CN1297295C - Constipation treating Chinese medicinal composition - Google Patents
Constipation treating Chinese medicinal composition Download PDFInfo
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- CN1297295C CN1297295C CNB2004100096994A CN200410009699A CN1297295C CN 1297295 C CN1297295 C CN 1297295C CN B2004100096994 A CNB2004100096994 A CN B2004100096994A CN 200410009699 A CN200410009699 A CN 200410009699A CN 1297295 C CN1297295 C CN 1297295C
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- constipation
- atractylodis macrocephalae
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- rhizoma atractylodis
- radix rehmanniae
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a Chinese medicinal composition for treating constipation which comprises white atractylodes rhizome, dried rehmannia root and cimicifuga rhizome. The present invention also relates to a preparing method of the composition, the use of the composition, and medicine containing the composition as the active constituent.
Description
Technical field
The present invention relates to treat the Chinese medicine composition of constipation, said composition is a feature with the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae, Rhizoma Cimicifugae; Also relate to the preparation method and the purposes of said composition and comprise the medicine of said composition as effective ingredient.
Background technology
Constipation is common clinically, frequently-occurring disease, after surgery, its sickness rate is higher after women puerperal, chemicotherapy and among the old asthenia crowd, but is applicable to that the medicine of this type constipation is less; And in the charthartic of listing, often contain flavour of a drug such as Radix Et Rhizoma Rhei, Folium Sennae, Aloe, Radix Polygoni Multiflori at present, this class medicine is an anthraquinone class cathartic, by certain side effect, is unsuitable for this type of patient and takes.Therefore develop relieving constipation medicine safely and effectively, it is just very necessary to remove the misery that this type of patient makes the matter worse.
Summary of the invention
The present invention relates to treat the Chinese medicine composition of constipation, said composition is a feature with the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae, Rhizoma Cimicifugae; Also relate to the preparation method and the purposes of said composition and comprise the medicine of said composition as effective ingredient.
The traditional Chinese medical science is thought: the Rhizoma Atractylodis Macrocephalae, and bitter, Gan Wen return through taste, and QI invigorating is good for the stomach.Say as " Bencao Jingshu ": " art, its gas virtue is strong, and its sweet in the mouth is dense, the pure sun of its property is the superb work of peace taste ", be usually used in temper, the weak card that waits of deficiency of spleen-YANG." book on Chinese herbal medicine converge with speech " said: " Rhizoma Atractylodis Macrocephalae, the key medicine of fostering taste also, insufficiency of the spleen strong, art can be mended it, " makes temper healthy and vigorous, fortuneization again often, then sick spontaneous recovery." " property of medicine opinion " say: " Rhizoma Atractylodis Macrocephalae, the broken dyspepsia that disappears." " primary disease is many not normal by transporting and transforming function of the spleen and stomach, due to food is stagnant not all right.Card is seen: distension and fullness in the abdomen, and pain with tenderness, the feed pain increases, and big constipation can not be separated any more, and thick fur is greasy, the sliding string of pulse condition.Can select the sweet temperature spleen invigorating of Rhizoma Atractylodis Macrocephalae stomach strengthening for use, bitter in the mouth removes in the stomach damp and hot, makes the controlled atmosphere harmonization of the stomach, and stagnant as to remove, diet is as usual." " book on Chinese herbal medicine is looked for the truth ": " why specially the Rhizoma Atractylodis Macrocephalae enriching spleen-QI? lid is bitter wet with spleen, anxious food bitter flavor having drying effect, and the spleen desire is slow, anxious food sweet flavor has the effect of relaxing; Rhizoma Atractylodis Macrocephalae bitter in the mouth and sweet can dry food tonifying the spleen, and the slow spleen of reactivation promotes the production of body fluid, and its property is the warmest, and clothes then can be with strong food rapid digestion of food, for spleen QI invigorating first key medicine also." Ran Xuefeng " Datong District's materia medica ": " Rhizoma Atractylodis Macrocephalae function, all from the warming middle-JIAO tonifying the spleen, dry temperature rise sun is studied and explained.”
Modern pharmacy is discovered: the Rhizoma Atractylodis Macrocephalae can make rabbit intestine in vitro voluntary activity tonicity raise, and shrinkage amplitude strengthens, and the lax amplitude recovery of the intestinal tube that epinephrine is caused can make weak gastrointestinal peristalsis strengthen, and promotes feces and discharges.Be originally can treat one of pharmacological basis of constipation.
The traditional Chinese medical science is thought: Radix Rehmanniae, nature and flavor sweetness and bitterness is cold, clearing away heat and cooling blood is arranged, the merit of loosening bowel to relieve constipation." book on Chinese herbal medicine meets former ": " patient is empty and hot person is arranged in addition ... big or small constipation for Radix Rehmanniae, interior special removing heat from blood, YIN nourishing, and I am unequal to the person of capturing, and in antipyretic, logical its constipated the best has the merit of moisturizing with it with this, and has the greasy trouble of taste also." but because the normal impairment of body fluid consumption of postoperative patient liquid, waste heat is reluctant to leave, the dryness-heat stagnating in the interior intestinal, deficiency of body fluid, intestinal is dry and astringent, conduct not normally, and disease is seen: constipation with dry stool, discharge difficulty, the abdominal distention discomfort, nausea and vomiting, lack of appetite is slow slow-witted, and pulse condition is slided number.Control and use Radix Rehmanniae YIN nourishing and the production of body fluid promoting, to reach the effect of supplementing fluid to relax the bowels.As seen the Radix Rehmanniae defecating feces excretion is just on the books from ancient times.
Recent two decades comes, and foreign scholar's yellow composition and pharmacological action has over the ground carried out big quantity research, and the main effective ingredient of YIN nourishing intestine moistening is catalpol and stachyose, and has affirmed that through clinical observation it has definite functions of loosening bowel relieving constipation.
The traditional Chinese medical science is thought: Rhizoma Cimicifugae, heat-clearing and toxic substances removing, ascending up spleen-Qi and Yang.Compendium of Material Medica is referred to as " persons particularly liable to develop skin infection's panacea ", so can be used for the various disease conditions due to the pyretic toxicity." Treatise on the spleen and stomach ": " this product has the merit of ascending up spleen-Qi and Yang, and all can use the various of sinking of QI of middle-JIAO the Clear and Bright that yang invigorating sink, and real is the key medicine of ascending up spleen-Qi and Yang." " medicine justice ": " Rhizoma Cimicifugae is kind carries clearing heat in QI system, make the gas rising of sun clearly, and the gas of turbid sun descends." " book on Chinese herbal medicine converge with speech ": " and Rhizoma Cimicifugae, the agent of the table yang invigorating that looses also, as the gas of internal injury, taste are decayed, and the branch of the Zhiyin of sinking, or liquor-saturated full exhaustion due to sexual indulgence diminish yang-energy, to sinking into to cause among the moon, or the large intestine deficiency of vital energy, or weigh down to expand and do not receive, Rhizoma Cimicifugae all can be treated it.”
Modern pharmacological research finds that Rhizoma Cimicifugae extract has calmness, heat clearing away effect.
Among the present invention, Rhizoma Atractylodis Macrocephalae spleen invigorating QI invigorating is monarch, the Radix Rehmanniae clearing away heat and cooling blood, promote the production of body fluid to moisturize and be minister, to help the Rhizoma Atractylodis Macrocephalae increasingization Resina Draconis degree that promotes the production of body fluid, the Rhizoma Cimicifugae priming is gone into spleen, stomach, lung and large intestine, for assistant makes, help Rhizoma Atractylodis Macrocephalae elevate a turnable ladder yang-energy, help the Radix Rehmanniae pathogenic fire reducing that promotes the production of body fluid, play the spleen invigorating QI invigorating altogether, nourishing YIN and benefiting blood, promote the production of body fluid and moisturize, push away the merit of old relieving constipation.Wei Long gallop old docter of TCM treatment brilliantly quoted as proof in the constipation Li Le wall what is called " cure the disease and must ask its source, can not be without exception with lead a cow, under the Fructus Crotonis class ", the edge person is where, at taste also.Rise spleen sun the turbid descending gas with Rhizoma Atractylodis Macrocephalae, real in treating constipation originally.Add with Radix Rehmanniae and grow it, add with Rhizoma Cimicifugae helping yang invigorating, so we have the Zhuo of relieving constipation to imitate, should be used for puerperal, operation after, cause the ground Qi and blood deficiency behind the chemicotherapy, deficiency of body fluid, the constipation that the hypofunction of spleen fortune forms.
Definite, the present invention relates to:
1, Chinese medicine composition is a feature with Rhizoma Atractylodis Macrocephalae 10-14 weight portion, Radix Rehmanniae 6-10 weight portion, Rhizoma Cimicifugae 2-6 weight portion;
2, according to 1 Chinese medicine composition, be with the Rhizoma Atractylodis Macrocephalae 12 weight portions, Radix Rehmanniae 8 weight portions.Rhizoma Cimicifugae 4 weight portions are feature;
3, preparation is characterized in that the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae, Rhizoma Cimicifugae water extraction as the method for Chinese medicine composition as described in 1 or 2;
4, as the purposes of Chinese medicine composition as described in 1 or 2 in the medicament preparation, this medicament is used for the treatment of constipation;
5, the medicament of treatment constipation comprises as Chinese medicine composition and pharmaceutically acceptable carrier as described in 1 or 2.
The effect of present composition treatment constipation obtains the confirmation of following experimental technique.
Method: mice is divided into blank group, model control group, positive control lactulose 2.0g/kg group, present composition 2.0g/kg group, 1.0g/kg group, 0.5g/kg group at random, rat is divided into blank group, model control group, positive control lactulose 2.0g/kg group, present composition 4.0g/kg group, 2.0g/kg group, 1.0g/kg group, 10 every group.Remove in the rat feces water content test continuously gastric infusion 3 beyond the highest heavens, other tests are disposable gastric infusion.
The result: take to animal that the defecation frequency of three dosage groups of the 2nd hour present composition mice all is significantly increased behind the present composition, comparing with the blank group is significant difference, the P value all＜0.01, positive control drug lactulose group P＜0.05.The 1st hour and the 4th hour each test group all do not demonstrate the defecation that promotes normal mouse after the administration.
Mice is through the long-time water of prohibiting, constipation or do not have just, faecal pellet is hard, defecation frequency obviously reduces, compare with the blank group, P value all＜0.01, the model establishment.Each dosage group of the present composition all can increase the defecation frequency of mice with constipation significantly, present composition 2.0g/kg organizes the 1st, 2,4 hour defecation frequency and compares with model control group, the P value all＜0.01,1.0g/kg group P value difference＜0.05,＜0.01,＜0.05,0.5g/kg group is except that effect in the 1st hour is not obvious, 2nd, 4 hours defecation frequency is compared with model control group, and the P value all＜0.05.
Present composition 2.0g/kg group can be accelerated the fltting speed of normal mouse intestinal contents, P＜0.05 of comparing with the blank group, and 1.0g/kg organizes, the effect of 0.5g/kg group dosage is not remarkable.Three dosage groups all can be accelerated the fltting speed of mice with constipation intestinal contents, the P value of comparing with blank group difference＜0.01,＜0.01,＜0.05.
The water content of each dosage treated animal small intestinal and feces does not all have tangible increase, the data of surveying compare with the blank group, the P value is all＞0.05.
Can obviously increase the shrinkage amplitude of the normal colonic smooth muscle of Cavia porcellus when present composition final concentration 8.0mg/ml, 4.0mg/ml, 2.0mg/ml; All can obviously increase the shrinkage amplitude of the normal colonic smooth muscle of rabbit when final concentration 8.0mg/ml, 4.0mg/ml,＜0.01 equal with the P value of comparing before the administration.Positive control drug motilium final concentration for 5.0ug/ml time effect identical with the present composition, P＜0.05.
Present composition final concentration is when 8.0mg/ml, 4.0mg/ml, 2.0mg/ml, all obviously the antagonism atropine to the paralysis effect of the colonic smooth muscle of Cavia porcellus, the obvious statistical significance of having compared with the atropine group, P value respectively＜0.01,＜0.01 and＜0.05; The antagonism atropine only limits to final concentration when 8.0mg/ml, the 4.0mg/ml to the paralysis effect of colon in rabbits smooth muscle, the P value of comparing with the atropine group respectively＜0.01 and＜0.05, and final concentration this effect when 2.0mg/ml is not remarkable.All the have clear improvement effect of colonic smooth muscle paralysis due to the atropine of positive control drug motilium 5.0ug/ml, 2.5ug/ml, 1.25ug/ml, 0.625ug/ml.
Conclusion: 1. the present composition can promote the fltting speed of intestinal contents, increases normal mouse and mice with constipation defecation frequency.2. can strengthen the shrinkage amplitude of the stripped colonic smooth muscle of normal and paralysis.3. not seeing increases in the enteric cavity and the water content effect of feces.
The specific embodiment
Describe the present invention referring now to the following example, they only supply illustration, never are interpreted as the restriction to invention scope.Scope of the present invention is limited by claims.
Embodiment 1
Get Rhizoma Atractylodis Macrocephalae 12kg, Radix Rehmanniae 8kg, Rhizoma Cimicifugae 4kg, add 10 times of water gagings, reflux 2 times, each 1 hour, merge extractive liquid, filters, and filtrate decompression is concentrated into relative density 1.06-1.08, cold preservation 24 hours, filter, spraying drying powder-forming adds an amount of lactose, mixing granulation; The aluminum plastic film packing, promptly.
Embodiment 2
Get Rhizoma Atractylodis Macrocephalae 10kg, Radix Rehmanniae 6kg, Rhizoma Cimicifugae 2kg, down with embodiment 1.
Embodiment 3
Get Rhizoma Atractylodis Macrocephalae 14kg, Radix Rehmanniae 10kg, Rhizoma Cimicifugae 6kg, down with embodiment 1.
Embodiment 4
Get Rhizoma Atractylodis Macrocephalae 12kg, Radix Rehmanniae 8kg, Rhizoma Cimicifugae 4kg, add 10 times of water gagings, reflux 2 times, each 1 hour, merge extractive liquid, filtered, and filtrate decompression is concentrated into relative density 1.06-1.08, and cold preservation 24 hours filters spraying drying powder-forming, the gelatine capsule of packing into; Packing, promptly.
Embodiment 5
Get Rhizoma Atractylodis Macrocephalae 12kg, Radix Rehmanniae 8kg, Rhizoma Cimicifugae 4kg, add 10 times of water gagings, reflux 2 times, each 1 hour, merge extractive liquid, filters, and filtrate decompression is concentrated into relative density 1.06-1.08, cold preservation 24 hours, filter, spraying drying powder-forming is with appropriate excipients mix homogeneously, tabletting; Packing, promptly.
Embodiment 6
Get Rhizoma Atractylodis Macrocephalae 12g, Radix Rehmanniae 8g, Rhizoma Cimicifugae 4g, add 10 times of water gagings, reflux 2 times, each 1 hour, merge extractive liquid, filtered, and filtrate decompression is concentrated into relative density 1.06-1.08, and cold preservation 24 hours filters, and spraying drying powder-forming adds an amount of lactose, mixing granulation; The aluminum plastic film packing, promptly.
Claims (5)
1, a kind of Chinese medicine composition for the treatment of constipation, it is characterized in that making raw materials of effective components is Rhizoma Atractylodis Macrocephalae 10-14 weight portion, Radix Rehmanniae 6-10 weight portion, Rhizoma Cimicifugae 2-6 weight portion.
2, Chinese medicine composition according to claim 1, it is characterized in that making raw materials of effective components is the Rhizoma Atractylodis Macrocephalae 12 weight portions, Radix Rehmanniae 8 weight portions, Rhizoma Cimicifugae 4 weight portions.
3, prepare the method for Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae, Rhizoma Cimicifugae water extraction.
4, the purposes of Chinese medicine composition in medicament preparation as claimed in claim 1 or 2, this medicament is used for the treatment of constipation.
5, the medicament of treatment constipation is characterized in that being made up of the carrier of claim 1 or 2 described Chinese medicine compositions and pharmaceutically acceptance.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100096994A CN1297295C (en) | 2004-10-22 | 2004-10-22 | Constipation treating Chinese medicinal composition |
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| CNB2004100096994A CN1297295C (en) | 2004-10-22 | 2004-10-22 | Constipation treating Chinese medicinal composition |
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| CN1762451A CN1762451A (en) | 2006-04-26 |
| CN1297295C true CN1297295C (en) | 2007-01-31 |
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| CNB2004100096994A Active CN1297295C (en) | 2004-10-22 | 2004-10-22 | Constipation treating Chinese medicinal composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199638B (en) * | 2007-12-14 | 2010-09-08 | 马应龙药业集团股份有限公司 | Granules for treating enteric canal constipation disease and preparing method thereof |
| CN102688373A (en) * | 2012-06-06 | 2012-09-26 | 张俊波 | Medicine for treating astriction and preparation method for medicine |
| CN105572027B (en) * | 2016-02-19 | 2019-02-19 | 中国水利水电科学研究院 | Concrete cracking whole process simulation testing machine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088805A (en) * | 1993-01-01 | 1994-07-06 | 李业尧 | ' Xumishutong |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088805A (en) * | 1993-01-01 | 1994-07-06 | 李业尧 | ' Xumishutong |
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| CN1762451A (en) | 2006-04-26 |
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