CN1299694C - Flavone composition for sobering and liver protection and its use - Google Patents
Flavone composition for sobering and liver protection and its use Download PDFInfo
- Publication number
- CN1299694C CN1299694C CNB2005100536170A CN200510053617A CN1299694C CN 1299694 C CN1299694 C CN 1299694C CN B2005100536170 A CNB2005100536170 A CN B2005100536170A CN 200510053617 A CN200510053617 A CN 200510053617A CN 1299694 C CN1299694 C CN 1299694C
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- Prior art keywords
- flavone
- composition
- medicine
- preparation
- puerarin
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- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
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- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
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- BMLIIPOXVWESJG-UHFFFAOYSA-N silychristin A Natural products C1=C(O)C(OC)=CC(C2C(C3=C(C(=CC(=C3)C3C(C(=O)C4=C(O)C=C(O)C=C4O3)O)O)O2)CO)=C1 BMLIIPOXVWESJG-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Ratio silymarin/puerarin | Dosage mg/kg (the weight of animals) | |
Silymarin group 1 | - | 50 |
Silymarin group 2 | - | 100 |
Puerarin group 1 | - | 150 |
Puerarin group 2 | - | 300 |
Compositions group 1 | 1∶3 | 200 |
Compositions group 2 | 1∶3 | 300 |
Number of animals (n) | AST(u/L) | ALT(u/L) | Hepatic tissue LPO (nmol/g) | Hepatic tissue GSH (μ g/g) | Liver is carefully knitted GSH-Px (u/ml) | |
The blank group | 10 | 75.1±12.5 | 33.2±8.7 | 30.2±15.1 | 913.4±115.3 | 66.7±3.1 |
The pathological model group | 12 | 136.9±33.9 | 59.6±15.1 | 66.7±17.5 | 442.1±101.7 | 41.9±2.9 |
Silymarin group 1 | 12 | 88.3±25.2 ** | 44.8±18.3 * | 39.6±17.6 ** | 790.5±124.8 ** | 54.9±3.4 * |
Silymarin group 2 | 12 | 71.2±22.6 ** | 39.6±13.2 ** | 34.5±10.9 ** | 879.6±123.6 ** | 60.8±4.4 ** |
Puerarin group 1 | 12 | 128.7±38.2 | 60.3±18.5 | 44.9±19.0 * | 456.3±89.9 | 50.2±5.1 |
Puerarin group 2 | 12 | 101.2±27.9 * | 51.7±18.2 | 40.5±15.9 * | 523.4±99.1 * | 55.3±3.4 * |
Compositions group 1 | 12 | 86.3±22.4 ** | 42.1±16.6 * | 30.3±13.8 ** | 821.5±111.6 ** | 60.9±3.8 ** |
Compositions group 2 | 12 | 66.7±17.5 *** | 35.8±9.8 ** | 25.4±11.9 *** | 932.4±121.4 *** | 667±4.0 ** |
Blood determining alcohol (mg/L) | 0.5h | 1h | 2h | 3h | 5h | |
Matched group | 66.7±5.9 | 93.8±8.6 | 87.5±5.7 | 81.2±4.5 | 75.2±6.6 | |
The puerarin group | 60.7±3.9 | 88.7±6.7 | 80.5±4.4 | 70.5±3.5 | 61.2±2.9 | P<0.05 |
Compositions group 1 | 48.9±3.1 | 75.7±4.6 | 70.4±3.3 | 62.3±2.2 | 50.2±1.9 | P<0.01 |
Compositions group 2 | 41.2±2.3 | 69.8±5.9 | 63.7±4.2 | 55.8±3.1 | 45.1±2.1 | P<0.001 |
Claims (10)
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Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102599503B (en) * | 2012-03-14 | 2014-04-16 | 上海善力健保健食品有限公司 | Sober-up and liver-protecting health food and making method thereof |
CN102671066A (en) * | 2012-05-18 | 2012-09-19 | 江西农业大学 | Hangover-alleviating compound and preparation method thereof |
CN103623046A (en) * | 2013-12-24 | 2014-03-12 | 浙江康乐药业股份有限公司 | Composite playing auxiliary protection role in chemical and alcoholic liver injury, preparation method of composite and application of composite in health-care food |
CN105942497A (en) * | 2016-05-04 | 2016-09-21 | 江苏神华药业有限公司 | Composition with effects of neutralizing effect of alcoholic drinks and nourishing liver and preparation method of composition |
CN106721793A (en) * | 2016-12-05 | 2017-05-31 | 张俊宝 | A kind of caulis bambusae in taenian hangover-alleviating health-care oral liquid |
CN108244658B (en) * | 2018-04-20 | 2021-08-20 | 大连军门保健食品有限公司 | An anti-hangover and hepatoprotective agent containing herba Cichorii nutrients, and its preparation method |
CN110432418A (en) * | 2018-05-05 | 2019-11-12 | 陈泂杉 | A kind of production method of liver-protecting and alcoholism-relieving drink |
CN110038044A (en) * | 2019-04-23 | 2019-07-23 | 陈飞筱 | A kind of alcohol-decomposing powder and preparation method thereof |
CN110237155A (en) * | 2019-07-31 | 2019-09-17 | 王鹏 | One kind sober up patch and preparation method thereof |
CN111494564B (en) * | 2020-04-30 | 2021-07-27 | 江苏中兴药业有限公司 | Preparation method of compound liver-protecting and alcohol-dispelling tablet |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1163127A (en) * | 1996-04-25 | 1997-10-29 | 赵爱平 | Puerarin and its extracting method |
CN1188800A (en) * | 1997-01-22 | 1998-07-29 | 山东省达瀚实业总公司 | Wine with liver protective function and making method thereof |
US20040162270A1 (en) * | 2003-02-18 | 2004-08-19 | Better Living Chemistry | Compositions for prevention and treatment of symptoms associated with ethyl alcohol consumption |
CN1560062A (en) * | 2004-03-11 | 2005-01-05 | 白栓锁 | Process of extracting puerariae and making food and medicine addied with it |
-
2005
- 2005-03-09 CN CNB2005100536170A patent/CN1299694C/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1163127A (en) * | 1996-04-25 | 1997-10-29 | 赵爱平 | Puerarin and its extracting method |
CN1188800A (en) * | 1997-01-22 | 1998-07-29 | 山东省达瀚实业总公司 | Wine with liver protective function and making method thereof |
US20040162270A1 (en) * | 2003-02-18 | 2004-08-19 | Better Living Chemistry | Compositions for prevention and treatment of symptoms associated with ethyl alcohol consumption |
CN1560062A (en) * | 2004-03-11 | 2005-01-05 | 白栓锁 | Process of extracting puerariae and making food and medicine addied with it |
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