CN1304923A - Preparing process and application of calcium levulinate - Google Patents
Preparing process and application of calcium levulinate Download PDFInfo
- Publication number
- CN1304923A CN1304923A CN00133696A CN00133696A CN1304923A CN 1304923 A CN1304923 A CN 1304923A CN 00133696 A CN00133696 A CN 00133696A CN 00133696 A CN00133696 A CN 00133696A CN 1304923 A CN1304923 A CN 1304923A
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- CN
- China
- Prior art keywords
- calcium
- levulinate
- product
- preparation
- levulinic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Soy Sauces And Products Related Thereto (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
A process for preparing calcium levulinate as calcium-supplementing preparation features the direct reaction of levulinic acid with calcium hydroxide. Said calcium levulinate can be used as nutrients enriching agent of food or for preparing medicine in the form tablet, capsule, or injection. Its advantages are high calcium content, no toxicity and hypersensitivity, and convenient application.
Description
The present invention relates to a kind of novel calcium-supplementing preparation, particularly the preparation method of calcium levulinate and application.
In recent years, many calcium-supplementing preparations are arranged on the market, those positive Yak marrow bone-strengthening powders of being produced by Harbin red sun group are arranged, the gluconic acid Ca oral liquid that Harbin No.3 Pharmaceutical Factory is produced, and the Gaizhonggai (calcium lactate) of Harbin No.6 Pharmaceutical Factory's production etc., all be the calcium supplement health care product that people are familiar with, but that one of above-described calsium supplement shortcoming is a price is expensive; If two out of town trips take inconvenience, three are one day requirement that the calcium contents concentration of preparation is supplied the people at all inadequately.
Purpose of the present invention is exactly in order to solve the existing problem of above-mentioned calcium-supplementing preparation, and a kind of efficient, inexpensive, easy, quick, the reliable calcium-supplementing preparation calcium levulinate preparation method and the application that provide.
Content Description of the present invention is as follows:
A kind of preparation method of the novel system chaste tree calcium levulinate of replenishing the calcium is characterized in that: this product is to adopt levulinic acid (left-handed saccharic acid of L-or levulinic acid) to get with the calcium hydroxide direct reaction.
Reaction formula:
Production process: the calcium hydroxide of metering is added in the reactor, add water, under agitation make it dissolving, drip levulinic acid down in room temperature (20～25 ℃), make it the PH=6.7 that reacts completely, then through decolorization filtering, freezing, low temperature (0～5 ℃) crystallization, filtration, through washing, dry finished product.
The application of this novel calcium-supplementing preparation calcium levulinate is characterized in that: can be used as food enrichment, strengthen calcium nutrition, can be used for soy sauce, seasonings, beer, beverage, carbonated drink, milk and dairy product, soymilk and bean product.Both can use separately, also can same calcium lactate, calcium agent such as calcium chloride is composite, be used for medicine both to have can be made into tablet, capsule also can be made injection or compositely be injection.
The performance of this product calcium levulinate and characteristics:
1. the calcic height is pressed (C
5H
7O
3)
2Ca calculates, calcium contents 14.8%, and calcium content is higher than calcium lactate.
2. the molten amount of calcium is big, because calcium levulinate calcic height, solubleness is big, and 25 ℃ of solubleness are more than 30%, so in the volume solvent, the molten amount of calcium levulinate is big, can in time replenishes and put in place.
3. nontoxic, no supersensitivity is more suitable for doing injection or transfusion.
4. mouthfeel is good, in the reinforcement scope, does not almost have taste.
5. nonirritant, pH value is 7, no acid-basicity stimulates.
6. good stability in the use, can not produce precipitation and rotten, and stable in properties is the material of replenishing the calcium reliably.
7. consistency is good, can be composite with calcium materials such as calcium lactate, calcium chloride.
8. the mode of replenishing the calcium is easy, can variation, can pass through variety carrier, and comprise that multiple pharmaceutical dosage form, soy sauce, sauce, beer, beverage, carbonated drink, milk and milk powder soymilk and bean product etc. replenish the calcium.
9. the genus ionic calcium is easy to absorb advantages of good calcium supplying effect.
10. belong to the lower molecular weight organic calcium, see through the intestines wall easily and be absorbed.
Embodiment 1
78 gram calcium hydroxides are added in the reactor, add water, under agitation make it dissolving, drip levulinic acid 205ml down in room temperature (20～25 ℃), make it to react completely pH value 6.7-6.8, through decolouring, filtration, freezing, low temperature (0～5 ℃) crystallization, filtration, dry that finished product 207 restrains through washing.
Embodiment 2
546 gram calcium hydroxides are added in the reactor, add water, under agitation make it dissolving, drip levulinic acid 1440ml down in room temperature (20～25 ℃), make it to react completely, control pH value 6.7-6.8 is through decolouring, filtration, freezing, low temperature (0～5 ℃) crystallization, filtration, dry that finished product 1503 restrains through washing.
This process of producing product does not have the three wastes, and the product liner is a polyethylene plastic bag, packs with polypropylene woven bag outward, 20 kilograms/bag every bag, is stored in shady and cool dry place.
Target level of product quality (company standard)
Name of product: calcium levulinate
Other title: calcium levulinate, Calcium Levulate.
(1) vacuum Air drying product is 2 crystal water.
Drying products below (2) 50 ℃ is 1 crystal water.
Drying products does not have crystal water more than (3) 50 ℃.
This product drying temperature is generally more than 50 ℃, no crystal water.
Molecular formula: (C
5H
7O
3)
2The Ca structural formula:
Molecular weight: 270 calcium contentss: 14.8% company standard:
| Project | Index |
| Content (%) | ≥99 |
| Outward appearance | White powder |
| Moisture content (%) | ≤1％ |
| Lead content | ≤10mg/kg |
| Arsenic content | ≤10mg/kg |
| Molten point (℃) | 122～126℃ |
| Vitriol | ≤20mg/kg |
Claims (2)
1. the preparation method of a novel calcium-supplementing preparation calcium levulinate is characterized in that: this product is to adopt levulinic acid (left-handed saccharic acid of L-or levulinic acid) to get with the calcium hydroxide direct reaction.
Reaction formula:
Production process: the calcium hydroxide of metering is added in the reactor, add water, under agitation make it dissolving, drip levulinic acid down in room temperature (20～25 ℃), make it the PH=6.7 that reacts completely, then through decolorization filtering, freezing, low temperature (0～5 ℃) crystallization, filtration, through washing, dry finished product.
2. the application of preparation method's products obtained therefrom calcium levulinate of a novel calcium-supplementing preparation calcium levulinate as claimed in claim 1, it is characterized in that: calcium levulinate can be used as food enrichment, strengthens calcium nutrition, can be used for soy sauce, seasonings, beer, beverage, carbonated drink, milk and dairy product, soymilk and bean product; Both can use separately, also can same calcium lactate, calcium agent such as calcium chloride is composite, be used for medicine both to have can be made into tablet, capsule also can be made injection or compositely be injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00133696A CN1111150C (en) | 2000-12-04 | 2000-12-04 | Preparing process and application of calcium levulinate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00133696A CN1111150C (en) | 2000-12-04 | 2000-12-04 | Preparing process and application of calcium levulinate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1304923A true CN1304923A (en) | 2001-07-25 |
| CN1111150C CN1111150C (en) | 2003-06-11 |
Family
ID=4595909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00133696A Expired - Fee Related CN1111150C (en) | 2000-12-04 | 2000-12-04 | Preparing process and application of calcium levulinate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1111150C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104447285A (en) * | 2014-12-25 | 2015-03-25 | 广州白云山天心制药股份有限公司 | Novel crystal form of calcium levulinate monohydrate |
| CN103408604B (en) * | 2013-08-12 | 2016-07-13 | 青岛大学 | The alginic acid monosaccharide calcium synthetic method being raw material with shell and alginic acid |
| CN109456170A (en) * | 2018-11-29 | 2019-03-12 | 浙江金伯士药业有限公司 | A kind of novel preparation method of calcium levulinate |
-
2000
- 2000-12-04 CN CN00133696A patent/CN1111150C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103408604B (en) * | 2013-08-12 | 2016-07-13 | 青岛大学 | The alginic acid monosaccharide calcium synthetic method being raw material with shell and alginic acid |
| CN104447285A (en) * | 2014-12-25 | 2015-03-25 | 广州白云山天心制药股份有限公司 | Novel crystal form of calcium levulinate monohydrate |
| CN109456170A (en) * | 2018-11-29 | 2019-03-12 | 浙江金伯士药业有限公司 | A kind of novel preparation method of calcium levulinate |
| CN109456170B (en) * | 2018-11-29 | 2021-06-01 | 浙江金伯士药业有限公司 | Preparation method of calcium levulinate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1111150C (en) | 2003-06-11 |
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| CF01 | Termination of patent right due to non-payment of annual fee |