CN1316927C - Beverage for relieving with drawal syndrome for druggy recovery period - Google Patents
Beverage for relieving with drawal syndrome for druggy recovery period Download PDFInfo
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- CN1316927C CN1316927C CNB031215165A CN03121516A CN1316927C CN 1316927 C CN1316927 C CN 1316927C CN B031215165 A CNB031215165 A CN B031215165A CN 03121516 A CN03121516 A CN 03121516A CN 1316927 C CN1316927 C CN 1316927C
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Abstract
The present invention relates to a beverage for relieving an anxious syndrome for rehabilitation persons during convalescence. The present invention is characterized in that the beverage comprises 5 ml to 200 ml/L of aqueous extract of birch fungus. The present invention applies the beverage which comprises the aqueous extract of the birch fungus to clinical practice. Shown in a statistical result, various symptoms of the anxious syndrome expressed by subjects who drink the beverage of the present invention are all relieved.
Description
Technical field:
The present invention relates to a kind of beverage of alleviating drug abstainer convalescence anxious syndrome, specifically, is the beverage that contains the CHAGA water extract.
Background technology:
Drugs (heroin, morphine and methamphetamine etc.) addict removes at drugs and to have no progeny, or anxious syndrome can occur after making the detoxification that ins all sorts of ways, as: anxiety, depression, agitation, insomnia, nervous palpitaition, thirsty, dry lip, drak urine, dry skin etc.Therefore the addict received treatment still needs to take some drugs at the detoxification convalescence, with anxiety, insomnia or the sleep-disorder of alleviating this period, to symptoms such as the serious hope of drugs, agitations.But take clinical some used medicines at present for a long time, except meeting causes drug side-effect,, also can cause its dependence and serious hope medicine more seriously for this special crowd of addict received treatment.
Existing on the market at present various beverages, as the cola type soda etc., its main feature is comfortable taste, promote the production of body fluid to quench thirst, keep the skin wet, adjust dielectric in the body.These beverage application during the crowd, only can be replenished body water in drug rehabilitation, solve symptoms such as it is thirsty, dry lip, drak urine, dry skin, but can not remove its sleep-disorder, to the serious hope of drugs, irritated problem.
Therefore,, a kind ofly can alleviate anxious syndrome, not cause that again the beverage to the adjunctive therapeutic of medicine association is in demand, but still do not have this kind beverage at present for the addict received treatment.
CHAGA is a kind of mushroom material that is grown on the plant, its medicinal title be Inonotus obliquus (Phaeoporus obliquus) in foreign language datum, its formal name used at school often occurs with " Inonotus obliquus " or " Fuscoporia oblique ".
Summary of the invention:
The invention provides a kind of beverage that contains the CHAGA water extract, can alleviate drug abstainer convalescence anxious syndrome.
Beverage of the present invention can be all kinds that those of ordinary skills know in the prior art, the beverage of various tastes.
In beverage, the content range of CHAGA water extract is 5ml~200ml/L;
Described CHAGA water extract is meant the employing water-extraction method, extracts the resulting water extract of active ingredient in the CHAGA.Its concentration is the about 80 liters of concentrates of per 10 kilograms of CHAGA raw material outputs.Extraction process is:
(1) CHAGA is soaked in water 2~4, gets supernatant;
(2) the solid dregs of a decoction were soaked in water 3~5 again, get supernatant;
(3) again the solid dregs of a decoction were soaked in water 2~4, get supernatant;
(4) merge above-mentioned three times and soak supernatant, filter, concentrate.
The preparation method who contains CHAGA water extract beverage is on the basis of various traditional beverage preparation, has added the CHAGA water extract and has formed, and the preparation method of these conventional beverage to those skilled in the art, is conventional production method.These conventional beverage comprise fruit juice class, soda class, as cola type, carbonated drink type etc.
The beverage that the present invention will contain the CHAGA extract is used for the clinical practice of quitting drug abuse, observed the many cases volunteer, be drugs (heroin, morphine and methamphetamine etc.) addict, remove at drugs and to have no progeny, or make the anxious syndrome that is occurred after the detoxification that ins all sorts of ways, and as: anxiety, depression, agitation, insomnia, nervous palpitaition, thirsty dry lip, drak urine, dry skin etc.Statistical result showed, drink beverage of the present invention after, the experimenter shows the various symptoms of having alleviated anxious syndrome, has realized above-mentioned technical purpose.
The present invention is on the basis of conventional beverage preparation, added the CHAGA water extract, produce and a kind ofly new can alleviate the beverage of drug abstainer at convalescent anxious syndrome, the patient every day in the essential water liquid that replenishes, also obtain rehabilitation and assisted a ruler in governing a country treatment, well realized purpose of the present invention.
The specific embodiment:
The preparation of embodiment 1 CHAGA extract
(1) with CHAGA broken or cutting into about 1cm
3Bulk adds pure water in 1 to 8 ratio in container, temperature remains on about 5-20 ℃, and sealing is soaked after 72 hours and got supernatant;
(2) add pure water in 1 to 8 ratio again, temperature remains on about 5-15 ℃, and sealing is soaked after 96 hours and got supernatant.
(3) add pure water in 1 to 5 ratio again, temperature remains on about 5-15 ℃, and sealing is soaked after 72 hours and got supernatant.
(4) 3 supernatants are mixed, 180 eye mesh screens filter; To filter back liquid concentrates with vacuum concentration pot;
(5) per 10 kilograms of CHAGA raw materials are answered 80 liters of concentrates of output (125 gram CHAGAs/liter).Behind the illumination-based disinfection, collect standby.
The preparation of embodiment 2 cola type CHAGA water extract sodas
1) prescription: (85%) 225 milliliter of 35 kilograms of saccharin sodiums of white sugar, 40 gram edible phosphoric acid
550 milliliters of 700 milliliters of cola essences of citric acid 500 gram caramel colorants
20 liters of CHAGA water extracts (CHAGA 125g/L)
Pure water adds to 100 liters
Above-mentioned prescription can about 100 liters of syrup, again in 400 liters of carbonated waters of ratio perfusion of 1: 4 altogether 500 liters of beverages, but packing 1000 bottles (500 milliliters/bottle) is standby.
2) technological process of production:
The clinical testing of embodiment 3 CHAGA extract concentrated solutions
Object:
54 routine volunteer addicts all are the heroin addiction person of hospitalization.The opium that all meets International Classification of Disease 10th edition relies on diagnostic criteria.37 routine detoxification persons all are the male sex, mean age 33.57a ± s8.3a; History of drug abuse 2.96a ± s1.06a; Drug abuse amount 1.89gd
-1± s0.38gd
-1The drug abuse mode: scald and inhale 26 examples, intravenous injection is 11 examples (iv).54 routine detoxification persons all finish clinical observation experiment, do not have 1 example and withdraw from test.Urine opiates qualitative detection is positive when being admitted to hospital, and taking drugs apart from last is no more than 24h.Getting rid of the various organic hearts, lung disease and liver kidney damages.
Usage:
Everyone every day 2-3 time, each aseptic CHAGA extract concentrated solution of 10-30 milliliter (per 10 milliliters of concentrates add the pure water latting drown after warm water take) in 1 to 2 ratio.
Method:
Mensuration depressed and anxiety adopts HAMD (Hamilton depression scale, HAMD) and HAS (Hamilton anxiety scale, HAMA), (being begin treatment behind the 2h that is admitted to hospital) and 20d-25d (treatment back) carry out the inquiry scoring before the d1 treatment of being admitted to hospital.
Data are handled statistics: test data is represented with x ± s.Adopt variance analysis (ANOVA), continue and check with Newman-Keuls.Judge the conspicuousness standard with P<0.05.
Result of the test such as following table.
Anxious syndrome | CHAGA extract group (31 example) | Control group (23 example) |
The depressive anxiety sleep-disorder is craved for drugs | 0.36±s0.31 0.29±s0.38 0.84±s0.53 0.47±s0.47 | 2.01±s0.41 1.20±s0.48 2.24±s0.89 1.58±s0.33 |
The clinical testing of embodiment 4 cola type CHAGA water extract sodas
Subjects:
Convalescence volunteer after the 47 routine heroin addict detoxifications
Trial drug:
The cola type CHAGA water extract soda of embodiment 2
The result:
Influence such as following table to convalescence HAMD (HAMD) total points after the heroin addict detoxification and HAS (HAMA) total points:
Control group (n=24) | Beverage group (n=23) | |||
Before the use | After the use | Before the use | After the use | |
HAMD HAMA | 28.64±s5.91 25.35±s7.91 | 26.28±s9.11 26.07±s6.80 | 27.34±s9.26 - 23.43±s6.58 - | 15.34±s7.72*** ### ↓40% 15.78±s6.65*** ### ↓33% |
* *P<0.001 uses the back relatively with control group.
###P<0.001 is used relatively preceding with the beverage group.
-P>0.05 is used relatively preceding with control group.
By table as seen, the overall score no change of back before use HAMD of control group and HAMA still significantly surpasses cut off value (HAMD total points cut off value: no depression 0-8; Mild or moderate depression>20 minute; Major depression>35 minute.HAMA total points cut off value: no anxiety 0-14 branch; LA>14 minute; Moderate anxiety>21 minute; Serious anxiety>29 minutes) [4], show before the depression of control group after use and anxiety and the use the same, no significant change.
Obvious variation had taken place in the overall score of HAMD and HAMA before and after the beverage group was used, HAMD is by the 15.34 ± s7.72 that uses after 27.34 preceding ± s9.26 is reduced to use, HAMA reduces to 15.78 ± s6.68 by 23.43 ± s6.85, has significant differences (P<0.001).The overall score that B group is used back HAMD and HAMA and control group use back HAMD (26.28 ± s9.11) and HAMA (26.07 ± s6.80) overall score is compared, and also obviously reduction exists significant differences (P<0.001).This explanation, after using this beverage, detoxification person's depression and anxiety are compared with comparing still with after control group uses before self uses, and have reduced by 40% and 33% respectively.
Claims (4)
1. the application of CHAGA water extract in preparation alleviation drug abstainer convalescence anxious syndrome beverage.
2. application according to claim 1, described CHAGA water extract is prepared into beverage.
3. application according to claim 2 contains CHAGA water extract 5ml-200ml/L in the described beverage, wherein said CHAGA water extract is meant that water extracts the concentrate of the water extract of the active ingredient gained in the CHAGA; 80 liters of concentrates of per 10 kilograms of CHAGA raw material outputs.
4. application according to claim 3, described beverage is a soda.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB031215165A CN1316927C (en) | 2003-04-03 | 2003-04-03 | Beverage for relieving with drawal syndrome for druggy recovery period |
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CNB031215165A CN1316927C (en) | 2003-04-03 | 2003-04-03 | Beverage for relieving with drawal syndrome for druggy recovery period |
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CN1535626A CN1535626A (en) | 2004-10-13 |
CN1316927C true CN1316927C (en) | 2007-05-23 |
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CNB031215165A Expired - Fee Related CN1316927C (en) | 2003-04-03 | 2003-04-03 | Beverage for relieving with drawal syndrome for druggy recovery period |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2772589C1 (en) * | 2021-07-19 | 2022-05-23 | Федеральное государственное бюджетное образовательное учреждение высшего образования «Амурский государственный университет» | Method for obtaining a functional drink |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102851164A (en) * | 2012-09-08 | 2013-01-02 | 吴鎏桢 | Inonotus obliquus dry red wine |
CN103142661B (en) * | 2013-04-02 | 2015-01-14 | 金波 | Preparation method of inonqqus obliquus water-extract fine powder |
CN103284322B (en) * | 2013-04-02 | 2016-07-06 | 徐志强 | A kind of medicated cigarette and other goods and preparation method thereof that can suppress addict that drugs are craved for heart addiction |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2171114C1 (en) * | 2000-12-20 | 2001-07-27 | ЗАО "Фармацевтическое предприятие "Мелиген" | Elixir exhibiting sedative and general tonic effect |
RU2173991C1 (en) * | 2000-03-30 | 2001-09-27 | Сибирский государственный медицинский университет | Method of treatment of patients with duodenum ulcer disease of moderate severity |
CN1398902A (en) * | 2002-05-21 | 2003-02-26 | 崔基成 | Extraction process of Fuscoporia obliqua polysaccharide |
-
2003
- 2003-04-03 CN CNB031215165A patent/CN1316927C/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2173991C1 (en) * | 2000-03-30 | 2001-09-27 | Сибирский государственный медицинский университет | Method of treatment of patients with duodenum ulcer disease of moderate severity |
RU2171114C1 (en) * | 2000-12-20 | 2001-07-27 | ЗАО "Фармацевтическое предприятие "Мелиген" | Elixir exhibiting sedative and general tonic effect |
CN1398902A (en) * | 2002-05-21 | 2003-02-26 | 崔基成 | Extraction process of Fuscoporia obliqua polysaccharide |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2772589C1 (en) * | 2021-07-19 | 2022-05-23 | Федеральное государственное бюджетное образовательное учреждение высшего образования «Амурский государственный университет» | Method for obtaining a functional drink |
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CN1535626A (en) | 2004-10-13 |
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