CN1265331A - Electric-pulse chemical curing instrument - Google Patents
Electric-pulse chemical curing instrument Download PDFInfo
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- CN1265331A CN1265331A CN 99112706 CN99112706A CN1265331A CN 1265331 A CN1265331 A CN 1265331A CN 99112706 CN99112706 CN 99112706 CN 99112706 A CN99112706 A CN 99112706A CN 1265331 A CN1265331 A CN 1265331A
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- circuit
- pulse
- programmable
- clock
- foot
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Abstract
The electric pulse chemical cure instrument of the present invention relates to the field of medical apparatus technology, and which consists of rationing pulse generator circuit, high-voltage switch circuit, adjustable high-voltage regulator circuit, treatment program control circuit and electrocardiac synchronizing circuit. It is supeior in that it combines chemotherapy and electric pulse therapy, that is, instantaneous high-voltage electric pulse is utilized to stimulate tissue so as to increase the transmissivity of cell membrane to chemical anticarcinogen.
Description
The invention belongs to technical field of medical instruments.
In traditional chemical anticancer therapy, because the shielding action of cell membrane, cancer therapy drug can not pass cell membrane smoothly and enter in the cell, and performance is less than due cytotoxicity.In traditional electrotherapy, only use low-voltage DC or action of low-voltage pulse unidirectional current, cause tumor cell inside and outside microenvironment to change, destroy tumor cell, and do not use antitumor drug.
The purpose of this invention is to provide and a kind of tumor is carried out the instantaneous pressure impulse stimulation, make on the cell membrane and to form temporary transient, reversibility micropore, it is electroporation, permeability of cell membrane increases, make the chemical anticarcinogenic drug that is difficult to originally by cell membrane be entered cell easily, bring into play its cytotoxicity, promptly a kind of electric-pulse chemical curing instrument.
Technical scheme of the present invention is as follows:
This therapeutic instrument is made of pulse generating circuit, high voltage switch circuit, high pressure adjustable stabilized voltage supply, treatment procedure control circuit and electrocardio synchronous circuit.
1, quantitatively pulse generating circuit is made up of clock circuit, pulsewidth programmable circuit, programmable frequency divider and programmable counter.
In clock circuit, quartz crystal Q and inverter ic
1, R
1, C
1, C
2The agitator of forming, the generation frequency is f
0Clock pulses, through IC
2After the shaping, give frequency divider IC
3, IC
3To f
0Carry out the frequency division clocking.
In the pulsewidth programmable circuit, frequency divider IC
3Q foot and coincidence counter IC
6The CLK foot connect, realize IC
6, IC
7Q counts to clock, and its counter value is sent into digital comparator IC
4, IC
5A group input, IC
4, IC
5The B group input termination number that presets able to programme, IC
4The equal ground connection of 4,5,6 feet, the counting zero-time by IC
8Control.
In using the frequency programmable dividing circuit, pulsqe distributor IC
19CLK meet Q foot, IC
19EN meet the Q of frequency divider
1, IC
19The R end in contact signal.
In using programmable counter, IC
11, IC
10CLK end input clock Q, at Trigin end input trigger impulse.
2, high voltage switch circuit amplifies by two on-off circuits the pulse that quantitative pulse generator produces.
3, high pressure adjustable stabilized voltage supply, high-tension transformer ST charges to output capacitance behind rectifying and wave-filtering; Tandem type integrated regulated power supply, error amplifier are by adjusting the pipe output voltage.Pulsewidth modulation (PWM) type switching power supply, pwm circuit is taken a sample to output voltage, and error is amplified, and modulates the width of its output pulse, stablizes its output voltage.
4, treatment procedure control circuit requires quantitative pulse generating circuit is controlled according to treatment.
5, electrocardiogram synchronous circuit, this circuit is handled patient's electrocardiogram, detects Electrocardiographic R ripple, triggers quantitative impulse circuit through IC30 time-delay back, make the electric pulse effect the time be engraved on the Safe period of cardiac cycle.
Advantage of the present invention is: this instrument combines chemotherapy with point electric impulse therapeutic, utilize the instantaneous pressure electric pulse that tissue is stimulated, increase the permeability of cell membrane, make originally to be difficult to be entered cell, and bring into play its cytotoxicity by the chemical anticarcinogenic drug of cell membrane.
Be described in detail embodiment below in conjunction with figure and technical scheme.
Fig. 1 is the electric-pulse chemical curing instrument theory diagram;
Fig. 2 is quantitative pulse generating circuit theory diagram;
Fig. 3 is a clock circuit;
Fig. 4 is the pulsewidth programmable circuit;
Fig. 5 is a programmable frequency divider;
Fig. 6 is a programmable counter;
Fig. 7 is a high voltage switch circuit;
Fig. 8 is the high pressure adjustable stabilized voltage supply;
Fig. 9 is the treatment procedure control circuit;
Figure 10 is the electrocardiogram synchronous circuit.
Quantitatively pulse generating circuit produces the burst pulse of some, its pulse width (duration), and pulse period and pulse number change according to treatment procedure, and the time that pulse produces is subjected to the control of pulse generating circuit internal clocking or is controlled by the electrocardio synchronizing signal.In order to improve the precision of pulse parameter, pulse generating circuit is made of digital circuit or single-chip microcomputer, and the clock signal of use is produced by quartz oscillator.Pulse output is delivered on the driver of high voltage switch circuit after the high voltage level conversion, drives the conducting or the shutoff of high voltage switch circuit.The control high voltage regulated power supply is switched to duration, cycle and the number of times on the tumor tissues.
In order to improve the safety of instrument, adopt the biswitch device, open or turn-off the both positive and negative polarity of high voltage power supply simultaneously, switch element can use VMOS field effect transistor, bipolar transistor, controllable silicon or IGBT device.
The high pressure adjustable stabilized voltage supply at first is transformator T
5Civil power is become required High Level AC Voltage, behind rectifying and wave-filtering to output capacitance C
7The charging, with charge storage at C
7In, dashing slowly and put soon, the output voltage of power supply has determined the amplitude of electric pulse output.
Claims (1)
1, a kind of electric-pulse chemical curing instrument is characterized in that: this therapeutic instrument is divided into quantitative pulse generating circuit, high voltage switch circuit, high pressure adjustable stabilized voltage supply, treatment procedure control circuit and electrocardio synchronous circuit;
A, quantitative pulse generating circuit are made up of clock circuit, pulsewidth programmable circuit, programmable frequency divider and programmable counter;
In clock circuit, quartz crystal Q and inverter ic
1, R
1, C
1, C
2The agitator of forming, the generation frequency is f
0Clock pulses is through IC
2After the shaping, give frequency divider IC
3, IC
3To f
0Carry out the frequency division clocking;
In the pulsewidth programmable circuit, frequency divider IC
3Q
iFoot and coincidence counter IC
6The CLK foot connect, realize IC
6, IC
7Q counts to clock, and its count value is sent into digital comparator IC
4, IC
5A level input, IC
4, IC
5Able to programme the giving of B group input termination put number, IC
4The equal ground connection of 4,5,6 feet, the counting zero-time by IC
8Control;
In using the frequency programmable dividing circuit, pulsqe distributor IC
19CLK meet Q foot, IC
19EN meet the Q of frequency divider
1Foot, IC
19The R end in contact signal;
In using programmable counter, IC
11, IC
10CLK end input clock Q, at Trigin end input trigger impulse;
B, high voltage switch circuit amplify by two on-off circuits the pulse that quantitative pulse generator produces;
C, high pressure adjustable stabilized voltage supply, high-tension transformer TS charge to output capacitance behind rectifying and wave-filtering; Tandem type integrated regulated power supply, error amplifier are by adjusting the pipe output voltage.Pulsewidth modulation (PWM) type switching power supply, pwm circuit is taken a sample to output voltage, and error is amplified, and modulates the width of its output pulse, stablizes its output voltage;
D, treatment procedure control circuit carry out programming Control to quantitative pulse generating circuit as requested;
E, electrocardiogram synchronous circuit, this circuit is handled patient's electrocardiogram, detects the R ripple in the electrocardiogram, through IC
30Quantitative pulse generating circuit is triggered in time-delay back, is engraved on the Safe period of cardiac cycle when making the amount of electric pulse effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99112706 CN1265331A (en) | 1999-03-01 | 1999-03-01 | Electric-pulse chemical curing instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99112706 CN1265331A (en) | 1999-03-01 | 1999-03-01 | Electric-pulse chemical curing instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1265331A true CN1265331A (en) | 2000-09-06 |
Family
ID=5275984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99112706 Pending CN1265331A (en) | 1999-03-01 | 1999-03-01 | Electric-pulse chemical curing instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1265331A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745178B (en) * | 2009-12-17 | 2013-01-02 | 重庆大学 | Portable high-voltage nanosecond squarer |
| CN101888874B (en) * | 2007-10-11 | 2013-11-13 | 京畿州海莱乌医院 | An electroporation device for improved electrical field control |
-
1999
- 1999-03-01 CN CN 99112706 patent/CN1265331A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101888874B (en) * | 2007-10-11 | 2013-11-13 | 京畿州海莱乌医院 | An electroporation device for improved electrical field control |
| CN101745178B (en) * | 2009-12-17 | 2013-01-02 | 重庆大学 | Portable high-voltage nanosecond squarer |
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