CN1290514C - Safety effective pulp devitalizer - Google Patents
Safety effective pulp devitalizer Download PDFInfo
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- CN1290514C CN1290514C CN 200410022056 CN200410022056A CN1290514C CN 1290514 C CN1290514 C CN 1290514C CN 200410022056 CN200410022056 CN 200410022056 CN 200410022056 A CN200410022056 A CN 200410022056A CN 1290514 C CN1290514 C CN 1290514C
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Abstract
The present invention relates to a pulp devitalizer of an oral cavity material and a preparation method thereof. The pulp devitalizer is composed of a pulp devitalization medicine, a local anaesthesia medicine, excipient, a penetrating agent, a colorant and a forming agent, wherein both the devitalization medicine and the local anaesthesia analgesic medicine do not adopt the national special control poisons and anaesthetic: cocaine and arsenic trioxide. Thus, the raw materials of the medicine are sufficient, and the market demand can be satisfied. The formula medicines in the present invention have the advantages of high stability, convenient storage, strong penetrating power, good diffusibility, apparent and quick odgnolysis, and small toxic side effect. No one allergic reaction occurs in the clinical observation for four years, the teeth are not polluted, and the cost is only one-one hundred thirty-fourth of the prior art. The present invention can be widely suitable for odontopathy patients of adults and children.
Description
Technical field the present invention relates to oral cavity material and preparation method thereof, oral cavity material that particularly uses in devitalization of dental pulp and preparation method thereof.
Background technology discloses a kind of " safety pulp devitalizer " in CN1225818A, what its prescription used is paraformaldehyde, cocaine hydrochloride, azone, lanoline and Gentian Violet.The employed cocaine hydrochloride of this deactivator has recessive, dependency, belongs to the narcotics of national special control, only limits the regimental above state-run national hospital in county to declare, and examines strictness, special messenger, special counter management.Because the particularity of cocaine hydrochloride, the medicine source is subjected to great restriction to exploitation, the production of deactivator, and the market demand can not get solving, and numerous odontopathy patients particularly child can not get safe and effective treatment for a long time.Secondly, the cocaine hydrochloride toxic and side effects is big, and it is safe in utilization to influence the patient; Its stability of drug is poor, easily decompose, reduced curative effect, and because stability of drug is poor, period of storage is short, cost is high.Another composition of the prescription of patent application is an azone, its permeability a little less than, be unfavorable for the infiltration of analgesic drug product and inactivation medicine.The coloring agent Gentian Violet consumption that uses in the prescription is grasped and is not with great difficulty made tooth, the dyeing of neck portion, influences patient's beautiful teeth.
In other deactivator prescription of prior art as: " clinical efficacy of paraformaldehyde deactivator " (" tooth body dental pulp periodontal magazine " 2000:10 (2)) report uses procaine hydrochloride to make the narcotic analgesic medicine.Because use procaine people hypersensitive more, therefore, medication is dangerous.It is a kind of local anesthetic, and penetrance is weak, produce effects is slow, anesthetic potency is weak, the weak point of holding time.The inventor also once studied the multiple narcotic analgesic medicine that comprises procaine as tetracaine hydrochloride, bupivacaine hydrochloride etc., and weak points such as the pain relieving produce effects is slow, toxic side effect is strong are all arranged, and can't be applied on the devitalization of dental pulp material.Therefore, the direction that the long-term analgesic cocaine hydrochloride of seeking in the replacement deactivator has become stomatological medical pharmacist, doctor to make joint efforts, but still do not have breakthrough so far.
At present, employed pulp devitalizer also has the arsenic trioxide deactivator on clinical oral, and its arsenic trioxide also is national special control poison.The shortcoming that in inactivation, has or not self limiting and jumping characteristic inactivation, destructive extremely strong, very strong neurotoxin, blood vessel toxin and corrosivity are arranged, the adjustment of excipient can not be eliminated toxicity at all, use is absolutely unsafe, because its toxin and deactivation are very strong, generally seal the medicine time at 24-48 hour, particularly unsuitable for children uses.
Summary of the invention the present invention provides a kind of safe and efficient pulp devitalizer in order to overcome above-mentioned weak point of the prior art just, do not adopt the such country of cocaine and arsenic trioxide one class control poison and anesthetics, good stability, be beneficial to storage, penetrating power is strong, diffusibility good, the pain relieving produce effects is quick, the pulp devitalizer that toxic and side effects is less, cost is low.
Prescription of the present invention is: be made up of devitalization of dental pulp medicine 7%～60%, local anesthetic 5%～55%, excipient 1%～15%, penetrating agent 1%～15%, coloring agent 1%～7%, forming agent 4%～35%, wherein, (1) the devitalization of dental pulp medicine has: paraformaldehyde, (2) local anesthetic has: lidocaine hydrochloride, dyclonine hydrochloride, (3) excipient has: acid-washed asbestos, sodium carboxymethyl cellulose, (4) penetrating agent has: laurocapram, the tall and erect ketone of nitrogen, dimethyl sulfoxine, (5) forming agent has: lanoline, (6) coloring agent has: algae is red, pinkish red.Above-mentioned each class can be used wherein a kind of.
Preparation method of the present invention is: excipient, (1) use pulverizer to break into fine powder, cross 80 mesh sieves, and be standby; (2) the devitalization of dental pulp medicine breaks into fine powder with pulverizer, crosses 80 mesh sieves, and is standby; (3) to be made into 10% solution with distilled water painted, standby for coloring agent; (4) carry out following preparation by formula ratio in the prescription, taking by weighing local anesthetic puts into mortar and grinds fine powder is disperseed, after adding the penetrating agent grinding, with " equivalent rise progressively dilution method " excipient, devitalization of dental pulp medicine, coloring agent are mixed, gradation adds in the mortar with local anesthetic, penetrating agent mixed grinding even, adds forming agent again, grinds and makes its molding, can be made into the olive shape of every 2g weight, cylindrical, bar shaped, circle, keep in Dark Place.
Good effect the present invention compared with prior art has following advantage:
1. inactivation medicine and narcotic analgesic medicine all do not adopt national special control poison, anesthetics, and therefore, the medicine material abundance can be met the need of market.Because the formulation of drug good stability is beneficial to storage, the time can preserve 3 years.
2. use lignocaine in the prescription or the dyclonine permeability is strong, diffusibility strong, the pain relieving produce effects is quick, toxic and side effects is less, and one routine anaphylaxis does not take place in clinical observation in 4 years.Anesthetic potency is 2 times of procaine, holds time than long 2 times of procaine.It is the optimum selection of deactivator analgesic.
3. use the osmosis of laurocapram stronger five times than the tall and erect ketone of nitrogen, use dimethyl sulfoxine, have antiinflammatory, pain relieving, the osmosis of lignocaine or dyclonine has been strengthened in the effect that permeability is strong, makes the analgesic effect of medicine very good.
4. painted being convenient to and the mummification agent difference is beneficial to doctor's operation, but uses the red or pinkish red distinct color of algae not make tooth staining again, is better than coloring agent of the prior art, avoids tooth dyeing is influenced beautiful teeth.
Cost low, only be to contain 1/134th of cocaine deactivator, the financial burden that alleviates extensive patients greatly.
6. product can be made into olive shape, is better than the deactivator of not molding, is convenient to doctor's operation and grasps consumption, helps again storing, and keeps drug effect.
Specific embodiment the present invention below with reference to embodiment with being described in further detail:
1. 1 kinds of safe and efficient pulp devitalizers of embodiment, paraformaldehyde 60g, lidocaine hydrochloride 5g, acid-washed asbestos, 15g, laurocapram 15g, the red 1ml of algae, lanoline 4g form.Its preparation process is as follows: with acid-washed asbestos, uses pulverizer to break into fine powder, crosses 80 mesh sieves, and standby; Paraformaldehyde breaks into fine powder with pulverizer, crosses 80 mesh sieves, and is standby; Algae is red, and to be made into 10% solution with distilled water painted, standby; Carry out following preparation by formula ratio in the prescription, the lidocaine hydrochloride that takes by weighing is put into the mortar grinding disperses fine powder, add laurocapram, after with " equivalent rise progressively dilution method " the red liquid of acid-washed asbestos, paraformaldehyde and algae being mixed, gradation adds in the mortar with lidocaine hydrochloride, laurocapram mixed grinding even, the color even unanimity.Add lanoline again, grind and make its molding, can be made into the olive shape of every 2g weight, keep in Dark Place.
2. 1 kinds of safe and efficient pulp devitalizers of embodiment, paraformaldehyde 7g, lidocaine hydrochloride 55g, acid-washed asbestos 8g, the tall and erect ketone 8g of nitrogen, pinkish red 7ml, lanoline 15g form.Its preparation process is as follows: with acid-washed asbestos, uses pulverizer to break into fine powder, crosses 80 mesh sieves, and standby; Paraformaldehyde breaks into fine powder with pulverizer, crosses 80 mesh sieves, and is standby; It is pinkish red that to be made into 10% solution with distilled water painted, standby; Carry out following preparation by formula ratio in the prescription, the lidocaine hydrochloride that takes by weighing is put into the mortar grinding disperses fine powder, add the tall and erect ketone of nitrogen, with " equivalent rise progressively dilution method " with acid-washed asbestos, paraformaldehyde and pinkish red liquid mix the back gradation add in the mortar with lidocaine hydrochloride, the tall and erect ketone mixed grinding of nitrogen even, the color even unanimity.Add lanoline again, grind and make its molding, can be made into the bar shaped of every 2g weight, keep in Dark Place.
3. 1 kinds of safe and efficient pulp devitalizers of embodiment, paraformaldehyde 36g, dyclonine 20g, sodium carboxymethyl cellulose 2g, dimethyl sulfoxine 6g, pinkish red 1ml, lanoline 35g form.Its preparation process is as follows: paraformaldehyde breaks into fine powder with pulverizer, crosses 80 mesh sieves, and is standby; It is pinkish red that to be made into 10% solution with distilled water painted, standby; Carry out following preparation by formula ratio in the prescription, the dyclonine that takes by weighing is put into the mortar grinding disperses fine powder, add dimethyl sulfoxine, with " equivalent rise progressively dilution method " with sodium carboxymethyl cellulose, paraformaldehyde and pinkish red liquid mix the back gradation add in the mortar with dyclonine, dimethyl sulfoxine mixed grinding even, the color even unanimity.Add lanoline again, grind and make its molding, can be made into the cylindrical of every 2g weight, keep in Dark Place.
4. 1 kinds of safe and efficient pulp devitalizers of embodiment, paraformaldehyde 48g, dyclonine hydrochloride 24g, acid-washed asbestos 4.6g, laurocapram 2.4g, the red 1ml of algae, lanoline 20g form.Its preparation process is as follows: with acid-washed asbestos, uses pulverizer to break into fine powder, crosses 80 mesh sieves, and standby; Paraformaldehyde breaks into fine powder with pulverizer, crosses 80 mesh sieves, and is standby; Algae is red, and to be made into 10% solution with distilled water painted, standby; Carry out following preparation by formula ratio in the prescription, the dyclonine hydrochloride that takes by weighing is put into the mortar grinding disperses fine powder, add laurocapram, with " equivalent rise progressively dilution method " with the red liquid of acid-washed asbestos, paraformaldehyde and algae mix the back gradation add in the mortar with dyclonine hydrochloride, laurocapram mixed grinding even, the color even unanimity.Add lanoline again, grind and make its molding, can be made into the olive shape of every 2g weight, keep in Dark Place.
5. 1 kinds of safe and efficient pulp devitalizers of embodiment, paraformaldehyde 34g, lidocaine hydrochloride 34g, acid-washed asbestos 7g, laurocapram 4g, the red 1ml of algae, lanoline 20g form.Its preparation process is as follows: acid-washed asbestos just, and use pulverizer to break into fine powder, cross 80 mesh sieves, standby; Paraformaldehyde breaks into fine powder with pulverizer, crosses 80 mesh sieves, and is standby; Algae is red, and to be made into 10% solution with distilled water painted, standby; Carry out following preparation by formula ratio in the prescription, the lidocaine hydrochloride that takes by weighing is put into the mortar grinding disperses fine powder, add laurocapram, with " equivalent rise progressively dilution method " with the red liquid of acid-washed asbestos, paraformaldehyde and algae mix the back gradation add in the mortar with lidocaine hydrochloride, laurocapram mixed grinding even, the color even unanimity.Add lanoline again, grind and make its molding, can be made into the circle of every 2g weight, keep in Dark Place.
Claims (2)
1. safe and efficient pulp devitalizer, its prescription is characterised in that: be made up of devitalization of dental pulp medicine 7%～60%, local anesthetic 5%～55%, excipient 1%～15%, penetrating agent 1%～15%, coloring agent 1%～7%, forming agent 4%～35%
1.1 the devitalization of dental pulp medicine has: paraformaldehyde;
1.2 local anesthetic has: lidocaine hydrochloride, dyclonine hydrochloride;
1.3 excipient has: acid-washed asbestos, sodium carboxymethyl cellulose;
1.4 penetrating agent has: laurocapram, dimethyl sulfoxine;
1.5 forming agent has: lanoline;
1.6 coloring agent has: algae is red, pinkish red;
In when prescription, above-mentioned each class can be used wherein a kind of.
2. method for preparing the safe and efficient pulp devitalizer of claim 1, its preparation process is characterised in that:
2.1 excipient uses pulverizer to break into fine powder, crosses 80 mesh sieves, and is standby;
2.2 the devitalization of dental pulp medicine breaks into fine powder with pulverizer, crosses 80 mesh sieves, and is standby;
2.3 it is painted, standby that coloring agent is made into 10% solution with distilled water;
2.4 carry out following preparation by formula ratio in the prescription, taking by weighing local anesthetic puts into mortar and grinds fine powder is disperseed, after adding the penetrating agent grinding, after with " equivalent rise progressively dilution method " excipient, devitalization of dental pulp medicine and coloring agent being mixed, gradation adds in the mortar even with anaesthetic and penetrating agent mixed grinding, the color even unanimity.Add forming agent again, grind and to make its molding, can be made into the olive shape of every 2g weight, cylindrical, bar shaped, circle, keep in Dark Place.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410022056 CN1290514C (en) | 2004-03-19 | 2004-03-19 | Safety effective pulp devitalizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410022056 CN1290514C (en) | 2004-03-19 | 2004-03-19 | Safety effective pulp devitalizer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1562074A CN1562074A (en) | 2005-01-12 |
| CN1290514C true CN1290514C (en) | 2006-12-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410022056 Expired - Fee Related CN1290514C (en) | 2004-03-19 | 2004-03-19 | Safety effective pulp devitalizer |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764303A (en) * | 2011-05-05 | 2012-11-07 | 朗力生物医药(武汉)有限公司 | Preparation for safe and efficient arsenic-free pulp devitalizer and application thereof |
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- 2004-03-19 CN CN 200410022056 patent/CN1290514C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1562074A (en) | 2005-01-12 |
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