CN1200709C - Dextromethorphan hydrobromide dropping pill and preparation method thereof - Google Patents
Dextromethorphan hydrobromide dropping pill and preparation method thereof Download PDFInfo
- Publication number
- CN1200709C CN1200709C CN 03100844 CN03100844A CN1200709C CN 1200709 C CN1200709 C CN 1200709C CN 03100844 CN03100844 CN 03100844 CN 03100844 A CN03100844 A CN 03100844A CN 1200709 C CN1200709 C CN 1200709C
- Authority
- CN
- China
- Prior art keywords
- drop pill
- dextromethorphan hydrobromide
- preparation
- milligrams
- dextromethorphan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006187 pill Substances 0.000 title claims abstract description 42
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 7
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 7
- 229920002545 silicone oil Polymers 0.000 claims description 9
- 238000002844 melting Methods 0.000 claims description 8
- 230000008018 melting Effects 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 5
- 229960001985 dextromethorphan Drugs 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims description 3
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 claims description 2
- 229950009789 cetomacrogol 1000 Drugs 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 230000005496 eutectics Effects 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 2
- 238000003181 co-melting Methods 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000428 dust Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- -1 dextromethorphan hydrobromides Chemical class 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000007500 overflow downdraw method Methods 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 230000026676 system process Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03100844 CN1200709C (en) | 2003-01-23 | 2003-01-23 | Dextromethorphan hydrobromide dropping pill and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03100844 CN1200709C (en) | 2003-01-23 | 2003-01-23 | Dextromethorphan hydrobromide dropping pill and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1449755A CN1449755A (en) | 2003-10-22 |
CN1200709C true CN1200709C (en) | 2005-05-11 |
Family
ID=28683903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 03100844 Expired - Lifetime CN1200709C (en) | 2003-01-23 | 2003-01-23 | Dextromethorphan hydrobromide dropping pill and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1200709C (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7939567B2 (en) * | 2006-02-24 | 2011-05-10 | Blue Blood Biotech Corp. | Dextromethorphan-based method for treating acne |
-
2003
- 2003-01-23 CN CN 03100844 patent/CN1200709C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1449755A (en) | 2003-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: YUWANG PHARMACEUTICAL CO., LTD., SHANDONG PROV. Free format text: FORMER OWNER: ZHANG YICHENG Effective date: 20140909 Free format text: FORMER OWNER: LIU XIQIAN Effective date: 20140909 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Liu Xiqian Inventor after: Fan Shuqin Inventor after: Liu Rucui Inventor before: Zhang Yicheng Inventor before: Liu Xiqian |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 010010 HOHHOT, INNER MONGOLIA AUTONOMOUS REGION TO: 251200 DEZHOU, SHANDONG PROVINCE Free format text: CORRECT: INVENTOR; FROM: ZHANG YICHENG LIU XIQIAN TO: LIU XIQIAN FAN SHUQIN LIU RUCUI |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140909 Address after: 251200 Shandong city of Yucheng province thoroughfare Road No. 2731 Patentee after: SHANDONG YUWANG PHARMACEUTICAL CO.,LTD. Address before: 010010 the Inner Mongolia Autonomous Region Hohhot, 412 Wuda Road Patentee before: Zhang Yicheng Patentee before: Liu Xiqian |
|
CX01 | Expiry of patent term |
Granted publication date: 20050511 |
|
CX01 | Expiry of patent term |