CN1310954C - Preparation method of chromium alginate - Google Patents
Preparation method of chromium alginate Download PDFInfo
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- CN1310954C CN1310954C CNB031097510A CN03109751A CN1310954C CN 1310954 C CN1310954 C CN 1310954C CN B031097510 A CNB031097510 A CN B031097510A CN 03109751 A CN03109751 A CN 03109751A CN 1310954 C CN1310954 C CN 1310954C
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- chromium
- alginate
- preparation
- lalgine
- trivalent inorganic
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Abstract
The present invention discloses a preparation method of chromium alginate (Cr<+3>). In the preparation method, alginate and trivalent inorganic chromic salt are used as raw materials; the solutions of the alginate and the trivalent inorganic chromic salt, which respectively have a proper mass ratio, are mixed, stirred, filtered, cleaned and dried under certain conditions. The chromium alginate is an ideal product for manually replenishing chromium, and can be used as an additive for foods, health care products or animal feeding stuffs. The chromium alginate can be prepared by conventional production equipment and has simple preparation process and low production cost.
Description
Technical field
The present invention relates to a kind of preparation method of Lalgine chromium.Lalgine chromium can be used as the additive of food, healthcare products or animal-feed.
Background technology
Trivalent chromium has biochemical effect, is one of metabolic important element of human body.If lack the chromium element in the organism, Regular Insulin just can not be brought into play its normal function, can not keep normal carbohydrate metabolism.For various reasons, the modern easily suffers from chromium deficiency disease.National research council is mended the chromium amount to various crowds clear and definite index.Medical research shows: replenishing of chromium should be based on organic chromic salts, and Lalgine chromium is wherein a kind of preferably.
(US 6 at United States Patent (USP) for people such as Takeshi Hom-ma, the polymeric preparation method of a kind of Lalgine polyvalent metal salt (wherein metal comprises calcium, zinc, beryllium, copper, barium, cadmium, chromium, strontium, radium, iron, aluminium, cobalt, nickel and manganese) ball-type particulate is disclosed 274,174 B1).This preparation method be with sodium alginate aqueous solution and (or) the Lalgine aqueous solution joins in the water-insoluble solvent (as mulit-hydroxy fatty acid ester); Add emulsifying agent, under the effect of intimate mixing device (rotating speed 10000rmp), make emulsion dispersion, make the w/o type emulsion; The aqueous solution of calcium chloride is joined in the emulsion, need under the high-speed stirring of intimate mixing device (rotating speed 10000rmp), form the alginate calcium spheroidal particle equally.The alginates that obtains is used to prepare have releases the pharmaceutical carrier of controlling performance.The synthetic method of the preparation alginates that this patent adopted need be used the emulsifying agent and the tensio-active agent of a large amount of costlinesses, and operational path is long, needs to use specific installation, and production cost is higher.
Summary of the invention
The invention provides a kind of preparation method of Lalgine chromium, overcome above-mentioned shortcoming, use conventional production unit to get final product, preparation process is simple, and production cost is lower.
The invention is characterized in and use alginates and inorganic chromate salt to be raw material.Alginates can be sodium alginate or the alginates that extracts from sea-tangle, preferably sodium alginate.Inorganic chromate salt is Cr
3+Salt can be basic chromium sulfate, chromium nitrate, chromium trichloride, chromium acetate, preferably chromium nitrate.Synthetic method can adopt ion exchange method, precipitation absorption method etc.Reaction process is that massfraction is 0.1～10.0% (preferably 1.0～5.0%) sodium alginate soln is under 20～80 ℃ of (preferably 40～70 ℃) agitation conditions, in (preferably 5.0～10.0%) the inorganic chromate salt aqueous solution that slowly joins massfraction and be 1.0～20.0%; Continue to stir 1～8 hour (preferably 4～6 hours), then fibrous Lalgine chromium is filtered out; With the Lalgine chromium of distilled water wash gained 2～4 times, filter; Use soaked in absolute ethyl alcohol Lalgine chromium 30～60 minutes again, remove by filter aqueous ethanolic solution; At the normal pressure or the 0.02～0.09MPa that reduces pressure, dry under 50～100 ℃ of (preferably pressure is 0.05～0.07MPa, and temperature is 60～80 ℃) conditions; It is dry after pulverizing obtains dusty blue Lalgine chromium powder end.Chromium content is 1.0～5.0%.Granularity can reach 100～300 orders behind the sub-sieve.
Embodiment
Provide enforcement preferred version of the present invention below.
Preparation method of the present invention is dissolved in the 10g sodium alginate in the 1000ml distilled water, is made into massfraction and is 1.0% solution; Under 60 ℃ of agitation conditions, slowly join massfraction and be in 5.0% the chromium nitrate aqueous solution, continue again to stir 4 hours; Filter, use distilled water wash 3 times, extract moisture, add a small amount of dehydrated alcohol, soaked 40 minutes, leach; Dry under 0.06MPa pressure, 70 ℃ of conditions, obtain solid-state dusty blue Lalgine chromium after the drying, chromium content 2.3%.Through pulverizing, screening can obtain its 100～300 order meals again.
The Lalgine chromium of the present invention's preparation is the desirable goods of manually mending chromium, can be used as the additive of food, healthcare products or animal-feed.The present invention uses conventional production unit to get final product, and preparation process is simple, and production cost is low.
Claims (1)
1. the preparation method of a Lalgine chromium, it is characterized in that with massfraction being that slowly to join massfraction under 40～70 ℃ of agitation conditions be in 1.0～20.0% the trivalent inorganic chromate salt aqueous solution for 0.1～10.0% sodium alginate soln, the trivalent inorganic chromate salt is basic chromium sulfate or chromium nitrate or chromium chloride or chromium acetate, continue to stir 1～8 hour, press filtration is removed moisture; Use distilled water wash again 2～4 times, filter, add a small amount of soaked in absolute ethyl alcohol Lalgine chromium 30～60 minutes, filter and take out; At pressure is 0.05～0.07MPa, dry under 60～80 ℃ of conditions, obtains the Lalgine chromium of chromium content 1.0～5.0%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031097510A CN1310954C (en) | 2003-04-15 | 2003-04-15 | Preparation method of chromium alginate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031097510A CN1310954C (en) | 2003-04-15 | 2003-04-15 | Preparation method of chromium alginate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1443781A CN1443781A (en) | 2003-09-24 |
| CN1310954C true CN1310954C (en) | 2007-04-18 |
Family
ID=27814521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031097510A Expired - Fee Related CN1310954C (en) | 2003-04-15 | 2003-04-15 | Preparation method of chromium alginate |
Country Status (1)
| Country | Link |
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| CN (1) | CN1310954C (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001040315A1 (en) * | 1999-11-30 | 2001-06-07 | Dalian Yaweite Biology Engineering Co., Ltd. | The alginate having low molecular weight, methods of manufacturing it and its use |
| US6274174B1 (en) * | 1997-10-31 | 2001-08-14 | Nisshinbo Industries, Inc. | Aggregates of spherical multivalent metal alginate microparticles and methods of making them |
| CN1373000A (en) * | 2001-02-28 | 2002-10-09 | 中国科学院大连化学物理研究所 | Membrane emulsifying/internal gelatinizing coupled process for preparing gel beads of calcium alginate |
| CN1374338A (en) * | 2001-03-12 | 2002-10-16 | 中国科学院大连化学物理研究所 | Emulsifying and internal gelifying process of preparing calcium alginate gel beads |
-
2003
- 2003-04-15 CN CNB031097510A patent/CN1310954C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274174B1 (en) * | 1997-10-31 | 2001-08-14 | Nisshinbo Industries, Inc. | Aggregates of spherical multivalent metal alginate microparticles and methods of making them |
| WO2001040315A1 (en) * | 1999-11-30 | 2001-06-07 | Dalian Yaweite Biology Engineering Co., Ltd. | The alginate having low molecular weight, methods of manufacturing it and its use |
| CN1373000A (en) * | 2001-02-28 | 2002-10-09 | 中国科学院大连化学物理研究所 | Membrane emulsifying/internal gelatinizing coupled process for preparing gel beads of calcium alginate |
| CN1374338A (en) * | 2001-03-12 | 2002-10-16 | 中国科学院大连化学物理研究所 | Emulsifying and internal gelifying process of preparing calcium alginate gel beads |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1443781A (en) | 2003-09-24 |
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Granted publication date: 20070418 Termination date: 20100415 |