CN1290543C - Medicinal health protection product - Google Patents
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- CN1290543C CN1290543C CNB2004100069751A CN200410006975A CN1290543C CN 1290543 C CN1290543 C CN 1290543C CN B2004100069751 A CNB2004100069751 A CN B2004100069751A CN 200410006975 A CN200410006975 A CN 200410006975A CN 1290543 C CN1290543 C CN 1290543C
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Abstract
The present invention provides a composition of a medicinal health-care product, which is prepared from extract of matrimony vine which is matched with 8 requisite amino acids for human bodies (L-lysine hydrochlorine, L-leucine, L-methionine, L-valine, L-isoleucine, L-enylalanine, L-tryptophan, L-threonine). The pharmacodynamics tests prove that compare with the extract of matrimony vine with single taste or compound amino acids, the prepared preparation has cooperative effect on strengthening immunity and preventing chemical liver injuries (comprising tartaric acid essence hepatic injuries, medical hepatic injuries, fatty liver, etc.).
Description
Technical field:
The present invention relates to a kind of Medicines and Health Product, particularly the Medicines and Health Product compositions of forming by the aminoacid of the necessary exogenous absorption of the extract (comprising polysaccharide, alkaloid) of Chinese medicine Fructus Lycii and human body.
Background technology:
In recent years along with the variation of people's rhythm of life and the change of eating patterns, day by day increase because of the alcoholic liver injury due to long-term or the heavy drinking or eating patterns change the fatty liver crowd who causes, had a strong impact on people's the stablizing of healthy and family, society.Wine has pharmacological action widely to human body, and acute a large amount of drinking can cause nausea, vomiting, hypomnesis, absent minded, the impaired and emotional instability of fine movement ability, when serious even can cause respiratory paralysis and cause death.The diseases such as can causing mental disorder, immune damage, gastric injury, fatty liver, alcoholic hepatitis, liver cirrhosis of drinking for a long time, have rising that data shows esophageal carcinoma, onset of liver cancer rate as if also with drink relevant.
At fatty liver, the trend that the alcoholic liver sickness rate constantly rises, many medical institutions have strengthened the research of this respect, Chinese Medical Association's hepatology can just have been set up fatty liver and alcoholic liver disease group specially, and obtained certain achievement, determined the diagnostic criteria of alcoholic liver disease, just be described as the histological characteristic to alcoholic hepatitis: the obvious swelling of hepatocyte is the balloon sample and becomes, particularly the hepatocyte of lobule central authorities, sometimes visible huge mitochondrion etc. in the hepatocyte of ballooning degeneration, alcoholic liver disease has the evident characteristic that is different from other character hepatopathys in medical observation.Fatty liver, alcoholic liver are planted as sick, have caused the great attention of medical matters circle.
No matter be viral hepatitis or chemical liver injury, not because the infringement of virus directly causes liver cell lesion, but attack the hepatocyte of being invaded by virus by the human immune system, immune system is again by disappearing virus with virus in the antibody of human body generation.Therefore,, just can in time produce the antibody elimination virus, can reach rehabilitation by self reparation for ruinate hepatocyte if it is normal to have infected the human immune system of hepatitis B virus.And it is fairly obvious to the immune destruction of human body to drink, be the arch-criminal that many HBV carriers transfer chronic hepatitis to, more some people does not detect hepatitis virus clinically, but a large amount of secular drinking also make some people become alcoholic fatty liver, alcoholic fibrosis and ethanol hepatitis gravis patient.
Therefore, exploitation effectively alleviates or prevent alcoholic liver injury, the adjusting medicine of immunity of organism or the generally attention that health food is subjected to the national governments and the people.Aspect the research and development in this field, western countries are based on synthetic at present, and Asian countries then lays particular emphasis on the research and development of natural plants.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum, and sweet in the mouth, property are put down, and belong to medicine, eat homologous Chinese crude drug, have nourishing the liver and kidney, the function of replenishing vital essence to improve eyesight is used for the treatment of the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is not clear.Fructus Lycii mainly contains effective ingredient such as polysaccharide, aminoacid, trace element, has the important physical activity.Through the modern pharmacology evidence, wolfberry fruit extract has potentiation to nonspecific immunity, humoral immunization and cellular immune function, has the effect that protects the liver simultaneously.If can significantly strengthen the phagocytic activity of reticuloendothelial system to india ink; Lycium barbarum polysaccharide increases C
3B and Fc acceptor quantity and activity, and can weaken hydrocortisone acetate to C
3The inhibitory action of b and Fc receptor; Induce the BALDHC mice to produce the high IgE model of serum with AI (OH) 3, and carrying out immunity, oral labelling wolfberry fruit extract is given relatively with contrast simultaneously, the anti-DNPIgE level of serum obviously reduces (P＜0.01), points out it that IgE is done body and replys certain regulating action.Can also promote significantly simultaneously In vitro culture the 35th generation increased logarithmic phase the speed of growth of diploid cell; Lycium barbarum polysaccharide is to the T lymphocyte, and especially the immunity of thymus T cell mediated has selectivity potentiation.To the immunodeficient mouse evidence, wolfberry fruit extract can obviously improve its immune state, and it also can improve the immunity of normal mouse equally; Give immunosuppressant animal and use wolfberry fruit extract, can make T
HCell number obviously increases, and improves T
H/ Ts ratio significantly increases low IL-2 level, strengthens the expression that the T lymphocyte shows IL-2R.
In that being carried out test on immune function, 117 healthy elderlies (60-82 year) and 44 young and middle-aged normal persons show that the old people truly has cellular immune function to go down, after taking lycium barbarum polysaccharide, E-Flos Rosae Rugosae formation cell percentage, RBC number, LBT, serum lysozyme content (LZM), T cell absolute value obviously improve before all taking medicine, and wherein LBT and LZM content reach young and middle-aged level.Illustrate that lycium barbarum polysaccharide can increase the quantity of cell surface receptor, and the quantity by increasing the T cell and strengthen that it is active and immune system is produced regulating action, can be convinced according to old people's immunological function water and regulate its function with lycium barbarum polysaccharide.
Find through clinical observation, take four of lycium barbarum polysaccharide capsules every day and serve on bimestrial old man that have people's cholesterol and oily three fat more than 80 percent obviously to descend, after the medication, symptoms such as fatiguability, inappetence and blurred vision are obviously improved.The old man who takes for a long time, hair all no longer comes off, face also by wan and sallow become ruddy.
Wolfberry fruit extract has the effect that protects the liver simultaneously, and test shows, the reduction of phospholipid and total cholesterol level reduces blood AST activity in its liver due to can antagonism carbon tetrachloride, reduces the BSP retention.The Chinese science man is by a large amount of clinical trial certificates, and Chinese Chinese medicine material Fructus Lycii has promotion and adjusting immunologic function, protects the liver and defying age three big pharmacological actions.
Protein has diversified biological function in the human life activity, one of wherein important function is the immunization that influences body, catalytic action of enzyme or the like, so its importance in nutrition is subject to the people's attention widely.Different in kind and the range protein that varies all are to be made of by different groupizations 20 seed amino acids in the human body, in order to adapt to the synthetic needs of human body multiple proteins, human body must be obtained each seed amino acid from food, but before and after the fifties, people such as Rose have determined that 8 seed amino acids are that human body can not synthesize or synthetic speed far can not adapt to the body needs, and these aminoacid are referred to as must aminoacid.Be isoleucine, leucine, lysine, methionine, tryptophan, threonine, valine, phenylalanine.Must amino acid whose requirement WHO in human body and FAO also carried out concluding and determined.
Behind the human body feed protein, the protein in the food need change into each seed amino acid just can be absorbed by the body absorption of human body and utilization at human body.Each seed amino acid all has L-type and D-type, the utilization of people's physical ability mainly be L-aminoacid, various L-type aminoacid absorb in human body easily than its corresponding D type isomeric compound and utilize.
Different aminoacid is different in the intravital effect of people.Lysine is human body first essential amino acids, and it is synthetic kernel albumen, hemoglobin and promotes the regenerated important AA of brain nervous cell.The important carrier of body fat acid metabolic---carnitine is to form in lysine and the methionine metabolism.Lysine also participates in regulating the appetite metabolism of body, adds a small amount of aminoacid in meals, can improve old person's appetite, and the secretory volume of its pepsin and hydrochloric acid is obviously increased.Lysine can be supplied with the body rich nutrient contents, guarantees the synthetic of the interior key protein of body, promotes the growth promoter of body.Lysine also can strengthen the human body resistance against diseases, particularly to the resistance of upper respiratory tract infection, has been used for the auxiliary treatment of diseases such as malnutrition, chronic hepatitis clinically.
Isoleucine, leucine, three kinds of essential amino acids molecular structures of valine all have the aliphatic category of side chain, so be called branched-chain amino acid (BCAA).Their common Nutritions can reduce (1), and they account for 50% of food protein essential amino acids (EAA); (2) when saccharide, fatty energy matter lack or during dysbolismus, BCAA has regulating action to tissue protein is synthetic with decomposition, BCAA concentration in the blood, and (Phe, Tyr Trp) enter the effect of blood brain barrier can to regulate aromatic amino acid; (5) BCAA and corresponding keto acid thereof can be prevented treating the liver, renal failure etc.In addition, leucine stimulates the secretion of insulin function in addition.
Phenylalanine (Phe) belongs to aromatic amino acid, most of in vivo is tyrosine through the phenylalanine hydroxylase catalytic oxidation, and and synthetic together important neurotransmitter and the hormone of tyrosine, as epinephrine, norepinephrine, thyroxine, catecholamine etc., help the central nervous system to keep waking state, participate in the carbohydrate metabolism and the lipid metabolism of body.If phenylalanine hydroxylase deficiency in the body, then phenylalanine is oxidized to the reaction obstacle of tyrosine, can cause phenylketonuria, is modal amino acid metabolism defective.Thyroxine participates in energy metabolism, water-electrolyte metabolism and the bone metabolism of body, and its synthetic tyrosine that depends on, tyrosine derives from phenylalanine again, therefore, the shortage of phenylalanine in the meals, can influence the synthetic of the interior tyrosine of body, thereby cause the thyroid level to reduce, influence the metabolic activity of body.
Threonine (Thr) is the inhibition instrumentality of a kind of isozyme of aspartokinase, belongs to giving birth to the double ketogenic amino acid of sugar.In its molecular structure, contain hydroxyl, human body skin is had the water holding effect.Its hydroxyl in memebrane protein can combine with oligonucleotide chain, and the protection cell membrane is played an important role.
Tryptophan (Trp) is the neurotransmitter that body weight for humans is wanted---the precursor of 5-hydroxy tryptamine, and 5-hydroxy tryptamine is to guarantee the indispensable material of sleep.The free most loosely of tryptophan is combining with serum albumin in the blood, when serum albumin by blood plasma in free fatty acid in conjunction with after, non-binding type tryptophan could be included in by brain and synthetic 5-hydroxy tryptamine, thereby the synthetic ratio of 5-hydroxyl color ammonia in the content scalable brain of free tryptophan in the blood, thereby influence the brain metabolism.Tryptophan also is the precursor of synthetic nicotinic acid, when deficiency of tryptophan, can cause diseases such as pellagra.Increase the content of tryptophan in the meals, at first recover intravital nitrogen balance, next is used for recovering the blood pyridine nucleotide, excretes with the nicotinic acid metabolism at last.
Methionine (Mes) claim methionine again, and comprehensively choline and cholic acid in human body are again protein and the necessary aminoacid of some hormone (as insulin) in the synthetic epidermis.Methionine deficiency in the meals can influence the human body nitrogen balance, the human body choline is reduced and fatty liver easily takes place.Methionine and proteinic synthetic closely related, methionine deficiency can cause the protein synthesis obstacle.Methionine can increase the ratio of metabolic activity folic acid, promotes the metabolism of vitamin B to folic acid, prevents to produce diseases such as pernicious anemia.Methionine forms the S-ademetionine under ATP participates in, so methionine deficiency can influence again and needs the synthetic of material that the S-ademetionine supplies with such as epinephrine, choline, creatine etc.Cystine is the ingredient of the protein glutathion wanted of body weight for humans, and methionine can change cystine in vivo, and cystine also can change taurine into by the L-cysteine, thereby methionine also has certain influence to other non essential amino acid synthetic.Very special such as L-cysteine and L-third aminoacid, content is few especially in the general meals.The mediocrity takes and can promote the conversion of body internal protein effectively and be absorbed by the body and utilize, and especially often drinks or the people and the hepatopath of insobriety, and the specific crowd of this two class needs manyly especially to this amino acid.When a large amount of ethanol enters in the liver by blood circulation, liver just needs a large amount of L-half Guang aminoacid, L-alanine that ethanol is converted into harmless material, to alleviate the reaction of human body to ethanol, if there is not the supply of competent L-cysteine, L-alanine and various vitamin, liver just can be subjected to bigger infringement, the reparation of liver needs a large amount of aminoacid, as these aminoacid can not in time be provided, just hepatopathy has the probability of the hepatocarcinoma of changing into.Therefore, adopt to replenish method of compound amino-acid, the immunologic function of human body is regulated and alleviated ethanol has positive effect to the damage of liver, also can strengthen the health level of human body simultaneously.
Because special usefulness such as amino acid whose safe, efficient, nutrition, treatment, total flow every year of amino acid preparation, the product that adopts identical aminoacid and other functional factor to be combined into food supplement or health food went on the market with the speed cumulative year after year more than 20%.
But Chinese medicine health-care product and different types of aminoacid there is not report as yet in conjunction with making Medicines and Health Product.The present invention finds suitable amino acid ligand ratio through research; Add that wolfberry fruit extract can be used for the crowd at deficiency of the liver and kindey or body weakness.The aminoacids complex that wolfberry fruit extract and human body is necessary cooperates prescription, be used for the immunologic function adjusting and alleviate hepatic injury, has safe and effective effect, for people provide a kind of medical-care health food of new health, for immunologic hypofunction and the crowd that drinks for a long time provide a kind of new health food to select.
Summary of the invention:
The invention provides the Medicines and Health Product compositions of being made by eight kinds of exogenous aminoacid of wolfberry fruit extract and needed by human, said composition has the effect that prevents alcoholic liver injury, drug induced hepatic injury, chemical liver injury, fatty liver, adjusting immunity.
Compositions of the present invention is a kind of medicine, health food or food additive that treats and/or prevents alcoholic liver injury, drug induced hepatic injury, chemical liver injury, control fatty liver and enhancing immunity effect that have, and it is characterized in that being made through science screening proportioning by the aminoacid of the necessary exogenous absorption of wolfberry fruit extract (comprising polysaccharide, alkaloid) and human body.
Compositions of the present invention, its active component consists of:
Wolfberry fruit extract
The L-lysine hydrochloride
The L-leucine
The L-methionine
The L-valine
The L-isoleucine
The acid of L-phenylamino
The L-tryptophan
The L-threonine
Proportioning between each component is as follows:
The weight of wolfberry fruit extract is: 1 part
The weight of L-lysine hydrochloride is: 1-3 part
The leucic weight of L-is: 0.5-2 part
The weight of L-methionine is: 0.5-2 part
The weight of L-valine is: 0.3-1 part
The weight of L-isoleucine is: 0.3-1 part
The weight of L-phenylamino acid is: 0.4-1 part
The weight of L-tryptophan is: 0.4-1 part
The weight of L-threonine is: 0.2-1 part
Compositions of the present invention can be made for any dosage form that is fit to take, and preferably peroral dosage form also can be made into injection type.
Compositions of the present invention, wolfberry fruit extract wherein can obtain by following preparation technology:
The active component wolfberry fruit extract is the Chinese medicine Fructus Lycii, and water is carried through being selected from, alcohol extraction, water extract-alcohol precipitation, alcohol extracting-water precipitating step are made, water extract-alcohol precipitation wherein is that Fructus Lycii is through water extraction, the sedimentary step of alcohol, obtain precipitate, this precipitate is Fructus Lycii extract raw material of the present invention through filtration, drying, pulverizing, can pass through multiple extraction settling step in the concrete grammar, as following method:
Fructus Lycii adds water octuple amount and extracts three times, each 1 hour, filter lixiviating solution.Lixiviating solution is concentrated into proportion 1.12, adds 50% ethanol, precipitate 24 hours.Get supernatant recovery ethanol and be concentrated into proportion 1.25, added 85% ethanol precipitation again 24 hours, filter.Precipitate is dissolved in water to proportion 1.05, filters.Filtrate added 85% ethanol precipitation 24 hours, filtered.The precipitate vacuum drying is pulverized, and crosses 80 mesh sieves, gets Fructus Lycii extract.
Compositions of the present invention, aminoacid wherein are known products, buy the flourish aminoacid company limited from Ji, Chinese Jinzhou, and quality standard meets AJI97 USP24 FCCIV, Chinese Pharmacopoeia version in 2000.
Compositions of the present invention can be the dosage form of unit dose, according to the needs of preparation, wherein can add medicine or health product acceptable carrier.The ratio of carrier can account for the 0.1-99.9% of composition weight ratio according to the needs of preparation, and all the other are active component, and the amount of active component can be 20-400mg in the preparation of unit dose, and all the other are the medicine acceptable carrier.In the active component of 20-400mg, the ratio of each component is the ratio of the proportioning of above-mentioned each component.
Preparation of compositions method of the present invention can be the preparation method of the Medicines and Health Product pharmaceutical preparation of routine, as with raw material and adjuvant mix homogeneously, makes the different dosage forms that is fit to take according to the galenic pharmacy routine techniques.
Compositions of the present invention can be made any dosage form that is fit to take, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, syrup, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch, slow releasing preparation, controlled release preparation.Peroral dosage form preferably.
Composite preparation of the present invention, the preparation of its oral administration such as tablet and capsule are generally a kind of unit dose, and contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent.For tablet, also can carry out coating to tablet.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active component is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains raw material of the present invention and sterile carrier.According to carrier and concentration, this chemical compound can be suspended or dissolving.The preparation of solution is normally passed through material dissolution in a kind of carrier, filter-sterilized before it is packed into a kind of suitable bottle or ampoule, sealing then.For example a kind of local anesthetic of adjuvant, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
Prepare the parenteral suspension with essentially identical mode,, and before it is suspended in sterile carrier, it is carried out disinfection with oxirane except being is suspended in carrier with reactive compound rather than with its dissolving.Surfactant or wetting agent can be included in this compositions, are beneficial to the uniform distribution of this reactive compound.
Preparation of the present invention, when being prepared into medicament, optionally add suitable medicine or health product acceptable carrier, described carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention is determined usage and dosage according to patient's situation in use, but obeys 1-3 time every day, each 1-20 agent, as: 1-20 pin or grain or sheet.
Below by pharmacology test beneficial effect of the present invention is described:
Negative control group is normal letting animals feed, and test control group 1 is 8 seed amino acid groups, and test control group 2 is the Lycium barbarum polysaccharide extract group, and test group is Lycium barbarum polysaccharide extract+8 seed amino acid groups.
Table 1: to the result of rat histopathologic examination (X ± s)
| Group (mg/kg.bw) | Number of animals (only) | The fat stains scoring |
| Negative control group 50% ethanol group test control group 1 test control group 2 test group | 12 12 12 12 12 | 0.00±0.00 2.95±1.12^ 2.25±1.25 1.98±1.06* 1.21±0.87** |
^ represents that blank group and matched group compare P＜0.05; * expression is compared P＜0.05 with 50% ethanol group
Blank group contrast hepatocyte does not observe the hepatocyte of stained positive, and the dyeing of model group hepatocyte is positive; Tried thing and respectively organize the hepatic cell fattydegeneration integration and be lower than model group, wherein the most remarkable with test group difference.
Table 2: to rat MDA, GSH, TG assay
| Group (mg/kg.bw) | Number of animals (only) | MDA nmol/g | GSH umol/g | TG mmol/g |
| Negative control group 50% ethanol group test control group 1 test control group 2 test group | 12 12 12 12 12 | 0.71±0.20 1.25±0.39^ 0.55±0.08 0.52±0.05* 0.31±0.03** | 1.08±0.34 0.69±0.22 1.01±0.31 1.21±0.64 1.37±0.47 | 0.69±0.33 1.74±1.10 1.65±0.68 1.62±0.27 1.79±0.51 |
Table 3: to mice half hemolysis value (HC
50) influence
| Group (mg/kg.bw) | Number of animals (only) | Sample HC 50 | The P value |
| Negative control group test control group 1 test control group 2 test group | 10 10 10 10 | 172.58±48.68 192.05±56.25 239.08±56.36* 287.21±61.87** | ＜0.05 ＜0.01 |
Test group is apparently higher than the HC of matched group
50Value has significant difference.
Table 4: the influence of Turnover of Mouse Peritoneal Macrophages being engulfed the chicken red blood cell ability
| Group (mg/kg.bw) | Number of animals (only) | Phagocytic rate % | The P value | Phagocytic index | P |
| Negative control group test control group 1 | 10 10 | 42.90±11.38 49.30±7.39 | 0.77±0.32 0.87±0.36 |
| Test control group 2 test group | 10 10 | 58.60±6.06* 76.21±8.17** | ＜0.05 ＜0.01 | 1.11±0.39 1.29±0.41 | ＜0.05 ＜0.01 |
Table 5: to the active influence of NK cells in mice
| Group (mg/kg.bw) | Number of animals (only) | The NK cytoactive | The P value |
| Negative control group test control group 1 test control group 2 test group | 10 10 10 10 | 27.11±6.45 26.59±8.25 31.82±9.61 47.27±10.88** | ＜0.01 |
Behind the continuous irrigation stomach 30 days, the mice half hemolysis value that can obviously raise obviously strengthens the huge ability of biting chicken red blood cell of mouse peritoneal, and antagonist cellulation number also is improved to some extent, and can increase the NK cell activity.This shows that this prescription has enhanced function to animal immunizing power.
The invention has the advantages that curative effect is outstanding, few side effects, prescription is reasonable, and technology is simple, and taking convenience is widely applicable, and the chief is respectively got in the Chinese medicine and western medicine combination, cooperatively interacts, and complements each other, and has played harmonious effect.
The specific embodiment:
Embodiment 1
Capsules preparation technique:
L-lysine hydrochloride 37.5g
L-leucine 27g
L-methionine 27g
L-valine 10g
L-isoleucine 9g
L-phenylalanine 7.5g
L-tryptophan 7.5g
L-threonine 6g
Fructus Lycii extract 25g
Starch 60g
Make 1000 altogether
Operation: eight seed amino acids are crossed 80 mesh sieves respectively, starch and Fructus Lycii extract mix homogeneously, again with eight seed amino acid mix homogeneously, filled capsules, quality inspection, packing, promptly.
Embodiment 2
Tablet producing technology:
L-lysine hydrochloride 37.5g
L-leucine 27g
L-methionine 27g
L-valine 10g
L-isoleucine 9g
L-phenylalanine 7.5g
L-tryptophan 7.5g
L-threonine 6g
Fructus Lycii extract 25g
Starch 70g
Lactose 100g
Cross-linked pvp 20g
Fruit essence is an amount of
Low replacement HPMC solution is an amount of
Magnesium stearate 2g
Make 1000 altogether
Operation: eight seed amino acids are crossed 80 mesh sieves respectively, and starch, lactose and Fructus Lycii extract mix homogeneously are again with eight seed amino acid mix homogeneously, add cross-linked pvp, fruit essence is behind the mix homogeneously, with the low HPMC solution system soft material that replaces, 20 mesh sieves are granulated, 80 ℃ of oven dry, granulate, add the magnesium stearate mix homogeneously, tabletting, quality inspection, packing, promptly.
Claims (6)
1. Medicines and Health Product compositions is made up of active component and medicine or health product acceptable carrier, it is characterized in that the consisting of of its active component:
The weight of wolfberry fruit extract is: 1 part
The weight of L-lysine hydrochloride is: 1-3 part
The leucic weight of L-is: 0.5-2 part
The weight of L-methionine is: 0.5-2 part
The weight of L-valine is: 0.3-1 part
The weight of L-isoleucine is: 0.3-1 part
The weight of L-phenylalanine is: 0.4-1 part
The weight of L-tryptophan is: 0.4-1 part
The weight of L-threonine is: 0.2-1 part.
2. the compositions of claim 1 is any dosage form that is fit to take.
3. the compositions of claim 2 is peroral dosage form or injection type.
4. the compositions of claim 3 is tablet, capsule, oral liquid, syrup, granule, pill, powder, sublimed preparation or suspensoid.
5. the compositions of claim 1, its active component of the preparation of per 1000 unit dose is made with the component of following amount: L-lysine hydrochloride 37.5g
L-leucine 27g
L-methionine 27g
L-valine 10g
L-isoleucine 9g
L-phenylalanine 7.5g
L-tryptophan 7.5g
L-threonine 6g
Fructus Lycii extract 25g.
6. any one compositions of claim 1-5 treats and/or prevents application in the health product of alcoholic liver injury, drug induced hepatic injury, chemical liver injury or fatty liver in preparation, or treats and/or prevents application in the food additive of alcoholic liver injury, drug induced hepatic injury, chemical liver injury or fatty liver in preparation.
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| CNB2004100069751A CN1290543C (en) | 2004-03-03 | 2004-03-03 | Medicinal health protection product |
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| CNB2004100069751A CN1290543C (en) | 2004-03-03 | 2004-03-03 | Medicinal health protection product |
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| CN1290543C true CN1290543C (en) | 2006-12-20 |
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| WO2007049818A1 (en) * | 2005-10-27 | 2007-05-03 | Ajinomoto Co., Inc. | Anti-fatty liver, anti-obesity or hypolipidemic composition |
| CN101416746B (en) * | 2008-11-21 | 2012-03-07 | 株洲市湘东氨基酸有限公司 | Composite amino acid capsule and preparation method thereof |
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