CN1321499A

CN1321499A - Chinese patent medicine for curing deafness

Info

Publication number: CN1321499A
Application number: CN01114944A
Authority: CN
Inventors: 曲强
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-05-11
Filing date: 2001-05-11
Publication date: 2001-11-14
Anticipated expiration: 2021-05-11
Also published as: CN1150925C

Abstract

The present invention relates to a Chinese patent medicine for curing sudden deafness and sound perception-nervous deafness, and is formed from 16 Chinese medicinal materials of musk, borneol, bupleurum root, gastrodia root, psoralea fruit, pagolin scales and others. Said invention possesses the functions of freeing orifice, sharpening hearing, supplementing kidney, promoting blood circulation, removing stasis and promoting growth of new tissues, and can obviously raise volume of blood flow in internal ear and blood oxygen content, and can make various nutrient substances for nervus acusticus enter internal ear to repair damaged and degenerative autitory cell and raise its activity.

Description

A kind of Chinese patent medicine for the treatment of deafness

The present invention is a kind of Chinese patent medicine for the treatment of the polytype deafness.

Deafness is a kind of commonly encountered diseases, frequently-occurring disease, particularly sudden deafness and phonosensitive--nerve deafness, has rapid onset, and uppity characteristics, doctor trained in Western medicine mainly adopt the means of nutrition auricularis cell, and main medicine adopts ATP, coenzyme A, cytochrome C, vitamin B ₁, B ₆, V _CDeng, and cooperate the employing hyperbaric oxygentherapy, intravenous injection antithrombotic, blood circulation promoting medicine etc.At the principles of formulating prescriptions of this sick Chinese patent medicine then employing on prescription " liver heat removing pathogenic fire reducing, the expectorant of living are had one's ideas straightened out ", but curative effect is undesirable.

Purpose of the present invention mainly is at sudden deafness and phonosensitive--wide, the rapid onset of morbidity of nerve deafness, treatment in time recovers also fast characteristics and designs one group of new Chinese patent medicine prescription, not strong in order to overcome the specific aim that has prescription, the Therapeutic Principle is perfect inadequately, shortcomings such as dialectical and prescription is rigorous inadequately, thus curative effect improved.

Therapeutic regimen of the present invention is as follows: this Chinese patent medicine is made up of Moschus, Borneolum Syntheticum, Radix Bupleuri, Rhizoma Gastrodiae, Fructus Psoraleae, Squama Manis, Rhizoma Acori Graminei, Magnetitum, Radix Rehmanniae Preparata, Fructus Corni, Fu Ling, Cortex Moutan, Rhizoma Alismatis, Pheretima, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong.

Moschus in the prescription, Borneolum Syntheticum have awakening consciousness, go turbidly to have one's ideas straightened out, and stronger tonneau ear key, the effect that internal ear is recovered lost hearing are arranged.The modern medicine evidence, it helps the detoxifcation of acoustic nerve cell to recovery, the protection of degeneration acoustic nerve cell, and improve the irritability of acoustic nerve cell and improve its complex function, and then the obvious effect that improved one's hearing.

Squama Manis in the prescription has the effect of extremely strong sensible, collateral dredging, the sharp key of removing blood stasis with potent drugs.It and Moschus, Borneolum Syntheticum share, and can obviously strengthen the biological activity of the two, have the metabolic function of protection, reparation, propagation, excitement, detoxifcation and enhancing cell self that improves the acoustic nerve cell.These functions are confirmed in the test of cure process of animal internal ear pathological model.

Fructus Psoraleae in the prescription, Rhizoma Chuanxiong, Magnetitum, Rhizoma Acori Graminei, Rhizoma Gastrodiae are except that the effect with good blood circulation promoting and blood stasis dispelling, eliminating blood stasis to promote regeneration of blood, suppressing the hyperactive liver to relieve the wind syndrome, the logical ear of sharp key, the clinical proof of modern medicine, such medicine has special efficacy to the treatment nerve deafness, thus in this prescription with its special-purpose medicine as treatment deafness.(the deaf pharmacological action of such medicine treatment remains further to be studies confirm that.)

In the prescription other eight flavor Chinese medicines are prescription medicines of LIUWEI DIHUANG WAN, the effect that has the kidney invigorating, fills ear, mends kidney and promoting defecation and urination, the kidney invigorating audition improvement, for the important drugs of the treatment deafness of " treatment must aim at the pathogenesis of disease ", because " kidney opening at ear ", " kidney and Ze Er can hear the five notes of traditional Chinese music also ".

In sum, superiority of the present invention is in the prescription sudden and phonosensitive--the cause of disease of nerve deafness is grabbed relatively accurately, dialectical execute to control use properly, have accurate, the concise characteristics of medication.These all are the key factors that improves curative effect.In addition, medical material is used draft more, and medication is concise, therefore has curative effect height, advantage without any side effects and lower-cost.

The preparation technology of this Chinese patent medicine is as follows:

One, dosage form: this Chinese patent medicine dosage form can adopt the common dosage form of Chinese patent medicine, as water pill, honeyed pill, capsule etc.From be convenient to absorb, easy to carry and consider that with factor such as decoction active ingredient dose concordance the dosage form that this Chinese patent medicine is selected for use is the honeyed pill that is loaded in the PVC plate.Honeyed pill has 9 grams and 6 to restrain two kinds.

Two, drug ratio:

Moschus 3 gram Borneolum Syntheticums 0.5 gram Radix Bupleuri 1.5 grams

Rhizoma Gastrodiae 12 gram Fructus Psoraleaes 15 gram Squama Maniss 10 grams

Rhizoma Acori Graminei 18 gram Magnetitums 18 gram Radix Rehmanniaes Preparata 60 grams

Fructus Corni 45 gram volt Siberian cockleburs 45 gram Cortex Moutans 18 grams

Rhizoma Alismatis 18 gram Pheretimas 18 gram Radix Salviae Miltiorrhizaes 90 grams

Rhizoma Chuanxiong 12 grams three, technical process:

1, the medical material of will writing out a prescription is cleaned airing;

2, fineves such as Moschus, Borneolum Syntheticum are put into mortar grinding becoming fine powder;

3, other Chinese crude drugs are coarse fodder, will pulverize behind its mix homogeneously, with 80～100 mesh sieve mistakes

Sieve becomes coarse powder;

4, fine powder and coarse powder are put into epoxy one alkane gas tank respectively, sterilization;

5, will go out fine powder and a small amount of of bacterium, middle a small amount of, middle amount, a large amount of Chinese medicine coarse powder step by step and

All;

6, will endure out with the Mel of medicated powder equivalent, all medicated powder are added in Mel stir evenly, airing;

7, get ball with 9 grams and the wooden medicine mould of 6 grams, be pressed into PVC clad plate packing at last.

Pharmacodynamic study of the present invention proves, this Chinese patent medicine formula all has very strong biological activity to the acoustic nerve that is damaged by any cause of disease, particularly Ke Di Schwann Cells and the acoustic nerve cell to cochlea has very strong regeneration, can stimulate the acoustic nerve cytothesis and the raising that are damaged with degeneration active, regulate the effect of acoustic nerve cell.This prescription has good protective effect to the acoustic nerve cell, prevents that it from being decreased and necrosis.This prescription can improve the acoustic nerve cell and carry out splitted Physiological Medium, improve the ability of the media that stores the acoustic nerve cell, thereby reach the environment that improves the cell growth, induce the growth of acoustic nerve cell, impaired acoustic nerve cell is restored, and int cell improves its function.From the Chinese medicine angle, ear, blood circulation promoting and blood stasis dispelling, eliminating blood stasis to promote regeneration of blood are filled in sensible audition improvement, the kidney invigorating, and the other drug of partner treatment deafness, and blood flow, oxygen content and the various material to the nutritious effect of acoustic nerve that can improve internal ear enter internal ear.

The present invention has carried out animal toxicity test, and acute, chronic (three months) gastric infusion in the mice body, its liver,spleen,kidney tissue slice are observed all less than damage.Murine inner ear blood flow showed increased after the medication, flow velocity is accelerated, and causes deaf mice to giving the aminoglycosides ototoxic drug, observes after 1～3 month administration, and sonic stimulation is had good reaction.

The present invention has carried out clinical verification, has selected deafness patient 116 people, and wherein 104 people's ears are deaf, and 12 people are monaural deafness, is sudden, conductivity and phonosensitive--nerve and mixed deafness patient, suffers from ears for totally 220.The evaluation index of its clinical efficacy is: trouble ear audition reaches and is produce effects more than 15 decibels, and audition reaches 11～15 decibels for effective; Audition reaches 5～10 decibels and is little effect, and audition is lower than 5 decibels for invalid.Take this Chinese patent medicine, after 10～30 days, sudden and total effective rate transmission deafness are reached 90%.To phonosensitive--nerve deafness, mixed deafness, need take this Chinese patent medicine 20～80 days, its curative effect is as follows: wherein 55 trouble ears are produce effects, account for 25%; 90 trouble ears are effective, account for 41%; 57 are suffered from ear is little effect, accounts for 26%; 18 trouble ears are invalid, account for 8%.Simultaneously, take this Chinese patent medicine and the effect of well preventing is also arranged for the disease relapse that deafness patient more back causes because of reasons such as flu.

Claims

1, a kind of Chinese patent medicine for the treatment of deafness is characterized in that: be made up of Moschus, Borneolum Syntheticum, Radix Bupleuri, Rhizoma Gastrodiae, Fructus Psoraleae, Squama Manis, Rhizoma Acori Graminei, Magnetitum, Radix Rehmanniae Preparata, Fructus Corni, Fu Ling, Cortex Moutan, Rhizoma Alismatis, Pheretima, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong.