Flos Eriocauli 40-80: Radix Polygoni Multiflori 40-80: Fructus Lycii 40-60: Periostracum Serpentis 2-8: Flos Buddlejae 20-60: Radix Clematidis 40-80: Rhizoma Et Radix Notopterygii 40-80: Fructus Atriplicis Sibiricae 40-80: Rhizoma Polygonati 40-80: Sargassum 40-80: Periostracum Cicadae 40-80.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001104233A CN1137699C (en) | 2000-05-17 | 2000-05-17 | Compound cassia seed eye drops |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001104233A CN1137699C (en) | 2000-05-17 | 2000-05-17 | Compound cassia seed eye drops |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1323600A true CN1323600A (en) | 2001-11-28 |
| CN1137699C CN1137699C (en) | 2004-02-11 |
Family
ID=4580414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001104233A Expired - Fee Related CN1137699C (en) | 2000-05-17 | 2000-05-17 | Compound cassia seed eye drops |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1137699C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101081091B (en) * | 2007-04-25 | 2010-07-28 | 肖自力 | Vision-improving and intelligent-improving beverage |
| CN102670993A (en) * | 2012-05-09 | 2012-09-19 | 杨文江 | Chinese medicament for treating cataract |
| CN104857310A (en) * | 2015-06-12 | 2015-08-26 | 孙胜波 | Traditional Chinese medicine composition for treating cataract |
-
2000
- 2000-05-17 CN CNB001104233A patent/CN1137699C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101081091B (en) * | 2007-04-25 | 2010-07-28 | 肖自力 | Vision-improving and intelligent-improving beverage |
| CN102670993A (en) * | 2012-05-09 | 2012-09-19 | 杨文江 | Chinese medicament for treating cataract |
| CN102670993B (en) * | 2012-05-09 | 2013-12-18 | 杨文江 | Traditional Chinese medicine for treating cataract |
| CN104857310A (en) * | 2015-06-12 | 2015-08-26 | 孙胜波 | Traditional Chinese medicine composition for treating cataract |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1137699C (en) | 2004-02-11 |
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