CN1321647C - Medicine for wound healing and preparation method thereof - Google Patents
Medicine for wound healing and preparation method thereof Download PDFInfo
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- CN1321647C CN1321647C CNB2005100721326A CN200510072132A CN1321647C CN 1321647 C CN1321647 C CN 1321647C CN B2005100721326 A CNB2005100721326 A CN B2005100721326A CN 200510072132 A CN200510072132 A CN 200510072132A CN 1321647 C CN1321647 C CN 1321647C
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Abstract
The present invention relates to medicine for healing wounds and a preparing method thereof. The medicine is traditional Chinese medicine of external application. The medicine is the medical preparations of external application of powder, a paste cream agent, an attaching agent, a spraying agent, etc. made by using the water solubility part of mammal bile as main ingredients. The medicine has rapid, thorough and radical effects on canker wounds which can not be easily healed, such as, the bedsore and the non-healing wounds of diabetic patients, vasculitis ulceration wounds, burning and scalding wounds, knife and gun wounds, etc.
Description
Technical field
The present invention relates to medicine of a kind of healing of wound and preparation method thereof, particularly relate to a kind of external Chinese medicine and preparation method thereof.
Background technology
The Chinese and western drugs of the various ulcer of treatment is a lot of in the prior art, and still, it is long all to exist treatment time, and patient is painful big; Particularly, there is not the specific drug radical cure especially to wound and difficult healing ulcer such as some disunion wounds, vascular ulceration wound, burn and scald, weapons wounds as decubital ulcer, diabetics.
Along with the reach of science, it is found that somatomedin and by clinical practice in wound healing, but years of researches are found the clinical practice of somatomedin unsurmountable shortcoming is arranged, can particularly simple irritation cell hypertrophy cause that the problem of cell carcinogenesis makes somatomedin be difficult to enter clinical practice.Wound healing is a complexity and orderly process of tissue reparation, promotes that hyperplasia only is a stage of repair process, if be exactly unnecessary and deleterious utilizing the factors stimulated growth hypertrophy also when the healing later stage no longer needs quick hyperplasia.So scientist has proposed the notion of molecular combinations medicine, they wish the promotion combinations of factors in each stage of wound healing is got up to make new drug, this yes desirable more only.Was but wound healing made up of which in stage? does each stage have anything to promote the factor? before these basic science problems did not also solve, reasonably molecular combinations can only be illusion.Wound healing medical circle in 1996 is held international conference in Cambridge under such situation, and scientist has proposed to seek from traditional medicine the direction of wound healing new drug realistically.Chinese medicine is that China is the tool treasure that the whole mankind offers as a tribute, and seeking natural wound healing molecular combinations medicine from the strong Chinese crude drug of wound healing ability is the outlet that wound healing medical science is extricated oneself from a plight.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of healing of wound, can be fast, thoroughly, the wound of the difficult ulcer that heal such as the disunion wound of healing as decubital ulcer, diabetics, vasculitis ulceration wound, burn and scald, weapons wound.
Another object of the present invention provides a kind of preparation method of medicine of healing of wound, and this method is simple to operate, and can make the medicine of the very capable healing of wound of wound healing by this method.
Technical scheme of the present invention is as follows:
A kind of medicine of healing of wound is characterized in that: it is with gallbladder powder or biliary water solublity portion
Described gallbladder powder is that the Chinese medicine processing method is air-dry or dry, pulverize and make routinely with gallbladder.
Described gallbladder powder is according to a conventional method bile lyophilization, porphyrize to be made.
Described water-soluble portion is that described gallbladder powder or bile are sterilized, and is 2～20 mg/ml with physiological saline solution to concentration, makes behind the centrifugal removal insoluble matter.
Described medicine is made powder, cream cream, patch, spray.
Described gallbladder is mammiferous gallbladder, and it is selected from Fel Sus domestica or Fel Bovis seu Bubali or Fel Caprae seu Ovis, perhaps Fel Ursi, perhaps Fel Canitis.
Described medicine is to be main component with gallbladder powder or biliary water-soluble portion, and Chinese medicinal preparation method is made various external-use drug forms routinely;
Described gallbladder powder or biliary water-soluble portion are made by following method:
A, gallbladder powder or bile are carried out the sterilization of cobalt 60 irradiation sterilization methods, the width of cloth is penetrated dosage 800,000 Rad irradiation 10～20 hours;
B, will sterilize qualified gallbladder powder or bile dissolve with medical saline:
C, with gallbladder powder or bile solution that step b obtains, remove insoluble matter with centrifugal method, the aqueous solution that obtains is gallbladder powder or biliary water-soluble portion.
The concentration of the aqueous solution that described step c obtains is the 2-20 mg/ml.
Described gallbladder powder is air-dry or dry with conventional Chinese medicine processing method, and pulverizing is made.
Described gallbladder powder is according to a conventional method lyophilized powder to be made in the bile lyophilization.
The medicine of healing of wound of the present invention, various chronic difficult healing wound surface there is the effect of tangible promotion healing, to treatment decubital ulcer, the disunion wound of diabetics, vasculitis ulceration wound, various difficult healing wounds such as burn and scald have fast, thoroughly, the therapeutic effect of radical cure.Medicine of the present invention has very strong wound healing ability.
Medicine of the present invention can be made various external-use drug forms such as powder, cream cream, patch, spray by the conventional preparation method of Chinese medicine, and convenient different patient uses.
Below by the further proof effect of the present invention of clinical efficacy test:
The case brief introduction
| Name | Sex | Age | Indication and medical history are wanted in diagnosis | Medication effect of the present invention |
| Zhang Liping | The woman | 39 | The left lower extremity deep phlebitis, ulcus cruris, the skin darkness, granulation is stale, a small amount of pus tongue, wound surface 3 * 3cm has dark 0.7cm depression.Do not cure more than 5 years, cultivating has golden Portugal. | Medication wound surface recovery from illness in 3 days all incrustations in 1/2, the 6 day, incrustation in the 12nd day comes off. |
| Li Changzhong | 63 | Behind the bypass operation of coronary artery, the wound of dark 1.5cm area 0.5 * 0.5cm2 appears in the chest center, faint yellow secretions is arranged, do not heal more than a year, cultivating has golden Portugal. | 5 days wound healings of medication. | |
| Yang Lanbo | The woman | 67 | Diabetes merge the abdominal part cellulitis, fester. dark 0.5cm, area 4 * 2cm2. | One week of medication, the back wound surface inwardly shrank, and the membranaceous covering of two week back epidermises is healed fully through two weeks again. |
| Liu Shengyuan | The man | 62 | Diabetes merge foot's pyogenic infection, between outer and 45 toes of the left foot outside and right crus of diaphragm little toe 2 * 2 * 0.5cm size wound surface is arranged, January surplus not healing. | The all healings of two weeks of medication. |
| Gong Zhicheng | The man | 79 | Left foot 245 toe diabetes are bad, three wheat harvesting period disunion. | Medication two weeks recovery from illness. |
| Jade is examined | The woman | 37 | Right neck side lymphoid tuberculosis postoperative, 7 * 4cm size 0.4cm digs mouth deeply. | Medication two weeks recovery from illness. |
| Wang Hong | The woman | 46 | Right subclavian lymphoid tuberculosis postoperative, 8 * 3.5cm size, first quarter moon is surplus does not heal. | Medication two weeks recovery from illness. |
| Su Fei | The woman | 15 | Three of left forearm chronic ulcers, two 0.5 little * 0.8cm of 2 big * 1.5cm, disunion in two months. | Medication one all little planing surface healings, all healings after month. |
| Xu Ding | 64 | Wound fistula after the thoracotomy, pipe range 3cm, fistula mouth 0.3cm, disunion in two months. | Medication healing in 10 days is followed up a case by regular visits to after one month and is not had recurrence. | |
| Zhu Weifen | The woman | 45 | Behind the radical operation of mastocarcinoma of right side, otch central authorities liquefaction of fat is split, dark 0.3cm area 6 * 5cm. | 10 days wound surface of medication dwindle, and obviously dwindle a healing in month after three weeks. |
| Liu Ranting | 43 | The inboard ulcer of right foot, dark 0.1cm area 1 * 1cm, two weeks disunion | Medication healing in 2 days, all decrustations. | |
| Mi Peng | The woman | 38 | Right sufficient chronic ulcer did not heal in 3 years, dark 0.8cm area 6 * 3cm, and the patient has the sclerderm medical history. | Medication dwindled 1/3 in one month. |
| Hong Mingfu | 71 | A left side sufficient little toe outside sclerosis obliterans ulceration January is surplus does not heal dark 0.5cm area 2.5 * 1.2cm. | A medication recovery from illness in month. | |
| Wang Lunxi | 19 | Left leg laceration of skin concurrent infection, disunion in 35 days.Dark 0.5cm area 4 * 3cm. | Medication healing in 25 days. | |
| Han Fengquan | 80 | The dark 11 degree burns of shank were not healed in 30 days | Medication healing in 21 days. | |
| Qi Hongjun | 64 | Left side heel portion chronic ulcer, disunion in ten months, dark 1.5cm area 4 * 3cm. | After 2 weeks of medication, planing surface obviously dwindles. | |
| Sun Qiuyan | The man | 81 | Two lower extremities obliteranses, two deep veins of lower limb inflammation, 0.5cm is dark, and 5 * 5cm size did not heal in three months. | A recovery from illness in month after the medication. |
| Liu Binpei | 59 | The left lower extremity great saphenous varicose vein, the foot outside, companion left side chronic ulcer, disunion in 2 months, dark 0.7cm area 1 * 1cm 2 | Epidermis healing after the medication, the deep still has slough. | |
| Jia Maolin | 45 | The secondary infection of right leg wound, disunion half a year, dark 0.3cm area 4 * 3cm 2Surrounding tissue is stiff. | Invalid | |
| Li Zhiyuan | 37 | The vasculitis III phase, left side foot 45 toe ulcer, dark 0.3cm area 0.5 * 5cm 2With 1 * 0.3cm 2, disunion in three months, the surrounding tissue redness is stiff. | Invalid |
Sum up
Have among the 21 routine patients:
Staphylococcus aureus infected wound two examples of 1-5 disunion all healed at 5-10 days after the medication.
Diabetic ulcer three examples of 1-3 month disunion all heal in two weeks after the medication.
Lymphoid tuberculosis wound two examples of disunion half a year all heal in two weeks after the medication.
The case of one example, 11 a degree burns disunion in month, healing in 21 days after the medication.
1-12 month disunion open breast two examples, after the medication all healing in 5-10 days.
Patient's two examples of the long-term disunion of the phlebitis of lower extremities all heal in 2 weeks after the medication.
Many cases disunion chronic ulcer, 2-3 week healing after the medication.
The disunion in 3 years of one routine scleroderma patient's foot's ulcer is clearly better after the medication.
Take a turn for the better after the one routine great saphenous varicose vein patient foot chronic ulcer medication.
Two routine heel disunion wounds are stiff invalid because of surrounding tissue.
Total effectively warp is greater than 90%.
Drug powder of the present invention is applicable to aforementioned various difficult healing of wound, severe patient medication every day once, the next day of the lighter or the every other day medication once.Before the use, earlier wound surface is cleaned out, again medicated powder is applied (or water-soluble back drips) wound surface, cover the back wrapping with the vaseline oil sliver and get final product.
Medicine cream cream of the present invention is applicable to aforementioned burn and scald, wounds such as decubital ulcer, severe patient medication every day once, the next day of the lighter or the every other day medication once.Before the use, earlier wound surface is cleaned out, again ointment is applied wound surface and get final product.
Medicine patch of the present invention is applicable to the local ulcer in oral cavity, wounds such as slight decubital ulcer, and every other day changes dressings once.
Medicine spray of the present invention is applicable to aforementioned burn and scald, decubital ulcer, and wounds such as oral ulcer, severe patient sprays medicine 3-4 time every day, the lighter every day 1-2 time.
The content of dispersion of various dosage forms of the present invention is reference with the drug powder dosage of single composition, uses drug powder to execute when controlling, and drug powder is covered wound surface get final product.
The specific embodiment
The specific embodiment of the medicine of healing of wound of the present invention is as follows:
Embodiment 1
The preparation of gallbladder powder
Method 1: getting fresh mammal gallbladder, can be Fel Sus domestica or Fel Caprae seu Ovis or Fel Ursi or Fel Canitis, air-dry or dry with conventional Chinese medicine processing method, pulverizes, and porphyrize gets gallbladder powder.
Method 2: lyophilization, porphyrize are made lyophilized powder according to a conventional method to get fresh bile.
Embodiment 2: preparation gallbladder powder water-soluble portion
(a) gallbladder powder is sterilized according to sterilization with cobalt 60 (Co60) width of cloth, the width of cloth is penetrated dosage 800,000 Rad irradiation 10 hours;
(b) the gallbladder powder physiological saline solution that will sterilize qualified, making concentration of aqueous solution is 10 mg/ml;
(c) the gallbladder powder solution that step (b) is obtained is removed insoluble matter with centrifugal separation, and the aqueous solution that obtains is the water-soluble portion of gallbladder powder.
(d) the water-soluble portion lyophilization of gallbladder powder is made lyophilized powder.
Embodiment 3:
(a) gallbladder powder is being sterilized according to sterilization with cobalt 60 (Co60) width of cloth, the width of cloth is penetrated dosage 800,000 Rad irradiation 15 hours;
(b) the gallbladder powder physiological saline solution that will sterilize qualified, making concentration of aqueous solution is 20 mg/ml;
(c) the gallbladder powder solution that step (b) is obtained is removed insoluble matter with centrifugal separation, and the aqueous solution that obtains is the water-soluble portion of gallbladder powder.
(d) the water-soluble portion lyophilization of gallbladder powder is made lyophilized powder.
Embodiment 4:
(a) gallbladder powder is being penetrated dosage 800,000 Rad irradiation 20 hours with cobalt 60 (Co60) the sterilization width of cloth;
(b) the gallbladder powder physiological saline solution that will sterilize qualified, making concentration of aqueous solution is 2 mg/ml;
(c) the gallbladder powder solution that step (b) is obtained is removed insoluble matter with centrifugal separation, and the aqueous solution that obtains is the water-soluble portion of gallbladder powder.
(d) the water-soluble portion lyophilization of gallbladder powder is made lyophilized powder.
With the lyophilized powder of the gallbladder powder water-soluble portion that obtains among the embodiment 2-4, directly as drug powder of the present invention, be used for the treatment of various difficult healing of wound, during use the wound medication powder is covered, wrapping gets final product.
With the lyophilized powder of the gallbladder powder water-soluble portion that obtains among the embodiment 2-4 routinely pharmaceutical methods can also make the cream cream, patch, spray, convenient different patients' use.
In addition, change the gallbladder powder among the embodiment 2-4 into bile and make the lyophilized powder of biliary water-soluble portion, and can further be processed into various external-use drug forms with identical method.
Claims (10)
1, a kind of medicine of healing of wound is characterized in that: effective ingredient is the water-soluble portion or the biliary water-soluble portion of gallbladder powder.
2, the medicine of a kind of healing of wound according to claim 1 is characterized in that: described gallbladder powder is that the Chinese medicine processing method is air-dry or dry, pulverize and make routinely with gallbladder.
3, the medicine of a kind of healing of wound according to claim 1 is characterized in that: described gallbladder powder is according to a conventional method bile lyophilization, porphyrize to be made.
4, the medicine of a kind of healing of wound according to claim 1, it is characterized in that: described water-soluble portion is that described gallbladder powder or bile are sterilized, with physiological saline solution to concentration is 2～20 mg/ml, makes behind the centrifugal removal insoluble matter.
5, the medicine of a kind of healing of wound according to claim 1 is characterized in that: described medicine is made powder, cream cream, patch or spray.
6, the medicine of a kind of healing of wound according to claim 1 is characterized in that: described gallbladder is mammiferous gallbladder.
7, the preparation method of the medicine of a kind of healing of wound according to claim 1, it is characterized in that: described medicine is to be that the water-soluble portion or the biliary water-soluble portion of gallbladder powder is main component with the effective ingredient, and Chinese medicinal preparation method is made various external-use drug forms routinely;
The water-soluble portion of described gallbladder powder or biliary water-soluble portion are made by following method:
A, gallbladder powder or bile are carried out the sterilization of cobalt 60 irradiation sterilization methods, the width of cloth is penetrated dosage 800,000 Rad irradiation 10～20 hours;
B, will sterilize qualified gallbladder powder or bile dissolve with medical saline;
C, with gallbladder powder or bile solution that step b obtains, remove insoluble matter with centrifugal method, the aqueous solution that obtains is the water-soluble portion or the biliary water-soluble portion of gallbladder powder.
8, the preparation method of the medicine of a kind of healing of wound according to claim 7 is characterized in that: the concentration of the aqueous solution that poly-c of described step obtains is the 2-20 mg/ml.
9, the preparation method of the medicine of a kind of healing of wound according to claim 7 is characterized in that: described gallbladder powder is air-dry or dry with conventional Chinese medicine processing method, and pulverizing is made.
10, the preparation method of the medicine of a kind of healing of wound according to claim 7 is characterized in that: described gallbladder powder is according to a conventional method lyophilized powder to be made in the bile lyophilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100721326A CN1321647C (en) | 2005-05-25 | 2005-05-25 | Medicine for wound healing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100721326A CN1321647C (en) | 2005-05-25 | 2005-05-25 | Medicine for wound healing and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1698656A CN1698656A (en) | 2005-11-23 |
| CN1321647C true CN1321647C (en) | 2007-06-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100721326A Expired - Fee Related CN1321647C (en) | 2005-05-25 | 2005-05-25 | Medicine for wound healing and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244395A (en) * | 1998-08-08 | 2000-02-16 | 陈荣生 | Externally-used burn and scald treating Chinese medicine ointment and its preparation |
| CN1481817A (en) * | 2002-09-11 | 2004-03-17 | 魏福华 | Powder for trauma |
| CN1166687C (en) * | 1998-07-03 | 2004-09-15 | 徐建兴 | Medicine combined by moleculae of growth factor and traumatic factor in gall |
-
2005
- 2005-05-25 CN CNB2005100721326A patent/CN1321647C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166687C (en) * | 1998-07-03 | 2004-09-15 | 徐建兴 | Medicine combined by moleculae of growth factor and traumatic factor in gall |
| CN1244395A (en) * | 1998-08-08 | 2000-02-16 | 陈荣生 | Externally-used burn and scald treating Chinese medicine ointment and its preparation |
| CN1481817A (en) * | 2002-09-11 | 2004-03-17 | 魏福华 | Powder for trauma |
Non-Patent Citations (3)
| Title |
|---|
| 中医治疗烧烫伤新方(下) 刘国应，开卷有益.求医问药，第3期 1995 * |
| 鱼胆治烧烫伤 新农业，第2期 1994 * |
| 鱼胆治烧烫伤 新农业，第2期 1994;中医治疗烧烫伤新方(下) 刘国应，开卷有益.求医问药，第3期 1995 * |
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| Publication number | Publication date |
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| CN1698656A (en) | 2005-11-23 |
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Effective date of registration: 20051209 Address after: No. 5, 402 gate, 947 floor, Haidian District, Beijing, Zhongguancun Applicant after: Kang Jian Co-applicant after: Xu Jianxing Address before: Beijing City, Chaoyang District, 409 North building first floor Applicant before: Beijing Zhongke Yisheng Gene Technology Co., Ltd. |
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