CN102210734A - Atractylis oil dripping pill and preparation method thereof - Google Patents
Atractylis oil dripping pill and preparation method thereof Download PDFInfo
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- CN102210734A CN102210734A CN201110147605XA CN201110147605A CN102210734A CN 102210734 A CN102210734 A CN 102210734A CN 201110147605X A CN201110147605X A CN 201110147605XA CN 201110147605 A CN201110147605 A CN 201110147605A CN 102210734 A CN102210734 A CN 102210734A
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Abstract
The invention discloses an atractylis oil dripping pill. Atractylis volatile oil is used as a medicinal active ingredient, and polyethylene glycol is used as a substrate, wherein the mass ratio of the atractylis volatile oil to the substrate is 1:(3-5), and the substrate is polyethylene glycol 6000 or a mixture of polyethylene glycol 6000 and polyethylene glycol 4000. The invention also discloses a preparation method of the atractylis oil dripping pill. By optimizing the process, the process conditions are stable, the continuous production can be realized, and the prepared dripping pill has the advantages of round shape, uniform particle size, uniform color and moderate hardness, meets the requirements and avoids the defects of soft capsules.
Description
Technical field
The present invention relates to a kind of Rhizoma Atractylodis oil drop pill and preparation method thereof, be specifically related to a kind of osteoporosis, Rhizoma Atractylodis oil drop pill that dissolution rate is good and preparation method thereof for the treatment of, belong to the Chinese medicine dripping pills technical field.
Background technology
Osteoporosis (osteoporosis is called for short OPS) is the common senile disease that a kind of fibre structure with low bone amount and osseous tissue deteriorates to characteristics, it is a serious disabling condition, be the research topic of very paying close attention in recent years both at home and abroad, add up according to World Health Organization (WHO), osteoporosis has been one of pandemic disease, in commonly encountered diseases, be listed as the 7th, the total number of patients in the world has surpassed 200,000,000 people, China's patients with osteoporosis is also a lot, and with aged tendency of population, sickness rate will further increase.Therefore, the preventing and controlling of this disease are demanded urgently developing and propelling, strive to find measure and medicine efficient, simple and easy, ideal protect against osteoporosis, to improve old people's quality of life and health level.
Feverfew RHIZOMA ATRACTYLODIS IANCEAE Atractylodes Lances (Thunb) is traditional medication, has a long history in clinical practice, and its function is mainly: spleen invigorating, dampness, resolving depression, ward off dirty.Cure mainly: painful abdominal mass abdominal distention, inappetence, seasonal epidemic pathogens flu, flaccidity of the lower limbs, nyctalopia and time muscles and bones flaccidity are soft etc.The modern TCM study of pharmacy shows that Rhizoma Atractylodis are antasthenic, is stomachic again, cures mainly inappetence, dyspepsia, rickets etc.03 year applicant has found a kind of new purposes of Rhizoma Atractylodis oil, promptly uses Rhizoma Atractylodis oil preparation for treating osteoporosis, and has applied for patent.Through clinical pilot studies, Rhizoma Atractylodis oil treatment osteoporosis has clinical effectiveness preferably, shows that Rhizoma Atractylodis oil contains the effective ingredient for the treatment of osteoporosis, has good effect and has no side effect, and has higher application and exploitation value.But existing Rhizoma Atractylodis oil only has soft capsule dosage form, and there are some shortcomings in soft capsule dosage form in clinical practice, mainly is that the long-term storage capsule shells is easily aging, and disintegrate at the appointed time influences the performance of drug effect.
Drop pill splashes in the not miscible condensed fluid after being meant solid or liquid medicine and substrate heat fused mixing, shrinks the preparation that condensation forms.Characteristics such as drop pill has that dose is few, disintegrate and stripping are rapid are good dosage forms for less, the fat-soluble stronger Chinese medicine of extracted amount.Since carrier to medicine have moistening, hinder gathering, solubilising and press down brilliant effect, medicine mainly exists with molecule, crystallite or colloidal state in substrate, the medicine total surface area increases, can not only increase dissolubility, dissolution rate and the absorption rate of pharmaceutically active ingredient in some slightly solubilities, and improve the bioavailability of effective ingredient.Therefore, Chinese medicine dripping pills is compared with traditional Chinese medicine preparation and is essentially different, and the more not available advantages of other Chinese medicine dosage forms are arranged.If Rhizoma Atractylodis oil is prepared into drop pill, then can overcome existing flexible glue and hide the problem that exists, make its application easier, extensive.
Summary of the invention
The present invention is in order to overcome the shortcoming that existing Rhizoma Atractylodis oil soft capsule exists on using, a kind of novel form of Rhizoma Atractylodis oil is provided---the Rhizoma Atractylodis oil drops, this drop pill can overcome the deficiency that soft capsule exists, and its presentation quality, ball shape roundness, hardness meet the requirements.
The present invention also provides the preparation method of this Rhizoma Atractylodis oil drop pill, and this method is simple to operate, and is easy to implement.
Patent 03112076.8 discloses the application of Rhizoma Atractylodis oil in preparation treatment osteoporosis agents, proposed Rhizoma Atractylodis oil and had the effect of treatment hyperosteogeny and can be made into dosage form such as capsule, but the drop pill of Rhizoma Atractylodis oil does not appear in the newspapers.There is very big deficiency in existing Rhizoma Atractylodis oil soft capsule in application, drop pill is a kind of good dosage form, its dose is few, disintegrate and stripping are rapid, therefore the inventor further studies the Rhizoma Atractylodis oil drops, by studying suitable drop pill substrate and preparation technology, drawn the Rhizoma Atractylodis oil drop pill that meets the demands, its concrete technical scheme is as follows:
A kind of Rhizoma Atractylodis oil drop pill is characterized in that: active constituents of medicine is a Rhzoma Atractylodis Lanceae volatile oil, and substrate is Polyethylene Glycol, and the mass ratio of Rhzoma Atractylodis Lanceae volatile oil and substrate is 1:3-5.
In the above-mentioned drop pill, the mass ratio of preferred Rhzoma Atractylodis Lanceae volatile oil and substrate is 1:3.
In the above-mentioned drop pill, described substrate is the mixture of polyethylene glycol 6000 or polyethylene glycol 6000 and Macrogol 4000, preferred polyethylene glycol 6000.
The preparation method of Rhizoma Atractylodis oil drop pill of the present invention, it is characterized in that: Rhzoma Atractylodis Lanceae volatile oil and substrate are mixed in proportion, heating and melting, then the volatile oil that melts and substrate are splashed under 75-90 ℃ and prepare drop pill in the condensing agent, the condensing agent temperature is 10-25 ℃, piller after the molding is removed surface condensation agent, drying, gets the Rhizoma Atractylodis oil drop pill.
In the above-mentioned preparation method, dripping during the preparation drop pill, preferably 10cm apart from being 10-15cm.
In the above-mentioned preparation method, described condensing agent is liquid paraffin, dimethicone.
In the above-mentioned preparation method, preferred, volatile oil and substrate splash into condensing agent under 80～85 ℃, and the temperature of condensing agent is 15 ℃.
The present invention has carried out a large amount of selectivity experiments to Rhizoma Atractylodis oil drops required substrate and preparation technology, the composition and the preparation technology that are suitable as drop pill substrate have finally been drawn: the proportion relation of the kind of used substrate, substrate and effective ingredient, drop pill preparation technology parameter.The preferred property of condition of the present invention is described below by the contrast experiment.
, choice of base
Rhizoma Atractylodis oil and PEG4000, PEG4000+PEG6000, PEG6000, PEG8000 are pressed 1: 5 mix homogeneously respectively,, drip distance 10 cm to drip 80 ℃ of system temperature, 15 ℃ of condensing agent temperature, dimethicone is a condensing agent.The result is passable with the drop pill molding that PEG 4 000 makes, but hardness is not enough, and is softer; With the drop pill forming that PEG4000+PEG6000 and PEG 6 000 make, hardness is good, and PEG 6 000 is best, and the drop pill hardness that PEG8000 makes is good, but it is bad to be shaped.
, Rhizoma Atractylodis oil and substrate composition influence
Rhizoma Atractylodis oil and PEG6000 are mixed with the Rhizoma Atractylodis oil drop pill in varing proportions, and preparation condition is fixing as follows: drip 80 ℃ of system temperature, drip apart from 10 cm, and 15 ℃ of condensing agent temperature, dimethicone is a condensing agent.Setting outward appearance is the main index of investigating, and comprises roundness (10 minutes), mass discrepancy (10 minutes), hardness (10 minutes), and estimating total points is 30 minutes.The results are shown in following table 1.
As can be seen from the above table, Rhzoma Atractylodis Lanceae volatile oil and substrate ratio form certain influence to drop pill, substrate ratio height, and denseness is relatively little, and roundness is better, but drug loading is little, is unfavorable for clinical practice; The substrate ratio is little, unsuitable curing molding, difference of hardness.
, drip the system Temperature Influence
Rhizoma Atractylodis oil is mixed by 1: 5 with PEG6000, change and drip the system temperature, other conditions the results are shown in Table 2 with table 1.
Last table shows that a system temperature is lower, and denseness is bigger, drips the system difficulty, easy hangover; Temperature is higher than 90 ℃, and the medicinal liquid denseness is little, easily drip system, but in the liquid coolant of uniform temp, condensation is rapid relatively, and roundness is poor slightly.
, the condensing agent Temperature Influence
Rhizoma Atractylodis oil is mixed by 1: 5 with PEG6000, change the temperature of condensing agent, other conditions the results are shown in Table 3 with table 1.
As can be seen from the table, condensing agent is in 10-15 ℃ of scope, and drop pill is easy to molding.Be higher than 25 ℃, drop pill hardness is poor slightly, and is lower than 10 ℃, because the rapid condensation of drop pill has little time to recover owing to the distortion that contacts with condensing agent and trail and produce, roundness is bad.
, drip the influence of distance
Rhizoma Atractylodis oil is mixed by 1: 5 with PEG6000, change and drip distance, other conditions the results are shown in Table 4 with table 1.
As can be seen from the table, drip apart from short, drop pill can not fully cool off, and adhesion phenomenon occurs, and roundness is poor, and it is good that a distance grows up to type, but production efficiency is low.
From top data as can be seen, have only the prescription of the present invention of employing and preparation technology parameter just can make drop pill superior in quality, that meet the demands.
In order to obtain better drop pill, draw preferred process conditions by following orthogonal experiment.
The preferred moulding process of orthogonal test
According to the experimental result that single factor is investigated, set factor level and see Table 5, wherein, A is Rhizoma Atractylodis oil and substrate composition, and B is the drop pill temperature, and C is the condensing agent temperature, and D is for dripping distance, and result of the test sees Table 6.As can be known from the results, 4 kinds of factors are RB to the technogenic influence size〉Rc〉RA〉RD, promptly drip the system temperature for influencing the principal element that drop pill is shaped, the condensing agent temperature is taken second place, and principal agent and substrate composition drip once more apart from worst.As seen be combined as A2B3C3D2 preferably by intuitive analysis, promptly principal agent and substrate composition are 1: 3, and dripping the system temperature is 80～85 ℃, drips apart from being 10 cm, and the temperature of condensing agent is 15 ℃, and dimethicone is a condensing agent.The drop pill of making by above-mentioned optimum process condition is light brown yellow, smooth surface, and the mass discrepancy limit, the molten diffusing time all meets 2010 editions two appendix regulations of the Pharmacopoeia of the People's Republic of China.The drop pill presentation quality of preparation is good, ball shape rounding, and the color and luster homogeneous, hardness is better.Experimental result proves that this stable process conditions is feasible.
Rhizoma Atractylodis oil of the present invention or Rhzoma Atractylodis Lanceae volatile oil refer to water from Rhizoma Atractylodis are carried the volatile oil of gained, Rhizoma Atractylodis are feverfew Atractylodes lancea (Thunb.) DC. Atractylode lancea(Thunb.) DC. or Atractylis chinensis Atracctylodes chinensis(DC.) dry rhizome of Koidz., its volatile oil leaching process is: adopt steam distillation to extract, process conditions are: add 4 quality times water, soak 2h, extract 7h.Contain atisine chloride atractydin, atractylone, eudesmol etc. in the Rhizoma Atractylodis oil of gained or the Rhzoma Atractylodis Lanceae volatile oil, volatile oil can increase the absorption of calcium, regulates the metabolism of calcium, and the treatment osteoporosis is had clinical effectiveness preferably.
The present invention prepares drop pill with the principle of solid dispersion, with the medicine high degree of dispersion in drug matrices, medicine exists with upper state forms such as molecularity, colloidal state crystallite or metastable particles, can reduce simultaneously the granularity of insoluble drug significantly, increase its diffusion area, help the stripping of medicine, accelerated the dissolution rate of effective ingredient, improve its assimilation effect, avoided the deficiency of soft capsule.And the present invention has optimized the process conditions of preparation process, makes preparation process condition stable, can ensured sustained development production, and made drop pill profile rounding, pellet sizes are evenly, color and luster homogeneous, hardness be moderate, meet the requirements.
The specific embodiment
The present invention will be further elaborated below by specific embodiment, should be understood that, following explanation only is in order to explain the present invention, its particular content not to be limited.
Embodiment 1
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, drop pill consists of: mass ratio is Rhzoma Atractylodis Lanceae volatile oil and the PEG6000 of 1:3, preparation method is: Rhizoma Atractylodis oil (Rhzoma Atractylodis Lanceae volatile oil) is mixed grinding well with Polyethylene Glycol (PEG6000), heating and melting, stir,, pour in the drop pill device to fusion fully, and make the drop pill device be incubated 80-85 ℃, behind 10 min, open the drop pill device and make it drop pill, fused materials evenly splashes in the dimethicone condensing agent by the water dropper of drop pill device, dripping distance is 10cm, the condensing agent temperature is 15 ℃, leaches piller after the molding, inhales the dimethicone that goes to the surface with filter paper, nature airing under the room temperature promptly makes the Rhizoma Atractylodis oil drop pill.
Adopt said method three batches of drop pill of preparation continuously, its exterior quality is as follows:
(1) outward appearance: the light brown yellow piller, the profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate.
(2) mass discrepancy and molten diffusing time: press 2010 editions two appendix predetermined operation of the Pharmacopoeia of the People's Republic of China, the mass discrepancy of 3 batches of drop pill is respectively ± and 1.56%, ± 1.96% and ± 2.06%; The molten diffusing time is respectively 18,22 and 25 min, and the result is up to specification.
(3) microbiological indicator: total number of bacteria≤1000/g; Mycete and yeast count≤100/g; Coliform count must not detect.
Adopt gas chromatography determination gained drop pill Chinese medicine content of effective
(1) experimental facilities and reagent
PHILIPS pu4400 gas chromatograph and corollary equipment data handling system thereof.The sagittol reference substance is provided content by China Academy of TCM's Chinese medicine〉99%, positive pentadecanol (1-Pentadecanol Fluka AG, Chem. Fabrik CH-9470 Buchs) content〉98%(GC), agents useful for same is analyzes alcohol.
(2) GC conditions
Select for use Chromosorb W (AW---DACS) as carrier, 10%SE-30 is as fixative, post 22m * 0.25mm, and 174 ℃ of column temperatures, temperature of vaporization chamber are 210 ℃.Detector is FID, and nitrogen flow rate is 40ml/min, air 49Kpa, hydrogen 58.8 Kpa.Sensitivity 10
2AuFS, decay 64, split ratio is 20:1.Measure β-eudesmol theoretical cam curve by this condition and be about 11000, show that the post effect is good.According to repeatedly measuring the theoretical cam curve result, this assay method of regulation tower number should be not less than 10000.
(3) test method
Adopt internal standard method to carry out quantitative analysis, select for use positive pentadecanol as internal standard substance, the about 6mg/ml of concentration.Calculating β-eudesmol by mensuration is 5.1 with positive pentadecanol separating degree between the two, prove that the two has good separating degree under these conditions, it is feasible to select for use positive pentadecanol to make internal standard substance, and β in the sample-eudesmol peak separates better, negative not interference.Before the test, get the about 0.1g of drop pill, put in the 5ml measuring bottle, accurate positive pentadecanol internal standard substance methanol solution (30.5mg/ml) 1ml that adds adds methanol to scale, shakes up, and as need testing solution, adopts internal standard method that the content of sagittol in the drop pill is detected then.
(4) conclusion
Measure the content of sagittol in three batch samples according to the method described above respectively, the results are shown in following table 7.
According to measurement result, every drop pill contains sagittol and is no less than 6mg.
Embodiment 2
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, drop pill consists of: mass ratio is Rhzoma Atractylodis Lanceae volatile oil and the PEG6000 of 1:4, preparation method is: Rhizoma Atractylodis oil (Rhzoma Atractylodis Lanceae volatile oil) is mixed grinding well with Polyethylene Glycol (PEG6000), heating and melting, stir,, pour in the drop pill device to fusion fully, and make the drop pill device be incubated 75 ℃, behind 10 min, open the drop pill device and make it drop pill, fused materials evenly splashes in the dimethicone condensing agent by the water dropper of drop pill device, dripping distance is 15cm, the condensing agent temperature is 15 ℃, leaches piller after the molding, inhales the dimethicone that goes to the surface with filter paper, nature airing under the room temperature promptly makes the Rhizoma Atractylodis oil drop pill.Gained drop pill profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate, adopts gas chromatography to record that sagittol content is 6.44 mg/ grains in the drop pill.
Embodiment 3
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, drop pill consists of: mass ratio is Rhzoma Atractylodis Lanceae volatile oil and the PEG6000 of 1:3, preparation method is: Rhizoma Atractylodis oil (Rhzoma Atractylodis Lanceae volatile oil) is mixed grinding well with Polyethylene Glycol (PEG6000), heating and melting, stir,, pour in the drop pill device to fusion fully, and make the drop pill device be incubated 85 ℃, behind 10 min, open the drop pill device and make it drop pill, fused materials evenly splashes in the dimethicone condensing agent by the water dropper of drop pill device, dripping distance is 10cm, the condensing agent temperature is 10 ℃, leaches piller after the molding, inhales the dimethicone that goes to the surface with filter paper, nature airing under the room temperature promptly makes the Rhizoma Atractylodis oil drop pill.Gained drop pill profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate, adopts gas chromatography to record that sagittol content is 6.97 mg/ grains in the drop pill.
Embodiment 4
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, drop pill consists of: mass ratio is Rhzoma Atractylodis Lanceae volatile oil and the PEG6000 of 1:5, preparation method is: Rhizoma Atractylodis oil (Rhzoma Atractylodis Lanceae volatile oil) is mixed grinding well with Polyethylene Glycol (PEG6000), heating and melting, stir,, pour in the drop pill device to fusion fully, and make the drop pill device be incubated 90 ℃, behind 10 min, open the drop pill device and make it drop pill, fused materials evenly splashes in the dimethicone condensing agent by the water dropper of drop pill device, dripping distance is 10cm, the condensing agent temperature is 25 ℃, leaches piller after the molding, inhales the dimethicone that goes to the surface with filter paper, nature airing under the room temperature promptly makes the Rhizoma Atractylodis oil drop pill.Gained drop pill profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate, adopts gas chromatography to record that sagittol content is 6.03 mg/ grains in the drop pill.
Embodiment 5
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, drop pill consists of: mass ratio is Rhzoma Atractylodis Lanceae volatile oil and the PEG6000 of 1:3, preparation method is: Rhizoma Atractylodis oil (Rhzoma Atractylodis Lanceae volatile oil) is mixed grinding well with Polyethylene Glycol (PEG6000), heating and melting, stir,, pour in the drop pill device to fusion fully, and make the drop pill device be incubated 85 ℃, behind 10 min, open the drop pill device and make it drop pill, fused materials evenly splashes in the liquid paraffin condensing agent by the water dropper of drop pill device, dripping distance is 10cm, the condensing agent temperature is 15 ℃, leaches piller after the molding, inhales the liquid paraffin that goes to the surface with filter paper, nature airing under the room temperature promptly makes the Rhizoma Atractylodis oil drop pill.Gained drop pill profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate, adopts gas chromatography to record that sagittol content is 6.87 mg/ grains in the drop pill.
Embodiment 6
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, drop pill consists of: mass ratio is Rhzoma Atractylodis Lanceae volatile oil and the PEG6000 of 1:3, PEG4000 mixture (the PEG4000 quality is less than 50% in the substrate), preparation method is: Rhizoma Atractylodis oil (Rhzoma Atractylodis Lanceae volatile oil) is mixed grinding well with Polyethylene Glycol (PEG6000), heating and melting, stir, to fusion fully, pour in the drop pill device, and make the drop pill device be incubated 85 ℃, behind 10 min, open the drop pill device and make it drop pill, fused materials evenly splashes in the liquid paraffin condensing agent by the water dropper of drop pill device, dripping distance is 10cm, the condensing agent temperature is 25 ℃, leaches piller after the molding, inhales the liquid paraffin that goes to the surface with filter paper, nature airing under the room temperature promptly makes the Rhizoma Atractylodis oil drop pill.Gained drop pill profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate.
Embodiment 7
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, preparation method is with embodiment 6, and different is that the PEG4000 quality is 45% in the substrate.Gained drop pill profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate.
Embodiment 8
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, preparation method is with embodiment 6, and different is that the PEG4000 quality is 35% in the substrate.Gained drop pill profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate.
Embodiment 9
Adopt the drop pill legal system to be equipped with the Rhizoma Atractylodis oil drop pill, preparation method is with embodiment 6, and different is that the PEG4000 quality is 15% in the substrate.Gained drop pill profile rounding, pellet sizes is even, the color and luster homogeneous, hardness is moderate.
Claims (8)
1. Rhizoma Atractylodis oil drop pill, it is characterized in that: active constituents of medicine is a Rhzoma Atractylodis Lanceae volatile oil, and substrate is Polyethylene Glycol, and the mass ratio of Rhzoma Atractylodis Lanceae volatile oil and substrate is 1:3-5.
2. drop pill according to claim 1 is characterized in that: the mass ratio of Rhzoma Atractylodis Lanceae volatile oil and substrate is 1:3.
3. drop pill according to claim 1 is characterized in that: described substrate is the mixture of polyethylene glycol 6000 or polyethylene glycol 6000 and Macrogol 4000.
4. the preparation method of the described Rhizoma Atractylodis oil drop pill of claim 1, it is characterized in that: Rhzoma Atractylodis Lanceae volatile oil and substrate are mixed in proportion, heating and melting, then the volatile oil that melts and substrate are splashed under 75-90 ℃ and prepare drop pill in the condensing agent, the condensing agent temperature is 10-25 ℃, piller after the molding is removed surface condensation agent, drying, gets the Rhizoma Atractylodis oil drop pill.
5. preparation method according to claim 4 is characterized in that: dripping apart from being 10-15cm during the preparation drop pill.
6. preparation method according to claim 5 is characterized in that: dripping apart from being 10cm during the preparation drop pill.
7. preparation method according to claim 4 is characterized in that: described condensing agent is liquid paraffin, dimethicone.
8. preparation method according to claim 6 is characterized in that: volatile oil and substrate splash into condensing agent under 80～85 ℃, and the temperature of condensing agent is 15 ℃.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107164079A (en) * | 2017-05-25 | 2017-09-15 | 甘肃滨河食品工业（集团）有限责任公司 | A kind of siritch and preparation method thereof and siritch dripping pill and preparation method thereof |
| CN110302218A (en) * | 2019-07-15 | 2019-10-08 | 湘南学院 | A kind of dripping pill and preparation method thereof |
| CN117482060A (en) * | 2023-12-28 | 2024-02-02 | 广州善元堂健康科技股份有限公司 | Traditional Chinese medicine dripping pill for reducing uric acid and preparation method thereof |
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| CN1440790A (en) * | 2003-04-02 | 2003-09-10 | 山东省中医药研究院 | Application of atractylodes rhizome oil in preparing medicine for osteoporosis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1440790A (en) * | 2003-04-02 | 2003-09-10 | 山东省中医药研究院 | Application of atractylodes rhizome oil in preparing medicine for osteoporosis |
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| Title |
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| 付超美等: "中药滴丸剂成型工艺的研究", 《中国药业》, vol. 13, no. 4, 30 April 2004 (2004-04-30), pages 27 - 28 * |
| 周雅琴等: "中药滴丸剂的研究进展", 《中国中药杂志》, vol. 31, no. 2, 31 January 2006 (2006-01-31), pages 101 - 105 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107164079A (en) * | 2017-05-25 | 2017-09-15 | 甘肃滨河食品工业（集团）有限责任公司 | A kind of siritch and preparation method thereof and siritch dripping pill and preparation method thereof |
| CN110302218A (en) * | 2019-07-15 | 2019-10-08 | 湘南学院 | A kind of dripping pill and preparation method thereof |
| CN117482060A (en) * | 2023-12-28 | 2024-02-02 | 广州善元堂健康科技股份有限公司 | Traditional Chinese medicine dripping pill for reducing uric acid and preparation method thereof |
| CN117482060B (en) * | 2023-12-28 | 2024-04-05 | 广州善元堂健康科技股份有限公司 | Traditional Chinese medicine dripping pill for reducing uric acid and preparation method thereof |
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| CN102210734B (en) | 2013-03-20 |
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