CN1289068C - Solid formulation containing isomaltone itol, its preparation method and uses - Google Patents
Solid formulation containing isomaltone itol, its preparation method and uses Download PDFInfo
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- CN1289068C CN1289068C CN 200310121638 CN200310121638A CN1289068C CN 1289068 C CN1289068 C CN 1289068C CN 200310121638 CN200310121638 CN 200310121638 CN 200310121638 A CN200310121638 A CN 200310121638A CN 1289068 C CN1289068 C CN 1289068C
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Abstract
The present invention relates to a solid preparation, a preparation method thereof and an application thereof, and the solid preparation is formed by adding traditional Chinese medicine and natural plant extraction ingredients into isomalt as a main raw material. The isomalt has the advantages of mildly sweet taste, good fragrance transfer, low heat, no caries generation and low moisture absorption, and the traditional Chinese medicine and the natural plant solid preparation made from the isomalt has the advantages of good forming, high hardness, tasting slipperiness, purely sweet taste, good mouth feel, good surface lightness and low moisture absorption. A final product has outstanding storage stability. The present invention also discovers the preparation method, and in the preparation method, no coking phenomenon is generated when the traditional Chinese medicine and plant extracts are added into syrup. A forming process can be carried out without coking phenomenon under high temperature, and the forming process under the high temperature is good for rapidly removing water content by baking and rapidly forming. The present invention enhances work efficiency, and agricultural industrialization can be conveniently carried out.
Description
Technical field
The present invention relates to a kind of is primary raw material with the hydroxyl isomaltulose, adds Chinese medicine, extracted form natural plant composition, the solid preparation that adopts the pouring type molding with and preparation method thereof.
Background technology
Application about hydroxyl isomaltulose, great majority are applied to food service industry, for example be used for the manufacturing of refrigerant sugar, but seldom adopt casting production, medicine trade also seldom has company's application, only several companies, BASF AG's patent CN1198094A for example, be to adopt extrusion forming technology, the Radix Glycyrrhizae benefit larynx throat of Johson ﹠ Johnson is to adopt stamping technology, no matter be extruding, punching press, sugared surface is all coarse, poor, the appearance poor of brightness, its outward appearance is not attractive in appearance when entering commercial field, will have a strong impact on image product, class and sale.
Summary of the invention
The purpose of this invention is to provide a kind of is primary raw material with the hydroxyl isomaltulose, adds Chinese medicine, natural plant extraction composition, adopts the solid preparation of pouring type molding, and the present invention also provides its preparation method simultaneously.
Technical scheme of the present invention is:
A kind of solid dosage forms that contains hydroxyl isomaltulose is added Chinese medicine or extracted form natural plant composition, gets by moulding by casting.
The solid dosage forms that contains hydroxyl isomaltulose is added Chinese medicine or extracted form natural plant composition, gets Chinese medicinal ingredients 0.2-30 part, hydroxyl isomaltulose composition 70-99.8 part by moulding by casting.
The solid dosage forms that contains hydroxyl isomaltulose comprises parts by weight: Chinese medicinal ingredients 0.2-14 part, hydroxyl isomaltulose composition 86-99.8 part.
The solid dosage forms that contains hydroxyl isomaltulose comprises parts by weight: Chinese medicinal ingredients 1-10 part, hydroxyl isomaltulose composition 90-99 part.
The solid dosage forms that contains hydroxyl isomaltulose also contains adjuvant, and wherein adjuvant and parts by weight are:
(A) saccharide: 5-20 part
(B) wetting agent: 0.2-5 part
(C) sweeting agent: 0.02-0.3 part.
The solid dosage forms that contains hydroxyl isomaltulose also contains adjuvant, and wherein adjuvant and parts by weight are:
(A) saccharide: in xylitol, the sorbitol one or both, umber: 5-20 part
(B) wetting agent: in maltose alcohol, the hydroxyl isomaltulose one or both, umber 0.2-5 part
(C) sweeting agent: in steviol glycosides, the sodium cyclamate one or both, umber: 0.02-0.3 part.
The solid dosage forms that contains hydroxyl isomaltulose also is added with 3/1000000ths to 15/1000000ths parts penetrating agent.For example Moschus class penetrating agent has the function that strengthens herbal medicine efficacy.
The preparation method that contains the solid dosage forms of hydroxyl isomaltulose follows these steps to make: (1) raw material of Chinese medicine extracting method routinely obtains Chinese medicine extract (A); (2) hydroxyl isomaltulose obtains hydroxyl isomaltulose syrup (B) through conventional technology heat fused; (3) with (A) and (B) filter cleaner, behind the filtrate mix homogeneously of gained, boil, boiling temperature is 140 ℃-200 ℃.
Preferred manufacturing procedure has following:
Under vacuum condition, boil vacuum pressure 4-8 kilogram.
Boil the evaporation of time control controlling the water circulation part, make water content in the final products be controlled at the 0.2-1.2% of product gross weight.
Follow these steps to make: (1) raw material of Chinese medicine extracting method routinely obtains Chinese medicine extract (A2); (2) isomaltulose mixes after the common process heat fused obtains isomaltulose syrup (B2) with adjuvants such as saccharide, humectant, sweeting agents; (3) with (A2) and (B2) filter cleaner, behind the filtrate mix homogeneously of gained, boil, boiling temperature is 140 ℃-200 ℃.
Boiling temperature is 150 ℃-170 ℃.
Some concrete solid dosage formss have:
Contain the solid dosage forms that the Chinese medicine component is specially Fructus Crataegi 9-15 part, Fructus Hordei Germinatus 6-12 part, Fructus Aurantii Immaturus 6-9 part, Rhizoma Dioscoreae 9-15 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to promote the production of body fluid appetizing, help digestion.
Contain the solid dosage forms that the Chinese medicine component is specially Semen Raphani 9-12 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to blood pressure lowering.
The solid dosage forms that contains edible calcium carbonate 2-10 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to replenish the calcium.
Contain the solid dosage forms that the Chinese medicine component is specially 9 parts in Radix Glycyrrhizae, 9 parts in Semen Armeniacae Amarum, 12 parts of Radix Platycodoniss and 70-99.8 part hydroxyl isomaltulose.Can be applicable to cough-relieving, the treatment pharyngolaryngitis.
Containing the Chinese medicine component is FRUCTUS TERMINALIAE IMMATURUS 5-15 part, the solid dosage forms of Fructus Momordicae 3-12 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to treat laryngopharynx swelling and pain, hoarseness, pharyngolaryngitis.
Containing the Chinese medicine component is Radix Glycyrrhizae fluidextract 0.1-0.8 part, Fructus Momordicae 3-10 part, the solid dosage forms of Fructus Canarii 3-12 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to cleaning throat and moistening larynx and separate the pharynx poison.
With above-mentioned all solid dosage formss, be applied to health food.
Principle and advantage of the present invention is embodied in:
Chinese medicine and natural plant extracts are combined with hydroxyl isomaltulose, be made into the dosage form of the solid sugar that is difficult for the moisture absorption attractive in appearance, given Chinese Chinese medicine new product form, the hydroxyl isomaltulose dosage form forming of Chinese medicine and natural plants, after adding flavoring agent good mouthfeel is arranged, make Chinese medicine occur, have good commercial to be worth with the health food form of mouthfeel of becoming reconciled attractive in appearance.
The present invention has found simultaneously and has solved that Chinese medicine, plant extract join in the syrup and the preparation method of noncoking makes with the dextrinose keto-alcohol to be the dosage form of raw material, can make natural plants, Chinese medicine class health and therapeutic type health product.
Along with the raising of social life level, sugar-free raw material low in calories, not dental caries is liked by consumer day by day.Hydroxyl isomaltulose has gentle sweet taste, good fragrance transmission, cariogenicity low in calories, non-, agent of low hygroscopicity, the solid preparation forming of making, hardness height, inlet is smooth, sweet taste is pure, mouthfeel good, in addition-individual key property is that chemical property is stable, heatproof, High Temperature High Pressure is removed moisture content in vacuum sugar boiling, raw material keeps primary characteristic, make that the caked sugar water content is few, surface brightness is good, and hygroscopicity is low.Can give the storage stability of final products excellence, below 85%, water absorption is very low in 40 ℃ of temperature, temperature, and the hard sugar that the sucrose glucose is done surfaces of tacky with this understanding.
Casting sugar surface is bright and clean, smooth, outward appearance is good, and the difficult point of casting technology is the moisture content of control finished product.Make sugared surface slowly form protective layer, and prevent that Chinese medicine and plant extract from occurring burning, darkening in high temperature sugar cook process.
Maltulose alcohol is compared with other sugar and is fit to be applied to moulding by casting usefulness.Even hydroxyl isomaltulose is in very high temperature, as 150-200 ℃, as control other conditions well, can be not burned, and table sugar such as sucrose are not suitable at the hot conditions compacted under in just coking below 140 ℃.Select hydroxyl isomaltulose, can carry out molding under higher temperature and not burned, the higher temperature compacted under helps drying by the fire fast anhydrate part and rapid shaping, increases work efficiency, and is convenient to industrialization.
Hydroxyl isomaltulose content is more than or equal to 70%, is in order to keep the characteristic of hydroxyl isomaltulose, and takes all factors into consideration the mouthfeel, cost, product stability of product in process of production and add other filler, sweeting agent.
Chinese medicinal ingredients 0.2-14 part, hydroxyl isomaltulose composition 86-99.8 part.Or Chinese medicinal ingredients 1-10 part, isomaltulose composition 90-99 part.Further given prominence to the characteristic of hydroxyl isomaltulose, compared with Chinese medicine extract, the hydroxyl isomaltulose price is low, has reduced the cost of product.
Select xylitol can improve the intestine moistening function, select sorbitol to reduce cost.
And the content of raising hydroxyl isomaltulose also can reduce the final products hygroscopicity, helps improving the storage life of product.When content reaches 96%, product is difficult for sticking together, and does not need to adopt independent packaging, and the hard sugar that sucrose, glucose are made then need adopt the candy paper packing, prevents to stick together.
Add stevioside or sodium cyclamate etc. and can correct the bitterness of Chinese medicine.
Wetting agent mainly is to make the inside and outside moisture content of solid dosage forms reach poised state, prevents that water absorbent surface is strong excessively, forms the globule.
Add the Chinese medicine penetrating agent and can accelerate the seepage velocity of active ingredient, shorten onset time.As Chinese medicine penetrating agents such as Moschus penetrating agent increase cool sense in the oral cavity, the degree of depth of throat, width.This also is not have in traditional Western-style sugar industry.
The purpose of vacuum is in order to extract the moisture content in the sugared body, and the low time of pressure is just long, and pressure is too high, to the equipment requirements height, also wastes energy, and through groping, temperature is at 150-170 ℃, and pressure is OK range at 4-8kg.
Specific embodiment
Describe the present invention in detail below in conjunction with embodiment:
Embodiment 1
| Hydroxyl isomaltulose | 99％ |
| Chinese medicine or plant extract | 1.0％ |
The major technology parameter:
155 ℃-160 ℃ of vacuum sugar boiling temperature, pressure 4-6kg.
Embodiment 2
| Hydroxyl isomaltulose | 99％ |
| Chinese medicine or plant extract | 1.0％ |
The major technology parameter:
160 ℃-165 ℃ of vacuum sugar boiling temperature, pressure 5-6kg.
The performance of embodiment 1,2 and sucrose, glucose relatively.
| Scheme | Produce season | Hygroscopicity (room temperature) | The buccal time | To tooth | Moisture content |
| Example 1 | Whole year production | The moisture absorption hardly | 20 minutes | Anti-caries | 0.4 |
| Example 2 | Whole year production | The moisture absorption hardly | 20 minutes | Anti-caries | 0.3 |
| Sucrose, glucose | Produce half a year | Be clamminess summer | 10 minutes | Cause dental caries | 1.5 |
Embodiment 3
| Hydroxyl isomaltulose | 95％ |
| Chinese medicine or plant extract | 4％ |
The major technology parameter:
155 ℃-160 ℃ of vacuum sugar boiling temperature, pressure 4-6kg.
Embodiment 4
| Hydroxyl isomaltulose | 95％ |
| Chinese medicine or plant extract | 4％ |
The major technology parameter:
160 ℃-165 ℃ of vacuum sugar boiling temperature, pressure 5-6kg.
Survival dose during embodiment 3,4 strengthens has improved curative effect.
Embodiment 5
| Hydroxyl isomaltulose | 99％ |
| Chinese medicine or plant extract | 1.0％ |
The major technology parameter:
150 ℃-155 ℃ of vacuum sugar boiling temperature, pressure 5-7kg compares with embodiment 1, reduces temperature, and pressurize can reach the effect of control moisture content equally, and moisture content can be controlled in par.
Embodiment 6
| Hydroxyl isomaltulose | 98％ |
| Chinese medicine or plant extract | 1.0％ |
The major technology parameter:
153 ℃-160 ℃ of vacuum sugar boiling temperature, pressure 5-8kg improves temperature, and water content is lower.
Embodiment 7
| Hydroxyl isomaltulose | 98％ |
| Chinese medicine or plant extract | 2％ |
The major technology parameter:
143 ℃-153 ℃ of vacuum sugar boiling temperature, pressure 6-8kg, this temperature is used for the low slightly Chinese medicine extract of thermostability.
Embodiment 8
| Hydroxyl isomaltulose | 90％ |
| Chinese medicine or plant extract | 7％ |
The major technology parameter:
150 ℃-160 ℃ of vacuum sugar boiling temperature, pressure 5-7kg.
Embodiment 9
| Hydroxyl isomaltulose | 90％ |
| Chinese medicine or plant extract | 7％ |
The major technology parameter:
150 ℃-170 ℃ of vacuum sugar boiling temperature, pressure 5-8kg is applicable to the Chinese medicine extract that heatproof is higher.
Embodiment 10
| Hydroxyl isomaltulose | 86％ |
| Chinese medicine or plant extract | 12％ |
The major technology parameter:
155 ℃-160 ℃ of vacuum sugar boiling temperature, pressure 4-7kg is applicable to the prescription that the Chinese medicine addition is more.
Embodiment 11
(1) the present invention has found simultaneously and has solved that Chinese medicine, plant extract join in the syrup and the preparation method of noncoking makes with the dextrinose keto-alcohol to be the dosage form of raw material, can make natural plants, Chinese medicine class health and therapeutic type health product.Be the comparison of two kinds of adding methods below.
Process conditions: temperature 150-165 ℃, pressure 5-7.5kg.
| Chinese medicine adding method | Add during sugar cook | Vacuum sugar boiling adds when removing moisture content |
| Shade | Color is dark | Light |
| Abnormal smells from the patient | The smell of burning is arranged | The no smell of burning |
| Carbonization | In the sugar body breeze is arranged | No breeze |
Along with the raising of social life level, sugar-free raw material low in calories, not dental caries is liked by consumer day by day.Hydroxyl isomaltulose has gentle sweet taste, good fragrance transmission, cariogenicity low in calories, non-, agent of low hygroscopicity, the solid preparation forming of making, hardness height, inlet is smooth, sweet taste is pure, mouthfeel good, the another one key property is that chemical property is stable, heatproof, High Temperature High Pressure is removed moisture content in vacuum sugar boiling, raw material keeps primary characteristic, make that the caked sugar water content is few, surface brightness is good, and hygroscopicity is low.Can give the storage stability of final products excellence, below 85%, water absorption is very low in 40 ℃ of temperature, temperature, and the hard sugar that the sucrose glucose is done surfaces of tacky with this understanding.Tabulation is that we investigate experiment to raw material properties below.
Table 1: chemical stability experiment
| Project | Hydroxyl isomaltulose | Sucrose, glucose |
| Heatproof | 180℃ | 145℃ |
| 150 ℃ of heating | No coking, metachromatism | Coking, color burn |
Table 2: hygroscopicity experiment (hard sugar of making 2g compares)
| Raw material | Time | Resting period | Deposit humidity | Weight increases % |
| Hydroxyl isomaltulose | 20 days | 20℃ | 63％ | 0.8 |
| 40 days | 20℃ | 63％ | 1.1 |
| 20 days | 20℃ | 76％ | 1.0 | |
| 40 days | 20℃ | 76％ | 1.9 | |
| Sucrose, glucose | 20 days | 20℃ | 63％ | 8.6 |
| 40 days | 20℃ | 63％ | 13.2 | |
| 20 days | 20℃ | 76％ | 21 | |
| 40 days | 20℃ | 76％ | 23 |
(2)
| Hydroxyl isomaltulose | 86％ |
| Chinese medicine or plant extract | 2％ |
| Sorbitol | 10％ |
| Maltose alcohol | 1％ |
Major technology parameter, technology:
Sorbitol, maltose alcohol and hydroxyl isomaltulose together add the water heating and dissolve, stir off, boil half an hour, filter, and add to enter the vacuum sugar boiling machine after Chinese medicine extract is mixed.Major parameter is as follows, 160 ℃-170 ℃ of temperature, and pressure 6-7kg, the adding of sorbitol has reduced cost, and the price of sorbitol only is half of hydroxyl isomaltulose, but sorbitol has stronger hygroscopicity, and consumption should not surpass 25%.
Embodiment 12
| Hydroxyl isomaltulose | 86％ |
| Chinese medicine or plant extract | 2％ |
| Sorbitol | 10％ |
| Maltose alcohol | 0.2％ |
Major technology parameter, technology:
After stevioside and maltose alcohol, hydroxyl isomaltulose together add water heating and dissolve the half an hour of stirring off, filter, add Chinese medicine extract, after entering vacuum sugar boiling after being mixed, major parameter is as follows, 160 ℃-170 ℃ of temperature, pressure 6-7kg, compare with embodiment 11, reduce maltose alcohol, water content can descend in the sugared body.
Embodiment 13
| Hydroxyl isomaltulose | 98％ |
| Chinese medicine or plant extract | 1％ |
| Sorbitol | 1％ |
| Maltose alcohol | 0.1％ |
| Moschus | 10PPM |
| Mentholum | 0.5％ |
Major technology parameter, technological parameter:
Hydroxyl isomaltulose, maltose alcohol, the amino sulphur sodium of cyclohexyl add the water heating together and dissolve and boil 0.5 hour, filtration obtains filter pulp and Chinese medicine extract, and vacuum sugar boiling under 155 ℃ of-170 ℃ of conditions of true temp is crossed funnel, add Moschus, Mentholum, cast, cooling obtains caked sugar.
With do not add Moschus, Mentholum prescription relatively
| Scheme | The cool sense in oral cavity intensity | The cool sense of throat | The cool sense in oral cavity width |
| Embodiment 13 | +++ | Below the larynx joint | +++ |
| Do not add penetrating agent | + | The position, oral cavity | + |
Embodiment 14: prescription
| Hydroxyl isomaltulose | 70％ |
| Chinese medicine or plant extract | 3％ |
| Maltose alcohol | 25％ |
| Mannitol | 3％ |
| Sodium cyclamate | 0.05％ |
| Oleum menthae | 0.5％ |
| Eucalyptus oil | 0.3％ |
| Mentholum | 0.4％ |
| Thymol | 10PPM |
Add Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods composition and the comparison of not adding Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods composition:
| Content | Embodiment 13 | Embodiment 14 |
| Cost | High | Descend 31.4% |
| The cool sense in oral cavity width | Lingual surface | To tongue limit cheek mucosa |
| The cool sense of throat | 1-2 cun down at larynx joint | The larynx joint is down to chest |
| The nasal cavity sensation | Do not have | The stuffy nose relieving chamber |
| Local antipruritic | Slowly | Hurry up |
Chinese medicine among the embodiment 14 is Radix Glycyrrhizae extractum, Radix Platycodonis extractum, aqua armeniacae is mainly used in by 3: 2: 1 mixing Oleum menthae, eucalyptus oil, Mentholums and eliminates pharyngeal mistake disease, is used for relieving cough and resolving phlegm, antiinflammatory with Radix Glycyrrhizae, Radix Platycodonis, the common onset of aqua armeniacae and eliminates pharyngeal discomfort rapidly.
Major technology parameter, technological parameter:
Hydroxyl isomaltulose, maltose alcohol, the amino sulphur sodium of cyclohexyl add the water heating together and dissolve and boil 0.5 hour, filtration obtains filter pulp and Chinese medicine extract, and vacuum sugar boiling under 155 ℃ of-170 ℃ of conditions of true temp is crossed funnel, add Moschus, Mentholum, cast, cooling obtains caked sugar.
Embodiment 15
Prescriptions of Chinese medicine consists of 15 parts of Fructus Crataegis, 12 parts in Fructus Hordei Germinatus, 9 parts of Fructus Aurantiis, 15 parts of Rhizoma Dioscoreaes, following four flavors decoct with water, and 10 times of water gagings were fried in shallow oil 1.5 hours for the first time, and 8 times of water gagings are one hour for the second time, decoction liquor is filtered, one night of quiet amount refilters, and the filtrate decompression vacuum concentration is to relative density 1.26-1.28.
| Hydroxyl isomaltulose | 95％ |
| Chinese medicine or plant extract | 3％ |
| Maltose alcohol | 1.5％ |
| Stevioside | 0.15％ |
| Essence | 0.1％ |
Major technology parameter, technological parameter:
Hydroxyl isomaltulose, maltose alcohol, the amino sulphur sodium of cyclohexyl add the water heating together and dissolve and boil 0.5 hour, filtration obtains filter pulp and Chinese medicine extract, and vacuum sugar boiling under 155 ℃ of-170 ℃ of conditions of true temp is crossed funnel, add Moschus, Mentholum, cast, cooling obtains caked sugar.
Embodiment 16
Prescriptions of Chinese medicine consists of 15 parts of Semen Cassiaes, 15 parts of Semen Raphani, more than two flavors take conventional decocting to boil 60% ethanol precipitation, through reclaiming ethanol, obtain extractum, relative density 1.20-1.26.
| Hydroxyl isomaltulose | 80％ |
| Chinese medicine extraction extractum | 5％ |
| Mannitol | 10％ |
| Essence | 0.1％ |
| Sodium cyclamate | 0.05％ |
Major technology parameter, technological parameter:
Hydroxyl isomaltulose, maltose alcohol, the amino sulphur sodium of cyclohexyl add the water heating together and dissolve and boil 0.5 hour, filtration obtains filter pulp and Chinese medicine extract, and vacuum sugar boiling under 155 ℃ of-170 ℃ of conditions of true temp is crossed funnel, add Moschus, Mentholum, cast, cooling obtains caked sugar.
Embodiment 17
Prescriptions of Chinese medicine consists of 15 parts of FRUCTUS TERMINALIAE IMMATURUS, 12 parts of Fructus Momordicaes, decocting and boils, filters, concentrates relative density 1.20.
| Hydroxyl isomaltulose | 85％ |
| Chinese medicine extraction extractum | 5％ |
| Mannitol | 10％ |
| Acesulfame potassium | 0.05％ |
Major technology parameter, technological parameter:
Hydroxyl isomaltulose, maltose alcohol, the amino sulphur sodium of cyclohexyl add the water heating together and dissolve and boil 0.5 hour, filtration obtains filter pulp and Chinese medicine extract, and vacuum sugar boiling under 155 ℃ of-170 ℃ of conditions of true temp is crossed funnel, add Moschus, Mentholum, cast, cooling obtains caked sugar.
Embodiment 18
Prescriptions of Chinese medicine consists of Radix Glycyrrhizae fluidextract 0.4kg, Fructus Momordicae 10kg, and Fructus Canarii 12kg, Fructus Momordicae, Fructus Canarii decocting method commonly used get extractum, relative density 1.02.
| Hydroxyl isomaltulose | 85％ |
| Chinese medicine extraction extractum | 5％ |
| Mannitol | 10％ |
| Acesulfame potassium | 0.05％ |
Major technology parameter, technological parameter:
Hydroxyl isomaltulose, maltose alcohol, the amino sulphur sodium of cyclohexyl add the water heating together and dissolve and boil 0.5 hour, filtration obtains filter pulp and Chinese medicine extract, and vacuum sugar boiling under 155 ℃ of-170 ℃ of conditions of true temp is crossed funnel, add Moschus, Mentholum, cast, cooling obtains caked sugar.
Embodiment 19, a kind of solid dosage forms that contains hydroxyl isomaltulose are added Chinese medicine or extracted form natural plant composition, get by moulding by casting.
Embodiment 20, comprise parts by weight: Chinese medicinal ingredients 0.2-30 part, hydroxyl isomaltulose composition 70-99.8 part.All the other are with embodiment 1.
Embodiment 21, contain the solid dosage forms of hydroxyl isomaltulose, comprise parts by weight: Chinese medicinal ingredients 0.2-14 part, hydroxyl isomaltulose composition 86-99.8 part.All the other are with embodiment 1.
Embodiment 22, contain the solid dosage forms of hydroxyl isomaltulose, comprise parts by weight: Chinese medicinal ingredients 1-10 part, isomaltulose composition 90-99 part.All the other are with embodiment 1.
Embodiment 23, contain the solid dosage forms of hydroxyl isomaltulose, it is characterized in that: also contain adjuvant, wherein adjuvant and parts by weight are: (A) saccharide: 5-20 part (B) wetting agent: 0.2-5 part (C) sweeting agent: 0.02-0.3 part.All the other are with embodiment 1.
Embodiment 24, contain the solid dosage forms of hydroxyl isomaltulose, also contain adjuvant, wherein adjuvant and parts by weight are: (A) saccharide: in xylitol, the sorbitol one or both, umber: 5-20 part (B) wetting agent: in maltose alcohol, the hydroxyl isomaltulose one or both, umber 0.2-5 part (C) sweeting agent: in steviol glycosides, the sodium cyclamate one or both, umber: 0.02-0.3 part.All the other are with embodiment 1.
Embodiment 25, contain the solid dosage forms of hydroxyl isomaltulose, it is characterized in that: the penetrating agent that also is added with 3/1000000ths to 15/1000000ths parts.All the other are with embodiment 1.
Embodiment 26, contain the preparation method of the solid dosage forms of hydroxyl isomaltulose, it is characterized in that: follow these steps to make: (1) raw material of Chinese medicine extracting method routinely obtains Chinese medicine extract (A); (2) isomaltulose mixes after the common process heat fused obtains hydroxyl isomaltulose syrup (B) with adjuvants such as saccharide, humectant, sweeting agents; (3) with (A) and (B) filter cleaner, behind the filtrate mix homogeneously of gained, boil, boiling temperature is 140 ℃-200 ℃.Under vacuum condition, boil vacuum pressure 4-8 kilogram.Boil the evaporation of time control controlling the water circulation part, make water content in the final products be controlled at the 0.2-1.2% of product gross weight.All the other are with embodiment 1.
Embodiment 27,
(1) boiling temperature is 140 ℃.8 kilograms of vacuum pressures, water content is controlled at 0.2, and all the other are with embodiment 26.
(2) boiling temperature is 145 ℃.7 kilograms of vacuum pressures, water content is controlled at 1.2, and all the other are with embodiment 26.
(3) boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(4) boiling temperature is 160 ℃.All the other are with embodiment 26.
(5) boiling temperature is 170 ℃.All the other are with embodiment 26.
(6) boiling temperature is 180 ℃.All the other are with embodiment 26.
(7) boiling temperature is 200 ℃.All the other are with embodiment 26.
Embodiment 28, concrete some contain the solid dosage forms of hydroxyl isomaltulose:
(1) contains the solid dosage forms that the Chinese medicine component is specially Fructus Crataegi 9-15 part, Fructus Hordei Germinatus 6-12 part, Fructus Aurantii Immaturus 6-9 part, Rhizoma Dioscoreae 9-15 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to promote the production of body fluid appetizing, help digestion.Boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(2) contain the solid dosage forms that the Chinese medicine component is specially Semen Raphani 9-12 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to blood pressure lowering.Boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(3) contain the solid dosage forms of edible calcium carbonate 2-10 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to replenish the calcium.Boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(4) contain the solid dosage forms that the Chinese medicine component is specially 9 parts in Radix Glycyrrhizae, 9 parts in Semen Armeniacae Amarum, 12 parts of Radix Platycodoniss and 70-99.8 part hydroxyl isomaltulose.Can be applicable to cough-relieving, the treatment pharyngolaryngitis.Boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(5) containing the Chinese medicine component is FRUCTUS TERMINALIAE IMMATURUS 5-15 part, the solid dosage forms of Fructus Momordicae 3-12 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to treat laryngopharynx swelling and pain, hoarseness, pharyngolaryngitis.Boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(6) containing the Chinese medicine component is Radix Glycyrrhizae fluidextract 0.1-0.8 part, Fructus Momordicae 3-10 part, the solid dosage forms of Fructus Canarii 3-12 part and 70-99.8 part hydroxyl isomaltulose.Can be applicable to cleaning throat and moistening larynx and separate the pharynx poison.Boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
0.2 part of embodiment 29, (1) Chinese medicinal ingredients, 99.8 parts of hydroxyl isomaltulose compositions, each 2.5 parts of xylitol and sorbitol, each 0.1 part of maltose alcohol, hydroxyl isomaltulose, each 0.01 part of steviol glycosides, sodium cyclamate, boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(2) Chinese medicinal ingredients is 0.2 part, 99.8 parts of hydroxyl isomaltulose compositions, and each 2.5 parts of xylitol and sorbitol, each 0.1 part of maltose alcohol, hydroxyl isomaltulose, each 0.01 part of steviol glycosides, sodium cyclamate, all the other are with implementing 1.30 parts of Chinese medicinal ingredients, 70 parts of hydroxyl isomaltulose compositions, boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(3) Chinese medicinal ingredients is 12 parts, 88 parts of hydroxyl isomaltulose compositions, and each 10 parts of xylitol and sorbitol, each 2.5 parts of maltose alcohol, hydroxyl isomaltulose, each 0.15 part of steviol glycosides, sodium cyclamate, boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(4) Chinese medicinal ingredients is 14 parts, 86 parts of hydroxyl isomaltulose compositions, and 7 parts of xylitol, maltose alcohol, 2 parts, 0.025 part of steviol glycosides, boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
1 part of Chinese medicinal ingredients, 99 parts of hydroxyl isomaltulose compositions, 4 parts of sorbitol, each 4 parts of hydroxyl isomaltulose, each 0.023 part of sodium cyclamate, boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
(5) Chinese medicinal ingredients is 10 parts, 90 parts of hydroxyl isomaltulose compositions, and 4 parts of sorbitol, each 4 parts of hydroxyl isomaltulose, each 0.023 part of sodium cyclamate, boiling temperature is 150 ℃.4 kilograms of vacuum pressures, water content is controlled at 0.8, and all the other are with embodiment 26.
Embodiment 30, with above-mentioned all solid dosage formss, be applied to health food.
Embodiment 31
The primary raw material prescription
| Hydroxyl isomaltulose | 95 parts |
| Chinese medicine or natural plant extracts | 3 parts |
| The adjuvant xylitol | 1.5 part |
| The adjuvant stevioside | 0.15 part |
| Adjuvant essence | 0.35 part |
The preparation method that contains the solid dosage forms of hydroxyl isomaltulose follows these steps to make: (1) raw material of Chinese medicine or natural plants extracting method routinely obtains Chinese medicine or natural plant extracts (A); (2) isomaltulose mixes after the common process heat fused was boiled 0.5 hour again with adjuvants such as other saccharides, humectant, sweeting agents, obtains hydroxyl isomaltulose syrup (B); (3) with (A) and (B) filter cleaner, behind the filtrate mix homogeneously of gained, method routinely boils, and boiling temperature is 140 ℃.Under vacuum condition, boil 6 kilograms of vacuum pressures.(4) molding obtains caked sugar.
Wherein natural plant extracts is selected natural plants Herba Pileae Scriptae extractum for use.
Embodiment 32 squeezing and pressing method molding, all the other are with embodiment 31.
Embodiment 33 pressing molding, all the other are with embodiment 31.
Embodiment 34 casting molding, all the other are with embodiment 31.Gained solid dosage forms conventional aluminium plastic packaging is preserved 12 months no deliquescence.
Embodiment 35
| Hydroxyl isomaltulose | 90 parts |
| Chinese medicine or plant extract | 5 parts |
| The adjuvant maltose alcohol | 1.5 part |
| The adjuvant stevioside | 0.15 part |
| Adjuvant essence | 0.1 part |
The preparation method that contains the solid dosage forms of hydroxyl isomaltulose follows these steps to make: (1) raw material of Chinese medicine or natural plants extracting method routinely obtains Chinese medicine or natural plant extracts (A); (2) isomaltulose mixes after the common process heat fused was boiled 0.5 hour again with adjuvants such as other saccharides, humectant, sweeting agents, obtains hydroxyl isomaltulose syrup (B); (3) with (A) and (B) filter cleaner, behind the filtrate mix homogeneously of gained, method routinely boils, and boiling temperature is 200 ℃.Under vacuum condition, boil 8 kilograms of vacuum pressures.(4) molding obtains caked sugar.
Wherein natural plant extracts is selected natural plants Fructus Crataegi extractum for use.
Embodiment 36 squeezing and pressing method molding, all the other are with embodiment 35.
Embodiment 37 pressing molding, all the other are with embodiment 35.
Embodiment 38 casting molding, all the other are with embodiment 35.Gained solid dosage forms conventional aluminium plastic packaging is preserved 12 months no deliquescence.
Embodiment 39
| Hydroxyl isomaltulose | 90 parts |
| Chinese medicine or plant extract | 5 parts |
| The adjuvant maltose alcohol | 1.5 part |
| The adjuvant stevioside | 0.15 part |
| Adjuvant essence | 0.1 part |
The preparation method that contains the solid dosage forms of hydroxyl isomaltulose follows these steps to make: (1) raw material of Chinese medicine or natural plants extracting method routinely obtains Chinese medicine or natural plant extracts (A); (2) isomaltulose mixes after the common process heat fused was boiled 1 hour again with adjuvants such as other saccharides, humectant, sweeting agents, obtains hydroxyl isomaltulose syrup (B); (3) with (A) and (B) filter cleaner, behind the filtrate mix homogeneously of gained, method routinely boils, and boiling temperature is 175 ℃.Under vacuum condition, boil 4 kilograms of vacuum pressures.(4) molding obtains caked sugar.
Wherein natural plant extracts is selected 3 parts of natural plants Ziziphi Spinosae extractum for use, 2 parts of FRUCTUS TERMINALIAE IMMATURUS extractum.
Embodiment 40 squeezing and pressing method molding, all the other are with embodiment 39.
Embodiment 41 pressing molding, all the other are with embodiment 39.
Embodiment 42 casting molding, all the other are with embodiment 39.Gained solid dosage forms conventional aluminium plastic packaging is preserved 12 months no deliquescence.
Embodiment 43 casting molding replace with sucrose with hydroxyl isomaltulose, and all the other are with embodiment 31.The gained surface is brighter and cleaner, and is more smooth, no wire drawing, but every square centimeter cut par has the 2-3 bar, and because of the easy moisture absorption of sucrose, even double-layer seal bag or plastic-aluminum envelope are preserved, equal deliquescence has a strong impact on product quality after three months.
Embodiment 44 casting molding replace with Oligomeric maltose with hydroxyl isomaltulose, and all the other are with embodiment 35.Oligomeric maltose becomes type hardness tester not enough, is not suitable for casting, can't molding.
Embodiment 45 casting molding replace with fructose with hydroxyl isomaltulose, and all the other are with embodiment 39.The surface is brighter and cleaner, and is more smooth, no wire drawing, but every square centimeter cut par has the 4-6 bar, and cause and effect sugar is the moisture absorption easily, even double-layer seal bag or plastic-aluminum envelope are preserved, equal after two months deliquescence has a strong impact on product quality.
Embodiment 46 casting molding, the squeezing and pressing method molding, the contrast experiment attractive in appearance of the solid dosage forms of pressing molding:
| Extruding type punching press type cast type | The fineness contrast | Wire drawing | Surface scratch (every square centimeter cut par) | Number of bubbles | Surface color |
| Embodiment 32 squeezing and pressing methods | Rough surface | Have | The 12-16 bar | In a large number | Irregular colour is even, local whiting, color and luster muddiness |
| Embodiment 33 pressings | Rough surface | Have | The 11-14 bar | More | Irregular colour is even, the color and luster muddiness |
| Embodiment 34 | Any surface finish | Do not have | Do not have | Seldom | Color even, the color and luster crystalline substance |
| Casting | Smooth | Jade-like stone is bright | |||
| Embodiment 36 squeezing and pressing methods | Rough surface | Have | The 9-12 bar | In a large number | Irregular colour is even, local whiting, color and luster muddiness |
| Embodiment 37 pressings | Rough surface | Have | The 10-12 bar | More | Irregular colour is even, the color and luster muddiness |
| Embodiment 38 castings | Any surface finish is smooth | Do not have | Do not have | Seldom | Color even, color and luster is sparkling and crystal-clear bright |
| Embodiment 40 squeezing and pressing methods | Rough surface | Have | The 7-9 bar | In a large number | Irregular colour is even, local whiting, color and luster muddiness |
| Embodiment 41 pressings | Rough surface | Have | The 14-16 bar | More | Irregular colour is even, the color and luster muddiness |
| Embodiment 42 castings | Any surface finish is smooth | Do not have | Do not have | Seldom | Color even, color and luster is sparkling and crystal-clear bright |
The national standard of confection presentation quality all is the range estimation index.Still there is not quantitative target.
The solid dosage forms of 47 1 groups of hydroxyl isomaltulose Chinese medicines of embodiment or plant.Preparation method is pressed the operation of embodiment 39:
Main formula:
| Hydroxyl isomaltulose | 70 parts |
| Saccharide | Some parts |
| Chinese medicine or plant extract | 5 parts |
| The adjuvant maltose alcohol | 1.5 part |
| The adjuvant stevioside | 0.15 part |
| Adjuvant essence | 0.1 part |
Also contain adjuvant, wherein adjuvant and parts by weight are:
(1) saccharide is 20 parts of glucoses;
(2) saccharide is 20 parts of glucoses; 5 parts of xyloses.
(3) saccharide is 15 parts of oligomeric trehaloses.
(4) saccharide is 10 parts of oligomeric galactoses; 5 parts of xyloses.
(5) saccharide is 8 parts of arabinose; 5 parts of xyloses.
(6) saccharide is 8 parts of arabinose; 5 parts of xyloses.
(7) corn syrup is 10 parts.
(8) xylitol is 7 parts.
(9) sorbitol is 8 parts.
(10) with glucose, fructose, xylose, galactose, arabinose, mannose, sucrose, Oligomeric maltose, oligomeric trehalose, oligomeric galactose, corn syrup, high fructose syrup, lentinan, Radix Angelicae Sinensis polysaccharide, the ginseng polysaccharide, plantago asiatica linne polyoses, Aloe polysaccharide, stevioside, Flos Chrysanthemi disaccharidase glycosides, in functional low polyxylose, functional oligofructose, functional oligomeric isomaltose, functional soy oligosaccharide, the functional oligomeric lactulose any one or several and the main formula combination in any.
Embodiment 48
The solid dosage forms that above-mentioned all embodiment are related to pours into tablet form.
The solid dosage forms that above-mentioned all embodiment are related to pours into bulk form.
The solid dosage forms that above-mentioned all embodiment are related to pours into balled form.
Because the characteristics of casting itself, the shape of the model of being done is final forming shape.
Claims (8)
1, a kind of solid dosage forms that contains hydroxyl isomaltulose is characterized in that: comprise parts by weight: Chinese medicinal ingredients 0.2-30 part, hydroxyl isomaltulose composition 70-99.8 part.
2, the solid dosage forms that contains hydroxyl isomaltulose according to claim 1 is characterized in that: comprise parts by weight: Chinese medicinal ingredients 0.2-14 part, hydroxyl isomaltulose composition 86-99.8 part.
3, the solid dosage forms that contains hydroxyl isomaltulose according to claim 1 is characterized in that: comprise parts by weight: Chinese medicinal ingredients 1-10 part, hydroxyl isomaltulose composition 90-99 part.
4, the solid dosage forms that contains hydroxyl isomaltulose according to claim 1 is characterized in that: also contain adjuvant, wherein adjuvant and parts by weight are:
(A) saccharide: 5-20 part
(B) wetting agent: 0.2-5 part
(C) sweeting agent: 0.02-0.3 part.
5, the solid dosage forms that contains hydroxyl isomaltulose according to claim 1 is characterized in that: also contain adjuvant, wherein adjuvant and parts by weight are:
(A) saccharide: in xylitol, the sorbitol one or both, umber: 5-20 part
(B) wetting agent: in maltose alcohol, the hydroxyl isomaltulose one or both, umber 0.2-5 part
(C) sweeting agent: in steviol glycosides, the sodium cyclamate one or both, umber: 0.02-0.3 part.
6, the preparation method that contains the solid dosage forms of hydroxyl isomaltulose according to claim 1 is characterized in that: follow these steps to make: (1) raw material of Chinese medicine extracting method routinely obtains Chinese medicine extract (A); (2) hydroxyl isomaltulose obtains hydroxyl isomaltulose syrup (B) through conventional technology heat fused; (3) with (A) and (B) filter cleaner, behind the filtrate mix homogeneously of gained, boil, boiling temperature is 140 ℃-200 ℃.
7, the preparation method that contains the solid dosage forms of hydroxyl isomaltulose according to claim 6 is characterized in that: boil the evaporation of time control controlling the water circulation part, make water content in the final products be controlled at the 0.2-1.2% of product gross weight.
8, the preparation method that contains the solid dosage forms of hydroxyl isomaltulose according to claim 5 is characterized in that: follow these steps to make: (1) raw material of Chinese medicine extracting method routinely obtains Chinese medicine extract (A2); (2) isomaltulose mixes with saccharide, humectant, sweeting agent adjuvant after the common process heat fused obtains isomaltulose syrup (B2); (3) with (A2) and (B2) filter cleaner, behind the filtrate mix homogeneously of gained, boil, boiling temperature is 140 ℃-200 ℃.
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| CN 200310121638 CN1289068C (en) | 2002-12-31 | 2003-12-30 | Solid formulation containing isomaltone itol, its preparation method and uses |
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