CN1310958A - Health food or special nutritious food for regulating blood pressure, blood fat and delay senility - Google Patents

Abstract

A health care food or special nutritive food capable of regulating blood pressure, blood fat and delaying senility is prepared from celery extract as and delaying senility is notoginseng powder according to certain proportion. Toxicological experiment proves that said invented food is safe and health care function is precise.

Description

Blood pressure regulation, blood fat and anti-aging health food or food of special nutrients

The present invention relates to a kind of health food, particularly have the health food of blood pressure regulation effect, blood lipid regulation effect and delaying senility function.

Civilization, progress and development along with society, human longevity generally improves, and the illness relevant with the age, as hypertension, hyperlipidemia, animal is atherosis, and sickness rate such as degenerative disease obviously increase, this brings sufferings not only for ill crowd, also household and society is caused burden.Therefore how slow down aging improves quality of life and prevents chronic disease that a problem that attracts people's attention takes place to have become.

People know and eat fruit more; does vegetable can reduce disease take place, but is that what material has protective effect in the fruit and vegetable on earth? the chemical substance of having isolated from vegetable, fruit beyond the big class nutrient with modernism along with development of life science is referred to as phytochemical.Studies show that these phytochemicals are the non-trophic factors in the food; but has important biological function; as effects such as antioxidation, free radical resisting, blood lipid regulation, blood pressure regulation, the material of these biologically actives has protective effect in life, the physics that touches in the production environment, chemistry, murder by poisoning aspect biological for a long time to the mankind.We advocate and eat vegetable and fruit more, but because old people's odontoseisis, degradation reason under people's appetite of anorexia, some trouble chronic diseases and the appetite, often can not eat the fruit or the vegetable of q.s every day, it is edible for the crowd that therefore necessary non-trophic factors nutrient in vegetable or the fruit and biologically active extracts, makes with extra care, is developed to health food.

Life sciences has considerable progress in recent years, current puzzlement people's life problem is directly pointed in its research focus and service field, one of them noticeable problem is exactly the free radical that the human body peroxidating is produced, and is relevant with some cardiovascular disease, aging and cancer etc.Prevent and treat these diseases and will remove free radical, removing free radical usually has two kinds of methods: the one, increase the enzyme system of removing free radical in the human body, as superoxide dismutase, catalase, glutathion peroxidase, glutathione S-transferase etc.The 2nd, replenishing non-enzyme system is natural polyphenoils, as some vitamin, glutathion, trace element and non-trophic factors etc. with antioxidation.Domestic scholars Li Min etc. [Hygiene Toxicology magazine 10 (4): 220.1996] had once reported and had contained antioxidant content in the Sucus Oenanthes Javanicae, the lipid peroxide of hepatomicrosome film is obviously reduced, and lipofuscin is reduced, thereby the delaying senility function of Sucus Oenanthes Javanicae has been described indirectly.Therefore we with Herba Apii graveolentis as food resource, with high-tech means to its extraction and prepare the goods that are rich in phytochemical in the Herba Apii graveolentis.Its main feature is to be rich in phytoprotein, vitamin, mineral, chlorophyll and flavonoid etc.Vegetable protein is a small molecular protein because of it, can be absorbed by body effectively and energy is provided; Abundant mineral especially potassium ion and magnesium ion, calcium ion has the effect of prevention cardiovascular and cerebrovascular disease; Ferrum and zinc etc. have the effect that promotes upgrowth and development of children, and chlorophyll and flavonoid all have antioxidation and eliminate the free radical effect, and flavonoid also has blood fat reducing and blood pressure effect, thus slow down aging and the various chronic cardiovascular disease of prevention.

Herba Apii graveolentis is at the northern China aboundresources, and theory of Chinese medical science proves that already Herba Apii graveolentis has the effect of blood pressure lowering, treatment dizziness, headache.The modern analysis means prove again and contain in the Herba Apii graveolentis outside generally acknowledged component for reducing blood fat 3-n-butyl 2-benzo (c) furanone, in its water extract, also contain other component for reducing blood fat, [Planta Med.61:18 such as Singapore scholar Tsi, 1995] Herba Apii graveolentis is pulverized, use water extraction, water extract is concentrated, powder is made in lyophilization then, (dosage is 4 week of 10g/ rat/d) powder to be mixed feed rat in the feedstuff again, found that the Herba Apii graveolentis water extract can obviously reduce T-CHOL in the serum, the content of low-density lipoprotein cholesterol and triglyceride, and can increase the capacity of decomposition of liver to triglyceride.Illustrate that it has the blood lipid regulation effect.People such as Crozier [J.Agric Food Chem 45:590,1997] find through advanced person's extraction, separation, purification and identification of means analysis, main bioactive substance in the water extract is a flavonoid, (apigenin 5 for the apiin that mainly contains in the Herba Apii graveolentis, 7,4 '-trihydroxyflavone), can reach 1783.2mg/Kg, digicitrine (Luteolin, sweet-scented osmanthus flavin) can reach 333.4mg/Kg and other flavonoid.Flavone compound has curative effect preferably to ischemic heart desease, for example report more and can reach 94.5% for the total effective rate of Fructus Hippophae flavone blood pressure lowering, its mechanism of action is to work indirectly by regulating cytochrome p450 system, also some scholar thinks to work by the improvement of cell function, so can treat coronary heart disease, controlling blood pressure (West China pharmaceutical journal effectively again, 1999 the 14th volumes, the 4th phase), other has the crowd to report the hyperpietic, use the Fructus Hippophae flavone group to have antihypertensive effect, and slowly steadily, do not cause the Secondary cases increased heart rate in the blood pressure drops process, and energy high density lipoprotein increasing and change erythrocyte elasticity (West China pharmaceutical journal, 1999 the 14th volumes, the 3rd phase).Therefore the hypotensive activity of inferring Herba Apii graveolentis may be the comprehensive function result of flavonoid and potassium, magnesium, calcium ion etc.

People such as Hertog [J.Agric Food Chem 1992,40:1591,1992] discover to also have another one important biomolecule active substance-chlorophyll in the Herba Apii graveolentis water extract.Chlorophyll has electrophilic group, can catch and remove free radical; And have the mitochondrion of inhibition and microsomal membrane lipid peroxidation, and the oxidative damage due to the NAPH shortage.Also can improve activities of antioxidant enzymes in addition.Present known lipid peroxidation and free-radical oxidation damage are to quicken one of old and feeble major reason, so chlorophyll has delaying senility function.

The deep processing product extraction process of Herba Apii graveolentis can solve the problem of the non-trophic factors of the nutrient that extracts in the Herba Apii graveolentis and biologically active, instant simultaneously, and edible a spot of Herba Apii graveolentis extract is promptly quite eaten a large amount of Herba Apii graveolentis.

Task of the present invention is: overcome the deficiencies in the prior art, propose a kind of health food or food of special nutrients with blood pressure regulation, blood lipid regulation and delaying senility function.

Task of the present invention realizes as follows: Herba Apii graveolentis extract 40-60 part, surplus are Radix Notoginseng powder, and its production technology is: 1, Herba Apii graveolentis raw material → roguing → cleaning → fragmentation → squeeze the juice → homogenizing → concentrate → vacuum lyophilization or spray drying → Herba Apii graveolentis extract; 2, Radix Notoginseng piece → select → clean → airing → tan by the sun is to doing → pulverizing → homogenizing → sieve → Radix Notoginseng powder.

Characteristics of the present invention are to adopt Herba Apii graveolentis extract to be equipped with the health food that Radix Notoginseng powder exploitation has blood pressure regulation, blood lipid regulation and delaying senility function.The Chinese medicine Radix Notoginseng for the Araliaceae tuber, has another name called Radix Notoginseng, Panax pseudoginseng etc., and ancient medical book is its flavor efficacy on the books early.Sweet in the mouth, little hardship, warm in nature are returned liver, stomach warp.Have strengthening by means of tonics, stop blooding and invigorate blood circulation the effect of dissipating blood stasis analgesic therapy.Radix Notoginseng is except that being used for diseases such as traumatic injury, hemorrhage due to internal injury, the swollen pain of pain, be used for the common coronary heart disease of old people, myocardial infarction, angina pectoris clinically more, can be used for diseases such as hypertension, hyperlipidemia, animal sclerosis (Yu Shouyang chief editor, China's nutritional health food guide, Heilungkiang science tech publishing house, P134).Modern study shows that the functional component of Radix Notoginseng is mainly Radix Notoginseng total arasaponins (ginsenoside Rb1, Rg1, Rg2) and a small amount of ginsenoside Ra, Rb2, Rb and Re), still contain flavonoid glycoside in addition.

Domestic scholars flies when yellow, the Ran Hua report: the same Radix Ginseng of Radix Notoginseng merit, have the effect such as promote blood circulation of qi-supplementing, blood-engendering, conditioning nerve, heart tonifying supplementing the brain, blood pressure lowering, and think that Radix Notoginseng can treat old vertigo (the new traditional Chinese medical science was rolled up in 1999 the 31st, the 2nd phase).Cui Jintao report Radix Notoginseng has preventive and therapeutic effect (Chinese Hospitals pharmaceutical journal, 1999 the 1st phases) to cardiovascular disease.Researchs such as woods dawn prompting arasaponin has certain preventive and therapeutic effect (Acta Pharmacologica Sinica, 1993 the 14th volumes, the 14th phase) for animal atherosis generation and development.Other has report, and with the each 1g of Radix Notoginseng powder, take 2-3 every day, warm boiled water treatment hyperlipidemia patient 76 examples, and consequently, the cholesterol reducing effective percentage is 78% after 2 months, the triglyceride reducing effective percentage is 57.5%, (Journal of Traditional Chinese Medicine,, the 2nd phase in 1994).

Research for the Radix Notoginseng effect of bringing high blood pressure down thinks that calcium antagonist is to treat hypertensive medicine at present clinically preferably, the effect that arasaponin has blood vessel dilating, brings high blood pressure down, and these effects may influence cell Ca with it ²⁺Or Ca ⁺⁺It is relevant to move.Inquire into arasaponin monomer Rb with fluorescent technique and radiative aglycone combination experiments, to the outer Ca of myocardial cell ⁺⁺The effect of interior stream, results suggest, the Rb cellular calcium that opening causes to the myocardial cell voltage dependent channel raises inhibitory action, the endochylema Ca that the calcium channel opening that beta receptor is associated causes ⁺⁺Raising also has effect, and does not influence beta receptor itself (Chinese Pharmacological circular, 1994 the 11st volumes, the 2nd phase).By to the anesthetized rat duodenal administration, Radix Notoginseng 3.5g/Kg and 5.0g/Kg, recording blood pressure after 25 minutes, observe blood pressure within 60 minutes, the result shows that Radix Notoginseng has the effect of obvious reduction rat blood pressure, and heart rate there is not obvious influence (Chinese herbal medicine, 1994 the 25th volumes, the 8th phase).Except that above-mentioned data, Radix Notoginseng has anti thrombotic action, antiarrhythmic effect, to the protective effect of myocardial cell ischemia injury and reduce effect such as myocardial oxygen consumption report is also arranged.

In view of above-mentioned data, we will adopt the phytochemical of Herba Apii graveolentis deep processing extraction and be equipped with Radix Notoginseng powder and (be pulverized by Radix Notoginseng, even matter is made) be primary raw material, also can suitably be equipped with other and have the nutrient composition of blood pressure lowering or effect for reducing blood fat or the raw material resources of medicine-food two-purpose class, make and have blood pressure regulation, the health food of blood lipid regulation and delaying senility function.

Fig. 1 is a process chart of the present invention.

A most preferred embodiment of the present invention, get 40 parts of Herba Apii graveolentis extract, 60 parts of mix homogeneously of Radix Notoginseng powder and can be finished product (tablet, capsule, electuary) by bag distribution packaging, wherein, the processing technology of Herba Apii graveolentis extract and Radix Notoginseng powder is: a, Herba Apii graveolentis raw material → roguing → cleaning → fragmentation → squeeze the juice → homogenizing → concentrate → vacuum lyophilization or spray drying → Herba Apii graveolentis extract; B, Radix Notoginseng piece → select → clean → airing → tan by the sun are to doing → pulverize → even matter → sieve → Radix Notoginseng powder.

Second embodiment of the present invention gets 60 parts of Herba Apii graveolentis extract, 40 parts of mix homogeneously of Radix Notoginseng powder.

Claims (2)

1, a kind of health food or food of special nutrients with blood pressure regulation, blood fat and delaying senility function, it is characterized in that: its prescription is: 40 parts of Herba Apii graveolentis extract, 60 parts of Radix Notoginseng powder.

2, health food as claimed in claim 1 is characterized in that: its processing technology is:

A, Herba Apii graveolentis raw material → roguing → cleaning → fragmentation → squeeze the juice → homogenizing → concentrate → vacuum lyophilization or spray drying → Herba Apii graveolentis extract;

B, Radix Notoginseng piece → select → clean → airing → tan by the sun are to doing → pulverize → even matter → sieve → Radix Notoginseng powder;

C, Herba Apii graveolentis extract and Radix Notoginseng powder mixed by formula proportion promptly become health food.