CN1275656C - Biodegradable artificial breast wall and preparation method thereof - Google Patents
Biodegradable artificial breast wall and preparation method thereof Download PDFInfo
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- CN1275656C CN1275656C CN 200410025389 CN200410025389A CN1275656C CN 1275656 C CN1275656 C CN 1275656C CN 200410025389 CN200410025389 CN 200410025389 CN 200410025389 A CN200410025389 A CN 200410025389A CN 1275656 C CN1275656 C CN 1275656C
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- chitin fiber
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Abstract
The present invention relates to a biodegradable artificial thoracic wall and a preparing method thereof, which is used in the technical field of biomedicine. The artificial thoracic wall is formed from biodegradable chitin fiber reinforced poly-caprolactone composite material and has a lath-shaped network structure. The artificial thoracic wall comprises a molded board which is made of chitin fiber reinforced poly-caprolactone composite material and has a network structure, and lath-shaped artificial ribs made of chitin fiber reinforced poly-caprolactone composite material, wherein the molded board and the ribs are sewed to be fixed. The preparing method comprises: chitin fiber reinforced poly-caprolactone composite material is prepared firstly, the composite material is respectively made into a board with a network structure and lath-shaped artificial ribs, the edges of the shaped composite material board coincident with the radian of the thoracic wall are sewed with the broken ends of the artificial ribs by stainless steel wires to be firmly fixed, and then, the biodegradable artificial thoracic wall which is composed of the board and the artificial ribs and has a lath-shaped network structure is formed. The biodegradable artificial thoracic wall can avoid troubles and pains of secondary operation and can also prevent paradoxical breathing and thoracic wall subsidence after operation, so that the thoracic wall reconstruction is well realized.
Description
Technical field
The present invention relates to a kind of artificial breast wall and preparation method thereof, especially a kind of biodegradable artificial breast wall and preparation method thereof.Be used for the biologic medical technical field.
Background technology
The material of clinical employing repairing chest wall defect is more, can be divided into autologous tissue, allosome tissue, artificial material three classes.And, tend to use artificial materials repairing now for the bulk chest wall defect.At present the traditional material repaired of the chest wall defect that uses still can not be satisfactory, and polymeric biomaterial and bionic to develop rapidly to the mankind seek and develop ideal breast wall repairing material be that the artificial breast wall material provides new approach.
Find by literature search, Chinese patent title: artificial breast wall, application number: 93237708.4, the artificial breast wall that this patent is mentioned is made up of toughness rete thing and the artificial rib bar that is sandwiched in wherein, in the rib bar stainless steel silk is arranged, wherein toughness rete thing is made with knitted polyester cloth, and artificial rib is made with low-pressure polyethylene.During operation, stainless steel silk and human body rib fracture end are twined physiological tissue's polyester fiber suturing with thread management around toughness rete thing and the wound.Though this kind method also can be used for the chest wall defect reparation, the material that uses is nondegradable macromolecular material, will need second operation to take out substitution material inevitably after healing, will make patient stand the misery of operation again.In recent years, the focus of field of biomedical polymer materials research was the synthetic Biodegradable polymer material.These materials have special biological activity and excellent biological compatibility, and can be controlled by suitably designing with compound many performances to these materials in design process, comprise mechanical strength, hydrophilic, degradation rate etc.In addition, this type of material plays for the regeneration of organizational structure and reparation and significantly induces and facilitation.Therefore, have the good biocompatibility and the Biodegradable material of biodegradability, will become the important development trend of orthopaedics material.But do not find and the identical or similar bibliographical information of biodegradable thoracic wall theme of the present invention as yet at present.
Summary of the invention
The present invention is directed to deficiency and the defective of present chest wall defect reparation with artificial breast wall, a kind of biodegradable artificial breast wall and preparation method thereof is provided, make it in the knitting process, have enough intensity and hardness, can support fracture site to bear the external force of normal physiological activity; Begin degraded and lose intensity after knitting, external bearing capacity is transferred to gradually on the body bone, finishes thoracic wall and rebuilds.
The present invention is achieved by the following technical solutions, biodegradable artificial breast wall of the present invention is a kind of biodegradable artificial breast wall that is formed by Biodegradable material chitin fiber enhancing polycaprolactone composite material, this biodegradable artificial breast wall is netted-lath-shaped structure, form by two parts, a part strengthens the polycaprolactone composite material moulded board for having cancellated chitin fiber, is grown into by hole by fibrous connective tissue; Another part is that chitin fiber strengthens the artificial rib of lath-shaped that polycaprolactone composite material is made, keep the bone structure of artificial breast wall, prevent that paradoxical breathing from appearring in postoperative and thoracic wall subsides, be beneficial to newborn thoracic wall tissue substitute artificial breast wall, finish the self-recovery of chest wall defect.By the composite panel edges and the firm formation artificial breast wall of each artificial rib broken ends of fractured bone sutured that coincide with the thoracic wall radian after will formalizing with stainless steel silk.
It is by using short chitin fiber or long chitin fiber and polycaprolactone to prepare by the method for melt blending method for processing or compression molding that described chitin fiber strengthens polycaprolactone composite material.
Biodegradable artificial breast wall preparation method of the present invention, the chitin fiber for preparing is strengthened polycaprolactone composite material to be made respectively and has cancellated plate, makes the artificial rib of lath-shaped, firm by composite panel edges and each artificial rib broken ends of fractured bone sutured of coincideing with the thoracic wall radian after will formalizing with stainless steel silk at last, formation is by netted-lath-shaped structure biodegradable artificial breast wall dimerous.
Below the inventive method is done further to limit, concrete steps are as follows:
(1) it is tabular chitin fiber being strengthened the polycaprolactone composite material compression molding, carry out machine drilling, make it become network structure, then sterilize with oxirane disinfection with aperture and porosity, it is standby to put the interior cold preservation of 4 ℃ of refrigerators, and this is cancellated polycaprolactone plate.
(2) chitin fiber is strengthened the polycaprolactone composite material compression molding, cut into the artificial rib of lath-shaped, then with after the oxirane disinfection sterilization, it is standby to put in 4 ℃ of refrigerators cold preservation.
(3) before the use, prune polycaprolactone plate of preparation in (1) with operating scissors, make it to conform to the chest wall defect scope, it is moulding then sheet material to be put into hot water, and artificial breast wall material and thoracic wall radian are coincide, and puts into cold water immediately and formalizes, and makes it to keep this shape.
When (4) using, with stainless steel silk that the polycaprolactone panel edges after formalizing in (3) is firm with the artificial rib broken ends of fractured bone of each lath-shaped sutured of (2) middle preparation, remaining edge seals damaged with silk thread and the peripheral Intercostal muscle interrupted suture of chest wall defect.
The present invention possesses following advantage and positive role: 1. be easy to moulding and machine-shaping, performance is adjustable.2. has excellent biological compatibility.3. have good strength and hardness, good to the thorax supporting role, fixed.4. have biodegradability, the trouble that can remove second operation from is with painful.
The specific embodiment
Biodegradable artificial breast wall of the present invention is a kind of biodegradable artificial breast wall that is formed by Biodegradable material chitin fiber enhancing polycaprolactone composite material, be netted-lath-shaped structure, form by two parts, a part strengthens the polycaprolactone composite material moulded board for having cancellated chitin fiber, grow into by hole by fibrous connective tissue, another part is that chitin fiber strengthens the artificial rib of lath-shaped that polycaprolactone composite material is made, after will formalize with stainless steel silk with identical composite panel edges and the firm formation artificial breast wall of each artificial rib broken ends of fractured bone sutured of thoracic wall radian.
Provide embodiment below in conjunction with the inventive method.
Embodiment
It is tabular that chitin fiber is strengthened the polycaprolactone composite material compression molding, is of a size of 100 * 100 * 2mm.Material to preparation carries out machine drilling, and bore dia is 3mm, and spacing 2cm carries out machine drilling, makes it have ideal aperture and porosity network structure, and then with oxirane disinfection sterilization, it is standby to put in 4 ℃ of refrigerators cold preservation.Chitin fiber is strengthened the polycaprolactone composite material compression molding, cut into the artificial rib of lath-shaped, specification is: long 100mm, and wide is 8mm, thickness is 2mm.Then with after the oxirane disinfection sterilization, it is standby to put in 4 ℃ of refrigerators cold preservation.
After the anesthesia of adult healthy hybrid dog, part is excised three or four root bones, comprises Intercostal muscle and parietal pleura, and the chest wall defect scope that causes after the excision is about 10 * 10cm.After setting up the dog chest wall defect, the chitin fiber of pruning through machine drilling with operating scissors strengthens the polycaprolactone plate, make it to conform to the chest wall defect scope, then sheet material is put into 70～80 ℃ of hot water, moulding, artificial breast wall material and thoracic wall radian are coincide, put into cold water immediately and formalize, make it to keep this shape.With stainless steel silk that composite panel edges and each artificial rib broken ends of fractured bone sutured is firm, remaining edge seals damaged with No. seven silk threads and chest wall defect periphery Intercostal muscle interrupted suture.
The embodiment effect is as follows:
(1) postoperative ordinary circumstance.All experimental dog post-operative recovery are smooth, and postoperative was an ad lib in first day, and postoperative was pulled out intrathoracic drain in 3～5 days, pull out negative pressure ball in 5～7 days, and all dogs breathe steadily, do not have obvious paradoxical breathing and thoracic wall and subside, and wound healing is good, does not have redness, oozes out.Dog does not have operation and postoperative death.(2) chest X-ray.The experimental dog postoperative carries out chest X-ray January under anesthesia, polycaprolactone plate and artificial rib do not develop under X-ray, do not influence the observation of the inner lung tissue in thoracic cavity, two atelectasis are good, rib diaphragm angle is sharp keen, does not see aerothorax and hydrops, and the rib broken ends of fractured bone is high-visible, the fixation with steel wire ring is not seen to come off still in original position.(3) specimen inspection substantially.Postoperative is massacred experimental dog March, carries out the inspection of cardinal principle specimen.Found that repairing artificial breast wall sheet material is encased by the thick fibrous tissue of one deck, fibrous tissue is outer tight with the adhesion of thoracic wall flesh layer, and internal layer is tight with the lungs layer pleural adhesion that thickens, and the fibrous tissue place blood vessel hyperplasia that thickens is obvious.Artificial rib contacts closely with the rib broken ends of fractured bone, non-loosening, and the rib that artificial rib two ends are reproduced closely encases, and the artificial rib bar at all the other positions is wrapped up by fibrous tissue, and visible feltwork connective tissue becomes a whole thoracic wall with artificial rib between artificial rib.
Claims (3)
1, a kind of biodegradable artificial breast wall, it is characterized in that, strengthening polycaprolactone composite material by the Biodegradable material chitin fiber makes, be a netted lath-shaped structure, a part strengthens the polycaprolactone composite material moulded board for having cancellated chitin fiber, another part is that chitin fiber strengthens the artificial rib of lath-shaped that polycaprolactone composite material is made, two parts are by sutured, and it is by using short chitin fiber or long chitin fiber and polycaprolactone to prepare by the method for melt blending method for processing or compression molding that described chitin fiber strengthens polycaprolactone composite material.
2, a kind of preparation method of biodegradable artificial breast wall, it is characterized in that, use short chitin fiber or long chitin fiber and polycaprolactone to prepare chitin fiber enhancing polycaprolactone composite material earlier by the method for melt blending method for processing or compression molding, then the chitin fiber enhancing polycaprolactone composite material for preparing is made respectively and had cancellated plate, make the artificial rib of lath-shaped, firm by composite panel edges and each artificial rib broken ends of fractured bone sutured of coincideing with the thoracic wall radian after will formalizing with stainless steel silk at last, formation is by netted-lath-shaped structure biodegradable artificial breast wall dimerous.
3, the preparation method of biodegradable artificial breast wall according to claim 2 is characterized in that, the concrete steps of described method are as follows:
(1) it is tabular chitin fiber being strengthened the polycaprolactone composite material compression molding, carry out machine drilling, make it become network structure, then sterilize with oxirane disinfection with aperture and porosity, it is standby to put the interior cold preservation of 4 ℃ of refrigerators, and this is cancellated polycaprolactone plate;
(2) chitin fiber is strengthened the polycaprolactone composite material compression molding, cut into the artificial rib of lath-shaped, then with after the oxirane disinfection sterilization, it is standby to put in 4 ℃ of refrigerators cold preservation;
(3) before the use, prune polycaprolactone plate of preparation in (1) with operating scissors, make it to conform to the chest wall defect scope, it is moulding then sheet material to be put into hot water, and artificial breast wall material and thoracic wall radian are coincide, and puts into cold water immediately and formalizes, and makes it to keep this shape;
When (4) using, with stainless steel silk that the polycaprolactone panel edges after formalizing in (3) is firm with the artificial rib broken ends of fractured bone of each lath-shaped sutured of (2) middle preparation, remaining edge seals damaged with silk thread and the peripheral Intercostal muscle interrupted suture of chest wall defect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410025389 CN1275656C (en) | 2004-06-24 | 2004-06-24 | Biodegradable artificial breast wall and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410025389 CN1275656C (en) | 2004-06-24 | 2004-06-24 | Biodegradable artificial breast wall and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1593673A CN1593673A (en) | 2005-03-16 |
| CN1275656C true CN1275656C (en) | 2006-09-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410025389 Expired - Fee Related CN1275656C (en) | 2004-06-24 | 2004-06-24 | Biodegradable artificial breast wall and preparation method thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100441238C (en) * | 2006-08-16 | 2008-12-10 | 徐志飞 | Biodegradable reticular artificial chest wall and preparation method thereof |
| CN103525046A (en) * | 2013-07-31 | 2014-01-22 | 宁夏青林盛华科技有限公司 | Preparation method of blend fiber-reinforced polycaprolactone composite material of polycaprolactone/full-degraded natural fiber |
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