CN1305865A - Hollow polyarylsulfone fibre membrane and its preparing process - Google Patents
Hollow polyarylsulfone fibre membrane and its preparing process Download PDFInfo
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- CN1305865A CN1305865A CN 00112038 CN00112038A CN1305865A CN 1305865 A CN1305865 A CN 1305865A CN 00112038 CN00112038 CN 00112038 CN 00112038 A CN00112038 A CN 00112038A CN 1305865 A CN1305865 A CN 1305865A
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Abstract
A hollow polyarylsulfone fibre membrane contains polysulfone (1-99 Wt.%), polyethersulfone (1-99) and additive (0-2), and is prepared from raw liquid and core liquid. Said raw liquid contains polysulfone (0.2-20 Wt.%), polyethersulfone (0.2-20), solvent (70-80) and additive (0-10). Said core liquid contains solvent (0-60 Vol.%) and distilled water (40-100). Its advantages include high biologic stability and compatibility, high superfilter rate, and high removal rate of solute. It can be used for blood dialyzer.
Description
The present invention relates to medical material, in particular for carrying out hollow-fiber film and the manufacture method thereof that haemodialysis is used.
At present, slow, the acute renal patient that declines is carried out the hollow-fiber film that the material of the usefulness of haemodialysis has polysulfones (PSF) material to make, because polysulfone material is a high hydrophobicity, therefore, when making hollow-fiber film, all add hydrophilic material, as PVP (polyvinylpyrrolidone), to improve the hydrophily of film, as Chinese patent (publication number is CN1158273A), but can increase the activation of film after adding PVP to complement in the blood, and the content positive correlation of activation degree and PVP, thereby influence the intrinsic biocompatibility of PS membrane material.Japan Patent JP-A-300633/1992, JP-B-54373/1993, JP-A-23813/1994 discloses the preparation method of PS membrane, but can not satisfy the requirement of big ultrafiltration rate and high solute clearance rate when hemodialysis simultaneously.In addition, the patent of Sichuan Union University application (publication number CN1220183A) is the hollow-fiber film of making of polyether sulfone (PSE), since its vitrification point height, the materialization good stability, and pliability is good, good hydrophilic property, but its price height.
The purpose of this invention is to provide a kind of materialization good stability, good biocompatibility, ultrafiltration rate are big, solute clearance rate height, lower-cost hollow-fibre membrane and manufacture method thereof.
The technical scheme that realizes the object of the invention is: hollow-fiber film mainly is made up of polysulfones, polyether sulfone, and its percentage by weight polysulfones is 1-99, and polyether sulfone is 1-99, and additive is 0-2.
For making above-mentioned hollow polyarylsulfone fibre membrane, it is formed by hollow polyarylsulfone fibre membrane stoste and the manufacturing of core liquid, and the component of its hollow polyarylsulfone fibre membrane stoste and percentage by weight thereof are polysulfones 0.2-20, polyether sulfone 0.2-20, solvent 70-80, additive 0-10; The component of core liquid and percent by volume thereof are solvent 0-60, distilled water 40-100, above-mentioned solvent can adopt N-methyl-pyrrolidones or N, the N-dimethylacetylamide, additive is polyethylene glycol or polyvinylpyrrolidone, hollow polyarylsulfone fibre membrane stoste and core liquid are extruded hollow polyarylsulfone fibre membrane stoste from the outer hole with two concentrically ringed hollow fibre spinning heads respectively, endoporus is extruded core liquid, the hollow polyarylsulfone fibre membrane that generates moulding in tank also removes desolvates and additive, and hollow polyarylsulfone fibre membrane is positioned in the glycerine soaks, take out oven dry.
The hollow polyarylsulfone fibre membrane key component is polyether sulfone and polysulfones, and wherein the polyether sulfone solubility property is good, certain hydrophily is arranged, and polysulfones is easy to film forming, and low price is so cost is lower; Its materialization good stability, the intensity height can bear higher pressure; The biocompatibility excellence is very little to complement and immune influence; Hollow polyarylsulfone fibre membrane is a unsymmetric structure, is similar to the structure of glomerulus, and the dispersion coefficient of solute is big, the permeability height; Its molecular cut off of the dialyzer of making (promptly allowing the maximum molecular weight by solute) scope is clear and definite, and metabolite (comprises urea, flesh liver, Cobastab
12Deng) can pass through smoothly, and macromolecular substances such as albumin etc. can not so dialyzer has the ultrafiltration rate, clearance rate is big, improve curative effect and can reach efficient dialysis by still staying in the blood.
Embodiment 1
Press hollow polyarylsulfone fibre membrane stoste weight proportion, get 12 parts of polysulfones, 3 parts of polyether sulfones, 5 parts of additive polyvinylpyrrolidones, 80 parts of solvent N-methyl pyrrolidones mix under 90 ℃, and through press filtration, it is stand-by to remove bubble.Core liquid is 25 parts of solvent N-methyl pyrrolidones by volume, and distilled water mixes for 75 parts.Two liquid are pressed into the gear wheel metering pump metering respectively has two concentrically ringed hollow fibre spinning heads, hollow-fiber film stoste is extruded in the hole outside spinning head, endoporus is extruded core liquid, by 40 ℃ of Water Tanks with Temp.-controlled and moulding, in 70 ℃ of Water Tanks with Temp.-controlled, remove residual solvent and additive then, the extruded velocity of stoste is controlled at 8ml/min, core flow velocity 6.0ml/min.The hollow-fibre membrane that obtains, it forms weight ratio is polysulfones 79.5, polyether sulfone 19.8, additive polyvinyl pyrrolidone 0.7.
Embodiment 2
Get 20 parts of polysulfones by the percentage by weight of hollow polyarylsulfone fibre membrane stoste, 0.2 part of polyether sulfone, 4.8 parts of additives polyethylene glycol (also can not doping), solvent N, 75 parts of N dimethylacetylamides, core liquid proportioning is N, N dimethylacetylamide and distilled water volume ratio are 20: 80.The hollow polyarylsulfone fibre membrane that employing makes with the method for embodiment 1, it forms weight ratio is polysulfones 98.8, polyarylsulfone (PAS) 1, polyethylene glycol 0.2 is a polysulfones 99 if do not add additives polyethylene glycol then form weight ratio, polyarylsulfone (PAS) 1.
Embodiment 3
Press the weight proportion of hollow polyarylsulfone fibre membrane stoste, get 0.15 part of polysulfones, 15 parts of polyether sulfones, 3.5 parts of additives polyethylene glycol, solvent N, 80 parts of N dimethylacetylamides, the volume proportion of core liquid is N, N dimethylacetylamide/distilled water=1/99 (core liquid can only adopt distilled water here).Method by embodiment 1 manufactures hollow polyarylsulfone fibre membrane, and the weight ratio of its composition is a polysulfones 1, polyarylsulfone (PAS) 98, polyethylene glycol 1.
Embodiment 4
Hollow polyarylsulfone fibre membrane stoste weight is 10 parts of 5 parts of polyether sulfones of polysulfones, 10 parts of polyethylene glycol, and 75 parts of N-methyl pyrrolidones, the proportioning of core liquid and operating procedure method are with embodiment 1.The weight ratio of its composition of hollow polyarylsulfone fibre membrane that obtains is that polysulfones is 65, and polyether sulfone is 33, and polyethylene glycol is 2.
By the different proportionings of hollow polyarylsulfone fibre membrane stoste and the different proportionings of core liquid, its fibre inner diameter of the hollow polyarylsulfone fibre membrane of producing is 250-500 μ m, the thick 30-80 μ of membranous wall m, maximum tolerable pressure 120Kpa in the above-mentioned manufacture process.
Above-mentioned hollow polyarylsulfone fibre membrane can be made high flux tunica fibrosa dialyzer, and its effective film area is 0.6-2.0m
2Fibre inner diameter 200-500 μ m, the thick 30-80 μ of membranous wall m, maximum tolerable pressure 120Kpa, pure water ultrafiltration rate 200-20000ml/Kpa, h, external solute clearance rate: urea 100-300ml/min, flesh liver 100-300ml/min, cobalamin 50-200ml/min is widely used in making efficient, high-throughout hemodialyzer.
Claims (4)
1, a kind of hollow polyarylsulfone fibre membrane, it is held to levy and is: its main component is by polysulfones, and polyether sulfone is formed, and its percentage by weight polysulfones is 1-99, and polyether sulfone is 1-99, and additive is 0-2.
2, make the method for above-mentioned hollow polyarylsulfone fibre membrane, it is characterized in that: it is to be formed by hollow polyarylsulfone fibre membrane stoste and the manufacturing of core liquid, wherein, the component of hollow polyarylsulfone fibre membrane stoste and percentage by weight thereof are polysulfones 0.2-20, polyether sulfone 0.2-20, solvent 70-80, additive 0-10; The component of core liquid and percent by volume thereof are solvent 0-60, distilled water 40-100.
3, method according to claim 2 is characterized in that: solvent is phonetic alkane ketone of N-methyl-pyrrole or N, and N-dimethylacetylamide, additive are polyethylene glycol or polyvinylpyrrolidone.
4, according to claim 1,2 described methods, it is characterized in that: the solvent in the solvent in the hollow polyarylsulfone fibre membrane stoste and the core liquid will adopt identical material when using.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112038 CN1305865A (en) | 2000-01-18 | 2000-01-18 | Hollow polyarylsulfone fibre membrane and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112038 CN1305865A (en) | 2000-01-18 | 2000-01-18 | Hollow polyarylsulfone fibre membrane and its preparing process |
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| CN1305865A true CN1305865A (en) | 2001-08-01 |
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| CN 00112038 Pending CN1305865A (en) | 2000-01-18 | 2000-01-18 | Hollow polyarylsulfone fibre membrane and its preparing process |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100563800C (en) * | 2002-12-20 | 2009-12-02 | 甘布罗伦迪亚股份公司 | Permoselective membrane and manufacture method thereof |
| CN104894747A (en) * | 2015-05-20 | 2015-09-09 | 苏州市贝克生物科技有限公司 | Polysulfone fiber hemodialysis membrane and preparation method thereof |
| CN106139928A (en) * | 2016-08-31 | 2016-11-23 | 威海威高血液净化制品有限公司 | Endotoxin filter membrane and manufacture method thereof in a kind of dialysis solution water |
| CN110079887A (en) * | 2011-02-04 | 2019-08-02 | 弗雷塞尼斯医疗保健控股公司 | For fibroplastic performance enhancement additive and polysulfone fibre |
| CN112121645A (en) * | 2020-10-09 | 2020-12-25 | 江西三鑫医疗科技股份有限公司 | Preparation method of hollow fiber membrane for dialysate filter |
-
2000
- 2000-01-18 CN CN 00112038 patent/CN1305865A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100563800C (en) * | 2002-12-20 | 2009-12-02 | 甘布罗伦迪亚股份公司 | Permoselective membrane and manufacture method thereof |
| CN110079887A (en) * | 2011-02-04 | 2019-08-02 | 弗雷塞尼斯医疗保健控股公司 | For fibroplastic performance enhancement additive and polysulfone fibre |
| CN111549448A (en) * | 2011-02-04 | 2020-08-18 | 弗雷塞尼斯医疗保健控股公司 | Performance enhancing additives for fiber formation and polysulfone fibers |
| USRE48703E1 (en) | 2011-02-04 | 2021-08-24 | Fresenius Medical Care Holdings, Inc. | Performance enhancing additives for fiber formation and polysulfone fibers |
| CN110079887B (en) * | 2011-02-04 | 2021-12-24 | 弗雷塞尼斯医疗保健控股公司 | Performance enhancing additives for fiber formation and polysulfone fibers |
| CN111549448B (en) * | 2011-02-04 | 2022-07-22 | 弗雷塞尼斯医疗保健控股公司 | Performance enhancing additives for fiber formation and polysulfone fibers |
| USRE50084E1 (en) | 2011-02-04 | 2024-08-20 | Fresenius Medical Care Holdings, Inc. | Performance enhancing additives for fiber formation and polysulfone fibers |
| CN104894747A (en) * | 2015-05-20 | 2015-09-09 | 苏州市贝克生物科技有限公司 | Polysulfone fiber hemodialysis membrane and preparation method thereof |
| CN106139928A (en) * | 2016-08-31 | 2016-11-23 | 威海威高血液净化制品有限公司 | Endotoxin filter membrane and manufacture method thereof in a kind of dialysis solution water |
| CN106139928B (en) * | 2016-08-31 | 2019-05-21 | 威海威高血液净化制品有限公司 | Endotoxin filter membrane and its manufacturing method in a kind of dialyzate water |
| CN112121645A (en) * | 2020-10-09 | 2020-12-25 | 江西三鑫医疗科技股份有限公司 | Preparation method of hollow fiber membrane for dialysate filter |
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