CN1281251C - Medicine for treating chronic hepatitis and liver cirrhosis - Google Patents

Abstract

The present invention provides a medicine for curing chronic hepatitis and liver cirrhosis, which comprises the following components according to parts by weight: 1 to 3 parts of nutgrass galingale rhizome, 7 to 11 parts of mushroom, 5 to 10 parts of perilla seed oil, 2 to 5 parts of virgate wormwood herb and 50 to 80 parts of duck meat. The present invention has no toxic and side effect, no damage to the liver, wide adaptive range and high effect; the medisine can enhance and adjust the autoimmune function of the human body and increase defense cells in the human body.

Description

The medicine of treatment chronic hepatitis, liver cirrhosis

Technical field:

The present invention is relevant with the medicine of treatment hepatitis, and is relevant with the medicine of treatment chronic hepatitis, liver cirrhosis especially.

Background technology:

The history in existing more than 2000 year of Chinese traditional treatment hepatopathy is used the hardened exploration of Chinese traditional treatment chronic hepatitis regulating liver-QI for many years, has obtained certain achievement.The traditional Chinese medical science to chronic hepatitis and liver cirrhosis clinically mainly show as jaundice, wetly hinder, gather, tympanites, deficient and liver,spleen,kidney three dirty functional disorders, the liver blood stasis of blood stagnates, liver network obstruction causes pent-up, the stagnation of QI, blood stasis, water retention.The chronic hepatitis course of disease surpasses more than half a year, be detected in B-mode, third type, the hepatitis that the fourth type is three types, wherein hepatitis B accounts for more than 80%, by pathological changes, immune state is divided into the different of aspect such as clinical manifestations: chronic persistent hepatitis, chronic active hepatitis, the chronic severe hepatitis that while causes owing to multiple virus, clear because of damp and hot heresy end therefrom, glue is solid day by day, with the passing of time touching, the liver network blocks, and injures QI and blood, the function of internal organs, further develop its essence of damage and develop into liver cirrhosis, Chinese traditional treatment is with inrigorating qi and promoting blood circulation, nourishing blood to suppress the hyperactive liver is the basis, and according to the emphasis or the nourishing the liver and kidney of different pattern of syndrome, or replenishing YIN and removing heat, or temperature compensation spleen, kidney, or invigorating spleen for diuresis, activating blood and promoting diuresis, methods such as promoting the circulation of QI to induce diuresis, symptomatic treatment in acute condition, relieving the primary symptom in a chronic case.Through clinical verification Chinese medicine, as: the Radix Astragali, Radix Codonopsis, Radix Ginseng, Radix Scutellariae, Placenta Hominis, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Lycii, Carapax Trionycis, Radix Curcumae, Caulis Spatholobi, Cortex Moutan, Herba Artemisiae Scopariae, Radix Bupleuri, Herba Patriniae, Fructus Schisandrae Chinensis etc. are formed compound recipe.Fibrosis adds Ganoderma, Cordyceps, Radix Salviae Miltiorrhizae, lifting albumen with Fructus Jujubae, Placenta Hominis, Colla Corii Asini, Colla Plastri Testudinis, Concha Ostreae etc.Clearing away heat-damp and promoting diuresis is selected Herba Artemisiae Scopariae, Rhizoma Polygoni Cuspidati, Radix Gentianae, Herba Plantaginis, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis etc. for use.Eliminating evil Radix Sophorae Tonkinensis, Radix Isatidis, Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici, Rhizoma Smilacis Glabrae, Flos Lonicerae, the Fructus Forsythiae etc. of adding detoxify.Vital energy regualting and blood circulation-promoting is selected Radix Curcumae, Radix Bupleuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Pericarpium Arecae, Herba Lycopi, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae, Radix Paeoniae Rubra, Fructus Citri Sarcodactylis etc. for use.Cirrhotic ascites is selected Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria, Polyporus, Rhizoma Alismatis, Exocarpium Benincasae, withered green bamboo, Lagenaria siceraria(Molina) Standl.var.depressa Ser., Radix Aucklandiae (Radix Vladimiriae), Pericarpium Citri Reticulatae etc. for use.

The above-mentioned animal and plant crude drug of enumerating only is the employed part of each school of the traditional Chinese medical science, and it is of a great variety, and usage is different.Because the pathogenesis complexity, changeful, should be familiar with common pathologic basis in clinical, distinguish each patient's characteristics again, also to distinguish deficiency and excess, distinct primary and secondary simultaneously, grasp pathogenesis, the prediction conversion process.Because the medicine that enters human body need too much use and increase the weight of burden of liver through liver metabolism mostly, adds the toxic and side effects of top medicine, take the medicine infringement that causes liver for a long time, after the drug withdrawal state of an illness easily repeatedly, the late result instability.

Summary of the invention:

The objective of the invention is to have no side effect, improve and adjustment human body self immunologic function, increase defense cell in the body in order to provide a kind of, harmless to liver, the medicine of wider, the more effective treatment chronic hepatitis of subject range, liver cirrhosis disease.

The object of the present invention is achieved like this:

The present invention treats the medicine of chronic hepatitis, liver cirrhosis, it is characterized in that comprising by weight following component:

Rhizoma Cyperi 1～3,

Mushroom 7～11,

Fructus Perillae oil 5～10,

Herba Artemisiae Scopariae 2～5,

Duck meat 50～80.

Above-mentioned medicine comprises following component by weight:

Rhizoma Chuanxiong 2～5,

The Radix Paeoniae Alba 2～5,

Radix Ginseng 2～5,

Mushroom 7～11,

Fructus Lycii 2～4,

Fructus Perillae oil 5～10,

Rhizoma Cyperi 1～3,

Radix Glycyrrhizae 1～3,

Herba Artemisiae Scopariae 2～5,

Duck meat 50～80.

Above-mentioned medicine comprises following component by weight:

Rhizoma Chuanxiong 2.2,

The Radix Paeoniae Alba 3.3,

Radix Ginseng 2.7,

Mushroom 9.5,

Fructus Lycii 2.7,

Fructus Perillae oil 8.1,

Rhizoma Cyperi 1.6,

Radix Glycyrrhizae 1.6,

Herba Artemisiae Scopariae 2.2,

Duck meat 68.

Rhizoma Chuanxiong, the Radix Paeoniae Alba that the present invention treats in the medicine of chronic hepatitis, liver cirrhosis disease have the effect of suppressing the hyperactive liver pain relieving, blood-activating and qi-promoting; The effect of Radix Ginseng, Fructus Lycii strongly invigorating primordial QI, nourishing the liver and kidney, invigorating the spleen to benefit the lung; Herba Artemisiae Scopariae clearing away damp-heat, jaundice eliminating subcutaneous ulcer; Rhizoma Cyperi, Radix Glycyrrhizae promoting QI circulation for relieving depression, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing; Duck meat inducing diuresis to remove edema, YIN nourishing are supported lung; Fructus Perillae oil skin expansion blood vessel, blood circulation promoting, the secretion of facilitating digestion liquid increase gastrointestinal peristalsis; Mushroom is improved immunologic function, is good for the stomach and spleen.Modern medicine is thought: mushroom is rich in vegetable protein and carbohydrate and various trace elements, and antivirus action is arranged.Fructus Perillae oil is rich in the necessary aminoacid of human body such as linolenic and linoleic.The present invention cooperates duck meat by above Chinese medicine, and the animal and plant protein and the aminoacid that easily absorb through the modern scientific method synthesized human, and reasonably medicine is complementary have been realized the principle of Chinese medicine treatment chronic hepatitis, liver cirrhosis disease treating both the principal and secondary aspects of a disease.The immunoreation deficiency of Drug therapy chronic hepatitis patient of the present invention makes human body weaken the identification ability of hepatitis virus, continues to exist so that liver cell lesion goes round and begins again, and the effect of disease protracted course of disease is remarkable.For being because of hepatic fibrosis hamartoplasia by development of chronic hepatitis, helicity is shunk the quality hardening, hepatic sinusoid is destroyed, force hepatic vein branch pressurized, blood flows out the factors of being obstructed and develops and next liver cirrhosis disease, have the hepatic vein branch thin blood vessel of activation, thereby reach thick, thick, the long fibre structure of degraded, recover the optimum efficiency of liver reserve function because of compressing, knob song.

After medicine of the present invention is processed the process of preparing Chinese medicine according to the Pharmacopoeia of the People's Republic of China (200 editions), can be made into " granule ", " pill " reaches different peroral dosage forms such as " tablets ".

Medicine of the present invention is to chronic hepatitis (based on hepatitis B), cirrhosis patients in decompensation patient's clinical treatment, chronic hepatitis B patient 263 examples wherein, and cirrhosis patients in decompensation patient's 138 routine clinographies are as follows:

One, chronic hepatitis B patient, medical history were checked before the treatment more than 3 years

1, sign performance: 1. loss of appetite: 241 examples; 2. fatigue and weak: 257 examples; 3. heating: 135 examples; 4. jaundice: 124 examples; 5. pain in the hepatic region: 184 examples; 6. hepatic facies, liver palm, spider angioma: 135 examples; 7. ascites: 82 examples; 8. hemorrhage: 37 examples;

2, " two double " result of laboratory test

263 routine chronic hepatitis B patients are: hepatitis B surface antigen (+) positive, hepatitis B virus e antigen (+) positive, core antibody (+) positive (being commonly called as " great three positive ")

Two, decompensated liver cirrhosis (in, late period) patient's 138 examples, wherein 125 examples are liver cirrhosis behind the hepatitis B, 13 examples are alcoholic cirrhosis.Check before the treatment:

1, sign performance: 1. fatigue and weak, diet is depressed, nauseating, abdominal distention is uncomfortable: 115 examples; 2. arrive a large amount of ascites, lower limbs edema in: 87 examples; 3. hematemesis: 23 examples; 4. have blood in stool, gingiva, nasal bleeding: 51 examples; 5. dim complexion, liver palm: 124 examples; 6. whole body is crocus (jaundice): 8 examples; 7. hepatic encephalopathy symptom: 8 examples;

2, liver function test

More than serum bilirubin 240～340umol/L, albumin is less than 32g/L, and the transaminase is greater than more than the 80u/L, and serum prothrombin time prolongs 4～6s, and albumin, globulin ratio are inverted.

3, " two double " check result:

125 routine patient's hepatitis B surface antigens (HbsAc), e antigen (HbeAg), core antibody (anti--HBc) positive simultaneously (promptly " great three positive ").

4, ultrasound diagnosis:

The liver form is not normal, and tuberal region echo strengthens in the liver parenchyma, surface irregularity, the edge indentation, in the intraperitoneal to a large amount of echolesses dark space (in to a large amount of ascites), inner diameter of portal vein broadening, side offshoot and trunk thromboembolism, spleen enlargement.

Three, above chronic hepatitis, liver cirrhosis patient, use Drug therapy situation of the present invention:

1, chronic hepatitis (hepatitis B) " great three positive " patient treatment is 70 days, wherein 237 examples are changed into by " great three positive ": surface antigen (HbsAg), e antibody (anti--Hbe), (anti--HBc) positive (being commonly called as " small three positive "), 26 examples change into core antibody in addition: surface antigen, core antibody positive.Appetite increases, and sleep state is good, and jaundice disappears, and ascites (removing 17 exceptions) is all eliminated, and bleeding disappears.Stable phase surpasses three months, and part patient is not recurrence more than six months.

2, liver cirrhosis disease patient was through treatment in 150 days, liver cirrhosis patient " great three positive " all changes " small three positive " or " 15 sun " into behind the 125 routine hepatitis ies, the mental status is good, appetite increases, and hematemesis, bleeding such as have blood in stool disappear, and hepatic facies, liver palm disappear, jaundice disappears, to a large amount of ascites complication patients, have 52 routine ascites to disappear in 87 examples, all the other flat umbilicus abdominal circumferences dwindle more than the 3.0cm.There are 121 routine liver function tests normal, alaninyl transferring enzyme (ALT)≤35IU/L, winter is pacified sour aminotransferase (AST)≤35TU/L, bilirubin (Bil)≤17umol/L, albumin 〉=35g/L, 89 routine patient's spleen is soft to some extent contracts, 35 routine spleens are stablized constant, the uneven rough surface that changes into of liver surface, the edge becomes rough shape by zigzag, and the portal vein embolization phenomenon disappears basically, and the hepatitis interstitialis chronica of effectively degrading is thick, thick, long fibre, the liver blood flow amount increases, and reaches liver reserve function basically and recovers.Above-mentioned patient's stable phase surpasses 100 days, and part patient is above 8 months.

From above clinical case, can affirm that medicine of the present invention is the significant curative effect of chronic hepatitis, liver cirrhosis disease: 1., after therapeutic process and drug withdrawal, do not recur, do not rebound because medicine of the present invention has no side effect.2. by improving and adjust autoimmune function, enhancing body defense cell, antiviral, fibrosis delay.3. dredge occluding vascular gradually, improve the liver blood circulation, impel liver cell regeneration, the thick thick fiber of degrading recovers liver reserve function.4. effectively remove portal vein embolization, prevent hematemesis, have blood in stool etc.

This shows that medicine of the present invention has significant curative effect for chronic hepatitis, liver cirrhosis disease.Medicine subject range of the present invention is wider.Also be applicable to cerebral thrombosis, the auxiliary treatment of the large and small vascular complication of diabetes.

The specific embodiment:

The embodiment of the invention sees Table 1.

Table 1:

Claims (3)

1, the medicine of treatment chronic hepatitis, liver cirrhosis is characterized in that comprising by weight following component:

Rhizoma Cyperi 1～3,

Mushroom 7～11,

Fructus Perillae oil 5～10,

Herba Artemisiae Scopariae 2～5,

Duck meat 50～80.

2, the medicine of treatment chronic hepatitis as claimed in claim 1, liver cirrhosis is characterized in that comprising by weight following component:

Rhizoma Chuanxiong 2～5,

The Radix Paeoniae Alba 2～5,

Radix Ginseng 2～5,

Mushroom 7～11,

Fructus Lycii 2～4,

Fructus Perillae oil 5～10,

Rhizoma Cyperi 1～3,

Radix Glycyrrhizae 1～3,

Herba Artemisiae Scopariae 2～5,

Duck meat 50～80.

3, the medicine of treatment chronic hepatitis as claimed in claim 2, liver cirrhosis is characterized in that comprising by weight following component:

Rhizoma Chuanxiong 2.2,

The Radix Paeoniae Alba 3.3,

Radix Ginseng 2.7,

Mushroom 9.5,

Fructus Lycii 2.7,

Fructus Perillae oil 8.1,

Rhizoma Cyperi 1.6,

Radix Glycyrrhizae 1.6,

Herba Artemisiae Scopariae 2.2,

Duck meat 68.