CN1287834C - Powder for treating coronary heart disease and angina pectoris and its preparing process - Google Patents
Powder for treating coronary heart disease and angina pectoris and its preparing process Download PDFInfo
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- CN1287834C CN1287834C CN 200410057368 CN200410057368A CN1287834C CN 1287834 C CN1287834 C CN 1287834C CN 200410057368 CN200410057368 CN 200410057368 CN 200410057368 A CN200410057368 A CN 200410057368A CN 1287834 C CN1287834 C CN 1287834C
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Abstract
The present invention discloses a traditional Chinese medicine granular preparation for treating coronary disease and angina pectoris, which uses thirteen kinds of medicine, such as astragalus root, pilose asiabell root, lilyturf root, fleeceflower root, longspur epimedium, pueraria root, Chinese angelica, red sage root, Chinese honeylocust spine, seaweed, kelp, oyster and aurantii immaturus, as raw materials. The raw materials are processed by different physical or chemical methods based on different physicochemical properties of effective components of each kind of traditional Chinese medicine so as to prepare an effective agent. The present invention has unique formula. The present invention has obvious therapeutic effects on treating coronary disease and angina pectoris clinically.
Description
1. technical field
The present invention relates to a kind of treatment coronary heart disease, anginal granule, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, relates to the preparation method of this medicine simultaneously.
2. background technology
Angina pectoris is common clinical, frequently-occurring disease, treats more thorny.Western medical treatment is used nifedipine, nitroglycerin more, but curative effect is all not ideal.Angina pectoris belongs to the traditional Chinese medical science " thoracic obstruction ", " precordial pain with cold limbs " category, and its basic pathogenesis is a deficiency in origin and excess in superficiality.Deficiency in origin refers to the void of QI and blood, negative and positive, and mark refers to the stagnation of QI, blood stasis, cold coagulation, phlegm-damp etc. in fact.And the main component Radix Astragali of the present invention has QI invigorating, improves body rabbit epidemic disease power, strengthens the myocardial contraction effect; Yin nourishing Radix Ophiopogonis.Can improve hypoxia-bearing capability because of containing materials such as polysaccharide, several amino acids; Radix Salviae Miltiorrhizae is invigorated blood circulation, and can reduce the blood denseness, and coronary blood flow increasing reduces surface activity of blood platelet and poly-Chinese bush cherry.Have antithrombotic and form and improve the rheological property of blood effect; The Sargassum softening and eliminating sputum has blood fat reducing, study of anti-atherogenic effect.Full side has supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, the effect for the treatment of both the principal and the secondary aspects of a disease at the same time.Be suitable for the thoracic obstruction it, deficiency of both QI and YIN, the expectorant stasis of blood is handed over card such as resistance grade.For treating the most widely XINTONGKOU PIAN of angina pectoris clinical practice: volume 2 phases, the 83 pages of records in April 9 in 2000 of Chinese tcm emergency: the XINTONGKOU PIAN antianginal is evident in efficacy similar with the nifedipine curative effect.But the ischemic electrocardiogram is gentle obviously to be better than nifedipine aspect the coronary heart disease cardinal symptom to XINTONGKOU PIAN improving, and this merit that has treating both the principal and the secondary aspects of a disease at the same time with it is inseparable, and without any side effects.The time 2002 the 13rd the 9th phases of volume of precious traditional Chinese medical science traditional Chinese medicines: the XINTONGKOU PIAN group obviously is better than storax pill for treating coronary heart disease to angina pectoris symptom total effective rate and Electrocardiographic improvement rate.It rule pharmacy the 10th volume the 4th friend 51 November in 1998: make port eye liquid treatment angina pectoris 100 examples diligently, use sorbide nitrate to compare with 100 examples.Obvious effective rate, total effective rate are respectively 64.0% and 95.0% as a result, and the obvious effective rate of matched group, total effective rate are respectively 34.0% and 84.0%.Two groups have utmost point significant difference (P＜01), show that XINTONGKOU PIAN is treated coronary heart disease, curative effect to treat angina pectoris is remarkable.
Although at present XINTONGKOU PIAN in occupation of market, is widely used in clinically with its reliable curative effect, contain sugar in the oral liquid, be not suitable for diabetic to take; And oral liquid is inconvenient to carry, transport for liquid preparation; Because of storing with the passing of time or phenomenon such as the improper easy generation precipitation of condition of storage influences the stability of medicine.
3. summary of the invention
The object of the present invention is to provide a kind of treatment coronary heart disease, anginal granule; Another object of the present invention provides the preparation method of this dosage form.
Pharmaceutical preparation of the present invention is made by the following weight raw material:
Radix Astragali 10%-20% Radix Codonopsis 5%-15% 2%-10% Radix Ophiopogonis
Radix Polygoni Multiflori 1%-8% Herba Epimedii 1%-8% Radix Puerariae 8%-18%
Radix Angelicae Sinensis 1%-8% Radix Salviae Miltiorrhizae 5%-15% Spina Gleditsiae 1%-8%
Sargassum 5%-15% Thallus Laminariae (Thallus Eckloniae) 5%-15% Concha Ostreae 5%-15%
Fructus Aurantii Immaturus 0.5%-5%.
Pharmaceutical preparation of the present invention is made by the following weight raw material:
Radix Astragali 13%-18% Radix Codonopsis 6%-11% 4%-8% Radix Ophiopogonis
Radix Polygoni Multiflori 3%-7% Herba Epimedii 3%-7% Radix Puerariae 10%-15%
Radix Angelicae Sinensis 3%-7% Radix Salviae Miltiorrhizae 7%-11% Spina Gleditsiae 3%-7%
Sargassum 6%-11% Thallus Laminariae (Thallus Eckloniae) 6%-11% Concha Ostreae 6%-11%
Fructus Aurantii Immaturus 1%-%.
The optimum weight proportioning of each raw material of pharmaceutical preparation of the present invention is roughly:
8.5% Radix Ophiopogonis 6.1% of the Radix Astragali 16.8% Radix Codonopsis
Radix Polygoni Multiflori 4.8% Herba Epimedii 4.8% Radix Puerariae 13.3%
Radix Angelicae Sinensis 4.8% Radix Salviae Miltiorrhizae 9.1% Spina Gleditsiae 4.8%
Sargassum 8.5% Thallus Laminariae (Thallus Eckloniae) 8.5% Concha Ostreae 8.5%
Fructus Aurantii Immaturus 2.4%.
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add alcohol reflux 1-3 time that 4-12 doubly measures 40-80%, and each 0.5-3 hour, filter, merging ethanol liquid is deposited in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 4-12 times of water gaging, fry in shallow oil 1-3 time, decoct respectively 0.5-3 hour, merge decoction liquor, and filtrate decompression is concentrated into relative density 1.01-2.0 one-tenth clear paste; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 40-80%, cold preservation 24-48 hour, filter, filtrate recycling ethanol also is concentrated into relative density 1.1-1.5 (60 ℃), adds right amount of auxiliary materials system granule or drying and makes fine powder and add right amount of auxiliary materials system granule more promptly.
The used adjuvant difference of different method of granulating comprises: starch, dextrin, Icing Sugar, lactose, magnesium stearate, maltodextrin, citric acid, tartaric acid, sodium bicarbonate, A Siba are sweet, stevioside, cyclamate, protein sugar etc.
1. above-mentioned alcohol deposit fluid is filtered, filtrate recycling ethanol also is concentrated into the extractum of relative density 1.1～1.5 (60 ℃), adds an amount of 1: 1-3: the mixture mixing of 1 Icing Sugar and starch, and to drink and add 90% ethanol and make soft material, the drying of granulating gets final product.
2. above-mentioned alcohol deposit fluid is filtered, filtrate recycling ethanol also is concentrated into the extractum of relative density 1.1-1.5 (60 ℃), adds appropriate amount of starch or dextrin and A Siba is sweet or stevioside or protein sugar add 60-90% ethanol is made soft material, dry the getting final product of granulating.
3. above-mentioned alcohol deposit fluid is filtered, filtrate recycling ethanol also is concentrated into the extractum of relative density 1.1-1.5 (60 ℃), and vacuum drying is pulverized, and adds the magnesium stearate of an amount of lactose and 0.1%-1% and the protein sugar of 0.1-1%, mixing, dry granulation.
4. above-mentioned alcohol deposit fluid is filtered, filtrate recycling ethanol also is concentrated into the extractum of relative density 1.1-1.5 (60 ℃), spray drying, pulverize, the A Siba that adds the magnesium stearate of an amount of lactose, maltodextrin and 0.1%-0.5% and 0.1-1% is sweet, mixing, dry granulation.
5. above-mentioned alcohol deposit fluid is filtered, filtrate recycling ethanol also is concentrated into the extractum of relative density 1.1-1.5 (60 ℃), vacuum drying, pulverize, add an amount of 2: 1-3: the mixture mixing of 1 Icing Sugar and starch, drink and to add 90% ethanol and make soft material, dry the getting final product of granulating.
6. above-mentioned alcohol deposit fluid is filtered, filtrate recycling ethanol also is concentrated into the extractum of relative density 1.1-1.5 (60 ℃), vacuum drying or spray drying, extract powder is divided equally two powder, a copy of it adding citric acid or tartaric acid, and another part adds an amount of sodium bicarbonate, granulate respectively, dry mixing promptly gets effervescent granule.
7. above-mentioned alcohol deposit fluid is filtered, filtrate recycling ethanol also is concentrated into the extractum of relative density 1.1-1.5 (60 ℃), vacuum drying or spray drying, extract powder evenly adds the magnesium stearate of citric acid or tartaric acid and sodium bicarbonate and an amount of lactose of correctives and 0.1%-1%, dry granulation, mixing promptly get effervescent granule.
Dosage form treatment angina pectoris of the present invention has better curative effect.For showing that dosage form of the present invention is remarkable equally to angina pectoris therapeutical effect and XINTONGKOU PIAN, and successfully solved former medicine and contain sugar and be not suitable for diabetic to take, be inconvenient to carry, transport; Because of storing with the passing of time or phenomenon such as the improper easy generation precipitation of condition of storage influences the problems such as stability of medicine.We have done a large amount of experimentatioies, and experiment is used to further specify the present invention below.
Dosage form Pharmacodynamic test of active extract of the present invention
Summary: preparation of the present invention is Chinese medicine four kind new medicines, and main component is: 13 herbal medicines such as the Radix Astragali, Radix Codonopsis, Radix Ophiopogonis, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae are formed.Prove through zoopery, can obviously prolong the mice hypoxia endurance time, pituitrin is caused that the rat heart muscle acute ischemia has certain antagonism, the ST section that ligation causes to rat coronary artery is raised has tangible reduction effect, and the myocardial infarct size that coronary artery ligation is caused obviously dwindles.In addition, the serum lipids in rats that hello high lipid food is caused has the effect of reduction.
Purpose: mainly observe the particulate pharmacological activity such as resist myocardial ischemia of XINTONGKOU PIAN and the present invention, its action intensity of two kinds how.
Be subjected to the reagent thing: medicine of the present invention Shandong southern Shandong pharmaceutical factory provides.XINTONGKOU PIAN is provided by Shandong southern Shandong pharmaceutical factory, lot number 920815.
Animal subject: white mice is the Kunming kind, and rat is the Wistar kind, provides by the breeding of Heilongjiang Traditional Chinese Medicine university Experimental Animal Center.
Method and result
One, to the influence of anoxia in mice
According to normal pressure hypoxia endurance test method, get 50 of healthy male mices, body weight is between the 19-21 gram, is divided into five groups at random by body weight, be respectively the logical granule of the heart high, medium and low (20,10,5g/kg) dosage group; XINTONGKOU PIAN 10ml/kg dosage group and normal control group.Each administration group is by above-mentioned dosed administration, matched group is given consubstantiality hydrops, be oral administration, after the administration 50 minutes, mice is put into the airtight wide mouthed bottle of 150ml (bottle is equipped with 10 gram slaked limes), bottle is airtight, start stopwatch immediately, write down the respiratory arrest time of every Mus, at last the respiratory arrest time of each treated animal is carried out statistical procedures, the result is auspicious to see Table 1:
Table 1 preparation of the present invention is to the influence of mice hypoxia-bearing capability
| Group | Example number (only) | Dosage (g/kg) | Time-to-live (X ± SD second) | The P value |
| Dosage low dosage XINTONGKOU PIAN in the normal control high dose | 10 10 10 10 10 | 20ml 20 10 5 10ml | 410.8±67.42 489.2±81.92 472.8±58.66 467.7±70.80 477.4±69.57 | ＜0.05 ＜0.05 ＞0.05 ＜0.05 |
Table 1 is the result show, high dose group, oral liquid group are compared with the normal control group respectively, the time-to-live of mice under the normobaric hypoxia condition obviously prolonged, but compare no evident difference between each administration group.
Two, dosage form of the present invention is to the influence of expeirmental myocardial ischemia
1, pituitrin is caused the influence of rat heart muscle ischemia
Get body weight 180-230 gram healthy white rat, the male and female dual-purpose is divided into four groups at random by body weight, is respectively model control group, gives consubstantiality hydrops; Positive controls is given XINTONGKOU PIAN 15ml/kg; The heart leads to granule high and low dose group, to logical granule 15g/kg of the heart and 5g/kg, is oral administration.By above-mentioned dosage successive administration 5 days, rat anaesthetized with 20% urethane 5ml/kg intraperitoneal administration in 1 hour after the last administration, lie on the back fix after, trace every Mus II normal ECG that leads.Then, through tongue intravenous injection pituitrin 0.70 μ/kg, injection speed is in 7 seconds, thereafter 15 ", 30 ", 1 ', 2 ', 5 ', 10 ' duplicate record electrocardiogram changes.
Effect is judged: can be divided into for two phases, the first phase because of electrocardiogram behind the normal rat injection of pituitrin changes: immediately by 30 seconds, be that the T ripple raises after the injection, the ST line is raised; The second phase: injected back 30 seconds to several minutes, the T ripple is low flat, and two-phase, inversion, heart rate are slack-off, director during P-R and the Q-T.Negative the above-mentioned first phase or second phase ischemic variation person not occur, respectively organize negative rate at last, and make X
2Check, the result sees table 2 for details:
Table 2 the present invention causes the influence of rat heart muscle acute ischemia to pituitrin
| Group | Example number (only) | Dosage (g/kg) | Negative number (only) | Negative rate (%) | The P value |
| Model contrast high dose low dosage XINTONGKOU PIAN | 10 9 10 10 | 20ml 15 5.0 15 | 2 5 5 7 | 20 66.7 50.0 70 | ＜0.05 ＞0.05 ＜0.05 |
Table 2 is the result show; model group has 20% animal not occur that above-mentioned electrocardiogram changes behind the intravenous injection pituitrin and the negative rate of logical granule high and low dose of the heart and XINTONGKOU PIAN group is respectively 66.7%, 50.0% and 70%; treated; high dose group and oral liquid have evident difference (P＜0.05), illustrate that the present invention causes that to pituitrin the rat heart muscle acute ischemia has protective effect.
2, the ligation rat coronary artery is caused the influence of myocardial infarction
Get some rats, body weight is that the male and female dual-purpose is divided into four groups at random between 240～320 grams, gavages the heart logical granule 20g/kg, 5g/kg every day respectively, and XINTONGKOU PIAN 20g/kg, matched group give with the volume normal saline, and successive administration begins experiment after 6 days.With 20% urethane 0.65g/kg light anaesthesia, cut off the front hair, sterilization, along the about 2cm of left mid-clavicular line longitudinal incision skin, separate the flesh layer the 4th with the 5th intercostal, open the thoracic cavity, cut off pericardium, the light right side thorax of pressing is extruded heart, behind arterial cone and left auricle Coronary vein place's ligation coronary artery, heart is put back to the breast corridor, and the stitching thoracic wall, inject penicillin every day, streptomycin is protected from infection.Is the center with Gentian Violet at left border of sternum the 4th intercostal 1cm place, and 1cm makes 5 points altogether up and down, after coronary artery ligation, 2h and the 1st, the 2nd, carries out the ECG ST section mapping on the 3rd day.After the coronary artery ligation 72 hours, rat is put to death, take out heart, the flush away blood stains, reject atrium and right ventricle, claim left ventricle heavy, with being about to the left ventricle crosscut into about being the 2mm sheet, put into the N-BT dye liquor, in 37 ℃ of water bath with thermostatic control 15min, cut the infarcted myocardium that is colored, weigh, calculate the percentage ratio that infarct accounts for left ventricular mass, the result sees table 3,4 for details.
The influence that table 3 couple coronary ligation rat ∑ ST changes (X ± SDmV)
| Group | Example number (only) | Dosage (g/kg) | After the ligation (h) | |||
| 2 | 24 | 48 | 72 | |||
| Normal control high dose low dosage XINTONGKOU PIAN | 9 10 8 9 | 20ml 20ml 5ml 20ml | 4.52±1.86 2.08±1.21 2.27±1.84 2.58±1.06 | 4.27±1.83 2.13±1.33 2.58±1.62 2.07±0.92 | 3.51±1.17 1.70±1.06 2.11±1.26 1.92±1.52 | 2.27±1.12 1.44±0.82 1.67±0.63 1.74±0.78 |
Annotate: compare with matched group,
*P＜0.05
*P＜0.01
Table 4 pair coronary ligation rat causes the influence of myocardial infarction
| Group | Example number (only) | Dosage (g/kg) | Infarcted myocardium accounts for left ventricle proportion (X ± SD) | The P value |
| Normal control high dose low dosage XINTONGKOU PIAN | 9 9 8 8 | 20ml 20ml 5ml 20ml | 16.24±4.47 9.67±3.81 10.44±4.59 12.42±2.89 | ＜0.01 ＜0.05 ＜0.05 |
Table 3 is the result show, normal control group ST section is obviously raised behind the rat coronary ligation, and 2h reaches the peak after the ligation, and continue 3 days, also raise behind each administration group coronary ligation, but the rising degree all is starkly lower than the normal control group, and compares no evident difference between each administration group.Table 4 as seen, tangible myocardial infarction phenomenon appears behind the rat coronary ligation, normal control group infarcted myocardium accounts for left ventricle and weighs 16.24%, each administration group is respectively 9.67%, 10.88% and 12.42%, compare with matched group and to have evident difference, show that the present invention can obviously reduce the myocardial infarction degree.
3, to the influence of high fat rat blood serum cholesterol, triglyceride
Select 50 of body weight 170～240 gram male rats, be divided into five groups at random, except that first group of hello normal diet, all the other each groups are all fed high lipid food (prescription: 2% cholesterol, 10% Adeps Sus domestica, 0.2% methylthiouracil, 88% normal diet), the oral dose administration that each group of hello high lipid food is pressed table 5, model group with hyperlipemia is given consubstantiality hydrops, administration every day 1 time, continuous 20 days, blood (getting blood fasting in preceding 12 hours) is got in the last administration after 6 hours, measure serum cholesterol and content of triglyceride, the mensuration of cholesterol adopts isopropanol extraction high ferro glacial acetic acid-sulphuric acid development process, the mensuration of triglyceride adopts isopropanol extraction acetylacetone,2,4-pentanedione development process, and the result sees table 5 for details.
The influence of table 5 pair hyperlipidemia rats serum cholesterol, triglyceride
| Group | Example number (only) | Dosage (g/kg) | Cholesterol level (X ± SDmmol/L) | Content of triglyceride (X+SDmmol/L) |
| Normal control model high dose low dosage XINTONGKOU PIAN | 10 9 10 10 10 | 20ml 20ml 20ml 5ml 20ml | 4.23±0.697 8.57±1.869 6.29±1.139 7.43±1.472 6.40±1.113 | 1.048±0.165 2.613±0.521 1.714±0.513 1.885±0.431 1.755±0.468 |
Annotate: compare with model group
*P＜0.01
By table 5 as seen, after rat feeds high lipid food, can obviously cause serum cholesterol, content of triglyceride rising (model group is compared with the normal control group).Except that low dose group of the present invention does not have the obvious influence serum cholesterol, other each group has tangible reduction effect to feeding the rat blood serum cholesterol, the triglyceride that cause with high lipid food.
Conclusion
Above-mentioned experimental result shows that its action intensity of the present invention is basic identical with oral liquid.The animal via oral administration, the rat heart muscle acute ischemia high dose group (15g/kg) that pituitrin is caused has obvious antagonism, and is basic identical with the effect of oral liquid group; The ST section that ligation causes to rat coronary artery is raised has tangible reduction effect, and the myocardial infarct size that causes behind the coronary ligation is obviously dwindled; The content of feeding rat blood serum cholesterol that high lipid food causes, triglyceride raise have tangible reduction effect.Show that the logical granule of the heart has the effect of certain reduction serum cholesterol triglyceride, this plays a part useful for preventing and treating coronary heart disease.
The following example all can be realized the effect of above-mentioned experimental example
Embodiment 1:
Radix Astragali 10g Radix Codonopsis 15g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 8g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 1g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 3 times of 4 times of amounts 40% at every turn, and each 0.5 hour, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 4 times of water gagings, fry in shallow oil 3 times, decoct respectively 0.5 hour, merge decoction liquor, and filtrate decompression is concentrated into 1.10 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 40%, cold preservation 24-48 hour, filter, filtrate recycling ethanol also is concentrated into relative density 1.5 (60 ℃), and the ratio that adds Icing Sugar and starch is: 1: 1, and mixing, add 90% ethanol and make soft material in right amount, the system granule is drying to obtain.
Embodiment 2:
Radix Astragali 20g Radix Codonopsis 5g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 8g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 1g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 1 time of 12 times of amounts 80% at every turn, and each 3 hours, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 12 times of water gagings, fry in shallow oil 1 time, decoct respectively 3 hours, merge decoction liquor, and filtrate decompression is concentrated into 1.40 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 80%, cold preservation 24-48 hour, filter, filtrate recycling ethanol also is concentrated into relative density 1.4 (60 ℃), and the ratio that adds Icing Sugar and starch is: 2: 1, and mixing, add 90% ethanol and make soft material in right amount, the system granule is drying to obtain.
Embodiment 3:
Radix Astragali 20g Radix Codonopsis 15g 2g Radix Ophiopogonis
Radix Polygoni Multiflori 8g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 6g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 1g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 5 times of amounts 50% at every turn, and each 1 hour, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 10 times of water gagings, fry in shallow oil 3 times, decoct respectively 1 hour, merge decoction liquor, and filtrate decompression is concentrated into 1.18 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 50%, cold preservation 24-48 hour, filter, filtrate recycling ethanol also is concentrated into relative density 1.3 (60 ℃), and the ratio that adds Icing Sugar and starch is: 3: 1, and mixing, add 80% ethanol and make soft material in right amount, the system granule is drying to obtain.
Embodiment 4:
Radix Astragali 20g Radix Codonopsis 15g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 1g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 5g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 1g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 65% at every turn, and each 1.5 hours, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, decoct respectively 1.5 hours, merge decoction liquor, and filtrate decompression is concentrated into 1.2 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 24-48 hour, filter, filtrate recycling ethanol also is concentrated into relative density 1.2 (60 ℃), vacuum drying, and the ratio that adds Icing Sugar and starch is: 2.5: 1, mixing, add 80% ethanol and make soft material in right amount, the system granule is drying to obtain.
Embodiment 5:
Radix Astragali 20g Radix Codonopsis 15g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 8g Herba Epimedii 1g Radix Puerariae 18g
Radix Angelicae Sinensis 5g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 1g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 7 times of amounts 70% at every turn, and each 2 hours, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 7 times of water gagings, fry in shallow oil 2 times, decoct respectively 2 hours, merge decoction liquor, and filtrate decompression is concentrated into 1.18 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 65%, cold preservation 24 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.18 (60 ℃), and vacuum drying adds dextrin equivalent, and A Siba is sweet an amount of, mixing adds 60% ethanol and makes soft material in right amount, and the system granule is drying to obtain.
Embodiment 6:
Radix Astragali 20g Radix Codonopsis 15g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 8g Herba Epimedii 8g Radix Puerariae 8g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 1g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 8 times of amounts 75% at every turn, and each 2.5 hours, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 6 times of water gagings, fry in shallow oil 2 times, decoct respectively 2.5 hours, merge decoction liquor, and filtrate decompression is concentrated into 1.15 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 70%, cold preservation 48 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.2 (60 ℃), and vacuum drying adds starch equivalent, and stevioside is an amount of, mixing adds 65% ethanol and makes soft material in right amount, and the system granule is drying to obtain.
Embodiment 7:
Radix Astragali 20g Radix Codonopsis 15g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 8g Herba Epimedii 5g Radix Puerariae 18g
Radix Angelicae Sinensis 1g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 1g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 3 times of 9 times of amounts 50% at every turn, and each 1.5 hours, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 5 times of water gagings, fry in shallow oil 2 times, decoct respectively 1.5 hours, merge decoction liquor, and filtrate decompression is concentrated into 1.10 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 75%, cold preservation 36 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.28 (60 ℃), and vacuum drying adds starch, dextrin equivalent, and protein sugar is an amount of, mixing adds 60% ethanol and makes soft material in right amount, and the system granule is drying to obtain.
Embodiment 8:
Radix Astragali 10g Radix Codonopsis 5g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 8g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 15g Spina Gleditsiae 1g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 10 times of amounts 45% at every turn, and each 1.5 hours, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, decoct respectively 2 hours, merge decoction liquor, and filtrate decompression is concentrated into 1.25 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 24 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.3 (60 ℃), and vacuum drying adds lactose equivalent, and protein sugar is an amount of, mixing adds 75% ethanol and makes soft material in right amount, and the system granule is drying to obtain.
Embodiment 10:
Radix Astragali 10g Radix Codonopsis 15g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 1g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 8g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 50% at every turn, and 2 hours each time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.2 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 65%, cold preservation 24 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.2 (60 ℃), vacuum drying, two parts of xeraphium five equilibriums, a citric acid that adds, another part adds sodium bicarbonate, respectively add lactose equivalent again, protein sugar is an amount of, respectively mixing, respectively add 75% ethanol and make soft material in right amount, make granule respectively, drying, mixing promptly gets effervescent granule.
Embodiment 11:
Radix Astragali 10g Radix Codonopsis 5g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 1g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 8g
Sargassum 15g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 3 hours for the first time, 2 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 10 times of water gagings, fry in shallow oil 2 times, and 2.5 hours for the first time, 2 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.15 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.1 (60 ℃), spray drying, two parts of xeraphium five equilibriums, a tartaric acid that adds, another part adds sodium bicarbonate, respectively add dextrin equivalent again, protein sugar is an amount of, respectively mixing, respectively add 70% ethanol and make soft material in right amount, make granule respectively, drying, mixing promptly gets effervescent granule.
Embodiment 12:
Radix Astragali 10g Radix Codonopsis 5g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 1g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 8g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 15g Concha Ostreae 5g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, magnesium stearate an amount of (account for and do particulate 0.1%), dry granulation, packing, promptly.
Embodiment 13:
Radix Astragali 10g Radix Codonopsis 5g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 1g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 8g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 15g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, magnesium stearate an amount of (account for and do particulate 0.3%), dry granulation, packing, promptly.
Embodiment 14:
Radix Astragali 10g Radix Codonopsis 5g 10g Radix Ophiopogonis
Radix Polygoni Multiflori 1g Herba Epimedii 8g Radix Puerariae 18g
Radix Angelicae Sinensis 8g Radix Salviae Miltiorrhizae 5g Spina Gleditsiae 8g
Sargassum 5g Thallus Laminariae (Thallus Eckloniae) 5g Concha Ostreae 12g
Fructus Aurantii Immaturus 5g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, magnesium stearate an amount of (account for and do particulate 0.5%), dry granulation, packing, promptly.
Embodiment 15:
Radix Astragali 13g Radix Codonopsis 11g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 7g Radix Puerariae 15g
Radix Angelicae Sinensis 6g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 3g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 1g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, magnesium stearate an amount of (account for and do particulate 1%), dry granulation, packing, promptly.
Embodiment 16:
Radix Astragali 18g Radix Codonopsis 6g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 7g Radix Puerariae 15g
Radix Angelicae Sinensis 6g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 3g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 1g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, adding ethanol makes and contains alcohol amount and reach 60%, cold preservation 36 hours filters, and filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, xeraphium adds lactose, maltodextrin is a small amount of, magnesium stearate an amount of (account for and do particulate 0.2%), dry granulation, packing, promptly.
Embodiment 17:
Radix Astragali 18g Radix Codonopsis 11g 4g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 7g Radix Puerariae 15g
Radix Angelicae Sinensis 5g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 3g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 1g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain alcohol amount and reach 60%, cold preservation 36 hours filters, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 0.5%), magnesium stearate an amount of (account for and do particulate 0.3%), dry granulation, packing, promptly.
Embodiment 18:
Radix Astragali 18g Radix Codonopsis 11g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 3g Herba Epimedii 7g Radix Puerariae 15g
Radix Angelicae Sinensis 5g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 3g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 1g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 1%), magnesium stearate an amount of (account for and do particulate 0.4%), each is an amount of for citric acid, sodium bicarbonate, dry granulation, packing, promptly.
Embodiment 19:
Radix Astragali 18g Radix Codonopsis 11g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 3g Radix Puerariae 15g
Radix Angelicae Sinensis 5g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 3g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 1g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 0.8%), magnesium stearate an amount of (account for and do particulate 0.6%), tartaric acid, sodium bicarbonate an amount of (respectively account for and do particulate 5%), dry granulation, packing, promptly.
Embodiment 20:
Radix Astragali 18g Radix Codonopsis 11g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 7g Radix Puerariae 10g
Radix Angelicae Sinensis 4g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 3g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 1g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 0.8%), magnesium stearate an amount of (account for and do particulate 0.6%), tartaric acid, sodium bicarbonate an amount of (respectively account for and do particulate 10%), dry granulation, packing, promptly.
Embodiment 21:
Radix Astragali 18g Radix Codonopsis 11g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 7g Radix Puerariae 10g
Radix Angelicae Sinensis 7g Radix Salviae Miltiorrhizae 7g Spina Gleditsiae 3g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 6 times of amounts 55% at every turn, and 2 hours for the first time, 1.5 hours for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.08 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 0.8%), magnesium stearate an amount of (account for and do particulate 0.6%), citric acid, sodium bicarbonate an amount of (respectively account for and do particulate 2%), dry granulation, packing, promptly.
Embodiment 22:
Radix Astragali 18g Radix Codonopsis 11g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 7g Radix Puerariae 10g
Radix Angelicae Sinensis 7g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 7g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 2g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 5 times of amounts 55% at every turn, and 1.5 hours for the first time, 1 hour for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.12 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 0.8%), magnesium stearate an amount of (account for and do particulate 0.6%), citric acid (account for and do particulate 2%), sodium bicarbonate (account for and do particulate 1%), dry granulation, packing, promptly.
Embodiment 23:
Radix Astragali 18g Radix Codonopsis 6g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 7g Radix Puerariae 10g
Radix Angelicae Sinensis 7g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 7g
Sargassum 11g Thallus Laminariae (Thallus Eckloniae) 6g Concha Ostreae 6g
Fructus Aurantii Immaturus 3g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 5 times of amounts 55% at every turn, and 1.5 hours for the first time, 1 hour for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.12 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 0.6%), magnesium stearate an amount of (account for and do particulate 0.6%), citric acid (account for and do particulate 3%), sodium bicarbonate (account for and do particulate 1%), dry granulation, packing, promptly.
Embodiment 24:
Radix Astragali 13g Radix Codonopsis 6g 8g Radix Ophiopogonis
Radix Polygoni Multiflori 7g Herba Epimedii 7g Radix Puerariae 10g
Radix Angelicae Sinensis 7g Radix Salviae Miltiorrhizae 11g Spina Gleditsiae 7g
Sargassum 6g Thallus Laminariae (Thallus Eckloniae) 11g Concha Ostreae 11g
Fructus Aurantii Immaturus 3g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 5 times of amounts 55% at every turn, and 1.5 hours for the first time, 1 hour for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.12 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 0.6%), magnesium stearate an amount of (account for and do particulate 0.6%), citric acid (account for and do particulate 1%), sodium bicarbonate (account for and do particulate 0.6%), dry granulation, packing, promptly.
Embodiment 25
Radix Astragali 16.8g Radix Codonopsis 8.5g 6.1g Radix Ophiopogonis
Radix Polygoni Multiflori 4.8g Herba Epimedii 4.8g Radix Puerariae 13.3g
Radix Angelicae Sinensis 4.8g Radix Salviae Miltiorrhizae 9.1g Spina Gleditsiae 4.8g
Sargassum 8.5g Thallus Laminariae (Thallus Eckloniae) 8.5g Concha Ostreae 8.5g
Fructus Aurantii Immaturus 2.4g
Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add the alcohol reflux 2 times of 5 times of amounts 55% at every turn, and 1.5 hours for the first time, 1 hour for the second time, filter, merge ethanol liquid and deposit in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 8 times of water gagings, fry in shallow oil 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filtrate decompression is concentrated into 1.12 one-tenth clear paste of relative density; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 60%, cold preservation 36 hours, filter, filtrate recycling ethanol also is concentrated into relative density 1.12 (60 ℃), spray drying, and it is a small amount of that xeraphium adds lactose, protein sugar (account for and do particulate 0.6%), magnesium stearate an amount of (account for and do particulate 0.6%), citric acid (account for and do particulate 1%), sodium bicarbonate (account for and do particulate 0.6%), dry granulation, packing, promptly.
Claims (8)
1, a kind of treatment coronary heart disease, anginal granule is characterized in that effective ingredient made by the following weight proportion raw material:
Radix Astragali 10%-20% Radix Codonopsis 5%-15% 2%-10% Radix Ophiopogonis
Radix Polygoni Multiflori 1%-8% Herba Epimedii 1%-8% Radix Puerariae 8%-18%
Radix Angelicae Sinensis 1%-8% Radix Salviae Miltiorrhizae 5%-15% Spina Gleditsiae 1%-8%
Sargassum 5%-15% Thallus Laminariae (Thallus Eckloniae) 5%-15% Concha Ostreae 5%-15%
Fructus Aurantii Immaturus 0.5%-5%.
2, the described granule of claim 1 is characterized in that the weight proportion of each raw material is:
Radix Astragali 13%-18% Radix Codonopsis 6%-11% 4%-8% Radix Ophiopogonis
Radix Polygoni Multiflori 3%-7% Herba Epimedii 3%-7% Radix Puerariae 10%-15%
Radix Angelicae Sinensis 3%-7% Radix Salviae Miltiorrhizae 7%-11% Spina Gleditsiae 3%-7%
Sargassum 6%-11% Thallus Laminariae (Thallus Eckloniae) 6%-11% Concha Ostreae 6%-11%
Fructus Aurantii Immaturus 1%-3%.
3, the described granule of claim 1 is characterized in that the weight proportion of each raw material is:
8.5% Radix Ophiopogonis 6.1% of the Radix Astragali 15.9% Radix Codonopsis
Radix Polygoni Multiflori 4.8% Herba Epimedii 4.8% Radix Puerariae 13.3%
Radix Angelicae Sinensis 4.8% Radix Salviae Miltiorrhizae 9.1% Spina Gleditsiae 4.8%
Sargassum 8.5% Thallus Laminariae (Thallus Eckloniae) 8.5% Concha Ostreae 8.5%
Fructus Aurantii Immaturus 2.4%.
4, according to the preparation method of claim 1,2 or 3 described granules, it is characterized in that: Radix Puerariae, Radix Salviae Miltiorrhizae adopt alcohol extracting method, add alcohol reflux 1-3 time that 4-12 doubly measures 40-80%, and each 0.5-3 hour, filter, merging ethanol liquid is deposited in addition; Medicinal residues are admixed in the thick simply pieces of all the other Radix Codonopsis etc. ten, add 4-12 times of water gaging, fry in shallow oil 1-3 time, decoct respectively 0.5-3 hour, merge decoction liquor, and filtrate decompression is concentrated into relative density 1.01-1.4 one-tenth clear paste; Merge with alcohol reflux liquid, add ethanol and make and contain the alcohol amount and reach 40-80%, cold preservation 24-48 hour, filter, filtrate recycling ethanol is concentrated into relative density 1.1-1.5 under 60 ℃, adds right amount of auxiliary materials system granule or drying and makes fine powder and add right amount of auxiliary materials system granule more promptly.
5, preparation method according to claim 4 is characterized in that used adjuvant is: starch, dextrin, Icing Sugar, lactose, magnesium stearate, maltodextrin, citric acid, tartaric acid, sodium bicarbonate, A Siba are sweet, in the stevioside, cyclamate, protein sugar one or more.
6, preparation method according to claim 5, adjuvant is lactose and magnesium stearate and sweeting agent when it is characterized in that dry granulation; Conventional granulation adjuvant is Icing Sugar and starch.
7, preparation method according to claim 6, the ratio of Icing Sugar and starch is when it is characterized in that wherein conventional the granulation: 1: 1-3: 1; Adjuvant magnesium stearate consumption for proportion in finished particle is during dry granulation: 0.1%-1%.
8, preparation method according to claim 7, the ratio of Icing Sugar and starch is when it is characterized in that wherein conventional the granulation: 2: 1-3: 1; Adjuvant magnesium stearate consumption for proportion in finished particle is during dry granulation: 0.1%-0.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410057368 CN1287834C (en) | 2004-08-30 | 2004-08-30 | Powder for treating coronary heart disease and angina pectoris and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410057368 CN1287834C (en) | 2004-08-30 | 2004-08-30 | Powder for treating coronary heart disease and angina pectoris and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1628794A CN1628794A (en) | 2005-06-22 |
| CN1287834C true CN1287834C (en) | 2006-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410057368 Active CN1287834C (en) | 2004-08-30 | 2004-08-30 | Powder for treating coronary heart disease and angina pectoris and its preparing process |
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| Country | Link |
|---|---|
| CN (1) | CN1287834C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884679B (en) * | 2009-05-15 | 2012-04-18 | 天津太平洋制药有限公司 | Food therapy preparation for preventing and treating cardiovascular diseases based on theories of preventive treatment of disease and medicine food homology |
| CN113876885A (en) * | 2021-11-10 | 2022-01-04 | 山东新时代药业有限公司 | Preparation method of Xintong preparation |
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2004
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Also Published As
| Publication number | Publication date |
|---|---|
| CN1628794A (en) | 2005-06-22 |
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Owner name: LUNAN PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER OWNER: LUNAN PHARMACY CO. LTD. Effective date: 20050812 |
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Assignee: Lunan Pharmaceutical Co., Ltd. Assignor: Lunan Pharmaceutical Group Co., Ltd. Contract record no.: 2010370000516 Denomination of invention: Powder for treating coronary heart disease and angina pectoris and its preparing process Granted publication date: 20061206 License type: Exclusive License Open date: 20050622 Record date: 20100909 |
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Assignee: Lunan Pharmaceutical Co., Ltd. Assignor: Lunan Pharmaceutical Group Co., Ltd. Contract record no.: 2010370000516 Date of cancellation: 20131016 |
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