CN1290567C - Medicine for cold and pain of abdomen before and during menstruation and its preparation - Google Patents

Abstract

The present invention relates to a medicine for treating coldness and pain of lower abdomen before or during women's menstruation and a preparing method thereof. The present invention is characterized in that the components of the material medicine comprise: angelica sinensis, flatsedge rhizome, spicebush roots, common fennel fruits, curcuma aromatica and myrrh. The present invention can be prepared into any common oral dosage form. The present invention has the effects of warming channel, removing blood stasis, regulating menstruation and reliving pain; the present invention is used for treating the coldness and pain of lower abdomen before or during women's menstruation caused by cold-dampness stagnation, little menses, dim color, fear of cold, insufficient temperature of hands and feet and even worse symptoms such as cold sweating, nausea and vomiting, etc. after menstruation.

Description

The treatment women is through preceding or through medicine and preparation method thereof of row cold and pain in the lower abdomen

Technical field:

The present invention relates to treat the women through preceding or be medicine of dysmenorrhea and preparation method thereof, belong to the field of Chinese medicines through the row cold and pain in the lower abdomen.

Background technology:

Dysmenorrhea is a disease very common in the gynecological clinic, and with the passing of time its course of disease does not heal repeatedly, and doctor trained in Western medicine does not still have ideal medicine at present.Modern Chinese medicine is thought, causes the reason of dysmenorrhea a lot.Dysmenorrhea mechanism has branch cold, hot, empty, reality, but be many with excess syndrome as qi depression to blood stasis, cold and stagnate, damp and hot heap soil or fertilizer over and around the roots resistance etc., all because of pathogen retardance mechanism of qi, makes vim and vigour running not smooth, and menses rush down and not smooth, stagnation of QI and blood may bring about pain.

At present, common in the clinical practice have TIANQI TONGJING JIAONANG, Shao Fu Zu Yu Wan, a YUEYUESHU TONGJIBAO KELI etc.TIANQI TONGJING JIAONANG main qi depression to blood stasis of institute and menorrhalgia of cold-stagnation and blood-stasis type; Shao Fu Zu Yu Wan is led the long-pending piece pain of few abdomen or long-pending piece is arranged but non-pain; The also main menorrhalgia of cold-stagnation and blood-stasis type of YUEYUESHU TONGJIBAO KELI.It is set that above Chinese medicine mostly is the blood stasis type dysmenorrhea, so, how based on blood-activating analgetic, or help the product that removing blood stasis is arranged, the general course of treatment is longer.Still there is not the medicine of suiting the medicine to the illness for cold and stagnate type dysmenorrhea clinically.

Summary of the invention:

Technical problem to be solved by this invention is to avoid above-mentioned existing in prior technology weak point, provide a kind of women of treatment through preceding or through the row cold and pain in the lower abdomen medicine.This medicine specifically at cold and stagnate type dysmenorrhea, has the warming the meridian blood stasis dispelling, the effect of menstruction regulating and pain relieving.

Another technical problem to be solved by this invention provides the preparation method of this Chinese medicine composition.

Pharmaceutical composition of the present invention mainly is to be made by following bulk drugs:

Radix Aconiti Lateralis Preparata 1.5-4.0 part Flos Carthami 1.5-4.0 part Oletum Trogopterori 1.0-3.0 part

Pollen Typhae 1.0-3.0 part Semen Litchi 1.5-4.0 part

At this component, its preparation method comprises the following steps:

A, the Radix Aconiti Lateralis Preparata with described weight proportion, Flos Carthami, Oletum Trogopterori, Pollen Typhae, Semen Litchi decoct with water secondary, merge decocting liquid twice, get medicinal liquid Y1; Medicinal liquid Y1 triple effect is concentrated, get concentrated solution Y2; Concentrated solution Y2 is added ethanol makes and contain alcohol amount 30-70%, leave standstill, extract supernatant, reclaim ethanol and concentrate, clear paste G1;

B, with clear paste G1, in addition an amount of Icing Sugar, dextrin spray drying one-step palletizing, granule M1; Promptly getting pharmaceutically active forms.

In order to improve curative effect, can make by described primary raw material medicine and following bulk drugs:

Radix Angelicae Sinensis 1.5-4.0 part Rhizoma Cyperi 1.0-3.0 part Radix Linderae 0.5-1.5 part

Fructus Foeniculi 0.5-1.5 part Radix Curcumae 1.0-3.0 part Myrrha 0.5-1.5 part

At this component, its preparation method has following steps:

A, the Radix Angelicae Sinensis with described weight proportion, the Radix Linderae, Fructus Foeniculi, Rhizoma Cyperi, Myrrha, Radix Curcumae are extracted volatile oil with steam distillation jointly, volatile oil Y11, the distillation after aqueous solution Y12, medicinal residues Y13;

Radix Aconiti Lateralis Preparata, Flos Carthami, Oletum Trogopterori, Pollen Typhae, the Semen Litchi of b, medicinal residues Y13 and described weight proportion decoct with water secondary, merge decocting liquid twice, get medicinal liquid Y14; Medicinal liquid Y14 and aqueous solution Y12 triple effect are concentrated, get concentrated solution Y15; Concentrated solution Y15 is added ethanol makes and contain the alcohol amount and be 30-70%, leave standstill, extract supernatant, reclaim ethanol and concentrate, clear paste G2;

C, with clear paste G2, in addition an amount of Icing Sugar, dextrin spray drying one-step palletizing, granule M2;

D, volatile oil Y11 is added β-CD saturated aqueous solution, stirs, leave standstill, filter precipitate; Precipitate 30-60 ℃ of cold drying, is got clathrate M3.

E, granule M2 and clathrate M3 are mixed, promptly get the pharmaceutically active composition.

The inventor thinks: cold and stagnate, and the visitor disturbs in dash appointing in uterus, hinders in mechanism of qi, and menses are capable and not smooth, stagnation of QI and blood may bring about pain, this is the pathogenesis place of dysmenorrhea due to the cold and stagnate.So medicine of the present invention is formed upright purport in the warming the meridian blood stasis dispelling, assistant is with promoting blood flow to regulate menstruation, and regulating QI to relieve pain has just satisfied the demand for the treatment of cold and stagnate type dysmenorrhea medicine clinically.

In medicine of the present invention is formed, select the Radix Aconiti Lateralis Preparata recuperating depleted YANG and rescuing the patient from collapse for use, dispersing cold for relieving pain, same with Radix Angelicae Sinensis with being " simple and easy side's opinion " Small Meridian-Warming Decoction, cure mainly irregular menorrhea, the dirty cold type of pain of blood; The Oletum Trogopterori promoting blood circulation and stopping pain, with the Pollen Typhae compatibility be " office side " SHIXIAO SAN, institute stops in the main blood stasis, month wait uncomfortable, lower abdomen shoot etc.; Myrrha is the product of promoting blood circulation and stopping pain also, is usually used in diseases such as amenorrhea, dysmenorrhea; The Flos Carthami blood circulation promoting and blood stasis dispelling stimulates the menstrual flow, and is usually used in dysmenorrhea, and diseases such as amenorrhea due to stagnation of blood, postpartum stagnation stomachache are the key medicine of gynecological's regulating menstruation; The Radix Curcumae promoting QI circulation for relieving depression, promoting blood circulation and stopping pain is usually used in menoxenia, dysmenorrhea and note of the ancient Chinese abdominal mass mass in the abdomen etc. due to the irritability stasis; The Rhizoma Cyperi depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving, normal and the Radix Linderae, Fructus Foeniculi compatibility cure mainly colic of cold type and suffer from abdominal pain cold coagulation dysmenorrhoea; Radix Linderae Xin Kaiwen looses, promoting the circulation of QI to relieve pain, and " book on Chinese herbal medicine is highly necessary " with this and Rhizoma Cyperi, Radix Angelicae Sinensis, Rhizoma Chuanxiong compatibility, and vim and vigour are got along well abdominal distention and pain to cure mainly before the tire puerperal; The Semen Litchi cold relieving is loose and is stagnated, and regulating QI to relieve pain, essentials of Matea Medica claim these product " go into Liver and kidney, the gas that stagnates that looses is warded off the cold-evil, controls gastric abscess, married woman's vim and vigour pain "; The Fructus Foeniculi warming kidney for dispelling cold, depressed liver-energy dispersing and QI regulating, and can pain relieving is usually used in colic of cold type, few abdomen cold type of pain, " book on Chinese herbal medicine converge speech " claim this " warming spleen and stomach for dispelling cold, all gas of main row, be the few abdomen Zhiyin of lower abdomen branch will product also ".

Compared with the prior art, beneficial effect of the present invention is embodied in:

1, medicine of the present invention has the warming the meridian blood stasis dispelling, the menstruction regulating and pain relieving effect.Cure mainly before the warp due to the cold and stagnate or through the row cold and pain in the lower abdomen, the disease menstruation of holding concurrently is stepped back, and amount is few, the dim polylith of color, fear of cold, the hands and feet being not warm, dripping cold sweat very then, nausea and vomiting etc.

2, in the Study on Preparation of this medicine, physicochemical property according to each medicine in the side, adopted respectively that water is carried, precipitate with ethanol, put forward technologies such as oil, one-step palletizing, beta-schardinger dextrin-inclusion, by continuous experiment and deep research, filter out optimal process routes, make this process route when guaranteeing curative effect and quality, have repeatable and easy-operating characteristics again.

3, the active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into any peroral dosage form commonly used as disintegrating agent, lubricant etc. with the method for Chinese medicinal of routine, as granule, tablet, capsule, oral liquid etc.

Example can further specify the beneficial effect of medicine of the present invention by experiment, comprises the pharmacodynamics test and the clinical observation on the therapeutic effect test of medicine of the present invention.

Medicine of the present invention is to the effect of rat TREATMENT OF DYSMENORRHOEA:

1, suppresses prostaglandin F _{2 α}Or the reaction of the inductive animal dysmenorrhea of oxytocin, suppress isolated uterine and shrink, and have certain antiinflammatory, analgesia, improve the effect of syndrome of blood stasis rat blood rheological characteristic.

2, the effect that has the reaction of antagonism animal class dysmenorrhea.13,6.5, the 3.25g/kg gastric infusion can reduce PGF _{2 α}The number of animals of the rat dysmenorrhea of bringing out reaction and turn round the body number of times reduces blood plasma and intrauterine PGF _{2 α}Content.And rat and Mouse Uterus contraction (similar dysmenorrhea reaction) due to the obvious antagonism oxytocin of energy, reduce number of animals and the writhing response number of times of turning round body.Act on similar to the dysmenorrhea treasured.

3, has the uterotonic effect of inhibition.In vitro tests, but 3.33,6.66, the 13.3mg crude drug/ml concentration dependent ground suppresses the isolated rat uterine contraction, reduces uterotonic frequency, amplitude and energy, and can concentration dependent ground antagonism oxytocin and PGF _{2 α}The enhancing of the isolated rat uterine contraction activity that causes.

4, has certain anti-inflammatory and analgesic effect.13,6.5,3.25g/kg (rat), 26,13,6.5g/kg (mice) gastric infusion can significantly suppress rat paw edema and mice caused by dimethylbenzene xylene ear swelling due to the carrageenin, suppress acetic acid and cause the mouse writhing reaction, reduce and turn round the body number of times, obviously influence but hot plate is caused the preclinical nothing of mice pain reaction.

Growth of young rats grow is not had obviously influence, gastric infusion, continuous 3 weeks to childhood rat body weight, uterus and ovary weight and plasma estradiol content do not have obvious influence.

5, the effect of the hemorheological property of improving the syndrome of blood stasis rat is arranged.Adrenalin hydrochloride subcutaneous injection+ice-water bath can cause rat serum blood stasis syndrome model.13, the 6.5g/kg gastric infusion can obviously reduce syndrome of blood stasis rat whole blood contrast viscosity and packed cell volume, improves the hemorheological property of syndrome of blood stasis rat.

The similar granule medicament 26,13 of the effect of granule medicament of the present invention, 6.5g/kg (mice), 13,6.5,3.25g/kg (rat) to decoct, decoct 13g/kg (mice) or 6.5g/kg (rat) gastric infusion all energy antagonism oxytocin induced mice, rat uterus shrink (similar dysmenorrhea reaction), reduce number of rats and the writhing response number of times of turning round body, and can obviously suppress the mice caused by dimethylbenzene xylene ear swelling, reduce acetic acid and cause the mouse writhing reaction.

Drug therapy cold and stagnate type dysmenorrhea clinical observation on the therapeutic effect of the present invention

One, physical data

The clinical observation case is totally 60 examples, and wherein treatment group, each 30 example of matched group, age are the dysmenorrhea patient of 18-to 34-year-old and meet traditional Chinese medical science cold and stagnate card typing standard.Patient's age, the course of disease and dysmenorrhoea degree basically identical between group, there was no significant difference has comparability.

Two, Therapeutic Method

Adopt randomized controlled.Treatment group drug particles of the present invention, oral, a twice-daily, one time 10 gram, ten days is a course of treatment.The matched group YUEYUESHU TONGJIBAO KELI, oral, a twice-daily, one time 10 gram, ten days is a course of treatment.Two groups of medications are basic identical at aspects such as outward appearance, color and luster, abnormal smells from the patient, mouthfeels.All the patient stops using the medicine relevant with treating primary disease and other Therapeutic Method during treating.

Three, diagnostic criteria

1, tcm diagnosis

The women is at intermenstrual period or in preceding 1 week, and the periodicity hypogastralgia occurring is primary symptom, with other discomfort, so that influences work and gives birth to the reviver.

Traditional Chinese medical science typing

Cold and stagnate card: through preceding or through the time limit cold and pain in the lower abdomen, pain alleviated while getting warmth, delayed menstrual cycle, amount is few, and is dim and piece is arranged through color, or as the decoction of black soybean sample, fear of cold, the hands and feet being not warm, profuse leukorrhea, tongue fur is white or be bored with stringy pulse or heavy string.

1, Western medicine diagnose

Through gynecologial examination, the genitals does not have the significant organic pathological changes and occurs periodically through lower abdomen pain person in preceding or menstrual period.

A, dysmenorrhea clinical symptoms standards of grading

Menstrual period or through preceding cold and pain in the lower abdomen 5 minutes, stomachache unbearably 1 minute,

Suffer from abdominal pain few 1 minute of obvious 0.5 minute, menstrual blood volume,

Through color dim and piece is arranged 1 minute, feel restless 1 minute,

Suffer a shock 2 minutes, pale complexion 0.5 minute,

Dripping cold sweat 1 minute, extreme cold of the limbs 1 minute,

Need lie up 1 minute, influence work and study 1 minute,

With general pain relieving measure pain do not alleviate 1 fen, companion waist ache 0.5 minute,

With general pain relieving measure pain postpone and 0.5 minute, companion's nausea and vomiting 0.5 minute,

Companion's rectal tenesmus 0.5 minute,

Pain at one day with interior 0.5 minute (every increase by one day increase by 0.5 minute)

B, pain degree grade scale

Severe: lower abdomen pain is felt restless unbearably before and after menstrual period or the menstruation, has a strong impact on work, study and daily life, must lie up, companion's waist is ached pale complexion, dripping cold sweat, extreme cold of the limbs, vomiting and diarrhoea, or rectal tenesmus adopt the pain relieving measure not have obvious alleviation.The clinical symptoms integration is more than 14 minutes.

Moderate: lower abdomen pain accompanies waist to ache unbearably before and after menstrual period or the menstruation, and nausea and vomiting, extremity are not warm, postpones with pain relieving measure pain.The clinical symptoms integration is at the 8-13.5 branch.

Slightly: lower abdomen pain is obvious before and after menstrual period or the menstruation, and companion's waist is ached, but can adhere to work, and no General Symptoms need be obeyed analgesic sometimes.The clinical symptoms integration is below 8 minutes.

2, curative effect judging standard

A, recovery from illness: the clinical integration in treatment back returned to 0 fen, stomachache and clinical symptom disappearance, and 3 menstrual cycle of drug withdrawal are not seen the recidivist.

B, produce effects: the clinical integration in treatment back reduce to before the treatment below 1/2nd, stomachache obviously alleviates, other symptoms take a turn for the better, and refuse to obey that analgesic can adhere to work.

C, effective: 1/2nd to 3/4ths before treatment back integration is reduced to and is treated, stomachache alleviates, other diseases improvements, the clothes analgesic can be adhered to work.

D, invalid: stomachache and clinical symptoms thereof do not have the changer after treating.

3, therapeutic outcome

Clinical observation result shows that 30 examples are organized in treatment, and 19 examples of fully recovering account for 63.33%, and produce effects 4 examples account for 13.33%, and effective 5 examples account for 16.67%, invalid 2 examples, and cure-remarkable-effectiveness rate accounts for 76.67%, clinical total effective rate about 93.33%.Treatment of control group group 30 examples, 12 examples of fully recovering account for 40%, and produce effects 5 examples account for 16.67%, and effective 7 examples account for 23.33%, invalid 6 examples, cure-remarkable-effectiveness rate accounts for 56.67%, clinical total effective rate about 80%.Two groups are relatively, treatment group curative effect apparently higher than matched group (p＜0.01 〉

Embodiment 1: the preparation of the granule of medicine of the present invention, capsule, tablet, oral liquid

1, take by weighing each crude drug (weight portion) by following prescription:

Radix Angelicae Sinensis	Rhizoma Cyperi	The Radix Linderae	Fructus Foeniculi	Radix Curcumae	Myrrha	Flos Carthami	Oletum Trogopterori	Pollen Typhae	Semen Litchi	Radix Aconiti Lateralis Preparata
											2	1.5	1	0.5	1.5	1.5	2.5	1.5	1	2	3
2.7	2	1	1	2	1	2.7	2	1	2.7	2.7
											4	2.5	1.5	0.5	2	0.5	3	2.5	1	2	3
3	1	1	1	3	1	4	1	1.5	2	4

2, Radix Angelicae Sinensis, the Radix Linderae, Fructus Foeniculi, Rhizoma Cyperi, Myrrha, the Radix Curcumae of described weight proportion are extracted volatile oil with vapor distillation jointly, volatile oil Y11, the distillation after aqueous solution Y12, medicinal residues Y13;

3, the Radix Aconiti Lateralis Preparata of medicinal residues Y13 and described weight proportion, Flos Carthami, Oletum Trogopterori, Pollen Typhae, Semen Litchi decoct with water secondary, merge decocting liquid twice, get medicinal liquid Y14; Medicinal liquid Y14 and aqueous solution Y12 triple effect are concentrated, get concentrated solution Y15; Concentrated solution Y15 is added ethanol makes and contain the alcohol amount and be 30-70%, leave standstill, extract supernatant, reclaim ethanol and concentrate, clear paste G2;

4, with clear paste G2, in addition an amount of Icing Sugar, dextrin spray drying one-step palletizing, granule M2;

5, volatile oil Y11 is added β-CD saturated aqueous solution, stirs, leave standstill, filter precipitate; Precipitate 30-60 ℃ of cold drying, is got clathrate M3.

To mix by step 4 gained granule M2 and step 5 gained clathrate M3, be pressed into bag, make granule.

To mix by step 4 gained granule M2 and step 5 gained inclusion complex M3, incapsulate, make capsule.

To mix by step 4 gained granule M2 and step 5 gained inclusion complex M3, and add appropriate amount of auxiliary materials, repressedly can become tablet.

To add step 5 gained volatile oil Y11 after diluting by step 3 gained clear paste G2, fill can become oral liquid.

Embodiment 2: granule, capsule, tablet, oral liquid prepare another embodiment:

At prescription described in the embodiment 1 and concrete preparation thereof, different is that step 3 is in the present embodiment:

Radix Aconiti Lateralis Preparata, Flos Carthami, Oletum Trogopterori, Pollen Typhae, the Semen Litchi of step 3, medicinal residues Y13 and described weight proportion decoct with water secondary, merge decocting liquid twice, get medicinal liquid Y14; Medicinal liquid Y14 and aqueous solution Y12 triple effect are concentrated, get concentrated solution Y15; Concentrated solution Y15 is added ethanol makes that to contain the alcohol amount be 40%, leave standstill, extract supernatant, reclaim ethanol and concentrate, clear paste G2;

Embodiment 3: granule, capsule, tablet, oral liquid prepare another embodiment:

At prescription described in the embodiment 1 and concrete preparation thereof, different is that step 3 is in the present embodiment:

Radix Aconiti Lateralis Preparata, Flos Carthami, Oletum Trogopterori, Pollen Typhae, the Semen Litchi of step 3, medicinal residues Y13 and described weight proportion decoct with water secondary, merge decocting liquid twice, get medicinal liquid Y14; Medicinal liquid Y14 and aqueous solution Y12 triple effect are concentrated, get concentrated solution Y15; Concentrated solution Y15 is added ethanol makes that to contain the alcohol amount be 50%, leave standstill, extract supernatant, reclaim ethanol and concentrate, clear paste G2.

Embodiment 4: another embodiment of granule, capsule, tablet, oral liquid preparation:

At prescription described in the embodiment 1 and concrete preparation thereof, different is that step 3 is in the present embodiment:

Radix Aconiti Lateralis Preparata, Flos Carthami, Oletum Trogopterori, Pollen Typhae, the Semen Litchi of step 3, medicinal residues Y13 and described weight proportion decocts with water secondary and merges decocting liquid twice, gets medicinal liquid Y14; Medicinal liquid Y14 and aqueous solution Y12 triple effect are concentrated, get concentrated solution Y15; Concentrated solution Y15 is added ethanol makes that to contain the alcohol amount be 60%, leave standstill, extract supernatant, reclaim ethanol and concentrate, clear paste G2.

Embodiment 5: another embodiment of granule, capsule, tablet, oral liquid preparation:

At prescription described in the embodiment 1 and concrete preparation thereof, different is that step 3 is in the present embodiment:

Radix Aconiti Lateralis Preparata, Flos Carthami, Oletum Trogopterori, Pollen Typhae, the Semen Litchi of step 3, medicinal residues Y13 and described weight proportion decocts with water secondary and merges decocting liquid twice, gets medicinal liquid Y14; Medicinal liquid Y14 and aqueous solution Y12 triple effect are concentrated, get concentrated solution Y15; Concentrated solution Y15 is added ethanol makes that to contain the alcohol amount be 70%, leave standstill, extract supernatant, reclaim ethanol and concentrate, clear paste G2.

Claims (4)

1, a kind of treat the women through preceding or through the row cold and pain in the lower abdomen medicine, it is characterized in that it mainly being to make by following bulk drugs:

Radix Aconiti Lateralis Preparata 1.5-4.0 part Flos Carthami 1.5-4.0 part Oletum Trogopterori 1.0-3.0 part

Pollen Typhae 1.0-3.0 part Semen Litchi 1.5-4.0 part.

2, treatment according to claim 1 women is characterized in that being made by described primary raw material medicine and following bulk drugs through preceding or through the medicine of row cold and pain in the lower abdomen:

Radix Angelicae Sinensis 1.5-4.0 part Rhizoma Cyperi 1.0-3.0 part Radix Linderae 0.5-1.5 part

Fructus Foeniculi 0.5-1.5 part Radix Curcumae 1.0-3.0 part Myrrha 0.5-1.5 part.

3, the preparation method of the described medicine of a kind of claim 1 is characterized in that comprising the following steps:

A, the Radix Aconiti Lateralis Preparata with described weight proportion, Flos Carthami, Oletum Trogopterori, Pollen Typhae, Semen Litchi decoct with water secondary, merge decocting liquid twice, get medicinal liquid Y1; Medicinal liquid Y1 triple effect is concentrated, get concentrated solution Y2; Concentrated solution Y2 is added ethanol makes and contain the alcohol amount, leave standstill, extract supernatant, reclaim ethanol and concentrate at 30-70%, clear paste G1;

B, with clear paste G1, in addition an amount of Icing Sugar, dextrin spray drying one-step palletizing, granule M1; Promptly getting pharmaceutically active forms.

4, the preparation method of the described medicine of a kind of claim 2 is characterized in that comprising the following steps:

The Radix Angelicae Sinensis of a, described weight proportion, the Radix Linderae, Fructus Foeniculi, Rhizoma Cyperi, Myrrha, Radix Curcumae are extracted volatile oil with steam distillation jointly, volatile oil Y11, the distillation after aqueous solution Y12 and medicinal residues Y13;

Radix Aconiti Lateralis Preparata, Flos Carthami, Oletum Trogopterori, Pollen Typhae, the Semen Litchi of b, medicinal residues Y13 and described weight proportion decoct with water secondary, merge decocting liquid twice, get medicinal liquid Y14; Medicinal liquid Y14 and aqueous solution Y12 triple effect are concentrated, get concentrated solution Y15; Concentrated solution Y15 is added ethanol makes and contain the alcohol amount and be 30-70%, leave standstill, extract supernatant, reclaim ethanol and concentrate, clear paste G2;

C, with clear paste G2, in addition an amount of Icing Sugar, dextrin spray drying one-step palletizing, granule M2;

D, volatile oil Y11 is added β-CD saturated aqueous solution, stirs, leave standstill, filter precipitate; Precipitate 30-60 ℃ of cold drying, is got clathrate M3.

E, granule M2 and clathrate M3 are mixed, promptly get the pharmaceutically active composition.