CN100346819C - Chinese medicinal preparation for treating prostate disease and its production method - Google Patents

Abstract

The present invention relates to a Chinese medical preparation for treating prostate disease and a preparation method thereof. The Chinese medical preparation comprises sixteen raw medical materials: tender catchweed bedstraw herb, cuneate lespedeza, hypoglaucous collett yam rhizome, houttuynia, dandelion, black ant, etc. The preparation method comprises: the ingredients are pulverized; ingredients with volatile oil are extracted by percolation; the rest ingredients are extracted with water; dry paste powder is obtained by filtration, drying and repulverization; the dry paste powder is uniformly mixed a proper quantity of auxiliary materials to prepare tablets, capsules, pills, granules, drop pills and other pharmaceutic preparations. The Chinese medical preparation has the functions of clearing heat, removing toxicity, removing dampness by diuresis and removing turbid urine. The present invention is used for chronic prostatitis downward flow of damp-heat, the cure rate, the excellence rate and the total effective rate of a treatment group are respectively 16.5%, 32% and 88%, and the present invention has no obvious adverse reaction or side effect and is safe in clinical application.

Description

A kind of Chinese medicine preparation and production method thereof for the treatment of prostatosis

Technical field

The present invention relates to a kind of Chinese medicine preparation, particularly treat the Chinese medicine preparation and the production method thereof of human prostate prostate disease.

Background technology

The human prostate prostate disease is the common disease of urinary system male reproductive system, and the sickness rate height accounts for urology department male patient's 35～40%, is mainly in 30～50 years old person between twenty and fifty.Can be divided into acute, chronic two kinds, wherein with chronic person for seeing more, its common symptom has: urethra has burning sensation, rise morning or defecation after, urethral orifice often has the milky thick secretions to overflow, frequent micturition, urgent micturition, dysurea in various degree can be arranged and can go down, seminal emission, premature ejaculation, have capsulitis person that hemospermia can be arranged with essence.Though there is not this name of disease in the Chinese medicine, according to its clinical manifestation, can belong to " pure and impure " category in the Chinese medicine, the primary disease morbidity is slowly, the cause of disease, pathology complexity, symptom performance variation, sign is not true to type yet, course of disease delay, prolonged difficulty is in the pessimistic prestige state many patients for a long time.

The etiology and pathogenesis of primary disease: can be because of sexual strain, or the masturbation bad habit is arranged, the impairment caused by overstrain vital essence, so that a little less than the deficiency of kidney-QI; Or invade because of damp and hot heresy is outer, or insobriety usually, so that transporting and transforming function of the spleen and stomach is not normal is given birth in damp and hot, damp and hot heresy flows in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, makes a bet smart chamber and causes a disease.And the we person of curing mainly is patient due to the damp and hot heresy.Cover damp and hot heresy, flow, the smart chamber of making a bet in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, thereby cause meridians heap soil or fertilizer over and around the roots resistance, and stagnation of QI-blood, thus frequent micturition, urgent micturition, dysurea produced, urethra has burning sensation, and urethral orifice has nebulousurine to overflow when urinating or defecating, and few abdomen, perineum, waist sacrum, testis have symptoms such as weighing down the pain that expands.State of an illness delay person, regular meeting undermines the spleen kidney again.

The normal medicine that uses to acute, chronic acute prostatitis western medical treatment is an antibiotics at present, because the antibiotic therapy bacterial prostatitis is generally acknowledged by many.Generally needn't add for nonbacterial prostatitis and to use antibiotic therapy, but when suspecting other cause pathogeny imcrobe infections such as mycoplasma, chlamydia are arranged clinically, most scholars advocate to use antibiotic, its objective is to make the medicine that reaches higher concentration in prostate.Some hospitals give Drug therapys such as penicillin, erythromycin, cephalosporin, midecamycin, tetracycline according to patient's different situations, the bibliographical information that has in recent years promise ketone medicine also can be used for the treatment of chronic acute prostatitis, according to the study, it is stronger that promise ketone medicine penetrates the capsula prostatica ability, can reach effectively antibacterial and bacteriocidal concentration in prostate, it is not only effective but also also effective to mycoplasma, chlamydia to Gram-negative and positive bacteria.At the modal antibiotic of the U.S. is promise ketone medicine, accounts for 60%.When suspection is had mycoplasma, chlamydia infection, also can first-selected erythromycin and tetracycline medication.The hospital that has uses Roxithromycin suppository treatment chronic bacterial prostatitis and nonbacterial prostatitis, and total effective rate is respectively 80% and 81.6%.To existing bacteria cultivation results and drug sensitive test person, should select sensitive antibiotic for use by susceptibility.According to the monitoring of China pathogenic bacterium drug resistance in recent years: higher drug resistance has appearred in ofloxacin, ciprofloxacin, norfloxacin, tetracycline, doxycycline, miloxacin, erythromycin, spiramycin, has selected responsive levofloxacin, Sparfloxacin, bactrim, josamycin, Roxithromycin and azithromycin etc. a little for use.The application antibiotic begins can heavy dose or drug combination.For having bladder outlet obstruction (BOO) symptom, urine hydromechanics to detect and also point out the chronic prostatitis of bladder neck obstruction, introduce on the document and adopt receptor blocking agent that nervous neck of bladder and prostate are relaxed, improve the urinary function disorder, eliminate in the prostate conduit system urine and backflow, and then improve or eliminate this type of patient's symptom.Receptor blocking agent has: Phenoxybenzamine, the flight of steps leading to a palace hall are shouted, Gao Chiling etc., and the document that has is introduced nonsteroidal antiinflammatory drug, for perineal position discomfort, dull pain, the uncomfortable person that urinates, can use nonsteroidal antiinflammatory drug, with mitigation symptoms and inflammation.Nonsteroidal antiinflammatory drug commonly used is: Phenylbutazone, ibuprofen, indometacin, ibuprofen, feprazone etc.For the nonbacterial prostatitis that backflows with the prostate urine, the document that has is introduced available allopurinol treatment, its reason is that urine PH level obviously raises in this type of patient's prostatic fluid, but and do not float cry of certain animals alcohol uric acid reducing level, thereby alleviate the prostatitis pain symptom.The introduction that also has, oxygen free radical scavenger and trace element can content obviously increase and subjective symptom alleviates, and have certain curative effect obvious.

Though see that by above-mentioned Western medicine and antibiotics are better to treatment for diseases effect caused by the bacteria, if but commonly used and abuse antibiotics, not only can make some antibacterials produce drug-resistant effects, the intravital beneficial bacteria of people can not be survived, and cause that other disease occurs or increases the weight of.Folks of china sum up for thousands of years and excavated many acute, chronic acute prostatitiss treatments Chinese medicine be better than antibiotic because Chinese medicine improves effect to aseptic prostatitis symptom.And non-bacterial is bacteroidal 8 times in the chronic prostatitis, so the treatment by Chinese herbs chronic prostatitis also can not be ignored.Use the treatment by Chinese herbs chronic prostatitis in recent years remarkable progress has also been arranged.The traditional Chinese medical science is thought: prostatitis has the deficiency and excess two ends, and real person has damp and hot (noxious dampness), blood stasis (fever at night), expectorant turbid (night is turbid); Void person comprises middle void, suffers from a deficiency of the kidney; Great majority for suffer from a deficiency of the kidney, damp and hot etc.According to document in recent years, the example of treatment by Chinese herbs chronic prostatitis is a lot, its effective percentage is all higher, reach as high as 98%, we find by retrieval and represent document below some: 1, the logical big Chen Ying of face [mechanism] Qingpu District, the Shanghai City central hospital of [autograph] WENGLITONG JIAONANG treatment chronic prostatitis observation of curative effect [author] Liu Min people from village, [periodical name] Chinese clinical medical magazine (Beijing) .2004,5 (19) .[digests] effect of purpose clinical observation WENGLITONG JIAONANG on the common frdquently encountered disease-chronic prostatitis (CP) of treatment adult male; Method adopts list WENGLITONG JIAONANG (34 example), WENGLITONG JIAONANG added with antibiotic (64 example), single 120 routine patients with chronic prostatitis with antibiotic (22 example) treatment respectively, and application America NI H chronic prostatitis syndrome shape is marked (CPSI), new Chinese medicine clinical research guideline is made comparisons as therapeutic outcome.20.2 ± 6.6 (with comparing p＜0.01 before the treatment) on average fall in 120 routine patient CPSI overall scores as a result.Symptom all has clear improvement, and effective percentage reaches 76.5%, 79.7%, 71.4% respectively for first group, second group, the 3rd group, and total effective rate reaches 75.5%, three group of relatively p＞0.05, no significant difference.2, the male Chen Jing peace of [autograph] SHUANGHUANLIAN treatment chronic bacterial prostatitis observation of curative effect [author] Li Mei Qin Ke river Tan's kitchen range celery [mechanism] Guangxi Zhuang Autonomous Region workers' hospital [periodical name] new medical science .2004 of China, 5 (21) .[digests] chronic bacterial prostatitis is because bacterial infection, causes the recurrent inflammatory reaction of prostate.And nonstandard antibiotic abuse, bacterial drug resistance constantly increases, and brings difficulty to treatment, the patient also because of symptom repeatedly, touching difficulty is more and misery is felt embarrassed to mention.We explore with Chinese medicine preparation SHUANGHUANGLIAN ZHUSHEYE treatment chronic bacterial prostatitis in recent years, have obtained some effects.3, the observation of curative effect [author] of [autograph] bavin trematodiasis pill for curing nonbacterial prostatitis side solemn golden coral of civilian rock Sun Pin [mechanism] Hospital No.1 Attached to Tianjin Traditional Chinese Medicine College, [periodical name] Chinese combination of Chinese and Western medicine magazine .2004,24 (8) .[digests] nonbacterial prostatitis (nonbacterial prostatitis, NP) being in the chronic prostatitis one type, is urinary system andrology common clinical and frequently-occurring disease.In December, 2000-July calendar year 2001 the author adopts pure Chinese medicinal preparation bavin trematodiasis pill for curing NP50 example, obtaining preferably clinical efficacy 4, [autograph] " drenches soup clearly " chronic chlamydia prostatitis 25 routine clinical observation [author] Huang Chen of treatment listens Xia Yufang [mechanism] Jiangyan City, Jiangsu Province institute of traditional Chinese medicine, the Jiangsu Chinese medicine .2004 of Jiangyan City, Jiangsu [periodical name], 25 (9) .[digests] purpose: observe the clear soup that drenches and treat the prostatitic curative effect of chronic chlamydia trachomatis (CT) property.Method: 50 routine patients diagnosed are divided into 2 groups at random: the treatment group is drenched soup clearly with Chinese medicine, 1 dose of day, decoction sooner or later; Matched group gives levofloxacin, and is oral, every day 2 times.Two groups was 1 course of treatment with 1 month all.According to symptom, sign, prostatic fluid routine and pathogen detection, and two groups of curative effects are compared in NIH's chronic prostatitis syndrome shape scoring (NIH-CPSI).The result: two groups of total effective rates are respectively 92.00%, 64.00% (P＜0.05).Conclusion: Chinese medicine drenches soup clearly treats chronic chlamydia prostatitis better curative effect is arranged.5, the Shaanxi traditional Chinese medical science .2004 of the turbid soup treatment Weinan City hospital of traditional Chinese hospital, Shaanxi Province, chronic prostatitis 70 examples [author] Li Jin [1] Wang Yu [2] Liu Jincai [1] [mechanism] [1] Baoji, Shaanxi province city the People's Hospital [2] [periodical name], 25 (8) .[digests are led in [autograph] blood stasis dispelling] purpose: observe the curative effect that dampness removingization is turbid, chronic prostatitis is treated in the drug matching of invigorating kidney, promoting blood circulation class.Method: with leading turbid soup (Herba Patriniae, Herba Lycopi, Spina Gleditsiae, Radix Salviae Miltiorrhizae, Fructus Alpiniae Oxyphyllae, Fructus Lycii etc.) plus-minus treatment chronic prostatitis 70 examples from intending blood stasis dispelling.Result: total effective rate 90.1%.Prompting: it is turbid that this method has dampness removingization to primary disease, blood circulation promoting and blood stasis dispelling, the effect that the kidney invigorating is treating stranguria.6, [autograph] two yellow stuff retention-enema treatment chronic prostatitiss 148 routine observation of curative effect [author] Tang Yunzhi [1] Liu Xuejun [1] primary tracks are given birth to [1] Deng Fengying [1] Li Jun [2] Xie Kaihan [3] [mechanism] [1] PLA 535 hospital's Dermatology ﹠ STD Dept.s, [2] Huaihua City treatment for the sexually transmitted diseases center, Second Artillery Force of PLA hospital general [3] [periodical name] the practical magazine .2004 of Chinese clinical medicine (5) .-58-59[digest] in December, 2002 to 2004 year April, we adopt Chinese medicine two yellow stuff retention-enema treatment chronic adenitises 148 examples, and effect is satisfied.7, the medical science selected works .2004 of [autograph] treatment by Chinese herbs chronic prostatitis recent developments [author] Wujiang letters [mechanism] Pingguo County,GuangXi institute of traditional Chinese medicine [periodical name], 23 (2) .-224-226[digests] chronic prostatitis (CP) is one of disease kind the most common in the male genitourinary system disease, good sending out in 20～40 years old person between twenty and fifty, in recent years be ascendant trend gradually, sickness rate is very high.Western medical treatment CP effect is undesirable, and treatment by Chinese herbs CP has obtained better curative effect over nearly 3 years, and the treatment by Chinese herbs chronic prostatitis of document summary mainly is the differentiation of symptoms and signs for classification of syndrome treatment, as damp-heat type, liver energy stagnation type, spleen-deficient, renal deficiency type, cold-dampness type, leukemia type etc.Damp and hot is the main inducing of its outbreak.With the passing of time damp and hot, injure the spleen kidney, or suffer from a deficiency of the kidney and spleen, to give birth in damp and hot, then wet more difficultyization of deficiency of spleen-QI, kidney qi are hindered then essence and are let out under easy; Sthenia is transforming into asthenia, and deficiency and excess is tied mutually, and send out primary disease, and the document that has proposes the medicinal Cortex Phellodendri of wet resistance syndrome of blood stasis, Rhizoma Atractylodis, Caulis Sargentodoxae, Herba Leonuri, Herba Patriniae, soil are obtained luxuriant growth, Herba Houttuyniae, Radix Curcumae, rhizoma sparganic, obtain art, Herba Lycopi, Spina Gleditsiae; The medicinal Rhizoma Cyperi (processed) of syndrome of qi stagnation and blood stasis, Rhizoma Atractylodis, Caulis Sargentodoxae, Herba Leonuri, Ba Pu, Fructus Trichosanthis, rhizoma sparganic, obtain art, Radix Curcumae, Herba Lycopi, Spina Gleditsiae, Semen Vaccariae, Squama Manis, overgrown with weeds luxuriant in.Control 136 examples altogether, cure 58 examples, produce effects 46 examples, invalid 32 examples, total effective rate 76.4%.Zhang Jianbin is divided into damp heat downward flowing type (120 example), qi stagnation and blood stasis type (81 example), liver-kidney yin deficiency (36 example), empty wet Sheng type (42 example) and kidney yang deficiency syndrome (21 example) with 300 routine CP patients, differentiation of symptoms and signs for classification of syndrome is treated with Chinese medicine decoction, result's 207 examples (69.0%) of fully recovering, 75 examples that take a turn for the better (25.0%), invalid 18 examples (6.0%), total effective rate 94.0%.Cured person treatment time, majority was 2-5 month from 2 thoughtful 15 months, and improvement person is many from treatment onset in 3-20 days.Zhang Guoting with control preceding soup (soil obtain Bodhisattva, Herba Hedyotidis Diffusae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Folium Pyrrosiae, Herba Polygoni Avicularis, Flos Chrysanthemi Indici, Semen Vaccariae seed, Pumex, Herba Plantaginis in, leather surface, Radix Achyranthis Bidentatae, Folium Bambusae, plucked string instrument with a fretted fingerboard silk in) treatment 130 examples, 20 was 1 course of treatment, with 1-3 the course of treatment, the result cures 56 examples (43.1%), effective 69 examples (53.1%), invalid 5 examples (3.8%), total effective rate 96.2%.Zou Jianan etc. are with clear interests kidney numbness side (Cortex Phellodendri, Radix Gentianae, the Radix Rehmanniae, Radix Rehmanniae Preparata, GOUBAZI, Semen Plantaginis, Fructus Corni, the Rhizoma Atractylodis Macrocephalae, Olibanum, Myrrha, Fructus Alpiniae Oxyphyllae, Radix Salviae Miltiorrhizae, Pheretima, Radix Et Rhizoma Rhei) plus-minus treatment 146 examples, matched group 140 examples are treated with Levofloxacin, are for 4 weeks the course of treatment.The result cures 57,18 examples respectively for two groups, effective 74,46 examples, and invalid 15,76 examples, total effective rate 89.7%, 45.7%, curative effect is excellent (P＜0.01) with clear interests kidney numbness side group.Pang Jianhua etc. treat 325 examples with Radix Salviae Miltiorrhizae, Herba Leonuri, Herba Lycopi, Herba Taraxaci, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Spina Gleditsiae, Semen Vaccariae seed, Herba Hedyotidis Diffusae, Semen Persicae, Flos Carthami, Herba Patriniae etc., matched group 101 example clothes QIANLIEKANG PIAN, and 2 months is 1 course of treatment.Two groups of recoveries from illness of result, 222,19 examples, produce effects 46,14 examples, effective 50,31 examples, invalid 7,37 examples, total effective rate 97.8%, 63.4%, curative effect is excellent (P＜0.01) with Chinese drug-treated group.The sea is forgotten just to poison numbness soup (Herba Patriniae, Rhizoma Paridis, Herba Taraxaci, Rhizoma Smilacis Glabrae, Radix Et Rhizoma Rhei, Rhizoma Corydalis, river ladder, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, river tongue, Flos Carthami) plus-minus treatment 220 examples, matched group 60 routine oral QIANLIEKANG PIAN to separate.1 month is 1 course of treatment, treats 1-3 the course of treatment.The result cures 70,9 examples respectively for two groups, 143,44 examples that take a turn for the better, and invalid 7,7 examples, effective percentage reaches 96.82%.

We are by the retrieval Chinese patent, found that also the prostatitic patent of many treatments has more than 100 part, following several parts of wherein representational extracts: 1, Chinese medicine preparation of [title] treatment prostatic hyperplasia and preparation method thereof [application (patent) number] 94109253.4[applies for (patent right) people] Wang Yaoqiang [summary] the invention belongs to a kind of Chinese medicine preparation and preparation method thereof, be used for the treatment of hyperplasia of prostate, this medicine is by Radix Curcumae, Herba Lysimachiae, Semen Plantaginis, Radix Angelicae Sinensis, various raw material of Chinese medicine such as Herba Dianthi are concocted to be processed into through single and are dressed up type with non-woven bag after coarser powder also mixes.2, [title] pills for prostata disease [application (patent) number] 95100184.1[applies for (patent right) people] the present invention of the 3rd the People's Hospital, ten thousand unicorns [address] Nanyang City, Henan Province [summary] is a kind of Chinese medicine medicine for the treatment of prostatosis, mainly contain Cortex Phellodendri, Semen Persicae, the Radix Linderae, Radix Paeoniae Rubra, the Radix Angelicae Dahuricae, flavor such as Rhizoma Corydalis Chinese medicine, by reasonable dosage, make dosage forms such as honeyed pill, play the concentration height that infiltrates capsula prostatica, the energy blood circulation promoting, eliminate edema, the tonneau water channel, improve the convoluted tubule of testis function, increase sexual organ's blood flow and property nerves reaction ability, promote the gonad secretion.Merge seminal vesiculitis, urethritis patient clinical verification by 140 routine prostatitis, urine retention, prostatic hyperplasia, prostatitis, cure rate 94-97%, produce effects 1-2%, effective 2-4%, total effective rate 100%.It is remarkable to have a determined curative effect than existing treatment prostatosis medicine, short treating period, and advantage such as have no side effect.3, [title] Chinese medicine qi-tonifying and diuresis decoction and method for making thereof [application (patent) number] 96114264.2[applies for (patent right) people] Li Qizhong; Ding Degang; Zhou Guoping; Gao Yongju; Ten No. seven Jinshui District the People's Hospitals, Zhengzhou City [summary] of Wang Wei [address] Zhengzhou City, Henan Province latitude five tunnel the invention relates to prostatitic Chinese medicine qi-tonifying and diuresis decoction of treatment and method for making thereof.This Chinese medicine is made up of eight flavor principal agent Rhizoma Smilacis Glabraes, the Cortex Eucommiae, Fructus Forsythiae, Herba Taraxaci, Semen Plantaginis, Bi , the Radix Astragali, Cortex Moutan, looks the state of an illness and adds other accessory drugs compositions such as Rhizoma Corydalis, Polyporus, the Radix Linderae etc. again.Its method for making is earlier Fructus Forsythiae and Cortex Moutan water to be distilled, and collects distillate, and medicinal residues decoct secondary with all the other compositions of respectively distinguishing the flavor of, the concentrated filtrate ethanol extraction, and extracting solution concentrates, and merges with distillation liquid, adds adjuvant, filtration, fill, sterilization.The drug effect of its treatment acute and chronic prostatitis is better than existing Chinese medicine, and effective percentage is 86%, and cure rate is 73%.4, the Chinese medicine of [title] a kind of specially for treating prostatosis [application (patent) number] 01107925.8[apply for (patent right) people] Chinese medicine of dormitory 1-13 number [summary] a kind of specially for treating prostatosis in Zhao Xiuxia [address] the Shanxi province Taiyuan city Xin Ze lane No. 16 37, the employing Radix Astragali, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami, Pheretima, Radix Angelicae Sinensis, Radix Saposhnikoviae, Radix Dipsaci, Radix Salviae Miltiorrhizae, the Rhizoma Anemarrhenae, Cortex Phellodendri, Cortex Cinnamomi composition.The actual clinical evidence of Chinese medicine of the present invention by for many years, Chinese medicine of the present invention all has tangible curative effect to prostatitis, prostate hyperplasia, prostatic hyperplasia and the disease that involves the position that causes because of prostatosis.The patient seldom has the recidivist after the treatment of a period of time.

The disclosed Chinese medicine preparation treatment of the above-mentioned document that retrieves prostatosis respectively has characteristics, the report effective percentage that has reaches more than 90%, for human treatment's prostatitis contributes, people still continue many Chinese medicines are studied at present, to excavate more Chinese medicine, make the Chinese medicine preparation of treatment prostatosis, be mankind's service.

Summary of the invention

In order to treat prostatosis better, the inventor is from the prescription of tradition Chinese herbal treatment among the people, through test for many years, discovery and arrangement, prescription in conjunction with Guangxi treatment prostatosis more among the people, experiment repeatedly, contrast, and, sum up a kind of to treating the Chinese medicine preparation of common prostatosis by modern detection and treatment means, and make with modern pharmaceutical technology, through clinical trial, proved that this medicine produce effects is fast, subjective symptoms and sign are obviously improved, not seeing has side effect, and is difficult for recurrence.A kind of new excellent drug is provided for the treatment by Chinese herbs prostatosis.

The present invention treats the Chinese medicine preparation of prostatosis and is made by following parts by weight of traditional Chinese medicines raw material:

Herba Galii Teneri 30-50 part Herba Lespedezae Cuneatae 30-50 part Rhizoma Dioscoreae Hypoglaucae  25-40 part Herba Houttuyniae 30-50 part

Herba Taraxaci 30-50 part Formica fusca 20-30 part Fructus Akebiae 30-50 part Semen Plantaginis 20-30 part

Poria 20-30 part Rhizoma Dioscoreae 20-30 part Fructus Alpiniae Oxyphyllae 5-20 part Semen Cuscutae 20-30 part

Semen Astragali Complanati 20-30 part Radix Rosae Laevigatae 25-40 part Radix Polygalae 8-15 part Radix Glycyrrhizae 1-12 part

The Chinese medicine preparation of the invention described above can be made other any dosage forms pharmaceutically such as tablet, capsule (comprising hard capsule, soft capsule, slow releasing capsule), pill, granule, oral liquid, drop pill, injection.

The Chinese medicine preparation function of the invention described above cures mainly:

Heat-clearing and toxic substances removing, dampness removing goes turbid.Be used for the chronic prostatitis syndrome of accumulated dampness-heat.Disease is seen frequent micturition, urgent micturition, dysurea, burning sensation is arranged, and urethral orifice has nebulousurine to overflow when urinating or defecating, and few abdomen, perineum, waist sacrum, testis have the bloated pain of bob.Yellow and greasy fur, slippery and rapid pulse.

The Chinese medicine preparation prescription foundation of the invention described above:

The pure and impure ball of ferrum broom is on the basis of Zhuang nationality in Guangxi folk remedy, write out a prescription according to Chinese medical theory, Herba Galii Teneri, Herba Lespedezae Cuneatae and Radix Rosae Laevigatae are Zhuang nationality in Guangxi, the Mulao, the Dong nationality's medical herbs commonly used in the side, and in addition, Herba Houttuyniae and Herba Plantaginis also are the medications of above-mentioned ethnic groups custom.Thereby this prescription has the ethnic drug characteristic, and it is remarkable to be used for the treatment of the chronic prostatitis effect, use for many years through many minority areas, Guangxi, and determined curative effect, respond well.

The Chinese medicine preparation of the invention described above is set forth indication pathogenesis and Therapeutic Principle with theory of Chinese medical science:

We establish for the chronic glue row adenitis due to the damp-heat accumulation.Herba Galii Teneri in the side, bitter cold, clearing away damp-heat, dissipating blood stasis, detumescence, detoxifcation; Herba Lespedezae Cuneatae, bitter in the mouth is cool in nature, heat-clearing and toxic substances removing, arresting seminal emission, sharp nebulousurine.Close and use it, its heat clearing away poison, dampness removing go turbid merit more outstanding, and Rhizoma Dioscoreae Hypoglaucae , dampness removing are turbid; Herba Houttuyniae, Herba Taraxaci, heat-clearing and toxic substances removing and dampness removing is turbid; Semen Plantaginis, Poria, promoting diuresis to eliminate damp pathogen; Fructus Akebiae, promoting blood circulation and stopping pain, diuresis.Above Six-element closes and uses it, and to strengthen heat-clearing and toxic substances removing, dampness removing goes turbid merit.Cover damp and hot heresy and stop up the resistance meridians, can cause stagnation of QI-blood, so again with the Formica fusca promoting blood circulation to remove obstruction in the collateral, QI invigorating is kept fit; State of an illness delay with the passing of time, regular meeting undermines taste again, thus just again with Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae with replenishing QI to invigorate the spleen, tonifying the kidney to consolidate the essence; Radix Polygalae, promoting the circulation of QI reduces phlegm turbid, tonifying the kidney to consolidate the essence; Radix Polygalae, promoting the circulation of QI reduces phlegm turbid.Radix Glycyrrhizae, coordinating the actions of various ingredients in a prescription is alleviated pain relieving, the messenger drug in the side of being.

More than all medicines share, play heat-clearing and toxic substances removing altogether, dampness removing goes turbid merit, so can be used for chronic prostatitis, syndrome of accumulated dampness-heat.

So we control, with heat-clearing and toxic substances removing, dampness removing goes the turbid method that is, and helps and control it with the spleen reinforcing kidney.

Above-mentioned mentioning: chronic prostatitis is the common disease of urinary system male reproductive system, and the sickness rate height accounts for urology department male patient's 35～40%, is mainly in person between twenty and fifty.The primary disease morbidity is slow, the cause of disease, pathology complexity, and symptom performance variation, sign is not true to type yet, course of disease delay, prolonged difficulty is in the pessimistic prestige state many patients for a long time.The pure and impure ball of ferrum broom is to develop on the basis of clinical practice for many years, through the treatment of hundreds of example patients with chronic prostatitis, think the present invention to eliminate few abdomen, perineum, testis and lumbosacral region painful pass to and frequent micturition, urine before or urethra burning sensation is arranged, adularescent secretions such as overflows at clinical symptoms in the urethra certain effect, one of the comparatively ideal medicine of treatment patients with chronic prostatitis at present of can yet be regarded as.

Below provide the preparation method of Chinese medicine preparation of the present invention:

Get ten Six-element Chinese medicines such as Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With above-mentioned medical material fine powder mixing, drying is ground into fine powder again, sieve, obtain dry powder,, make other any dosage forms pharmaceutically such as tablet or capsule, hard capsule, soft capsule, slow releasing capsule, pill, granule, oral liquid, drop pill, injection again according to the Chinese medicine preparation standard method.(process of injection is applied for a patent separately)

The character of Chinese medicine preparation of the present invention and function and cure mainly, usage and consumption:

[character] feeble QI, mildly bitter flavor

[function with cure mainly] has heat-clearing and toxic substances removing, and dampness removing goes turbid function.Be used for the chronic prostatitis syndrome of dampness-heat diffusing downward.Disease is seen frequent micturition, urgent micturition, dysurea, burning sensation is arranged, and few abdomen, testis weigh down the pain that expands.

[usage and consumption] is oral, a 6g, 3 times on the one.

The side of Chinese medicine preparation of the present invention separates:

From situations such as the ancient mat of document, experience or modern relevant herbal species researchs, each medicine of Chinese medicine preparation of the present invention is described below respectively:

1, Herba Galii Teneri: be the dry herb of Maguireothamnus speciosus Herba Galii Teneri Galium aparine L.This product is recorded in " one one of Chinese pharmacopoeia version in 1977.Acrid in the mouth is slightly cold.Go into Shao Yin, Taiyin channels.The function heat-clearing and toxic substances removing, inducing diuresis to remove edema is used for edema, urinary tract infection, dysentery, injury from falling down, swollen skin ulcer, the worm venom treated of pain.[pharmacological action] bacteriostasis: the dull and stereotyped paper disk method of 100% decoct has inhibitory action to staphylococcus aureus, escherichia coli, dysentery bacterium etc.Be used for the treatment of bacillary dysentery clinically.Hypotensive effect: alcohol extract can bring high blood pressure down and decreased heart rate not, to the quiet notes 1～1.5g of Canis familiaris L. crude drug promptly come into force [2]; Rubichloric acid. also is hypotensive effect to rabbit.[clinical practice] controls carbuncle sore tumefacting virus, as acute appendicitis (being equivalent to simple appendicitis), single with decoction or go in the compound recipe and use.

2, Herba Lespedezae Cuneatae: be the dry aerial parts of leguminous plant lespedeza cuneata Lespedeza cuneata (Dum Cours) G Don.This product " all do not record, and the quality of medicinal material standard adopts the thin layer chromatography of Pharmaceutical Factory of Guangxi Traditional Chinese Medicine College, measures Herba Lespedezae Cuneatae and contain pinite, flavonoid, phenolic constituent, tannin, sitosterol etc. by Chinese pharmacopoeia and " Guangxi quality of medicinal material standard ".The bitter in the mouth suffering, cold.The function invigorating the liver and kidney, lung benefiting the moon, dissipating blood stasis for subsidence of swelling.Treating the liver inflammation, seminal emission, the enuresis, nebulousurine, leucorrhea etc.Consumption 16～30g.The Herba Lespedezae Cuneatae beginning is stated from herbal for Relief of Famines." classification medical herbs " meaning: " control red collapsing, leucorrhea, dysentery disease." " Sichuan Chinese medicinal herbal " carry: " and control the weak enuresis, man's nebulousurine, the woman leucorrhea is a little less than the deficiency of YIN gas." " Fujian east book on Chinese herbal medicine " say: " lung moistening, yin nourishing, the liver benefiting, nourishing kidney.Control seminal emission, lumbago." " Chinese medicine voluminous dictionary " cloud: " dissipating blood stasis for subsidence of swelling.Control the enuresis, leucorrhea etc." [pharmacological action] be that cough-relieving is arranged, and eliminates the phlegm, relieving asthma and antibacterial action.

3, Rhizoma Dioscoreae Hypoglaucae : be the dry root of Dioscoreaceae plant powder back of the body Rhizoma Dioscoreae Dioscorea Collettii Hook.f.var.hypoglauca (Plib) Pei etTing (D.hypoglauca Palibin).This product is concealed in " one one of Chinese pharmacopoeia nineteen ninety-five version.Bitter in the mouth, flat.Return kidney, stomach warp.The function dampness removing goes turbid, and eliminating impediment dispels the wind.Be used for stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain.Consumption 9～15g.The Bi  beginning is stated from Shennong's Herbal, classifies middle product as, and later successive dynasties book on Chinese herbal medicine is all on the books." property of medicine opinion " day: " main man's lumbago is cold for a long time, is that the bladder retained water is arranged between kidney." the Compendium of Material Medica cloud: " control nebulousurine, pains in the penis, bad skin ulcer of hemorrhoid flaccidity." " Chinese medicine voluminous dictionary " carry: Bi  " dispels the wind dampness removing.The dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, dysuria, stranguria with turbid discharge, seminal emission, wet pad sore." [pharmacological action] this product has obvious analgesic and anti-inflammatory effects (P＜0.01); Immunologic function there is inhibitory action to some extent.Toxicity test is not seen toxic effect [8].

4, Herba Houttuyniae: be the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Acrid in the mouth, little plug.Return lung meridian.Function heat clearing away poison macromolecule.

5, Herba Taraxaci: for Compositae thing Herba Taraxaci Taraxacum mongolicum Hand.-Mazz. alkali ground Herba Taraxaci T.sinicumKitag. or belong to the dry herbs of several plants together.The function heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, diuresis is drenched bitterly.This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Bitter in the mouth, sweet, cold.Return liver, stomach warp.The function heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.Be used for furuncle swelling toxin, breast, scrofula, conjunctival congestion, pharyngalgia, lung, intestinal, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

6, Formica fusca: be the dry body of Formicidae animal bitooth multi-ant Polyrhachis dives Smith.This product is recorded in " Guangxi Chinese crude drug standard " second.Salty in the mouth is flat.The function QI invigorating is kept fit, promoting blood circulation to remove obstruction in the collateral, subduing swelling and detoxicating.Being used for rheumatic arthritis, bronchitis, neurosis, hepatitis, insomnia, stomachache, sexual impotence, furunculosis swells and ache.

7, Fructus Akebiae: be the dry mature fruit of Lardizabalaceae plant Caulis Akebiae Akebia trifoliate (Thunb.) Koidz.Var.australis (Diels) Rehd, threeleaf akebia A.Trifoliata (Thunb.) Koidz. or Caulis Akebiae A.quinata (Thunb.) Decne.This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Bitter in the mouth, cold.Return liver, gallbladder, stomach, urinary bladder channel.The function liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, diuresis, parasite killing.Be used for gastral cavity side of body distending pain, amenorrhea dysmenorrhea, dysuria, snake bite and insect sting.

8, the Fructus Akebiae beginning is stated from " Kaibao Bencao ".Supplement to the Herbal carries: " sharp defecation, a surname is logical, goes dysphoria with smothery sensation, and the moderns of food are not lend oneself to worry and anxiety, quench the thirst the therapeutic method to keep the adverse QI flowing downwards." " feeding habits book on Chinese herbal medicine " meaning: " main appetite heat-blockage, regurgitation are not eaten down, remove the three warmers exopathogenic heat." " Nanjing traditional herbal medicine ": " control lumbago." " Chinese medicine voluminous dictionary " cloud: " liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Control excessive thirst, dysentery, lumbago etc.”

9, Semen Plantaginis: be the dry mature seed of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd P.depressawilld..This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Sweet in the mouth is slightly cold.Return liver, kidney, lung, small intestine meridian.The function clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, makes eye bright, eliminates the phlegm.Be used for edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough etc.

10, Poria: be the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf.This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Sweet in the mouth, light is flat.GUIXIN, lung, spleen, kidney channel.The function promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.

11, Rhizoma Dioscoreae: be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Sweet in the mouth is flat.Return spleen, lung, kidney channel.Function spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.

12, Fructus Alpiniae Oxyphyllae: be the dry mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae Alpinia oxyphylla Miq..This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Flavor, suffering, temperature.Return spleen, kidney channel.The function tonification Liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination.Antiabortive, make eye bright antidiarrheal.Be used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down.

13, Semen Astragali Complanati: be the dry mature seed of leguminous plant astragatus complanatus Astragalus complanatus R.Br..This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Flavor, sweet, temperature.Return liver, kidney channel.Function temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination makes eye bright.Be used for lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.

14, Radix Rosae Laevigatae: be the dry root of rosaceous plant Fructus Rosae Laevigatae Rosa laevigata Michx..This product is recorded in " Fructus Citri sinensis thing medical material standard " nineteen ninety version.Sour in the mouth, puckery is flat.The function reinforcing the kidney and controlling nocturnal emission.Be used for sliding, the enuresis, dysentery is had loose bowels, bleeding not during menses, uterine prolapse, hemorrhoid.

15, Radix Polygalae: be milk wort Radix Polygalae Polygala tenuifolia willd. or leaf Radix Polygalae P.The dry root of sibirica C..This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Bitter in the mouth, suffering, temperature.GUIXIN, kidney, lung meridian.The function Fructus Alpiniae Oxyphyllae of calming the nerves is eliminated the phlegm, detumescence.Be used for disarmony between the heart and kidney, lose the eye dreaminess, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.

16, Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume G.glsbra L..This product is recorded in " one one of Chinese pharmacopoeia nineteen ninety-five version.Sweet in the mouth is flat.GUIXIN, lung, spleen, stomach warp.The function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

In sum, medicament sources Zhuang nationality in Guangxi folk remedy of the present invention, and write out a prescription with theory of Chinese medical science has that heat-clearing and toxic substances removing, dissipating blood stasis blood, dampness removing are turbid, the effect of spleen reinforcing kidney, is used for the treatment of chronic prostatitis.Herba Lespedezae Cuneatae and Radix Rosae Laevigatae are Zhuang nationality in Guangxi, chat man family, the Dong nationality and Miao ethnic group medical herbs commonly used in the side.In addition, Herba Houttuyniae and Herba Plantaginis also are above-mentioned national customs medications, thereby the pure and impure ball prescription of ant emperor rationally, according to comparatively clear and definite, meets the ethnic drug characteristic, and process Guangxi Minority area medication experience for many years shows determined curative effect.This product prescription drugs is totally ten Six-elements, consults 71 pieces of lists of references altogether, and each crude drug source of distinguishing the flavor of is clear, closes a flavour of a drug and all has modern study reports such as chemical constituent, pharmacological action clinical practice.

Below narrate the production method of the various preparations of the present invention:

The production method of pill

Get ten Six-element Chinese medicines such as Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and adding starch or Mel are an amount of, and mixing obtains dried cream powder.The reuse water pill, spray adds above-mentioned volatile oil, polishing, drying is made 1000g, promptly obtains pill.[character] this product is the concentrated watered pill of black; After removing the top layer, show brown to sepia; Feeble QI, mildly bitter flavor.The pure and impure ball of [title] ferrum broom.

2, the production method of tablet

Get ten Six-element Chinese medicines such as Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.Mix with an amount of filler, disintegrating agent, drying and adjuvant are made granule again, drying, and granulate, packing obtains product.Also can surperficial sugar coating, make coated tablet.Above-described filler, disintegrating agent, adjuvant are other adjuvant that meets the world and national Specification.Pure and impure of [title] ferrum broom.

3, the production method of granule

Get ten Six-element Chinese medicines such as Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.Get intermediate products dried cream powder and an amount of syrup mixing, granulate, packing gets finished product.The pure and impure granule of [title] ferrum broom.

4, capsular production method

Get ten Six-element Chinese medicines such as Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.With the appropriate amount of auxiliary materials mixing, encapsulated, In Aluminium Foil Packing, packing gets the finished capsule product agent.Above-described adjuvant is a magnesium stearate, or meets other adjuvant of international and national Specification.The pure and impure capsule of [title] ferrum broom.

5, the production method of slow releasing capsule:

Medicine of the present invention can further be made slow releasing capsule, its processing step is above-mentioned intermediate products dried cream powder to be added binding agent make microcapsule, total amount according to the intermediate products dried cream powder, the spermaceti or other blocker coating that add 0.5-5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, in the capsulae vacuus of packing into behind the mix homogeneously, is packaged into box or is hot pressed into aluminium-plastic panel and obtain product.The pure and impure slow releasing capsule of [title] ferrum broom.

6, the production method of soft capsule:

Get intermediate products dried cream powder, vegetable oil, Cera Flava by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the suspended matter fill is pressed into 1000 soft capsules, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out the soft capsule that gets product.The pure and impure soft capsule of [title] ferrum broom.

7, the production method of drop pill:

With the polyethylene glycol 6000 heating and melting, get the intermediate products dried cream powder again and add, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃ of-15 ℃ of liquid paraffin, and with the 50/component velocity system of dripping, drop pill gets product.

8, get intermediate products dried cream powder and an amount of syrup and Mel mixing, sterilization, fill gets the finished product soft extract.

Other dosage form such as oral liquid, Film coated tablets, buccal tablet etc. can carry out with reference to pharmacopeia or Chinese medicinal preparation method.

The specific embodiment

Embodiment 1

Get Herba Galii Teneri 40 grams, Herba Lespedezae Cuneatae 40 grams, Rhizoma Dioscoreae Hypoglaucae  33 grams, Herba Houttuyniae 40 grams, Herba Taraxaci 40 grams, Formica fusca 25 grams, Fructus Akebiae 40 grams, Semen Plantaginis 25 grams, Poria 25 grams, Rhizoma Dioscoreae 25 grams, Fructus Alpiniae Oxyphyllae 17 grams, Semen Cuscutae 25 grams, Semen Astragali Complanati 25 grams, Radix Rosae Laevigatae 33 grams, Radix Polygalae 13 grams, Radix Glycyrrhizae 5 grams, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and adding starch or Mel are an amount of, and mixing obtains dried cream powder.The reuse water pill, spray adds above-mentioned volatile oil, polishing, drying is made the 100g pill.[character] this product is the concentrated watered pill of black; After removing the top layer, show brown to sepia; Feeble QI, mildly bitter flavor.The pure and impure ball of [title] ferrum broom.

Embodiment 1A

Get Herba Galii Teneri 417 grams, Herba Lespedezae Cuneatae 417 grams, Rhizoma Dioscoreae Hypoglaucae  333 grams, Herba Houttuyniae 417 grams, Herba Taraxaci 417 grams, Formica fusca 250 grams, Fructus Akebiae 417 grams, Semen Plantaginis 250 grams, Poria 250 grams, Rhizoma Dioscoreae 250 grams, Fructus Alpiniae Oxyphyllae 167 grams, Semen Cuscutae 250 grams, Semen Astragali Complanati 250 grams, Radix Rosae Laevigatae 333 grams, Radix Polygalae 125 grams, Radix Glycyrrhizae 50 grams, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and adding starch or Mel are an amount of, and mixing obtains dried cream powder.The reuse water pill, spray adds above-mentioned volatile oil, polishing, drying is made the 1000g pill.The pure and impure ball of [title] ferrum broom.

Embodiment 2

Get Herba Galii Teneri 50 grams, Herba Lespedezae Cuneatae 50 grams, Rhizoma Dioscoreae Hypoglaucae  40 grams, Herba Houttuyniae 50 grams, Herba Taraxaci 50 grams, Formica fusca 30 grams, Fructus Akebiae 50 grams, Semen Plantaginis 30 grams, Poria 30 grams, Rhizoma Dioscoreae 30 grams, Fructus Alpiniae Oxyphyllae 20 grams, Semen Cuscutae 30 grams, Semen Astragali Complanati 30 grams, Radix Rosae Laevigatae 40 grams, Radix Polygalae 15 grams, Radix Glycyrrhizae 12 grams, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.Mix with an amount of filler, disintegrating agent, drying and adjuvant are made granule again, drying, and granulate, packing obtains the tablet product.Also can surperficial sugar coating, make coated tablet.

Embodiment 3

Get Herba Galii Teneri 48 grams, Herba Lespedezae Cuneatae 48 grams, Rhizoma Dioscoreae Hypoglaucae  38 grams, Herba Houttuyniae 48 grams, Herba Taraxaci 48 grams, Formica fusca 28 grams, Fructus Akebiae 48 grams, Semen Plantaginis 28 grams, Poria 28 grams, Rhizoma Dioscoreae 28 grams, Fructus Alpiniae Oxyphyllae 18 grams, Semen Cuscutae 28 grams, Semen Astragali Complanati 28 grams, Radix Rosae Laevigatae 38 grams, Radix Polygalae 10 grams, Radix Glycyrrhizae 8 grams, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.With an amount of magnesium stearate mixing, encapsulated, In Aluminium Foil Packing, packing gets the finished capsule product agent.

Embodiment 4

Get Herba Galii Teneri 35 grams, Herba Lespedezae Cuneatae 35 grams, Rhizoma Dioscoreae Hypoglaucae  30 grams, Herba Houttuyniae 35 grams, Herba Taraxaci 35 grams, Formica fusca 23 grams, Fructus Akebiae 35 grams, Semen Plantaginis 23 grams, Poria 23 grams, Rhizoma Dioscoreae 23 grams, Fructus Alpiniae Oxyphyllae 10 grams, Semen Cuscutae 23 grams, Semen Astragali Complanati 23 grams, Radix Rosae Laevigatae 25 grams, Radix Polygalae 9 grams, Radix Glycyrrhizae 3 grams, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieve, obtain dried cream powder,, add spermaceti or other blocker coating of 0.5-5% again according to the total amount of intermediate products dried cream powder, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, in the capsulae vacuus of packing into behind the mix homogeneously, is packaged into box or is hot pressed into aluminium-plastic panel and obtain product.

Embodiment 5

Herba Galii Teneri 30 grams, Herba Lespedezae Cuneatae 30 grams, Rhizoma Dioscoreae Hypoglaucae  25 grams, Herba Houttuyniae 30 grams, Herba Taraxaci 30 grams, Formica fusca 20 grams, Fructus Akebiae 30 grams, Semen Plantaginis 20 grams, Poria 20 grams, Rhizoma Dioscoreae 20 grams, Fructus Alpiniae Oxyphyllae 5 grams, Semen Cuscutae 20 grams, Semen Astragali Complanati 20 grams, Radix Rosae Laevigatae 25 grams, Radix Polygalae 8 grams, Radix Glycyrrhizae 1 gram, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.Get intermediate products dried cream powder and an amount of syrup mixing, granulate, packing gets finished product.The pure and impure granule of [title] ferrum broom.

Embodiment 6

Herba Galii Teneri 40 grams, Herba Lespedezae Cuneatae 40 grams, Rhizoma Dioscoreae Hypoglaucae  35 grams, Herba Houttuyniae 40 grams, Herba Taraxaci 40 grams, Formica fusca 26 grams, Fructus Akebiae 40 grams, Semen Plantaginis 26 grams, Poria 26 grams, Rhizoma Dioscoreae 26 grams, Fructus Alpiniae Oxyphyllae 8 grams, Semen Cuscutae 15 grams, Semen Astragali Complanati 26 grams, Radix Rosae Laevigatae 32 grams, Radix Polygalae 11 grams, Radix Glycyrrhizae 4 grams, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.Get intermediate products dried cream powder, vegetable oil, Cera Flava by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the suspended matter fill is pressed into 1000 soft capsules, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out the soft capsule that gets product.

Embodiment 7

Herba Galii Teneri 35 grams, Herba Lespedezae Cuneatae 40 grams, Rhizoma Dioscoreae Hypoglaucae  38 grams, Herba Houttuyniae 42 grams, Herba Taraxaci 38 grams, Formica fusca 22 grams, Fructus Akebiae 34 grams, Semen Plantaginis 26 grams, Poria 23 grams, Rhizoma Dioscoreae 25 grams, Fructus Alpiniae Oxyphyllae 19 grams, Semen Cuscutae 27 grams, Semen Astragali Complanati 21 grams, Radix Rosae Laevigatae 39 grams, Radix Polygalae 11 grams, Radix Glycyrrhizae 9 grams, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.Get intermediate products dried cream powder, vegetable oil, Cera Flava by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the suspended matter fill is pressed into 1000 soft capsules, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out the soft capsule that gets product.With the polyethylene glycol 6000 heating and melting, get the intermediate products dried cream powder again and add, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃ of-15 ℃ of liquid paraffin, and with the 50/component velocity system of dripping, drop pill gets product.

Embodiment 8

Herba Galii Teneri 30-50 part, Herba Lespedezae Cuneatae 30-50 part, Rhizoma Dioscoreae Hypoglaucae  25-40 part, Herba Houttuyniae 30-50 part, Herba Taraxaci 30-50 part, Formica fusca 20-30 part, Fructus Akebiae 30-50 part, Semen Plantaginis 20-30 part, Poria 20-30 part, Rhizoma Dioscoreae 20-30 part, Fructus Alpiniae Oxyphyllae 5-20 part, Semen Cuscutae 20-30 part, Semen Astragali Complanati 20-30 part, Radix Rosae Laevigatae 25-40 part, Radix Polygalae 8-15 part; Radix Glycyrrhizae 1-12 part

Herba Galii Teneri 47 grams, Herba Lespedezae Cuneatae 42 grams, Rhizoma Dioscoreae Hypoglaucae  41 grams, Herba Houttuyniae 43 grams, Herba Taraxaci 46 grams, Formica fusca 27 grams, Fructus Akebiae 41 grams, Semen Plantaginis 24 grams, Poria 20 grams, Rhizoma Dioscoreae 30 grams, Fructus Alpiniae Oxyphyllae 10 grams, Semen Cuscutae 26 grams, Semen Astragali Complanati 25 grams, Radix Rosae Laevigatae 24 grams, Radix Polygalae 9 grams, Radix Glycyrrhizae 8 grams, earlier with Poria, Rhizoma Dioscoreae crushing fine powder, mixing was sterilized 30 minutes for 110 ℃.Other gets Formica fusca and is ground into into coarse powder, makes the solvent percolation according to the percolation (appendix of Chinese Pharmacopoeia nineteen ninety-five version) of fluid extract with 6 times of amount 50-80% ethanol, collects percolate to colourless.Get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, ten Herba indigoferae Pseudotinctoriae such as all the other Herba Galii Teneri and extract volatile oil after medicinal residues, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is concentrated into the clear paste that relative density is 1.09～1.12 (70 ℃), put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, being concentrated into relative density is the clear paste of 1.20～1.25 (70 ℃).With the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, and obtains dried cream powder.Get intermediate products dried cream powder and an amount of syrup and Mel mixing, sterilization, fill gets the finished product soft extract.

Relevant toxicity test, pharmacodynamics, pharmacological research:

The inventor will make pill according to the method described above, declare province hygiene department and drug surveilance department and give provincial medicine inspecting institute and carry out toxicity test, pharmacodynamics, pharmacology test, and the result is as follows:

(1) the pure and impure ball long term toxicity test of ferrum broom

Give rat oral gavage with this product 117g (TG AX)/kg and 29.3g (crude drug)/kg (quite clinical plan is with 84.9 times and 21.3 times of daily dose), once a day, continuous 12 weeks.During administration, each treated animal activity, appetite, feces and weight increase are normal, small dose group platelet value is apparently higher than matched group next day after the drug withdrawal, all the other every numerical value of respectively organizing hemogram, blood biochemistry checking and organ coefficient compare through between group, the pathologic finding of there was no significant difference main organs does not see that by the change of the histology's correction due to the drug toxicity reproduction is not had influence yet yet.

(2) the pure and impure ball pharmacodynamic study of ferrum broom

The pure and impure ball of ferrum broom has obvious antagonism to castrated rats and normal mouse prostatic hyperplasia, externally antibacterially show to first chain, streptococcus pneumoniae, shigella, to read MIC in vain be 1: 16, large intestine and wound match bacterium are 1: 8, golden Portugal and green pus bacterium were respectively 1: 4 and 1: 2, and bacteriostatic test is not obvious to golden Portugal, large intestine and the effect of first chain bacterium in the body.This medicine can also improve mice HC50 value and exponential quantity is cleaned up at the charcoal end, suppresses rat granuloma hamartoplasia, and it is swollen and the dimethylbenzene mouse ear is swollen to alleviate the foot of carrageenin rat, and causing bitterly to hot plate analgesia and ester acid, mice does not have the significance effect.Rat there is certain analgesic and diuresis.

(3) the pure and impure pill reason of ferrum broom research

The pure and impure ball of ferrum broom has obvious antagonism to castrated rats and normal mouse prostatic hyperplasia.Extracorporeal bacteria inhibitor test is inhibited to first chain, streptococcus pneumoniae, will Hayes dysentery bacillus, Candida albicans, large intestine bar, typhoid fever village bacterium etc.Can improve mice half hemolysis value (H C50 value) and charcoal end and clean up exponential quantity, suppress rat granuloma hamartoplasia, it is swollen swollen with the dimethylbenzene mouse ear to alleviate carrageenin rat foot.Have analgesic and diuresis to rat.

(4) clinical experiment report

The chronic row adenitis of the pure and impure pill for curing of ferrum broom is faced and is ordered Test Summary

The turbid ball of ferrum broom of the present invention system is according to the Chinese medicine preparation of traditional Chinese medicine theory with the experience development, has heat-clearing and toxic substances removing, dampness removing goes turbid effect, and chronic prostatitis due to penting up is used for wetting.According to " provisions for new drugs approval ", " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " and " new Chinese medicine face order research reflect lead principle ", first Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi (120 example), second Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi (90 example) and The People's Hospital, Guangxi Zhuang Autonomous Region's (90 example) have carried out clinical trial to the pure and impure ball of ferrum broom, and the result is summarized as follows:

Purpose

Investigate the pure and impure ball of ferrum broom to the curative effect of chronic prostatitis and to the safety of human body.

Object and method

The judgement standard:

(1) Western medicine diagnose standard:

(1) symptom: frequent micturition, residual urine sense, dysurea, pain discomfort around perineum, hypogastric region and the anus.

(2) prostate palpation: air spots or asymmetric, or touch irregular poroma, tenderness, quality lose normal evenly elasticity.

(3) examination of prostatic fluid: WBC＞1500/mm3, or WBC＞10 under 400 times of mirrors/every visual field can make a definite diagnosis.

(4) semen efamination: because the limitation of massage of prostate, or prostatic fluid be can not obtain the time, desirable semen efamination, and WBC＞5/ high power field person can make a definite diagnosis prostate inflammation, but should be as the criterion with staining section.

(5) ultrasound investigation: section slightly is out of shape, but how not to enlarge, and tunicle is concavo-convex not whole, discontinuous, often with calculus of prostate and sound shadow.

(2) state of an illness weight classification:

Slightly: prostatic fluid WBC＞10/HP only, lecithin is normal substantially, does not have urinate symptom and reflexive pain, prostate touch no change.

Moderate: prostatic fluid WBC＞10/HP, lecithin reduces, and merges urinate symptom and reflexive pain, anus is examined and is checked that the prostate surface is still smooth, can have slightly asymmetric, the quality no change.

Severe: prostatic fluid WBC＞10/HP, lecithin is minimum, and anus is examined and is checked that the prostate two sides is rough, asymmetric, loses normal elasticity, is fibrosis or scleroma is arranged.

(3) differential diagnosis in tcm syndrome of dampness-heat diffusing downward: urine urgency-frequency dysurea, urethra scorching hot, dampness of scrotum, red tongue with yellow fur, rolling pulse.

(4) witness light and heavy degree grade scale and scoring method: see Table 1.

Table 1 witness light and heavy degree grade scale and scoring method

	Slightly (2 minutes)	Moderate (4 minutes)	Severe (6 minutes)
				Urgent urination and frequently the deficient urine of Urethra astringent pain urine amount look yellow red prostatic fluid anus refer to inspection	It is slight below 10 times to urinate every day, the burning sensation oliguria is arranged and not obvious yellow slightly WBC＞basic normal prostatic mild tenderness of 10/HP lecithin, smooth surface, quality is normal	The cusalgia of urinating every day 11～20 times; But can stand obviously deficient deep yellow not turbid WBC＞10/HP lecithin and reduce the prostate tenderness; The surface is still smooth, and is can slight asymmetric quality normal	The scorching hot twinge more than 21 times of urinating every day, be subjected to drop unbearably and, or the red muddy WBC of inaccessible obstructed Huang＞few prostate tenderness of 10/HP lecithin, rough asymmetric, lose normal elasticity, be fibrosis or scleroma is arranged

Three, test case standard:

1, include standard in: meet chronic prostatitis Western medicine diagnose standard, Chinese medical discrimination belongs to the syndrome of dampness-heat diffusing downward, and the person all can include the object of observation in.

2, exclusion standard:

(1) age is at under-18s or more than 55 years old, and the unmarried crosses every body constitution or to this medicine allergy sufferers.

(2) merge prostatic hyperplasia, serious neurosis, urethral stricture, tumor of prostate patient.

(3) be associated with serious former generation diseases such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic.

(4) do not meet the standard of including in, not medication in accordance with regulations can't be judged curative effect, or data is not congruent affects the treatment or safety judgement person.

Four, observation index:

1, safety observation:

(1) general health check-up project.

(2) blood, urine, just routine test.

(3) heart, liver, kidney function test.

2, health giving quality observation:

(1) related symptoms and sign.

(2) the prostate insecticide is examined.

(3) prostatic examination.

(4) prostate ultrasound diagnosis.

Five, observational technique: adopt district's group at random, contrast, non-blind method observe.

1, grouping: totally 300 examples, look into the random alignment table, by 8: 4 and 6: 3 district's group random packet.

2, the consumption course of treatment and medication:

1. treatment group: 200 examples, the pure and impure ball of ferrum broom, oral, every friendship 6g, every day 3 times.

2. matched group: 120 examples, QIANLIETONG PIAN [many pharmaceutical factories of winning, Guangzhou produce, and Guangdong is defended accurate word (1984) A13-022 of medicine numbers], oral, each 6, every day 3 times.

3. course of treatment: serve on for 4 weeks.

4. withdraw this medicine of other treatment during the checking.

Six, efficacy assessment standard:

1, clinical recovery: transference cure, anus are examined tenderness and are disappeared, and quality is normal or near normal, examination of prostatic fluid and ultrasound diagnosis are normal.

2, produce effects: symptom disappears substantially, and anus examines tenderness and quality all has improvement, examination of prostatic fluid WBC＜15/HP, and ultrasound diagnosis makes moderate progress.

3, effective: symptom has improvement.

4, invalid: as not reach above-mentioned standard.

Seven, the compiling and summing up of testing data:

1, is responsible for the observation of patient symptom, sign, physical and chemical index by the clinicist, and makes itemized record by the designing requirement of testing program and observation table.

2, organization of data: each routine raw data is carried out system finishing, conscientiously check each symptom, the data Ying Yu that does not meet designing requirement, records apparent error is given up.

3, date processing: as requested relevant data is carried out appropriate statistical procedures (ranked data are analyzed with Ridit, enumeration data X2 check analysis, enumeration data is with t check or U check analysis).

4, the summarization of data must be reacted proof procedure objective, comprehensively, exactly, and has the special messenger to be responsible for result's statistics.

5, note to observe bad melon, the time of origin of itemized record untoward reaction, reason, performance, degree also conscientiously differentiated, whether influences the carrying out of test and treatment measures etc.

The result

One, physical data: among the 300 routine qualified experimenters, 200 examples are organized in treatment, matched group 100 examples.

Two, two groups of comparabilities are checked:

1, two groups of age ratios are:

The table 2 liang group age (year) relatively (Ridit analysis)

	The example number	～27	～37	～47	～55
						Treatment group matched group	200 100	38 13	69 50	54 25	39 12

2, two groups of courses of disease are relatively:

The table 3 liang group course of disease (year) is (Ridit analysis) relatively

	The example number	～1 year	～5 years	～10 years	11 years～
						Treatment group matched group	200 100	115 51	72 41	12 8	1 0

Annotate: two groups of courses of disease compare, U=0.94, and P＞0.05, difference does not have significance.

3, two groups of state of an illness weights are relatively:

Table 4 liang group state of an illness weight is (Ridit analysis) relatively

	The example number	Slightly	Moderate	Severe
					Treatment group matched group	200 100	61 30	95 49	44 21

Annotate: two groups of state of an illness weights compare, U=0.04, and P＞0.05, difference does not have significance.

4, two groups of preceding total marks of treatment are relatively:

Total mark (X ± SD) comparison (t check) before the table 5 liang group treatment

	The example number	Integration before the treatment
			Treatment group matched group	200 100	22.11±8.25 20.74±7.98

Annotate: total mark compares before two groups of treatments, U=1.36, and P＞0.05, difference does not have significance.

Comparability detects and shows before the above-mentioned treatment, two groups before age, the course of disease, treatment the state of an illness, total mark etc. relatively, difference there are no significant meaning.The principal element that prompting influences two groups of prognosis has harmony.

Three, curative effect is relatively:

1, total effects is relatively:

Table 6 total effects is (Ridit analysis) relatively

The example number

Recovery from illness (%)

Produce effects (%)

Effectively (%)

Invalid (%)

Total effectively (%)

Treatment group matched group

200 100

33(16.5) 12(12.0)

64(32.0) 30(30.0)

79(39.5) 45(45.0)

24(12.0) 13(13.0)

176(88.0) 87(87.0)

Annotate: two groups of total effectses compare, U=1.04, and P＞0.05, difference does not have the significance meaning.

2, the clinical symptoms curative effect compares after 4 weeks of treatment:

Table 7 liang group patient treatment 4 all backs clinical symptoms curative effects are (Ridit analysis) relatively:

		The example number	Improve 3 grades	Improve 2 grades	Improve 1 grade	Do not have and improve
							Urgent micturition and frequently	Treatment group matched group	182 95	52 25	54 30	49 26	27 14
Urethra astringent pain	Treatment group matched group	179 88	53 26	52 25	57 25	17 12
							The urine amount is deficient	Treatment group matched group	188 90	52 25	56 23	52 27	28 15
The urine yellow skin is red	Treatment group matched group	187 89	44 22	60 21	57 30	26 16
							Prostatic fluid	Treatment group matched group	200 100	50 17	55 30	49 21	46 32
Anus refers to inspection	Treatment group matched group	200 100	24 11	53 26	65 26	58 37

Annotate: two groups of patient treatments see that respectively disease all has clear improvement after 4 weeks, P＜0.01, and difference has the significance meaning.Respectively see two groups of disease curative effects relatively, P all＞0.05, difference does not have significance.

Four, safety detects:

1, treatment group:

(1) routine blood test: detected 200 examples before the treatment, wherein, there is no unusual in the 200 example treatment back checks of normal range.

(2) fecal occult blood: detected 200 examples before the treatment, wherein, there is no unusual in the 200 example treatment back checks of normal range.

(3) electrocardiogram: detected 196 examples before the treatment, wherein, there is no unusual in the 196 example treatment back checks of normal range.

(4) ALT: detected 195 examples before the treatment, wherein, there is no unusual in the 195 example treatment back checks of normal range.

(5) BCr: detected 194 examples before the treatment, wherein, there is no unusual in the 194 example treatment back checks of normal range.

(6) BUN: detected 194 examples before the treatment, wherein, there is no unusual in the 194 example treatment back checks of normal range.

2, matched group:

(1) routine blood test: detected 100 examples before the treatment, wherein, there is no unusual in the 100 example treatment back checks of normal range.

(2) fecal occult blood: detected 100 examples before the treatment, wherein, there is no unusual in the 100 example treatment back checks of normal range.

(3) electrocardiogram: detected 96 examples before the treatment, wherein, there is no unusual in the 96 example treatment back checks of normal range.

(4) ALT: detected 95 examples before the treatment, wherein, there is no unusual in the 95 example treatment back checks of normal range.

(5) BCr: detected 94 examples before the treatment, wherein, there is no unusual in the 94 example treatment back checks of normal range.

(6) BUN: detected 94 examples before the treatment, wherein, there is no unusual in the 94 example treatment back checks of normal range.

Five, untoward reaction is observed: the untoward reaction symptom all do not occur after two groups of medications.

Model case

Example one, land, man, 35 years old, Nanning railroad suboffice worker.Because of perineum distending pain discomfort, urethra scorching hot, urine time increase to show effect repeatedly surplusly examined on July 15th, 1999 in 1 year.Perineum distending pain discomfort appears in private prosecution preceding no obvious inducement more than 1 year, urethra scorching hot, and number of micturitions increases, and external orifice of urethra toughness secretions more than occurring after an action of the bowels, is measured few.Dizzy weak, the hyposexuality of companion.Have a medical check-up: ordinary circumstance is good, and cardiopulmonary liver spleen is checked no abnormal.Red tongue, yellow and thin fur, slippery and rapid pulse.The prostate touch: prostate is little, two example symmetries, and Rolandic fissure exists, and smooth surface is flexible, mild tenderness.16/HP of examination of prostatic fluid: WBC, 128g/L, RBC 4.4 * 1012/L, WBC 5.6 * 109, ALT 20u/L, BCr 90 μ mol/L, BUN4.6mmol/L, urine RBC (-), Pro (-), FOB (-).Electrocardioscopy is normal.Tcm diagnosis: smart turbid (syndrome of dampness-heat diffusing downward).Western medicine diagnose: chronic prostatitis.Give the pure and impure pill for curing of ferrum broom, oral, each 6g, every day 3 times, 4 weeks of logotype.After 1 week of medication, the perineum distending pain alleviates.After 2 weeks, perineum distending pain and urethra scorching hot sense disappear, and urine dodges and obviously reduces, and example back urethral orifice has not had secretions and flowed out.The all diseases in 4 week backs disappear, and libido is normal.The prostate touch: the prostate lateral symmetry, smooth surface is flexible, no tenderness.Examination of prostatic fluid lecithin (++ ++), WBC (-), the prostate B ultrasonic shows: the prostate normal size, interior echo is even.Blood HB 125g/L, RBC 4.4 * 1012/L, WBC 5.4 * 109, ALT 18u/L, BCr 84 μ mol/L, BUN 4.2mmol/L, urine RBC (-), Pro (-), FOB (-).Electrocardioscopy is normal.Efficacy evaluation: clinical recovery.

Example two, fourth, man, 32 years old, the worker of Nanning City landscape bureau.Because of uncomfortable 2 years of perineum distending pain was examined on July 16th, 1999.Perineum distending pain discomfort appears in private prosecution preceding no obvious inducement more than 2 years, with urethra scorching hot, the urine retention sensation is arranged when urinating.The normal toughness secretions of external orifice of urethra occurs more than the urine end, and amount is few.Have a medical check-up: ordinary circumstance is good, and cardiopulmonary liver spleen is checked no abnormal.Red tongue, yellow and thin fur, slippery and rapid pulse.The prostate touch: prostate is often big, lateral symmetry, and Rolandic fissure exists, and smooth surface is flexible, mild tenderness.20/HP of examination of prostatic fluid: WBC, lecithin (++).The prostate B ultrasonic shows: the prostate normal size, interior echo is even.Blood HB 130g/L, RBC 4.8 * 1012/L, WBC 6.2 * 109, ALT 14u/L, BCr 92 μ mol/L, BUN 4.2mmol/L, urine RBC (-), Pro (-), FOB (-).Electrocardioscopy is normal.Tcm diagnosis: smart turbid (syndrome of dampness-heat diffusing downward).Western medicine diagnose: the former inflammation in chronic prostatitis.Give the pure and impure pill for curing of ferrum broom, oral, each 6g, every day 3 times, 4 weeks of logotype.After 1 week of medication, perineum distending pain discomfort alleviates.After 3 weeks, perineum distending pain and urethra scorching hot sense disappear, and urine retention anesthesia, urethral orifice do not have secretions and flow out.The all diseases in 4 week backs disappear.The prostate touch: the prostate lateral symmetry, smooth surface is flexible, no tenderness.Examination of prostatic fluid lecithin (++ ++), WBC (-), the prostate B ultrasonic shows: the prostate normal size, interior echo is even.Blood HB 128g/L, RBC 4.8 * 1012/L, WBC 6.4 * 109, ALT 16u/L, BCr 86 μ mol/L, BUN 4.5mmol/L, urine RBC (-), Pro (-), FOB (-).Electrocardioscopy is normal.Efficacy evaluation: clinical recovery.

Discuss and conclusion

1, treatment group recovery from illness, obvious effective rate and total effective rate are respectively 16.5%, 32% and 88%; Matched group cure rate, obvious effective rate and total effective rate are respectively 12%, 30% and 87%.Two groups of comparing differences do not have the significance meaning.The clinical efficacy of the pure and impure pill for curing chronic prostatitis of prompting ferrum broom is similar to the contrast medicine.

2, clinical symptoms, sign and efficacy result show, urgent micturition after two groups of patient and frequency, Urethra astringent pain, symptom such as the urine amount is deficient, the urine yellow skin is red and examination of prostatic fluid, rectal examination all have clear improvement.But two groups relatively, and difference does not have the significance meaning.The pure and impure ball of prompting ferrum broom can obviously improve the clinical symptoms of chronic prostatitis (syndrome of dampness-heat diffusing downward), and is similar to the contrast medicine.

3, this research has been carried out blood, just routine examination to 200 routine patients, and the heart, liver, kidney function test are not all found obvious adverse reaction and toxic and side effects.Prompting this product is clinical safe and reliable.

Claims (10)

1, a kind of Chinese medicine preparation for the treatment of prostatosis is characterized in that: its active component is made by following parts by weight of traditional Chinese medicines raw material:

Herba Galii Teneri 30-50 part Herba Lespedezae Cuneatae 30-50 part Rhizoma Dioscoreae Hypoglaucae  25-40 part Herba Houttuyniae 30-50 part

Herba Taraxaci 30-50 part Formica fusca 20-30 part Fructus Akebiae 30-50 part Semen Plantaginis 20-30 part

Poria 20-30 part Rhizoma Dioscoreae 20-30 part Fructus Alpiniae Oxyphyllae 5-20 part Semen Cuscutae 20-30 part

Semen Astragali Complanati 20-30 part Radix Rosae Laevigatae 25-40 part Radix Polygalae 8-15 part Radix Glycyrrhizae 1-12 part.

2, a kind of Chinese medicine preparation of treatment prostatosis as claimed in claim 1 is characterized in that: it is tablet, hard capsule, soft capsule, slow releasing capsule, pill, granule, oral liquid, drop pill or injection.

3, the Chinese medicine preparation of treatment prostatosis as claimed in claim 2 is characterized in that: the production method of pill is as follows:

Get Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae ten Six-element Chinese medicines, earlier with Poria, the Rhizoma Dioscoreae crushing fine powder, mixing, sterilized 30 minutes for 110 ℃, other gets Formica fusca and is ground into into coarse powder, percolation according to fluid extract, make the solvent percolation with 6 times of amount 50-80% ethanol, collect percolate, get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer to colourless, medicinal residues behind all the other ten Herba indigoferae Pseudotinctoriae and the extraction volatile oil, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate simmer down to clear paste is put coldly, and adding ethanol, to make medicinal liquid contain the alcohol amount be 60%, left standstill 16 hours, the leaching supernatant adds above-mentioned Formica fusca percolate, reclaims ethanol, the simmer down to clear paste, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieve, it is an amount of to add starch or Mel, and mixing obtains dried cream powder, the reuse water pill, spray adds above-mentioned volatile oil, polishing, drying, make 1000g, obtain pill.

4, the Chinese medicine preparation of treatment prostatosis as claimed in claim 2 is characterized in that: the production method of tablet is as follows:

Get Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae ten Six-element Chinese medicines, earlier with Poria, the Rhizoma Dioscoreae crushing fine powder, mixing, sterilized 30 minutes for 110 ℃, other gets Formica fusca and is ground into into coarse powder, percolation according to fluid extract, make the solvent percolation with 6 times of amount 50-80% ethanol, collect percolate, get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer to colourless, medicinal residues behind all the other ten Herba indigoferae Pseudotinctoriae and the extraction volatile oil, 3 decoct with water three times, and each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate is condensed into clear paste, puts coldly, and adding ethanol, to make medicinal liquid contain the alcohol amount be 60%, left standstill 16 hours, the leaching supernatant adds above-mentioned Formica fusca percolate, reclaims ethanol, the simmer down to clear paste, with the clear paste drying, with above-mentioned medical material fine powder mixing, drying, be ground into fine powder, sieve, obtain dried cream powder, again with an amount of filler that meets international and national Specification, disintegrating agent mixes, dry, make granule with adjuvant, drying, granulate, packing obtains product; Perhaps surperficial sugar coating is made coated tablet.

5, the Chinese medicine preparation of treatment prostatosis as claimed in claim 2 is characterized in that: the production method of granule is as follows:

Get Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae ten Six-element Chinese medicines, earlier with Poria, the Rhizoma Dioscoreae crushing fine powder, mixing, sterilized 30 minutes for 110 ℃, other gets Formica fusca and is ground into into coarse powder, percolation according to fluid extract is made the solvent percolation with 6 times of amount 50-80% ethanol, collect percolate to colourless, get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, medicinal residues behind all the other ten Herba indigoferae Pseudotinctoriae and the extraction volatile oil, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil filtered, filtrate simmer down to clear paste, put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, the simmer down to clear paste, with the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieve, obtain dried cream powder, get intermediate products dried cream powder and an amount of syrup mixing, granulate, packing gets finished product.

6, the Chinese medicine preparation of treatment prostatosis as claimed in claim 2 is characterized in that: capsular production method is as follows:

Get Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae ten Six-element Chinese medicines, earlier with Poria, the Rhizoma Dioscoreae crushing fine powder, mixing, sterilized 30 minutes for 110 ℃, other gets Formica fusca and is ground into into coarse powder, percolation according to fluid extract is made the solvent percolation with 6 times of amount 50-80% ethanol, collect percolate to colourless, get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, medicinal residues behind all the other ten Herba indigoferae Pseudotinctoriae and the extraction volatile oil, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate simmer down to clear paste is put coldly, and adding ethanol, to make medicinal liquid contain the alcohol amount be 60%, left standstill 16 hours, the leaching supernatant adds above-mentioned Formica fusca percolate, reclaims ethanol, the clear paste of simmer down to, with the clear paste drying, with above-mentioned medical material fine powder mixing, drying, be ground into fine powder, sieve, obtain dried cream powder, with the appropriate amount of auxiliary materials mixing, encapsulated, In Aluminium Foil Packing, packing gets the finished capsule product agent.

7, the Chinese medicine preparation of treatment prostatosis as claimed in claim 2 is characterized in that: the production method of slow releasing capsule is as follows:

Get Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae ten Six-element Chinese medicines, earlier with Poria, the Rhizoma Dioscoreae crushing fine powder, mixing, sterilized 30 minutes for 110 ℃, other gets Formica fusca and is ground into into coarse powder, percolation according to fluid extract is made the solvent percolation with 6 times of amount 50-80% ethanol, collect percolate to colourless, get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, medicinal residues behind all the other ten Herba indigoferae Pseudotinctoriae and the extraction volatile oil, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate simmer down to clear paste, put cold, it is 60% that adding ethanol makes medicinal liquid contain the alcohol amount, leaves standstill the leaching supernatant 16 hours, add above-mentioned Formica fusca percolate, reclaim ethanol, the clear paste of simmer down to is with the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, obtain dried cream powder, above-mentioned intermediate products dried cream powder is added binding agent make microcapsule,, add spermaceti or other blocker coating of 0.5-5% according to the total amount of intermediate products dried cream powder, make 2 respectively, 4,6,8 hours slow-release pills, every kind of piller is distinguished with different color and lusters, in the capsulae vacuus of packing into behind the mix homogeneously, is packaged into box or is hot pressed into aluminium-plastic panel and obtain product.

8, the Chinese medicine preparation of treatment prostatosis as claimed in claim 2 is characterized in that: the production method of soft capsule is as follows:

Get Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae ten Six-element Chinese medicines, earlier with Poria, the Rhizoma Dioscoreae crushing fine powder, mixing, sterilized 30 minutes for 110 ℃, other gets Formica fusca and is ground into into coarse powder, percolation according to fluid extract is made the solvent percolation with 6 times of amount 50-80% ethanol, collect percolate to colourless, get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, medicinal residues behind all the other ten Herba indigoferae Pseudotinctoriae and the extraction volatile oil, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate simmer down to clear paste, put cold, it is 60% that adding ethanol makes medicinal liquid contain the alcohol amount, leaves standstill the leaching supernatant 16 hours, add above-mentioned Formica fusca percolate, reclaim ethanol, the clear paste of simmer down to is with the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieves, obtain dried cream powder, get the intermediate products dried cream powder, vegetable oil, Cera Flava is by making suspended matter at 1: 1: 0.02, and with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the suspended matter fill is pressed into 1000 soft capsules, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir,, take out the soft capsule that gets product in dry below 25 ℃.

9, the Chinese medicine preparation of treatment prostatosis as claimed in claim 2 is characterized in that: the production method of drop pill is as follows:

Get Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae ten Six-element Chinese medicines, earlier with Poria, the Rhizoma Dioscoreae crushing fine powder, mixing, sterilized 30 minutes for 110 ℃, other gets Formica fusca and is ground into into coarse powder, percolation according to fluid extract is made the solvent percolation with 6 times of amount 50-80% ethanol, collect percolate to colourless, get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, medicinal residues behind all the other ten Herba indigoferae Pseudotinctoriae and the extraction volatile oil, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil, filter, filtrate simmer down to clear paste, put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, the clear paste of simmer down to, with the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieve, obtain dried cream powder,, get the intermediate products dried cream powder again and add the polyethylene glycol 6000 heating and melting, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃ of-15 ℃ of liquid paraffin, with the 50/component velocity system of dripping, drop pill gets product.

10, the Chinese medicine preparation of treatment prostatosis as claimed in claim 2 is characterized in that: the production method of soft extract is as follows:

Get Herba Galii Teneri, Herba Lespedezae Cuneatae, Rhizoma Dioscoreae Hypoglaucae , Herba Houttuyniae, Herba Taraxaci, Formica fusca, Fructus Akebiae, Semen Plantaginis, Poria, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Semen Astragali Complanati, Radix Rosae Laevigatae, Radix Polygalae, Radix Glycyrrhizae ten Six-element Chinese medicines, earlier with Poria, the Rhizoma Dioscoreae crushing fine powder, mixing, sterilized 30 minutes for 110 ℃, other gets Formica fusca and is ground into into coarse powder, percolation according to fluid extract is made the solvent percolation with 6 times of amount 50-80% ethanol, collect percolate to colourless, get Herba Houttuyniae and Fructus Alpiniae Oxyphyllae and extract volatile oil with the steam method of heating up in a steamer, medicinal residues behind all the other ten Herba indigoferae Pseudotinctoriae and the extraction volatile oil, decoct with water three times, each 2 hours, the residual liquid of collecting decoction and above-mentioned volatile matter distillation oil filtered, filtrate simmer down to clear paste, put coldly, add ethanol and make medicinal liquid contain the alcohol amount to be 60%, to leave standstill 16 hours, the leaching supernatant, add above-mentioned Formica fusca percolate, reclaim ethanol, the clear paste of simmer down to, with the clear paste drying, with above-mentioned medical material fine powder mixing, drying is ground into fine powder, sieve, obtain dried cream powder, get intermediate products dried cream powder and an amount of syrup and Mel mixing, sterilization, fill gets the finished product soft extract.