CN1263459C - Cell growth regulating factor O and its prepn process - Google Patents
Cell growth regulating factor O and its prepn process Download PDFInfo
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- CN1263459C CN1263459C CN 02151090 CN02151090A CN1263459C CN 1263459 C CN1263459 C CN 1263459C CN 02151090 CN02151090 CN 02151090 CN 02151090 A CN02151090 A CN 02151090A CN 1263459 C CN1263459 C CN 1263459C
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention relates to natural cell growth regulating factor O and a preparation method thereof. The preparation method comprises the following steps: sieving Gram-positive cocci and Gram-negative cocci or bacilli, and freezing and preserving a strain; conventionally cultivating the strain at a temperature of 4 to 38 DEG C and leaving beneficial thallus fragments via filtration for at least one time to remove harmful thalli, namely extracting natural genes; adding a certain amount of tryptophan in the natural genes; after safety test, sealing a water agent or freezing powder under a GMP standard to prepare the natural cell growth regulating factor O. 1 mu g of the natural genes of the prepared natural cell growth regulating factor O can be compounded with more than 1 mu g of tryptophan. The natural cell growth regulating factor O can prompt a body to activate and reinforce immunological functions so as to reinforce TC, re-repair and reshape senescent, necrotic, denatured, atrophic and fiberized tissue cells, and regenerate and replant capillary vessels to perform the functions of rejuvenescence and senescence delay.
Description
Technical field
What the present invention relates to is a kind of medicine and preparation method that is of value to the Growth of Biologic Cell regulation and control, belongs to a kind of biological medicine.
Background technology
The mankind, birth and old age, sickness and death are a kind of natural laws, along with wearing out of human body cell, the regeneration function of its cell will be lost gradually, human body enters aging period, and the intravital various cellular degenerations of people are had an operation as the old man and to be recovered to want the slow well evidence that is mostly more than the adolescent.The aging of people mainly shows on the cell senescence and deterioration of various internal organs, thereby in recent years, the medical expert of countries in the world is attempting to study relevant " the long-lived medicine " that increases man's lifespan.So-called long-lived medicine is exactly nothing but that this medicine can promote functions such as the enhancing of the regeneration of human body cell and repair ability and improvement.Yet the file that yet there are no similar contents such as " long-lived medicines " is published.On the other hand, even if the someone does not also enter old age, but still will there be its situation about can not normally repair of necrosis of human cell tissue in the part of its human body, as cervical spondylosis patient or prolapse of lumbar intervertebral disc patient or the like.These patients are in the majority with the older, degeneration, atrophy, downright bad cell fibrosis tissue existence mainly still because taken place in the mechanism of its morbidity in the part of its human body, conventional treatment method is exactly an excision, again plant foreign body or the corresponding tissues of transplanting such as tissue or metal then, this therapeutic method of surgery is passive, and does not have the positive therapeutic effect, and it can only be treated devastatingly, its effect is not desirable, also will produce rejection for a long time.Also have a kind of viagra, Fang Xingai etc. of using to treat, they have the tabulation effect to the fibrosis tissue of the organ of atrophy, degeneration, but do not have the pair cell tissue regeneration to be arranged, effect such as repair and mould again again, thereby in fact they do not have any good therapeutic effect that effects a permanent cure.
At present, the research and development of microorganism medical science is very fast, people have had darker understanding to various antibacterials and virus, as publishing in " medical microorganism " university teaching material on probation of distribution in June, 1979 by the People's Health Publisher, enumerated and introduced the kind of antibacterial and virus, and the biological character of each bacterioid or the like.Each bacterioid can be realized the technical security acceptance test to the antibacterial thalline by culture medium culturing and after filtering.In existing disclosed technical data, the content introduction of pair bacteria culture media is arranged, as meat soup and broth agar culture medium, pig heart infusion protein culture medium etc.; After the cultivation by these bacteria culture medias, the antibacterial thalline can split into the thalline material of reproductive capacity, and part cracks into the bacterial chip of no reproductive capacity simultaneously, and the antibacterial thalline also can produce secretory substance and stay culture medium complex etc. in incubation.In existing disclosed technical data, the method introduction of some aseptic filtrations is also arranged, it adopts filters such as filter membrane filter, Cai's seitz filter Seitz to realize, selects the aperture of certain filter opening and conventional filter can remove some thalline materials etc.Though at present people have had darker understanding to each bacterioid, only be confined to the category understood, exist many deficiencies to how utilizing antibacterial to carry out medical research such as preventing and treating diseases, stayed many blank spots medically.
Summary of the invention
The object of the present invention is to provide and a kind of human body cell is had the adjusting and controlling growth effect, strengthen the n cell growth regulatory factor O and the preparation method of functions such as the regeneration of inside of human body cell tissue, reparation, contain natural gene, the tryptophan that extracts in Gram-positive, negative cocci or the bacillus among this n cell growth regulatory factor O, and the configurable tryptophan that has more than the 1 μ g of 1 μ g natural gene.
1 μ g natural gene disposes 1 μ g---the tryptophan of 500mg among the described n cell growth regulatory factor O.
1 μ g natural gene disposes 1 among the described n cell growth regulatory factor O---the tryptophan of 200mg.
A kind of method of producing n cell growth regulatory factor O, it is earlier Gram-positive, negative cocci or bacillus to be screened and the freezing bacterial strain, with bacterial strain 4---the conventional cultivation under 38 ℃ of temperature, and after at least once removing by filter harmful bacteria, stay useful bacterial chip and promptly extract natural gene, in natural gene, quantitatively add tryptophan, after safety detection, under the GMP standard, be refined into water preparation or freezing powder pass envelope and form.Described useful bacterial chip, its component comprise the genetic stew of thalline, the secretions of thalline and the culture medium complex of this thalline.
Described bacterial strain is 10---the conventional cultivation under 35 ℃ of temperature, and after secondary filter is removed harmful bacteria at least, stay useful bacterial chip and promptly extract natural gene.
The present invention is by screening Gram-positive, negative cocci or bacillus, through cultivating, filter removal impurity and harmful substance, as the thalline that causes a disease, the useful bacterial chip that extraction stays is a natural gene, so-called natural gene is meant that filtrate such as useful bacterial chip do not change its molecular structure and chemical physical property, thereby be natural, institute's tht gene is meant that useful bacterial chip is a kind of little thalline measurement unit; This useful gene pairs human body cell has the adjusting and controlling growth effect, groups of cells to necrosis is woven with reparation and shaping action more again, after itself and tryptophan be mixed and made into n cell growth regulatory factor O, both have synergism, its effect will be more obvious, have and better impel body to activate raise immunity, TC is strengthened, and aging, necrosis, degeneration, atrophy, Fibrotic sexual organ's histiocyte are repaired again, mould again, blood capillary is regenerated, is grown, and myocardial cell and sexual organ recover one's youthful vigour, function in delaying senility thereby make.
N cell growth regulatory factor O of the present invention, its commodity happiness by name hole god, its effect is a sexual function improving,
Resisting fatigue increases immunity.Through animal safety test, acute, subacute toxicity test is negative, undue toxicity, long term toxicity test feminine gender.
Model case:
Case 1 is opened XX, the male, and 55 years old, sexual inadequacy is 7-8.Through the made medicine of the present invention---be clearly better behind the refreshing Comprehensive Treatment in happiness hole.
Case 2, old XX, the male, 76 years old, sexual inadequacy 5 years surplus; Behind the refreshing medicine Comprehensive Treatment in happiness hole, be clearly better.
Case 3 thanks to XX, the male, and 55 years old, sexual impotence was clearly better behind this medicine Comprehensive Treatment.
The specific embodiment
The present invention will be described in detail below in conjunction with embodiment: embodiment 1, earlier gram-positive cocci is screened and the freezing bacterial strain, with bacterial strain conventional cultivation under 6 ℃ of temperature, the general low more incubation time of temperature is long more, bacterial strain stays useful bacterial chip after successively removing by filter impurity and harmful bacteria four times after fully cultivating, be the extraction natural gene, because the gram coccus is a bacterial strain in spite of illness common in the clinical medicine, the public can obtain from public occasion, and therefore this strain need not special preservation.It through after cultivating fully and filtering, can be reached the purpose of removing disease carrying germ.Getting useful bacterial chip is natural gene 1 μ g, quantitatively adds the 1mg tryptophan therein, measures content and after safety detection, and water preparation or freezing dry powder close envelope and form under the GMP standard, after product inspection is qualified, and printing package.Described tryptophan is a kind of of amino acids, and it also is common a kind of biochemical product, and the public also can obtain on a public occasion easily.
Embodiment 2, earlier Gram-negative coccus is screened and the freezing bacterial strain, with bacterial strain conventional cultivation under 12 ℃ of temperature, bacterial strain stays useful bacterial chip after successively removing by filter impurity and harmful bacteria three times after fully cultivating, be the extraction natural gene; Getting useful bacterial chip is natural gene 1 μ g, quantitatively adds the 3mg tryptophan therein, measures content and after safety detection, water preparation closes envelope and forms n cell growth regulatory factor O under the GMP standard, after product inspection is qualified, and printing package.
Embodiment 3, earlier gram negative bacilli is screened and the freezing bacterial strain, with bacterial strain conventional cultivation under 20 ℃ of temperature, bacterial strain stays useful bacterial chip after removing impurity and harmful bacteria through the priority secondary filter after the abundant cultivation, be the extraction natural gene; Getting useful bacterial chip is natural gene 1 μ g, quantitatively adds the 8mg tryptophan therein, measures content and after safety detection, water preparation or freezing dry powder close envelope and form n cell growth regulatory factor O under the GMP standard, after product inspection is qualified, and printing package.
Embodiment 4, earlier Gram-positive bacillus is screened and the freezing bacterial strain, with bacterial strain conventional cultivation under 38 ℃ of temperature, bacterial strain stays useful bacterial chip through after once removing by filter impurity and harmful bacteria after fully cultivating, be the extraction natural gene, it is many more normally to filter number of times, and the useful bacterial chip of left (extraction) is that natural gene is just pure more.Getting useful bacterial chip is natural gene 1 μ g, quantitatively adds the 20mg tryptophan therein, measures content and after safety detection, water preparation or freezing dry powder close envelope and form n cell growth regulatory factor O under the GMP standard, after product inspection is qualified, and printing package.
Other embodiments of the invention all can dispose 1 μ g at gene 1 μ g---arbitrarily configuration in the scope of 500mg tryptophan.
Claims (4)
1, a kind of n cell growth regulatory factor O, it is characterized in that containing natural gene, the tryptophan that extracts in Gram-positive, negative cocci or the bacillus among this n cell growth regulatory factor O, wherein 1 μ g natural gene disposes the tryptophan of 1 μ g-500mg.
2, n cell growth regulatory factor O according to claim 1 is characterized in that described 1 μ g natural gene disposes the tryptophan of 1-200mg.
3, a kind of method of producing as claim 1 or 2 described n cell growth regulatory factor O, it is earlier Gram-positive, negative cocci or bacillus to be screened and the freezing bacterial strain, with bacterial strain conventional cultivation under 4-38 ℃ of temperature, and after at least once removing by filter harmful bacteria, stay useful bacterial chip and promptly extract natural gene, in natural gene, quantitatively add tryptophan, after safety detection, water preparation or freezing dry powder close to seal and form under the GMP standard.
4, the method for n cell growth regulatory factor O according to claim 3 is characterized in that described bacterial strain conventional cultivation under 10-35 ℃ of temperature, and stays useful bacterial chip promptly extract gene after secondary filter is removed harmful bacteria at least.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02151090 CN1263459C (en) | 2002-12-06 | 2002-12-06 | Cell growth regulating factor O and its prepn process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02151090 CN1263459C (en) | 2002-12-06 | 2002-12-06 | Cell growth regulating factor O and its prepn process |
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| Publication Number | Publication Date |
|---|---|
| CN1506058A CN1506058A (en) | 2004-06-23 |
| CN1263459C true CN1263459C (en) | 2006-07-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 02151090 Expired - Fee Related CN1263459C (en) | 2002-12-06 | 2002-12-06 | Cell growth regulating factor O and its prepn process |
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| Country | Link |
|---|---|
| CN (1) | CN1263459C (en) |
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2002
- 2002-12-06 CN CN 02151090 patent/CN1263459C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1506058A (en) | 2004-06-23 |
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