CN1188800A - Wine with liver protective function and making method thereof - Google Patents
Wine with liver protective function and making method thereof Download PDFInfo
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- CN1188800A CN1188800A CN97105640A CN97105640A CN1188800A CN 1188800 A CN1188800 A CN 1188800A CN 97105640 A CN97105640 A CN 97105640A CN 97105640 A CN97105640 A CN 97105640A CN 1188800 A CN1188800 A CN 1188800A
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- wine
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- silymarin
- liver
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Abstract
A liver-protecting wine as grains spirit is made up of silymarin extracted from its plant silybum marianum, and can serves to prevent over-oxidization of lipid, remove free radicals, promote synthesis of protein and increase the activity of SOD, so preventing and curing the damage of liver caused by alcohol, thioacetylamine, toxin of toxic mushroom, phalloidine and mucronatine and inhibiting the raise of transaminase.
Description
The invention belongs to healthcare products, particularly be that Silymarin is added wine with liver protective function and the production method thereof that makes in the food-drink.
Drinking amount is a lot of in social interaction now, amusement and the daily life, but long-term excessive consumption of alcohol can cause a series of hepar damnifications such as alcoholic liver poisoning, fatty liver, drinking, not to be harmful to the health or to be harmful to the health less be necessary, though antialcoholism tea, antialcoholic drug are arranged, but just relieve the effect of alcohol, along with Chinese economic development, the people's life improves very fast, to protective foods, the beverage of human body also require higher, the function that can play prevention, treatment, health care three unification with food-drink is people's yearning, so can not only drink, and the health promoting wine that can protect liver again is our striving direction.
The purpose of this invention is to provide a kind of is that raw material extracts the silymarin elaboration with Silymarin, is dissolved in scientific approach and makes wine with liver protective function and the production method thereof that has anti-liver alcoholism, protects physiologically actives such as liver in the grain neutral spirit.
The object of the present invention is achieved like this, is described as follows: a kind of combination formula of wine with liver protective function is: the moisture silibin elaboration 140-200 milligram that flies in per 500 milliliters of grain neutral spirits.
The production method of above-mentioned wine with liver protective function is:
1. it is standby to weigh up 20 milliliters of grain neutral spirits;
2. water intaking flies silibin elaboration 280-400 milligram and places glass beaker, adding 8-12 milliliter polyoxyethylene glycol-400 (being DEG-400) heats to 30-40 ℃ and makes its dissolving, be cooled to room temperature then, under whipped state, join again in the grain neutral spirit of having got ready, behind the mixing mother liquor;
3. get above-mentioned mother liquor with 50 times of grain neutral spirit dilutions, become 1000 milliliters of cubic capacitys, stir, again through filtering packing, wine with liver protective function.
In the production method of above-mentioned wine with liver protective function, used grain neutral spirit is the liquor of Luzhou-flavor preferably.
The process for purification of used silymarin elaboration is in the above-mentioned wine with liver protective function production method:
1. after the Silymarin seed being pulverized, use petroleum ether degreasing, extracted at least 8 hours continuously with vinyl acetic monomer then, reclaim vinyl acetic monomer then and obtain dense thick extract, add sherwood oil again and grind, obtain yellow powder;
2. get above-mentioned yellow powder and add that acetone is wetting to be mixed thoroughly, add the chromatographic silica gel mixing again, make the acetone solution composition all be adsorbed onto on the silica gel, go up chromatography column then and carry out chromatography (sample: silica gel=1: 3-5 is advisable), again with chloroform: mixed solvent wash-out methyl alcohol=100: 1), collect elutriant again with chloroform: methyl alcohol=100: 3 mixed solvent wash-outs, collecting elutriant checks with TLC, merge identical elutriant, reclaim solvent, get micro-yellow powder;
3. the powder behind the chromatography is carried out recrystallization in acetone, after to be crystallized the separating out, the filtering and washing crystallization promptly gets the silymarin elaboration.
Above-mentioned silymarin is the flavonoid compound that extracts by in the composite family Silymarin seed; has anti peroxidation of lipid; eliminate free radical; promote protein synthesis; improve the effects such as activity of superoxide dismutase (SOD); can protect significantly and stable liver plasma membrane; to ethanol; tetracol phenixin; thioacetamide; the poisonous fungus element; phallodine; the various liver injuries that hepatotoxic agents such as mucronatine cause have protection and therapeutic action in various degree; and the increasing of Alanine transaminase that tetracol phenixin causes there is certain interception; compare with the silymarin crude extract liver protection effect that records on the existing pharmacopeia, the silymarin elaboration liver protection effect that the present invention extracts is more remarkable.
Embodiment 1, combination formula are:
The prescription of wine with liver protective function is: in 500 milliliters of the scape wine in spring of Luzhou-flavor, contain 150 milligrams of Silymarin poison elaboration respectively, and 170 milligrams, the wine with liver protective function of three kinds of models such as 190 milligrams of grades.
The production method of embodiment 2, wine with liver protective function is:
Water intaking flies the silibin elaboration and inserts in the beaker for 340 milligrams, adds 10 milliliters and be heated to 35 ℃ of dissolvings simultaneously in cup, reduces to room temperature then, adds 20 milliliters of five-Grain Liquor liquor mixings then under constantly stirring, the wine with liver protective function mother liquor; With 50 times of five-Grain Liquor liquor dilutions, become 1000 milliliters of cubic capacitys then, stir, be distributed into 500 milliliters every bottle, include 170 milligrams of silymarin elaboration.Wine with liver protective function.
The process for purification of embodiment 3, silymarin elaboration is:
1. the Silymarin seed is pulverized, used petroleum ether degreasing again, extracted at least 10 hours continuously with vinyl acetic monomer again, reclaim vinyl acetic monomer again; Add again sherwood oil grind yellow powder; Mix thoroughly with acetone is wetting again; Add the chromatographic silica gel mixing again, make the composition of acetone solution all be adsorbed onto on the silica gel, go up chromatography column again and carry out chromatography (sample: silica gel=1: 4), with chloroform: methyl alcohol (100: 1) mixed solvent wash-out, again with chloroform: methyl alcohol (100: 3) mixed solvent wash-out, collect elutriant and check, remerge identical elutriant, reclaim solvent and get micro-yellow powder with TLC;
2. the micro-yellow powder behind the chromatography is carried out recrystallization in acetone, after to be crystallized the separating out, the filtering and washing crystallization promptly gets the silymarin elaboration.
Advantage of the present invention is a lot, and the preparation of wine with liver protective function science is because wherein containing the silymarin elaboration, through drink Significantly protection is arranged and stablize liver plasma membrane with experiment, to ethanol, carbon tetrachloride, sulfuration acetamide, poison Various hepatic injury tool protections and therapeutic action that the hepatotoxic agents such as gill fungus element cause are to increasing of glutamic-pyruvic transaminase Interception is arranged, and produce simple, easy to use, the effective popularization of being suitable for.
Claims (3)
1, a kind of wine with liver protective function is characterized in that: combination formula is: contain in 500 milliliters of grain neutral spirits and fly silibin elaboration 140-200 milligram.
2, a kind of production method of above-mentioned wine with liver protective function is characterized in that:
1. it is standby to weigh up 20 milliliters of grain neutral spirits;
2. water intaking flies silibin elaboration 280-400 milligram and places glass beaker, adding 8-12 milliliter polyoxyethylene glycol-400 (being DEG-400) heats to 30-40 ℃ and makes its dissolving, be cooled to room temperature then, under whipped state, join again in the grain neutral spirit of having got ready, behind the mixing mother liquor;
3. get above-mentioned mother liquor with 50 times of grain neutral spirit dilutions, become 1000 milliliters of cubic capacitys, stir, again through filtering packing, wine with liver protective function.
3, the production method of wine with liver protective function according to claim 2 is characterized in that: the process for purification of described silymarin elaboration is:
1. after the Silymarin seed being pulverized, use petroleum ether degreasing, extracted at least 8 hours continuously with vinyl acetic monomer then, reclaim vinyl acetic monomer then and obtain dense thick extract, add sherwood oil again and grind, obtain yellow powder;
2. get above-mentioned yellow powder and add that acetone is wetting to be mixed thoroughly, add the chromatographic silica gel mixing again, the acetone solution composition all is adsorbed onto on the silica gel, goes up chromatography column then and carry out chromatography, sample: silica gel=1: 3-5, again with chloroform: methyl alcohol=100: 1 mixed solvent wash-outs, collect elutriant again with chloroform: methyl alcohol=100: 3 mixed solvent wash-outs, collect elutriant and check with TLC, merge identical elutriant, reclaim solvent, get micro-yellow powder;
3. the powder behind the chromatography is carried out recrystallization in acetone, after to be crystallized the separating out, the filtering and washing crystallization promptly gets the silymarin elaboration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97105640A CN1188800A (en) | 1997-01-22 | 1997-01-22 | Wine with liver protective function and making method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97105640A CN1188800A (en) | 1997-01-22 | 1997-01-22 | Wine with liver protective function and making method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1188800A true CN1188800A (en) | 1998-07-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97105640A Pending CN1188800A (en) | 1997-01-22 | 1997-01-22 | Wine with liver protective function and making method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN1188800A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299694C (en) * | 2005-03-09 | 2007-02-14 | 董诗文 | Flavone composition for sobering and liver protection and its use |
| CN101961367A (en) * | 2010-11-10 | 2011-02-02 | 江苏省奥康生物科技有限公司 | Chinese medicinal composition for preventing alcoholic liver injury |
| CN101974398A (en) * | 2010-11-15 | 2011-02-16 | 宁蒗女儿珍生物工程有限公司 | Oleanolic acid health care wine |
| US9192638B2 (en) | 2009-10-28 | 2015-11-24 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
-
1997
- 1997-01-22 CN CN97105640A patent/CN1188800A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299694C (en) * | 2005-03-09 | 2007-02-14 | 董诗文 | Flavone composition for sobering and liver protection and its use |
| US9192638B2 (en) | 2009-10-28 | 2015-11-24 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| US9526753B2 (en) | 2009-10-28 | 2016-12-27 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| CN101961367A (en) * | 2010-11-10 | 2011-02-02 | 江苏省奥康生物科技有限公司 | Chinese medicinal composition for preventing alcoholic liver injury |
| CN101961367B (en) * | 2010-11-10 | 2012-05-23 | 江苏省奥康生物科技有限公司 | Chinese medicinal composition for preventing alcoholic liver injury |
| CN101974398A (en) * | 2010-11-15 | 2011-02-16 | 宁蒗女儿珍生物工程有限公司 | Oleanolic acid health care wine |
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