CN1279877C - Kidney arteria stent - Google Patents

Kidney arteria stent Download PDF

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Publication number
CN1279877C
CN1279877C CNB2004100414747A CN200410041474A CN1279877C CN 1279877 C CN1279877 C CN 1279877C CN B2004100414747 A CNB2004100414747 A CN B2004100414747A CN 200410041474 A CN200410041474 A CN 200410041474A CN 1279877 C CN1279877 C CN 1279877C
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China
Prior art keywords
ring
support
support ring
additional
renal artery
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Expired - Fee Related
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CNB2004100414747A
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Chinese (zh)
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CN1596843A (en
Inventor
易红
倪中华
顾兴中
汤文成
厉其昀
马根山
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Southeast University
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Southeast University
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Priority to CNB2004100414747A priority Critical patent/CN1279877C/en
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Abstract

The present invention discloses a kidney artery bracket, which relates to a forming operation of a percutaneous puncturing insertion type kidney artery bracket in a blood vessel cavity. The structure of the kidney artery bracket is distinguished from the structure of the existing market bracket having the defect that the existing market bracket is not suitable for a pathologic change structure due to the fact that the existing market bracket is not changed in an axial direction. The design of structure change and bracket rod cross section change is adopted, and the kidney artery bracket adapts to common local section pathologic change, and is particularly suitable for the pathologic change of a cut position. A 316L medical stainless steel microtubule or an L605(cobalt-chromium alloy) microtubule is engraved by laser to form the bracket. The left side of a first supporting ring is connected with a first additional ring at the most left side of the bracket, and the right side of the first supporting ring is connected with a second supporting ring by a first connecting ring. The second supporting ring is connected with a third supporting ring by a second connecting ring. The third supporting ring is connected with a fourth supporting ring by a third connecting ring. The fourth supporting ring is connected with a fifth supporting ring by a fourth connecting ring. The fifth supporting ring is connected with a near end conical ring by an expansion limiting security protection ring, and the right side of the near end conical ring is connected with an eighth additional ring.

Description

A kind of renal artery stent
Technical field
The present invention relates to percutaneous puncture insertion type renal artery stent blood vessel intracavity forming operation, belong to the technical field that medical apparatus and instruments is made.
Background technology
Problem: a side or two side main renal arteries or its branch or a side accessory renal artery or its are ramose narrow or inaccessible, inspire juxtaglomerular cell by influenced kidney and discharge the feritin enzyme and can cause hypertension.The cause of disease of renal artery stenosis mainly contains: Takayasu arteritis; Atherosclerosis; Fiber caryolytes structure is bad; Narrow behind the renal transplantation.Renal artery stenosis radiography performance: 1. renal artery stenosis or obturation: due to Takayasu arteritis and the atherosclerosis narrow multidigit in the renal artery root, apart from renal artery opening part and nearly 1/3 section, and due to the fibrillar muscle hypertrophy narrow multidigit in section far away, can involve branch.2. the expansion of narrow back: it is narrow to be common in the severe limitation, is fusiform dilatation more.3. aneurysm forms: can be shuttle shape or beading, beading is typical case's performance of muscle fiber dysplasia.4. collateral circulation forms: generally arise from kidney peplos tremulous pulse, lumbar arteries, ureter tremulous pulse etc.5. on the basis of the above, renal atrophy excess of the kidney matter development delay, light appears.
Solution: Drug therapy, surgical operation and endoluminal vascular plasty.Adopting renal artery inferior vena cava balloon dilation and renal artery stent implantation interventional therapy, have advantages such as wound is little, safe and simple and effective, is treatment renal vascular hypertension prefered method.Behind the atherosclerotic renal vascular disease people percutaneous transluminal angio plasty in 2 years restenosis take place up to 50%, especially be positioned at the renal artery opening part when speckle, put the danger that support has then reduced restenosis.Because renal vascular hypertension is often effective to antihypertensive drug, put more desirable than operation to the patient's Drug therapy or the percutaneous transluminal angio plasty companion support of old atherosclerotic lesion.In a word, that Wicresoft's renal artery stent art can be avoided is big, difficulty, the surgical operation that has a big risk, reduces complication (as hemorrhage, infection etc.), shortens and is in hospital and rehabilitation duration, and have in the future inaccessible once more of higher success rate and prevention blood vessel.
Renal artery stent is domestic to have only minority producer to produce, and is imitated external like product.Clinical use is still based on the import external product, and adopts periphery support (as the iliac artery support) to substitute more, and specially at actually rare on the arteriorenal support market, only there is PALMAZ support (FDA approval in 2002) existing domestic market.Because the renal artery pathological changes, often be positioned at opening part, must there be 1-2mm to project to large artery trunks after making support implant, this obviously influences the hemodynamics form, especially implants the back influence more very at needs bilateral support.Expansion after the narrow easy formation of opening part is narrow in addition, therefore existing support also is not suitable for the pathological changes that narrow back is expanded.
Summary of the invention
Technical problem: at the shortcoming of existing product; goal of the invention of the present invention is to propose a kind of renal artery stent that adapts to the narrow band safeguard protection ring of opening part, and this renal artery stent can improve existing stenting and handle the shortcoming that opening lesion employing support stretches into large artery trunks one segment distance.
Technical scheme: the renal artery stent of band safeguard protection ring of the present invention, by additional ring, support ring, connecting ring is formed, also be provided with restriction expansion safeguard protection ring on this support, first additional ring wherein, second additional ring, the 3rd additional ring, the 4th additional ring, the 5th additional ring, the 6th additional ring, the 7th additional ring, the 8th additional ring, first connecting ring, second connecting ring, the 3rd connecting ring, the 4th connecting ring is the roundlet annular, first support ring, second support ring, three-support ring, the 4th support ring, the 5th support ring, the near-end conical ring is a waveform, restriction expansion safeguard protection ring is a bending, the population structure of this support is: the left side of first support ring is connected with leftmost first additional ring of this support, the right of first support ring connects articulating second support ring by first, second support ring connects the articulating three-support ring by second, three-support ring connects articulating the 4th support ring by the 3rd, the 4th support ring connects articulating the 5th support ring by the 4th, the 5th support ring is by restriction expansion safeguard protection articulating near-end conical ring, and the right of near-end conical ring connects the 8th additional ring; Top at the low ripple of corrugated first support ring, second support ring, three-support ring, the 4th support ring, the 5th support ring, near-end conical ring is connected with second additional ring, the 3rd additional ring, the 4th additional ring, the 5th additional ring, the 6th additional ring, the 7th additional ring respectively.Rack far end is that nearly kidney end is made up of first additional ring, second additional ring, the 3rd additional ring, the 4th additional ring, first support ring, second support ring, three-support ring, first connecting ring, second connecting ring, the 3rd connecting ring; Reinforcement district, stage casing is made up of the 5th additional ring, the 6th additional ring, the 4th support ring, the 5th support ring, the 4th connecting ring; Mount proximal end is near the renal artery opening part, is made up of the 7th additional ring, the 8th additional ring, near-end conical ring.
Forniciform restriction expansion safeguard protection ring is that sine wave or pulse are wavy.Forniciform restriction expansion safeguard protection ring has two or more, is connected respectively between two support rings.Support structural change vertically shows as mount proximal end and far-end support ring bar cross section and reduces and increase far-end support ring wave height to launch girth to increase the far-end support ring to adapt to the characteristics of renal artery pathological changes in opening part and the expansion of narrow back.The number of strengthening the support ring in district and connecting ring by increase and decrease middle part reaches the length that increases or reduce support to adapt to different lesions length.Support is by adopting connecting ring to be formed by connecting between the support ring, support ring is along be non-consistent the design circumferentially, the interference when the minimizing pressure is held support, and its intermediate waves height is between 2/3 to 9/10 times of long wave height.
Characteristics of the present invention are: one, rack far end become the bar Cross section Design refer to first support ring bar width into the 90-98% of the width of the bar of second support ring doubly, and the width of the bar of second support ring be three-support ring bar width 90-98% doubly.Rack far end become wave height that structural design refers to first support ring into the 102-110% of the wave height of second support ring doubly, the wave height of second support ring be three-support ring wave height 102-110% doubly (make support ring launch girth big to the progressive change of far-end) by interrupting become big (being the expansion of narrow back) with the office's section tube chamber that adapts to renal artery and cause because of opening part is narrow.Two, mount proximal end refers to adopt can expand to horn mouth designs (utilize the common dog bone effect of balloon expandable stent, and after first expansion, adopt compliant balloon to achieve the goal) in the opening part further expansion, support expands to be opened the back and fits tightly with blood vessel wall projecting to the large artery trunks part, has avoided existing beam type to stretch out structure.Mount proximal end variable cross-section design refer to the near-end conical ring bar width for the 50-80% of the width of the bar of stage casing reinforcement district the 5th support ring doubly.Three,,, add restriction expansion safeguard protection ring at the mount proximal end edge for prevention causes that because of crossing expansion the arterial blood tube wall tears in mount proximal end protection ring design.Four, support ring is along be non-consistent the design circumferentially, the interference when the minimizing pressure is held support, and its intermediate waves height is between 2/3 to 9/10 times of long wave height.Five, additional ring and connecting ring interstitial hole can be used for loading the prevention of restenosis medicine, improve therapeutic effect thereby additional ring and the design of connecting ring interstitial hole can improve the support drug loading greatly.
Beneficial effect: supporting structure adopts and becomes structure and become the bar Cross section Design, has both guaranteed the intensity of support, can make support more adapt to shape of blood vessel (opening pathological changes and the expansion of narrow back) again.For prevention causes that because of crossing expansion the arterial blood tube wall tears, add restriction expansion safeguard protection ring at the mount proximal end edge, therefore increased safety.Connecting ring and additional ring interstitial hole can be used for loading the medicine of prevention of restenosis, thereby effectively improve the maintenance effect of support.The utility model proposes originality structural design and implementation method and can effectively solve renal artery opening part pathological changes problem; supporting structure is adopted the change structural design and adds the design of safeguard protection ring to adapt to the renal artery blood vessel in the stenotic lesion characteristics that opening part takes place, and is a kind of endovascular stent of safe, ideal treatment renal artery opening part pathological changes.The utlity model has than wide market application prospect.
Description of drawings
Fig. 1 support expansion of the present invention back view
The unfolded vertically structural representation of Fig. 2 the present invention.
In the unfolded vertically structural representation of Fig. 3 the present invention, on support, have the sketch map of two restriction expansion protection rings.
It is the structural representation of pulse type that Fig. 4 the present invention limits the expansion protection ring.
Fig. 5 the present invention limits the another kind of connected mode sketch map in the structure that the expansion protection ring is a pulse type.
Specifically comprise among the above figure: first additional ring 11, second additional ring 12, the 3rd additional ring 13, the 4th additional ring 14, the 5th additional ring 15, the 6th additional ring 16, the 7th additional ring 17, the 8th additional ring 18; First support ring 21, second support ring 22, three-support ring 23, the 4th support ring 24, the 5th support ring 25; First connecting ring 31, second connecting ring 32, the 3rd connecting ring 33, the 4th connecting ring 34; Restriction expansion protection ring 4; Near-end conical ring 5.
The specific embodiment
Renal artery stent of the present invention is a balloon expandable stent, is formed by 316L medical stainless steel metal tube or L605 (cochrome) microtubule engraving, and this support axially adopts along it and becomes structure and become the bar Cross section Design to adapt to the opening part pathological changes.
This support is made up of connecting ring and support ring, is divided into far-end, stage casing reinforcement district, near-end horn mouth totally three sections different structure districts.Reinforcement district, stage casing is that with the main distinction of far-end the sectional area of cradling piece is different with structure, mainly be presented as: the wave height of far-end support ring is greater than the wave height of stage casing reinforcement district support ring, make it launch girth and launch girth greater than stage casing reinforcement district, and the progressive increase of the sectional area of its cradling piece, cradling piece is in stage casing reinforcement district sectional area maximum, and stage casing reinforcement district cradling piece sectional area is constant.The near-end horn mouth refers to that support is attached on the main artery wall at formation horn mouth after the expansion, and near-end horn mouth cradling piece sectional area is less than stage casing reinforcement district cradling piece sectional area.The cradling piece variable cross-section can be taked to change the cradling piece width W and realize.
The related content and the change interpretation of technique scheme are as follows:
1. rack body is once carved by rustless steel microtubule or L605 microtubule laser and is formed, and has kept the globality of support.
2. the characteristics (opening part and narrow back expansion) of support structural change vertically to adapt to the renal artery pathological changes show as mount proximal end and distal rod cross section and reduce and increase far-end support ring wave height to launch girth to increase the far-end support ring.
3. the mount proximal end design makes it be easy to form horn mouth after expansion, utilizes the compliant balloon quadratic extension to obtain.
4. for preventing expansion injured blood vessel (mainly being vascular tear), add 4 designs of restriction expansion protection ring in mount proximal end.
5. 4 designs of restriction expansion protection ring are used between the far-end and stage casing reinforcement district of support.(see figure 2)
6. restriction expansion protection ring 4 structures are removed sinusoidal wave form connection shown in Figure 2, and other has two kinds of syndeton (see figure 4)s of pulse form
7. the expansion of narrow back easily takes place behind most renal artery stenosis, and (particularly severe office section is narrow, be fusiform dilatation) more, so rack far end utilizes the compliant balloon quadratic extension to make the rack far end expansion diameter greater than stage casing reinforcement district (stenosis area) expansion diameter after expansion, make the adherent performance of support and blood vessel better, improve the blood flow form.
8. the area in support ring bar cross section reduces and can realize by the width that reduces bar.
9. the width of support ring bar changes and can reach by adopting direct design degree of broadening to reach or adopting change to cut surplus.
10. support change structure can be the combination of above-mentioned variation.
11. the number of strengthening the support ring in district and connecting ring by increase and decrease middle part reach increase or
12. the length that reduces support is to adapt to different lesions length.
13. support additional ring and the design of connecting ring interstitial hole can be used for loading anti-narrow medicine.
Its concrete structure is: also be provided with restriction expansion safeguard protection ring 4 on this support, first additional ring 11 wherein, second additional ring 12, the 3rd additional ring 13, the 4th additional ring 14, the 5th additional ring 15, the 6th additional ring 16, the 7th additional ring 17, the 8th additional ring 18, first connecting ring 31, second connecting ring 32, the 3rd connecting ring 33, the 4th connecting ring 34 is the roundlet annular, first support ring 21, second support ring 22, three-support ring 23, the 4th support ring 24, the 5th support ring 25, near-end conical ring 5 is a waveform, restriction expansion safeguard protection ring 4 is a bending, the population structure of this support is: the left side of first support ring 21 is connected with leftmost first additional ring 11 of this support, the right of first support ring 21 connects second support ring 22 by first connecting ring 31, second support ring 22 connects three-support ring 23 by second connecting ring 32, three-support ring 23 connects the 4th support ring 24 by the 3rd connecting ring 33, the 4th support ring 24 connects the 5th support ring 25 by the 4th connecting ring 34, near end conical ring 5, the right of near-end conical ring 5 connects the 8th additional ring 18 to the 5th support ring 25 by restriction expansion safeguard protection ring 4; Top at the low ripple of corrugated first support ring 21, second support ring 22, three-support ring 23, the 4th support ring 24, the 5th support ring 25, near-end conical ring 5 is connected with second additional ring 12, the 3rd additional ring 13, the 4th additional ring 14, the 5th additional ring 15, the 6th additional ring 16, the 7th additional ring 17 respectively.
Forniciform restriction expansion safeguard protection ring 4 is that sine wave or pulse are wavy.Forniciform restriction expansion safeguard protection ring 4 has two or more, is connected respectively between two support rings.Support structural change vertically shows as mount proximal end and distal rod cross section and reduces and increase far-end support ring wave height to launch girth to increase the far-end support ring to adapt to the characteristics of renal artery pathological changes in opening part and the expansion of narrow back.The number of strengthening the support ring in district and connecting ring by increase and decrease middle part reaches the length that increases or reduce support to adapt to different lesions length.Support is by adopting connecting ring to be formed by connecting between the support ring, support ring is along be non-consistent the design circumferentially, the interference when the minimizing pressure is held support, and its intermediate waves height is between 2/3 to 9/10 times of long wave height.
Exemplifying embodiment: as Fig. 1; be the sketch map of a kind of renal artery stent with the safeguard protection ring at expansion state; this support is formed by 316L medical stainless steel microtubule or L605 (cochrome) microtubule laser engraving; this support is made up of connecting ring and support ring, is divided into far-end, stage casing reinforcement district, near-end horn mouth totally three sections different structure districts.Reinforcement district, stage casing is that with the main distinction of far-end the sectional area of cradling piece is different with structure, mainly be presented as: the wave height of far-end support ring is greater than the wave height of stage casing reinforcement district support ring, make it launch girth and launch girth greater than stage casing reinforcement district, and the progressive increase of the sectional area of its cradling piece, cradling piece is in stage casing reinforcement district sectional area maximum, and stage casing reinforcement district cradling piece sectional area is constant.The near-end horn mouth refers to that support is attached on the main artery wall at formation horn mouth after the expansion, and its cradling piece sectional area of near-end conical ring is less than stage casing reinforcement district cradling piece sectional area.The cradling piece variable cross-section can be taked to change the cradling piece width W and change cradling piece thickness T dual mode and realize.Support additional ring and the design of connecting ring interstitial hole can be used for loading anti-narrow medicine.Behind this support implantable intravascular, formation near-end horn mouth and the gradually big cone barrel of far-end more adapt to the lesion vessels form behind the employing compliant balloon quadratic extension, improve the hemodynamics form.

Claims (6)

1, a kind of renal artery stent, by additional ring, support ring, connecting ring is formed, it is characterized in that also being provided with on this support restriction expansion safeguard protection ring (4), first additional ring (11) wherein, second additional ring (12), the 3rd additional ring (13), the 4th additional ring (14), the 5th additional ring (15), the 6th additional ring (16), the 7th additional ring (17), the 8th additional ring (18), first connecting ring (31), second connecting ring (32), the 3rd connecting ring (33), the 4th connecting ring (34) is the roundlet annular, first support ring (21), second support ring (22), three-support ring (23), the 4th support ring (24), the 5th support ring (25), near-end conical ring (5) is a waveform, restriction expansion safeguard protection ring (4) is a bending, the population structure of this support is: the left side of first support ring (21) is connected with leftmost first additional ring of this support (11), the right of first support ring (21) connects second support ring (22) by first connecting ring (31), second support ring (22) connects three-support ring (23) by second connecting ring (32), three-support ring (23) connects the 4th support ring (24) by the 3rd connecting ring (33), the 4th support ring (24) connects the 5th support ring (25) by the 4th connecting ring (34), near end conical ring (5), the right of near-end conical ring (5) connects the 8th additional ring (18) to the 5th support ring (25) by restriction expansion safeguard protection ring (4); Top at the low ripple of corrugated first support ring (21), second support ring (22), three-support ring (23), the 4th support ring (24), the 5th support ring (25), near-end conical ring (5) is connected with second additional ring (12), the 3rd additional ring (13), the 4th additional ring (14), the 5th additional ring (15), the 6th additional ring (16), the 7th additional ring (17) respectively; The width of the bar of first support ring is the 90-98% of width of the bar of second support ring, and the width of the bar of second support ring is the 90-98% of width of the bar of three-support ring; The wave height of first support ring is the 102-110% of the wave height of second support ring, and the wave height of second support ring is the 102-110% of the wave height of three-support ring, becomes big to adapt to office's section tube chamber that renal artery causes because of opening part is narrow; Mount proximal end adopts and can expand to horn mouth designs, and the width of the bar of near-end conical ring is the 50-80% of the width of the bar of stage casing reinforcement district the 5th support ring; For prevention causes that because of crossing expansion the arterial blood tube wall tears, add restriction expansion safeguard protection ring at the mount proximal end edge.
2, a kind of renal artery stent according to claim 1 is characterized in that forniciform restriction expansion safeguard protection ring (4) is that sine wave or pulse are wavy.
3, a kind of renal artery stent according to claim 1 is characterized in that forniciform restriction expansion safeguard protection ring (4) has two or more, is connected respectively between two support rings.
4, a kind of renal artery stent according to claim 1, it is characterized in that support structural change vertically to adapt to the characteristics of renal artery pathological changes, show as mount proximal end and far-end support ring bar cross section and reduce and increase far-end support ring wave height to launch girth to increase the far-end support ring in opening part and the expansion of narrow back.
5, a kind of renal artery stent according to claim 1 is characterized in that reaching the length that increases or reduce support to adapt to different lesions length by the number that the support ring in district and connecting ring are strengthened in increase and decrease middle part.
6, a kind of renal artery stent according to claim 1, it is characterized in that support is by adopting connecting ring to be formed by connecting between the support ring, support ring is along be non-consistent the design circumferentially, the interference when the minimizing pressure is held support, its intermediate waves height be the long wave height 2/3 to 9/10 between.
CNB2004100414747A 2004-07-26 2004-07-26 Kidney arteria stent Expired - Fee Related CN1279877C (en)

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Application Number Priority Date Filing Date Title
CNB2004100414747A CN1279877C (en) 2004-07-26 2004-07-26 Kidney arteria stent

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CN1596843A CN1596843A (en) 2005-03-23
CN1279877C true CN1279877C (en) 2006-10-18

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101926699A (en) * 2010-07-13 2010-12-29 北京迈迪顶峰医疗科技有限公司 Atrial septal pore-forming scaffold and conveyor thereof
JP2020512914A (en) * 2017-03-21 2020-04-30 エンドスパン リミテッド Stent graft for sealing around external disturbances
CN113101024A (en) * 2021-04-08 2021-07-13 哈尔滨医科大学 Pulmonary artery drug eluting stent and stent kit

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