CN1275629C - Cinese traditional medicine for treating infectant virosis and preparation method - Google Patents
Cinese traditional medicine for treating infectant virosis and preparation method Download PDFInfo
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Abstract
The present invention relates to a traditional Chinese medicament for treating virus infectious diseases and a preparation method thereof. The traditional Chinese medicament is prepared from the following raw materials in weight proportions: 20 to 60 portions of astragalus root, 15 to 40 portions of largehead atractylodes rhizome, 15 to 35 portions of ledebouriella root, 15 to 40 portions of double blossom, 20 to 30 portions of dyers woad leaf, 15 to 35 portions of blackberrylily rhizome and 5 to 15 portions of radix glycyrrhiza. The traditional Chinese medicament has the advantages of cheap and abundant traditional Chinese medicinal materials without critical shortage, no toxic or side effect, no adverse reaction, high safety, high reliability and outstanding application curative effect. The purpose for preventing and treating epidemic and infectious diseases is obtained by selection, addition, subtraction and scientific processing, i.e. the purposes of prevention and treatment is achieved by supporting healthy energy to eliminate evil, strengthening body surface resistance and clearing away heat and toxic materials. The medicament has highly significant effect and great economical and social benefits and is suitable for popularization and application. The total effective rate of the medicament for treating Chinese medicine syndromes is 93%; therefore, the medicament plays a very important role in treating viruses, bacteria and infectious diseases, such as pestilence, SARS, etc.
Description
Affiliated field
The present invention relates to treat epidemic disease disease, it is the technical field of the Chinese medicine and preparation method thereof of infectious disease, especially can prevent and treat viral infection, atypical pneumonia, influenza and bacterial infection disease, i.e. a kind of Chinese medicine for the treatment of viral infectious of pestilence and preparation method thereof.
Background technology
In the recent period, due to illness malicious, antibacterial is caused a disease very serious and generally popular, and its sickness rate height, and spread speed is fast, becomes the key factor of serious harm people ' s health, obstruction economic development.Popular infection is arranged during as infectious diseases such as influenza virus, the recent SARS virus that takes place, this precipitate infectious disease, it is fast that it infects epidemic rate, the mortality rate height, people's healthy and life security in serious threat, and up to the present be international, domestic, the traditional Chinese medical science, doctor trained in Western medicine all not at this type of disease in prevention effectively and can reach the medicine of curing purpose, also make it to become a great problem of world medicine.
Because virus, the morbific rapid onset of antibacterial, infect popular strong, PD is fast, the pathological change complexity, once morbidity, human body integral body promptly goes to pot in a few days, cause various immune function to descend, lack of proper care, be the traditional Chinese medical science said " the big wound of healthy energy ", controlling should be with " strengthening vital QI to eliminate pathogenic factors ", " healthy energy is deposited interior, heresy can not do ".
The traditional Chinese medical science is the typhoid fever pestilence to the understanding of virus, antibacterial the earliest, seasonal disease pestilence etc.Chinese medicine has accumulated rich experience preventing and treating on the pestilence over the past thousands of years." pestilence " is just on the books as far back as the Spring and Autumn and the Warring States Periods, as putting down in writing in " gift Qi month ": " the row autumn first month of spring, the then big epidemic disease of its people "; " the row summertime last month of spring, then many diseases of people epidemic disease "; " row autumn in midsummer, the people bring disaster in epidemic disease ".Illustrate that pestilence and weather, environment are relevant, the traditional Chinese medical science is referred to as " pathogen ", also comprises " pestilence ", i.e. infectious disease.In strict generation, all have pestilence popular, and is very then in successive years, all on the books in the ancient books, as the Zhang Zhongjing treatise on Febrile Diseases etc., and wherein to falling ill rapidly, etiology unknown, morbidity colony is wide, evolution process etc. all has smart wall to discuss, and sums up multiple therapy methods and prophylactico-therapeutic measures.Constantly substantial perfect through successive dynasties medicine scholar, formed the pestilence system gradually, for the Chinese medicine prevention infectious disease lays a solid foundation.
How effectively control infects, and effectively kill and wound virus, according to Chinese medicine thousands of year in prevention and treatment experience abundant aspect epiphytotics the control, think that viral causing a disease belongs to the pestilence category, in the age that does not have to be born virusology, bacteriology, pestilence is summed up as " diseases caused by exogenous pathogenic factor pathogen, internal damage by the excessive seven emotions ", with the big wound of healthy energy, hypoimmunity and cause a disease.Therefore, using Chinese medicine is a kind of highly effective means, be the bigger effect of performance in control and treatment infectious disease, set up dialectical the executing of Chinese medicine and controlled principle, it is condensing the very intelligent of the Chinese nation, and utilize the Chinese medicine resource energetically, its scientific value is demonstrated fully, also injected new vitality simultaneously for the innovation of Chinese medicine.Therefore because of pestilence mostly is the diseases caused by exogenous pathogenic factor pathogen greatly, internal damage by the excessive seven emotions should be followed dialectical the executing of strengthening vital QI to eliminate pathogenic factors of " healthy energy deposit in, heresy can not be done " of the traditional Chinese medical science and control principle in treatment.
In the recent popular SARS control of China, the experience that the Shi Changyong professor prevents and treats infectious disease with the sense of political responsibility and the many decades of height, he thinks to deadly infectious disease, all is the exploratory stage at pathogenesis, clinical treatment, and adopting combination of Chinese and Western medicine effect is the control important channel.But to the disease transmission of not clear cause of disease, should adopt Chinese medicine is extremely effective means.
Summary of the invention
The objective of the invention is to be technical problem at above-mentioned existence, and a kind of Chinese medicine for the treatment of viral infectious is provided---" spirit of epidemic disease poison " granule and preparation method thereof, it is at virus, antibacterial, as the pathogenic characteristic of the extremely strong disease of infectiousness such as pestilence, SARS, and " spirit of epidemic disease poison " Chinese medicine of development and preparation method thereof.It is to improve body immunity, antiviral, antimicrobial traditional Chinese medical science organic conception, to coordinate the function of each internal organs organ, to improve the comprehensive immunity of human body.
The present invention is the thick medical science grounding in basic skills of Shi Changyong professor depth of field and the summary of many decades clinical experience, based on ancient prescription " YUPINGFENG SAN ", adds that Flos Lonicerae, Folium Isatidis, Rhizoma Belamcandae, Radix Glycyrrhizae are formed strengthening vital QI to eliminate pathogenic factors jointly, benefit is defended and consolidated the prescription of heat-clearing and toxic substances removing; And be processed into granule or oral liquid through science, be used for control due to illness poison, the caused various infectious disease of antibacterial.This medicine is controlled according to dialectical the executing of the disease that struggle between vital QI and pathogen showed with the qi blood balance negative and positive, attacks to mend and has both, and reaches eliminating evil purpose when nursing healthy energy, has embodied the organic conception of the traditional Chinese medical science.
The object of the present invention is achieved like this:
It is made of by weight following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=(20～60): (15～40): (15～35): (15～40): (20～30): (15～35): (5～15).
Chinese medicine of treatment viral infectious and preparation method thereof is characterized in that:
It is made of by weight following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=(20～60): (15～40): (15～35): (15～40): (20～30): (15～35): (5～15);
Its preparation method is:
(1) get the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Rhizoma Belamcandae by above-mentioned weight ratio, added concentration and be 70% alcohol reflux 1.0～1.5 hours, it is standby to collect volatile oil A; Alcohol extract reclaims ethanol, when temperature is 60 ℃, is concentrated into relative density 1.10～1.15, gets alcohol extract B, and is standby;
(2) get Radix Saposhnikoviae, Folium Isatidis, Radix Glycyrrhizae by above-mentioned weight ratio, mix with the above-mentioned Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Rhizoma Belamcandae medicinal residues, the decocting that adds 4～6 times of amounts boiled 60～100 minutes, filter, when temperature was 60 ℃, filtrate was concentrated into relative density 1.10～1.15, adding ethanol makes solution contain the alcohol amount to reach 70%, leave standstill, filter, get liquor C, standby;
(3) with above-mentioned liquor C and alcohol extract B mix homogeneously, when temperature is 60 ℃, be concentrated into the thick paste of relative density 1.30～1.35, add the adjuvant of 20%～40% amount of thick paste, make soft material, granulate, in baking oven, dried 3～5 hours granulate in 30～45 ℃ the low temperature, spray into volatile oil A, airtight 45-100 minute, packing, promptly.
Described adjuvant can be starch.
Advantage of the present invention is: the no valuable product of drawing materials, and used Chinese medicine source is sufficient, and no in great shortage, its preparation technology is simple, and is easy to operate, and the equipment less investment is suitable for big production.The present invention is nontoxic, side effect and untoward reaction, that obeys is safe and reliable, has the effect that to play control to popular and infectious disease, The present invention be directed to the treatment means of modern medicine and screening of medicaments scientifically, total effective rate is 93%, is 93% to the tcm syndrome total effective rate that produces therefrom, therefore to virus, antibacterial, as infectious diseases such as pestilence, SARS extremely important meaning is arranged, be fit to apply, its economic benefit and social benefit are boundless.
The present invention uses determined curative effect, through screening, plus-minus, scientifically process to reach the purpose of prevention and treatment, and have no side effect and untoward reaction, by strengthening vital QI to eliminate pathogenic factors, benefit defend consolidating superficial resistance, heat-clearing and toxic substances removing reaches and prevents and treats purpose, and its effect highly significant, this product can be made into granule or oral liquid.
Be the clinical effectiveness situation of the Chinese medicine " spirit of epidemic disease poison " of treatment viral infectious below:
Provide the clinical experiment report by the Liaoning Prov. Traditional Chinese Medicine Inst.
One, using " spirit of epidemic disease poison " and the curative effect of antivirus oral liquid compares
" spirit of epidemic disease poison " produced by Liaoning academy of traditional Chinese medicine.
Antivirus oral liquid is by street drug.
Time: when had the SARS epidemic situation 4～June in 2003
Experimental period: 60 days
1, method
Choose influenza clinical case totally 400 examples, wherein male 179 examples, women 221 examples.The oldest person 81 years old, reckling 3 years old, 46.2 years old mean age.The elder of the course of disease 2 months, the shortest 1 week of person.It is divided into treatment group, each 200 example of matched group at random.
The treatment group is taken " spirit of epidemic disease poison " oral liquid, and 3 times on the one, each 10 grams, warm boiled water, or gavage, begin to take 1 week, the check of 2 weeks after the medication when making a definite diagnosis.
Matched group is taken antivirus oral liquid, and 3 times on the one, each 10ml gram, warm water delivery service, or gavage, begin to take 1 week, the check of 2 weeks after the medication when making a definite diagnosis.
2, brief summary
Treatment group: produce effects person's 163 examples, responder's 28 examples, invalid 1 example;
Effective percentage 93%, obvious effective rate are 80%, and inefficiency is 4.5%.
Matched group: produce effects person's 25 examples, responder's 4 examples, invalid 6 examples;
Effective percentage 85.1%, obvious effective rate are 76%, and inefficiency is 15%.
Two, conclusion
From above clinical observation result, the course of disease phase of treatment group shortened than the former course of disease phase, no any discomfort, and subjective symptoms takes a turn for the better.Total effective rate 93%, obvious effective rate 80%, inefficiency is 4.5%.Matched group total effective rate 85.1%, obvious effective rate are 76%, and inefficiency is 15%, illustrate that treatment group curative effect is better than matched group.And the treatment group is apparently higher than matched group, proved that also this medicine has obvious curative effects to the infringement of influenza virus, and after the medication liver, renal function there is not influence, safe and reliable, have no side effect, drug effect is sure, be convenient to take, be difficult for recurrence, and consolidate and use better efficacy, especially excellent to viral infection, atypical pneumonia, influenza and bacterial infection disease patient effect.The preventive effect that it is useful can play positive effect in the prevention SARS, also can be for stoping the effect of playing crux that enters of SARS epidemic.
Be pharmacological evaluation below:
One, laboratory animal: rat
Get 30 of body weight 300 ± 20g rats, male and female half and half are divided into two groups at random.
The treatment group: take " spirit of epidemic disease poison " granule, every day three times, each 5 grams (by body weight/kilogram) were taken 7 days continuously.
Matched group: normal diet is fed.
Conclusion: the rat of treatment group has obviously prolonged the swimming endurance time, measure blood plasma cortisol content apparently higher than matched group, the adrenal gland is heavier, and the function of the Radix Astragali by adrenal cortex reinforcing in " epidemic disease poison spirit " is described, has improved the anti-stress ability of rat.
Two, laboratory animal: mice
Get 30 of body weight 20 ± 2g mices, male and female half and half are divided into two groups at random.
The treatment group: take " spirit of epidemic disease poison " granule, every day three times, each 0.5 gram (by body weight/kilogram) was taken 7 days continuously.
Matched group: normal diet is fed.
Conclusion: the mice of treatment group contains " epidemic disease poison spirit " granule of the Radix Astragali because of clothes have, and has increased the speed that the bright amino acid of its 3H participates in liver and serum albumin and can promote proteinic renewal.Phagocytic activity to the mouse lung macrophage has potentiation, and the treatment bronchitis is after 20 days, and IgG, IgM, IgA all raise.
Three, laboratory animal: rabbit
Get 30 of body weight 20 ± 0.2g rabbits, male and female half and half are divided into two groups at random.
The treatment group: take " spirit of epidemic disease poison " granule, every day three times, each 10 grams were taken 7 days continuously.
Matched group: normal diet is fed.
Conclusion: the rabbit of treatment group contains " spirit of epidemic disease poison " granule of the Radix Astragali because of clothes have, erythrocyte to rabbit has Stabilization, oral or intravenous injection can increase the rat capillary permeability that antihistamine and 5-hydroxy tryptamine cause, orally suppresses to pitch swelling at the bottom of the rat toe that dish glue causes.Intravenous injection causes that anesthetized cat or rat blood pressure obviously descend, and this effect is not blocked by diphenhydramine or atropine.
Introduction: because of Main Ingredients and Appearance in the present invention's " spirit of epidemic disease poison " granule is the Radix Astragali, because of containing various active compositions such as choline, betaine, folic acid, aminoacid, polysaccharide, flavone, glycoside in the Radix Astragali.Macromole such as astragalus polysaccharides, albumen partly has antiviral, enhancing antibody forms, prolongs cells in vitro survival isoreactivity, and flavonoid partly has antiviral, antibacterial action.Glycoside has the survival of the cells in vitro of prolongation, promotes immunoreation, the antiviral isoreactivity.As seen the Radix Astragali has dual regulation in the side.Assistant strengthens its antiviral and antibiotic effect with Flos Lonicerae, Folium Isatidis, Rhizoma Belamcandae etc., and with heat-clearing and toxic substances removing, set upright consolidating superficial resistance, QI invigorating is got rid of evils.Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, and flavour of a drug sweetness are convenient to take.
Function and effect: heart tonifying, diuresis, blood pressure lowering, protect the liver, lung moistening etc., strengthen the impermeabilisation effect of body immunity and blood capillary, have stronger antiviral, antibacterial action.
Cure mainly: be used for control due to illness poison, bacterial various infectious disease, as influenza, atypical pneumonia and bacterial infection disease; Has the effect that heat-clearing and toxic substances removing, benefit are defended consolidating superficial resistance, strengthening vital QI to eliminate pathogenic factors.
Dosage form: granule or oral liquid.
Usage and consumption:
(1) granule: boiled water is taken after mixing it with water, and three times on the one, each one bag, every bag 10 gram.
(2) oral liquid: three times on the one, one time 1 bag, one bag of 100/ml.
Describe the present invention in detail below in conjunction with embodiment.
Specific embodiment
Embodiment 1
The Chinese medicine of treatment viral infectious is made of by weight following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=30: 15: 15: 20: 20: 15: 5
Chinese medicine of treatment viral infectious and preparation method thereof is characterized in that:
It is made of by weight following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=30: 15: 15: 20: 20: 15: 5
Its preparation method is:
(1) get Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 15g, Flos Lonicerae 20g, Rhizoma Belamcandae 15g by above-mentioned weight ratio, added concentration and be 70% alcohol reflux 1.0 hours, it is standby to collect volatile oil A; Alcohol extract reclaims ethanol, is concentrated into relative density (60 ℃) 1.15, gets alcohol extract B, and is standby;
(2) get Radix Saposhnikoviae 15g, Folium Isatidis 20g, Radix Glycyrrhizae 5g by above-mentioned weight ratio, mix with the above-mentioned Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Rhizoma Belamcandae medicinal residues, add 4 times of amounts, promptly the water of 480ml decocted 60 minutes, filter, filtrate is concentrated into relative density (60 ℃) 1.15, adds ethanol and makes solution contain the alcohol amount to reach 70%, leave standstill, filter, get liquor C, standby;
(3) with above-mentioned liquor C and alcohol extract B mix homogeneously, be concentrated into the thick paste of relative density (60 ℃) 1.30, add 20% of thick paste, i.e. the starch of 24g, make soft material, granulate, in baking oven, dried 3 hours granulate in 30 ℃ the low temperature, spray into volatile oil A, airtight 45 minutes, packing, promptly.
Embodiment 2
The Chinese medicine of treatment viral infectious is made of by weight following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=35: 28: 25: 30: 25: 25: 10
Chinese medicine of treatment viral infectious and preparation method thereof is characterized in that:
It is made of by weight following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=35: 28: 25: 30: 25: 25: 10
Its preparation method is:
(1) get Radix Astragali 350g, Rhizoma Atractylodis Macrocephalae 280g, Flos Lonicerae 300g, Rhizoma Belamcandae 250g by above-mentioned weight ratio, added concentration and be 70% alcohol reflux 1.2 hours, it is standby to collect volatile oil A; Alcohol extract reclaims ethanol, is concentrated into relative density (60 ℃) 1.15, gets alcohol extract B, and is standby;
(2) get Radix Saposhnikoviae, Folium Isatidis, Radix Glycyrrhizae by above-mentioned weight ratio, mix with the above-mentioned Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Rhizoma Belamcandae medicinal residues, add 5 times of amounts, promptly the water of 8900ml decocted 80 minutes, filter, filtrate is concentrated into relative density (60 ℃) 1.15, adds ethanol and makes solution contain the alcohol amount to reach 70%, leave standstill, filter, get liquor C, standby;
(3) with above-mentioned liquor C and alcohol extract B mix homogeneously, when temperature is 60 ℃, be concentrated into the thick paste of relative density 1.33, add 30% of thick paste, be the starch of 350g, make soft material, granulate, in baking oven, dried 4 hours in 38 ℃ the low temperature, granulate sprays into volatile oil A, airtight 65 minutes, packing, promptly.
Embodiment 3
The Chinese medicine of treatment viral infectious, form by weight by following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=40: 40: 35: 40: 30: 35: 15
Chinese medicine of treatment viral infectious and preparation method thereof is characterized in that:
It is made of by weight following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=40: 40: 35: 40: 30: 35: 15
Its preparation method is:
(1) get Radix Astragali 4000g, Rhizoma Atractylodis Macrocephalae 4000g, Flos Lonicerae 4000g, Rhizoma Belamcandae 3500g by above-mentioned weight ratio, added concentration and be 70% alcohol reflux 1.5 hours, it is standby to collect volatile oil A; Alcohol extract reclaims ethanol, is concentrated into relative density (60 ℃) 1.10, gets alcohol extract B, and is standby;
(2) get Radix Saposhnikoviae 3500g, Folium Isatidis 4000g, Radix Glycyrrhizae 1500g by above-mentioned weight ratio, mix with the above-mentioned Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Rhizoma Belamcandae medicinal residues, add 6 times of amounts, promptly the water of 147000ml decocted 100 minutes, filter, filtrate is concentrated into relative density (60 ℃) 1.10, adds ethanol and makes solution contain the alcohol amount to reach 70%, leave standstill, filter, get liquor C, standby;
(3) with above-mentioned liquor C and alcohol extract B mix homogeneously, be concentrated into the thick paste of relative density (60 ℃) 1.35, add 40% of thick paste, i.e. the adjuvant of 4900g, make soft material, granulate, in baking oven, dried 5 hours granulate in 45 ℃ the low temperature, spray into volatile oil A, airtight 100 minutes, packing, promptly.
Claims (2)
1, the Chinese medicine of treatment viral infectious is characterized in that it is to be made by weight by following raw material:
The Radix Astragali: the Rhizoma Atractylodis Macrocephalae: Radix Saposhnikoviae: Flos Lonicerae: Folium Isatidis: Rhizoma Belamcandae: Radix Glycyrrhizae=20～60: 15～40: 15～35: 15～40: 20～30: 15～35: 5～15;
Its preparation method is:
(1) get the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Rhizoma Belamcandae by above-mentioned weight ratio, added concentration and be 70% alcohol reflux 1.0～1.5 hours, it is standby to collect volatile oil A; Alcohol extract reclaims ethanol, when temperature is 60 ℃, is concentrated into relative density 1.10～1.15, gets alcohol extract B, and is standby;
(2) get Radix Saposhnikoviae, Folium Isatidis, Radix Glycyrrhizae by above-mentioned weight ratio, mix with the above-mentioned Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Rhizoma Belamcandae medicinal residues, the decocting that adds 4～6 times of amounts boiled 60～100 minutes, filter, when temperature was 60 ℃, filtrate was concentrated into relative density 1.10～1.15, adding ethanol makes solution contain the alcohol amount to reach 70%, leave standstill, filter, get liquor C, standby;
(3) with above-mentioned liquor C and alcohol extract B mix homogeneously, when temperature is 60 ℃, be concentrated into the thick paste of relative density 1.30～1.35, add the adjuvant of 20%～40% amount of thick paste, make soft material, granulate, in baking oven, dried 3～5 hours granulate in 30～45 ℃ the low temperature, spray into volatile oil A, airtight 45-100 minute, packing, promptly.
2,, it is characterized in that described adjuvant can be starch according to the Chinese medicine of the described treatment viral infectious of claim 1.
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| CN107184875A (en) * | 2017-05-19 | 2017-09-22 | 信阳农林学院 | A kind of antibacterial Chinese medicine for veterinary use preparation |
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