CN1301716C - Slow-releasing Benproperine phosphate dripping pill and its prepn process - Google Patents
Slow-releasing Benproperine phosphate dripping pill and its prepn process Download PDFInfo
- Publication number
- CN1301716C CN1301716C CNB021338884A CN02133888A CN1301716C CN 1301716 C CN1301716 C CN 1301716C CN B021338884 A CNB021338884 A CN B021338884A CN 02133888 A CN02133888 A CN 02133888A CN 1301716 C CN1301716 C CN 1301716C
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- CN
- China
- Prior art keywords
- benproperine phosphate
- slow
- releasing
- suspension
- preparation technology
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- Expired - Lifetime
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Abstract
The present invention relates to a benproperine phosphate slow-releasing dripping pill and a preparation technology thereof. The dripping pill comprises the components of the following proportion by weight: 10 to 35 % of benproperine phosphate, 20 to 43% of stearic acids and 30 to 53% of poloxamer, wherein the stearic acids and the poloxamer are used as base materials. The stearic acid in the base materials can be replaced with octadecanol, and the poloxamer can be replaced with polyethylene glycol, polyethylene glycol (40), or stearic acid ester. The preparation technology comprises: adding benproperine phosphate to form a mixed suspension after the base materials are heated and melt, placing the suspension into a dropping tank of which the insulation can is provided with a dripper, dropping the suspension into condensed fluid to be condensed into a ball shape, and sucking up to form a finished product. The condensed fluid is dimethyl silicon oil or mineral oil, and the dimethyl silicon oil is the best. The present invention overcomes the defects in the existing benproperine phosphate slow-releasing pills. The present invention is manufactured into a dropping pill form to cause the medical preparation method to be simplified, and to cause the slow releasing degree, the uniformity, the content, etc. of products in small type production, middle type production and mass production of products to be stabilized.
Description
Technical field
The invention belongs to Benproperine phosphate pharmaceutical formulation technical field, be specifically related to a kind of Benproperine phosphate drop pill and preparation technology.
Technical field
The molecular formula of Benproperine phosphate is C
12H
27NO.H
3PO
4Molecular weight is 407.5; pharmaceutically, all have only the slow-releasing Benproperine phosphate sheet now both at home and abroad, its preparation technology is: earlier with stone and medicament mixed; add binding agent; make soft material, reuse granulator is granulated, and with drying equipment the wet granular of making is carried out drying; the reuse tablet machine suppress semi-finished product, last coating gets finished product.Its complex process is to the requirement height of equipment.In each stage of product lab scale, pilot scale, operation, because the operation and the plant equipment difference of employed pulverizing, granulation, drying, tabletting, influence the quality index instability of product, normal adjustment prescription and the technology of needing, wherein water solublity sucking-off or migration former, adjuvant is influential to the quality of drug release rate in the consumption of binding agent selection and concentration and the dry run.
Summary of the invention
The present invention relates to a kind of slow-releasing Benproperine phosphate dripping pill and preparation method, its objective is and overcome present slow-releasing Benproperine phosphate sheet above shortcomings, be made into dripping pill type, the preparation technology of medicine is simplified, make the slow release degree, the uniformity, content etc. of product in the little formula of product, Chinese style, the mass production stable.
Technical scheme of the present invention is as follows:
Slow-releasing Benproperine phosphate dripping pill, the percentage by weight of Benproperine phosphate is 10-35%, with the water-soluble base of the water-insoluble substrate of 20-43% weight and 30-53% weight as substrate, described water-insoluble substrate is selected from stearic acid, octadecanol, and described water-soluble base is selected from husky female, polyoxyethylene (40) stearate in pool Lip river.
Its preparation technology is: after the substrate heat fused, add Benproperine phosphate and become suspension, suspension is inserted in the dripping jar of couveuse band water dropper, splash in the condensed fluid, be condensed into spherical, after blotting finished product.Condensed fluid is dimethicone or liquid paraffin, with dimethicone the best.The heat fused temperature is 80-100 ℃; The temperature that the suspension insulation splashes in the condensed fluid is controlled at 80-110 ℃.
Above-mentioned slow-releasing Benproperine phosphate dripping pill external diameter is preferably 3.4mm.
Advantage of the present invention is:
1, constitute hydrophobic framework with stearic acid, constitute hydrophilic skeleton with poloxamer, regulate both consumptions, the release of scalable Benproperine phosphate reaches the slow release purpose.
2, saved dry run in the technology, saved the time, generally speaking, can finish the production of finished product the same day.
3, medicine is made dripping pill type, without the complicated technology of tablet, the technology of drop pill becomes suspension by medicine with the substrate melted by heat, quantitatively drip system by water dropper, shrink solidification forming in condensed fluid, this all is the rule that the states of matter between solid and liquid changes naturally, and making medicine and substrate fuse into entity does not have the gap, little with the air contact surface, be difficult for oxidation and volatilization, and do not have moisture to add hydrolabil medicine advantageous particularly in the operating process, so steady quality of product
4, equipment requirements is simple, easy operating, and no dust, sanitary condition and labor protection are good.
The specific embodiment
Example 1, in gross weight 1000 gram, choose Benproperine phosphate 27%, stearic acid 33%, poloxamer 40%.After the substrate heat fused, add Benproperine phosphate and become suspension, put into couveuse, temperature is controlled at insulation about 90 ℃, jar suspension is splashed in the dimethicone condensed fluid with dripping of band water dropper then, make it to be condensed into spherical, after taking out, blotting finished product.The products obtained therefrom release is qualified, and roundness is good.
Example 2, choose Benproperine phosphate 10%, stearic acid 37%, Polyethylene Glycol 53%, after the substrate heat fused, add Benproperine phosphate and become suspension, put into couveuse, temperature is controlled at insulation about 100 ℃, jar suspension is splashed in the condensed fluid liquid paraffin with dripping of band water dropper then, make it to be condensed into spherical, after taking out, blotting finished product.The products obtained therefrom release is qualified, and roundness is bad.
Example 3 is chosen Benproperine phosphate 27%, octadecanol 30, polyoxyethylene (40) stearate 43%, and preparation technology is identical with example 1 or example 2.
Example 4 is chosen Benproperine phosphate 35%, octadecanol 20%, and poloxamer 45%, preparation technology is identical with example 1.The products obtained therefrom release is qualified, and roundness is better.
Example 5 is chosen Benproperine phosphate 27%, stearic acid 43%, Polyethylene Glycol 30%, and preparation technology is identical with example 1.The products obtained therefrom release is qualified, and roundness is better.
Claims (5)
1, slow-releasing Benproperine phosphate dripping pill, the percentage by weight that it is characterized in that Benproperine phosphate is 10-35%, with the water-soluble base of the water-insoluble substrate of 20-43% weight and 30-53% weight as substrate, described water-insoluble substrate is selected from stearic acid, octadecanol and described water-soluble base and is selected from poloxamer, polyoxyethylene (40) stearate.
2, slow-releasing Benproperine phosphate dripping pill preparation technology according to claim 1 is characterized in that after the substrate heat fused, adds Benproperine phosphate and becomes suspension, suspension is inserted dripping in the jar of couveuse band water dropper, splash in the condensed fluid, be condensed into spherical, after blotting finished product.
3, preparation technology according to claim 2 is characterized in that condensed fluid is dimethicone or liquid paraffin.
4, preparation technology according to claim 2 is characterized in that the heat fused temperature is 80-100 ℃; The temperature that the suspension insulation splashes in the condensed fluid is controlled at 80-110 ℃.
5, preparation technology according to claim 2 is characterized in that the slow-releasing Benproperine phosphate dripping pill external diameter is 3.4mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021338884A CN1301716C (en) | 2002-10-09 | 2002-10-09 | Slow-releasing Benproperine phosphate dripping pill and its prepn process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021338884A CN1301716C (en) | 2002-10-09 | 2002-10-09 | Slow-releasing Benproperine phosphate dripping pill and its prepn process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1403087A CN1403087A (en) | 2003-03-19 |
| CN1301716C true CN1301716C (en) | 2007-02-28 |
Family
ID=4747449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021338884A Expired - Lifetime CN1301716C (en) | 2002-10-09 | 2002-10-09 | Slow-releasing Benproperine phosphate dripping pill and its prepn process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1301716C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070059358A1 (en) * | 2003-07-02 | 2007-03-15 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Matrix adjuvants and the drop pills prepared with them |
| CN106822226B (en) * | 2017-02-13 | 2020-05-26 | 惠州市九惠制药股份有限公司 | Anweiyang sustained-release dropping pill for treating gastric and duodenal bulbar ulcer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329890A (en) * | 2001-07-11 | 2002-01-09 | 黄振华 | Dual-layer slow releasing tablet of benproperine phosphate |
-
2002
- 2002-10-09 CN CNB021338884A patent/CN1301716C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329890A (en) * | 2001-07-11 | 2002-01-09 | 黄振华 | Dual-layer slow releasing tablet of benproperine phosphate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1403087A (en) | 2003-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181024 Address after: 408099 1 Tai Chi Road, Fuling District, Chongqing Patentee after: CHONGQING TAIJI MEDICAL RESEARCH INSTITUTE Co.,Ltd. Address before: 400010, 24 research area of Chongqing Hai building, 329 Minsheng Road, Yuzhong District, Chongqing. Patentee before: CHONGQING TAIJI MEDICINE SCIENCE AND TECHNOLOGY Co.,Ltd. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070228 |