CN1263146A - Mosquito-expelling bactericidal propolis medicated soap - Google Patents
Mosquito-expelling bactericidal propolis medicated soap Download PDFInfo
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- CN1263146A CN1263146A CN 00102995 CN00102995A CN1263146A CN 1263146 A CN1263146 A CN 1263146A CN 00102995 CN00102995 CN 00102995 CN 00102995 A CN00102995 A CN 00102995A CN 1263146 A CN1263146 A CN 1263146A
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Abstract
The present invention relates to a medicated soap using natural propolis material extract as mosquito-expelling germicide matter, and it possesses the functions of cleaning skin, germicide, stoping itching, deodorizing and expelling mosquito, etc..
Description
The present invention relates to a kind of mosquito-expelling bactericidal medicated soap, particularly relate to a kind of mosquito-expelling bactericidal medicated soap that contains the natural propolis extract.
Commercially available medicated soap kind is a lot, as germicidal soap, antipruritic medicated soap, mosquito repellent medicated soap etc.They also add other material in order to reach specific purposes except having the contained raw material of general soap.For example, in Chinese patent CN 1221786A, disclose a kind of medicated soap that contains the natural propolis extract, pruritus, skin fungus infection and dermatitis class tetter have been had certain effect.But because the propolis extract that uses in this patent is in room temperature to 78 ℃ following heating and refluxing extraction, effective constituent in the propolis is lost easily, impurity such as the beeswax in the raw material are dissolved in easily and extract in the solvent, have reduced effective constituent such as flavonoid and terpenic content.
A kind of mosquito repellent medicated soap that uses sulphur as the mosquito repellent raw material is disclosed at Chinese patent CN 1062377A; In Chinese patent CN 1124286A and CN 1043342A, disclose a kind of mosquito repellent medicated soap, mainly added herbal medicine, as the extract of Tetranthera citrata blade, absinth, kuh-seng, Wild Chrysanthemum etc.Though these mosquito repellent medicated soaps have certain repelling effect, because the smell of sulphur or herbal medicine makes us uncomfortable, perhaps the pungency to skin is strong, has limited its production application.These medicated soaps generally only have a kind of function except the soil removability that soap has simultaneously.
The objective of the invention is to remedy the deficiency of medicated soap in the prior art field, a kind of novel mosquito-expelling bactericidal medicated soap is provided, except the original dirt-removing functions of medicated soap, have special efficacies such as sterilization, antipruritic, deodorizing, mosquito repellent simultaneously.
To achieve these goals, the invention provides a kind of mosquito-expelling bactericidal medicated soap that contains the natural propolis extract, it is characterized in that it is to be made by the frequent regulation soap of following raw materials according method.
Soap base 70-90 weight part propolis extract 2-6 weight part
Zinic stearas 6-10 weight part Magnesium Stearate 1-3 weight part
Phenylethyl alcohol 1-3 weight part limonene 1-2.5 weight part
Polyoxyethylene glycol (4000) 4-8 weight part
Propolis extract has very strong inhibition killing action to gram positive bacterium, intestinal bacteria, Aspergillus flavus etc., the terpenoid substance that propolis extract contained, limonene and phenylethyl alcohol, especially terpenoid substance has the anophelifuge effect, Magnesium Stearate and Zinic stearas have fixedly anophelifuge, keep the effect of its action time.
Used soap base can be any conventional soap base, as man of great strength's board soap base.
Can also add one or more other conventional soapmaking additive in above-mentioned prescription, sanitas for example is as triumphant loose CG or Tubulicid, spices, menthol, hexadecanol, peruscabin, dioctyl phthalate etc.Wherein the addition of various additives is: triumphant loose CG or Tubulicid 0.02-0.08 weight part, spices 1-1.5 weight part, menthol 0.2-0.8 weight part, hexadecanol 2-8 weight part, peruscabin 0.3-0.8 weight part, dioctyl phthalate 0.3-0.8 weight part.
Obtain above-mentioned propolis extract as follows:
1) freezing and pulverizing: propolis raw material is freezing to 0-15 ℃, propolis is ground into the particle of particle diameter 3-8mm size.
2) pre-soaking: with the propolis particle of pulverizing, being placed on and soaking in the filling, is solvent with 95 weight % ethanol, adds solvent submergence raw material, soaks 12-36 hour.
3) segmentation countercurrent extraction:
The countercurrent extraction post C1-C3 that is 10-18 at first series connection with 3 aspect ratio, and make it be full of 95 weight % ethanol;
In first extraction column C1, supply the propolis raw material particle and the 95 weight % alcoholic acid mixtures of step (2) pre-soaking at charging opening A, flow direction such as accompanying drawing hollow core arrow points, column flow rate is 0.3-0.8m/hr, use screw impeller P1 to promote the propolis particle and slowly advance forward, the rotating speed of three screw impeller P1, P2, P3 be 20-50 change/hour;
Simultaneously in last extraction column C3, supply solvent, filled arrows direction in flow direction such as the accompanying drawing, column flow rate is 1-3.5m/hr, like this, raw material is relative mobile with the form of adverse current in the extraction column system with solvent.
Constantly supply raw material mixture and solvent carry out operation continuously.Finally in first C1 extraction column, collect extracting solution, in the end the insolubles that C3 obtains extracting in extraction column.
4) filtering and concentrating: extracting liquid filtering is removed solid impurity, pump into vacuum concentration pot, under 50 ℃, 0.8 normal atmosphere, remove and desolvate.
5) drying: the extracting solution of gained is dried to constant weight under 40-60 ℃.
Propolis extract prepared according to the methods of the invention carries out at normal temperatures, and effective constituent is not suffered a loss, and especially terpenoid substance content is higher for extraction yield height, active substance.
The preparation of medicated soap of the present invention soapmaking method routinely, but preferably be prepared by following method:
(1) with the polyoxyethylene glycol heat fused, under agitation add propolis extract, continue heated and stirred to even.Continuing progressively to add Zinic stearas, Magnesium Stearate, phenylethyl alcohol, lemon rubber alkene, additive under the heated and stirred, it is mixed then, standby.
(2) with the soap base heat fused, in heated and stirred, add the mixture of (1) preparation, it is mixed.Pour mixture in mould cooling forming.
Accompanying drawing is the countercurrent extraction synoptic diagram that obtains above-mentioned propolis extract according to the present invention.
Below by embodiment and application examples the present invention is further described.
The preparation of embodiment 1 mosquito-expelling bactericidal medicated soap A of the present invention
Press the row weight part and take by weighing each component:
Man of great strength's board soap base 80 weight part propolis extracts 6 weight parts
Zinic stearas 8 weight part Magnesium Stearates 2 weight parts
Phenylethyl alcohol 2 weight part limonene 1.5 weight parts
Menthol 0.5 weight part hexadecanol 6 weight parts
Triumphant loose CG 0.04 weight part peruscabin 0.5 weight part
Dioctyl phthalate 0.5 weight part polyoxyethylene glycol (4000) 6 weight parts
Nerolux perfume compound 1.5 weight parts
With the polyoxyethylene glycol heat fused, under agitation add propolis extract, continue heated and stirred to even.Continuing progressively to add hexadecanol, peruscabin, dioctyl phthalate, Zinic stearas, Magnesium Stearate, phenylethyl alcohol, lemon rubber alkene, menthol, essence under the heated and stirred then, triumphant loose CG, it is being mixed, standby.
With the soap base heat fused, in heated and stirred, add the mixture of preparation, it is mixed.Pour mixture in mould cooling forming, get final product mosquito-expelling bactericidal medicated soap A of the present invention.
The preparation of embodiment 2 mosquito-expelling bactericidal medicated soap B of the present invention
Press the row weight part and take by weighing each component:
Man of great strength's board soap base 80 weight part propolis extracts 6 weight parts
Zinic stearas 8 weight part Magnesium Stearates 2 weight parts
Phenylethyl alcohol 2 weight part limonene 1.5 weight parts
Polyoxyethylene glycol (4000) 6 weight parts
Other makes mosquito-expelling bactericidal medicated soap B of the present invention with embodiment 1.
The preparation of embodiment 3 mosquito-expelling bactericidal medicated soap C of the present invention
Press the row weight part and take by weighing each component:
Man of great strength's board soap base 90 weight part propolis extracts 6 weight parts
Zinic stearas 6 weight part Magnesium Stearates 2 weight parts
Phenylethyl alcohol 2 weight part limonene 1.5 weight parts
Menthol 0.5 weight part hexadecanol 6 weight parts
Triumphant loose CG 0.04 weight part polyoxyethylene glycol (4000) 6 weight parts
Other makes mosquito-expelling bactericidal medicated soap C of the present invention with embodiment 1.
The comparative example 1
Prepare the medicated soap of described propolis-containing extract by the described method of Chinese patent CN 1221786A, specific as follows.
Press the row weight part and take by weighing each component:
Man of great strength's board soap base 87 weight part propolis extracts: 6 weight parts
Aloe 4 weight part spearmint oils: 1.5 weight parts
Nerolux perfume compound 1.5 weight parts
Man of great strength's soap base is mixed with propolis down at 80 ℃, stirred 30 minutes with 70 rev/mins stir speed (S.S.)s, add aloe again and then stirred 25 minutes, add spearmint oil, nerolux perfume compound, continue to stir 10 minutes, the moulding oven dry promptly gets the medicated soap a by the described method preparation of Chinese patent CN 1221786A.
Used propolis extract obtains as follows, and 95% ethanol with 10 times of propolis weight refluxed 5 hours at 78 ℃, filtered extracting solution, and the ethanol of removing in the extract at vacuum concentration pot gets final product then.
Application examples 1
The anti-microbial property of the medicated soap a for preparing in medicated soap A of the present invention, the Comparative Examples relatively
Detect the anti-microbial property of the medicated soap a for preparing in medicated soap A of the present invention, the Comparative Examples as follows:
For trying bacterium: bacillus cereus (Bacilllus cereus var.Mycoides) 63301 is provided by biologics goods calibrating institute of the Ministry of Health.
Preparation for the examination bacterium: culturing bacterium to lawn covers with the surface in the 10ml Kolle flask, wash lawn with about 1ml stroke-physiological saline solution, put 65 ℃ of waters bath with thermostatic control 30 minutes, descended centrifugal 20 minutes at 2000 rev/mins again, supernatant discarded repeats 2-3 time, adds about 1ml stroke-physiological saline solution again, mixing is placed on 65 ℃ of waters bath with thermostatic control 30 minutes, with this as stoste.
Substratum: LB nutrient agar.
With the dissolve with ethanol of sample, be mixed with 1% solution respectively with 95 weight %;
Culture medium after sterilization is cooled to 50-55 ℃, adds the bacterium stoste that contains 100 times of dilutions, pour into together then in the culture dish, cool off standby;
In same culture dish, break away from and to place four Oxford cups equably, fill with the 95 weight % ethanolic solns of the medicated soap a for preparing in the medicated soap A of the present invention that prepared, the Comparative Examples respectively, and 95 weight % ethanolic solns, cultivated 17 hours at 37 ℃.
Measure antibacterial circle diameter, do 5 parallel laboratory tests, average.
The gained result is as shown in table 1, and as can be seen from Table 1, the anti-microbial property of medicated soap A of the present invention is better than the medicated soap a for preparing in the Comparative Examples.The anti-microbial property of the medicated soap a for preparing in table 1 medicated soap A of the present invention, the Comparative Examples
| Sample | Antibacterial circle diameter size (mm) |
| 95% ethanolic soln | 0 |
| 1% medicated soap A95% ethanolic soln of the present invention | 8.2±0.4 |
| The medicated soap a95% ethanolic soln for preparing in 1% Comparative Examples | 9.4±0.3 |
Application examples 2
The mosquito repellent performance of the medicated soap a for preparing in medicated soap A of the present invention, the Comparative Examples relatively
Experimental technique is as follows: put into 600 of white smear yellow-fever mosquitos in the cage of 40cm * 30cm * 30cm size, wherein male and female half and half, on hand with on the gloves of 300 meshes are arranged, soap in the medication of mesh position at random and wash skin, mark, two kinds of samples are respectively got 100 meshes, are contrast with untreated mesh, handle was put into every 1 hour in the cage 3 minutes then, counted the stung mesh count of thorn of each sample.Do 5 parallel laboratory tests, average.The result is as shown in table 2.
The mosquito repellent performance of the medicated soap a for preparing in table 2 medicated soap A of the present invention, the Comparative Examples relatively
Can see that from table 2 medicated soap of the present invention has good mosquito repellent performance, its repelling effect can be kept 4-8 hour.And it is relatively poor with the medicated soap a washing repelling effect for preparing in the Comparative Examples.
Mosquito-expelling bactericidal medicated soap of the present invention has the soil-removing action that general perfumed soap has, and the washing back is to skin nonirritant, good hand touch.Owing to possess the sterilizing ability that it possesses, can also be used to prevent and treat all kinds of tetter simultaneously, skin pruritus, fungal infection and dermatitis class tetter are had good effect.In addition, because it contains materials such as terpenes, delicate fragrance is pleasant, has the mosquito bite of preventing and de-odorised function again.This multi-functional medicated soap is indoor and outdoor work, at home lives, travels away from home etc. and bring great convenience.
Claims (6)
1. novel mosquito-expelling bactericidal medicated soap is characterized in that it is to be made by following raw materials according:
Soap base 70-90 weight part propolis extract 2-6 weight part
Zinic stearas 6-10 weight part Magnesium Stearate 1-3 weight part
Phenylethyl alcohol 1-3 weight part limonene 1-2.5 weight part
Polyoxyethylene glycol (4000) 4-8 weight part.
2. mosquito-expelling bactericidal medicated soap as claimed in claim 1 is characterized in that described propolis extract is as follows:
1) freezing and pulverizing: propolis raw material is freezing to 0-15 ℃, propolis is ground into the particle of particle diameter 3-8mm size;
2) pre-soaking: with the propolis particle of pulverizing, being placed on and soaking in the filling, is solvent with 95 weight % ethanol, adds solvent submergence raw material, soaks 12-36 hour;
3) segmentation countercurrent extraction:
The countercurrent extraction post C1-C3 that is 10-18 at first series connection with 3 aspect ratio, and make it be full of 95 weight % ethanol;
In first extraction column C1, supply the propolis raw material particle and the 95 weight % alcoholic acid mixtures of step (2) pre-soaking at charging opening A, column flow rate is 0.3-0.8m/hr, use screw impeller P1 to promote the propolis particle and slowly advance forward, the rotating speed of three screw impeller P1, P2, P3 be 20-50 change/hour;
Simultaneously supply solvent in last extraction column C3, column flow rate is 1-3.5m/hr, and like this, raw material is relative mobile with the form of adverse current in the extraction column system with solvent;
Constantly supply raw material mixture and solvent carry out operation continuously; Finally in first C1 extraction column, collect extracting solution, in the end the insolubles that C3 obtains extracting in extraction column;
4) filtering and concentrating: extracting liquid filtering is removed solid impurity, pump into vacuum concentration pot, under 50 ℃, 0.8 normal atmosphere, remove and desolvate;
5) drying: the extracting solution of gained is dried to constant weight under 40-60 ℃.
3. mosquito-expelling bactericidal medicated soap as claimed in claim 1 or 2 is characterized in that used soap base can be any soap base.
4. as any one described mosquito-expelling bactericidal medicated soap in the claim 1 to 3, it is characterized in that adding following one or more other additives:
Sanitas 0.02-0.08 weight part, spices 1-1.5 weight part, menthol 0.2-0.8 weight part, hexadecanol 2-8 weight part, peruscabin 0.3-0.8 weight part, dioctyl phthalate 0.3-0.8 weight part.
5. as any one described mosquito-expelling bactericidal medicated soap in the claim 1 to 4, it is characterized in that this sanitas is triumphant loose CG or Tubulicid.
6. as any one described mosquito-expelling bactericidal medicated soap in the claim 1 to 5, it is characterized in that this medicated soap has sterilization and anophelifuge effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00102995 CN1263146A (en) | 2000-03-14 | 2000-03-14 | Mosquito-expelling bactericidal propolis medicated soap |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00102995 CN1263146A (en) | 2000-03-14 | 2000-03-14 | Mosquito-expelling bactericidal propolis medicated soap |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1263146A true CN1263146A (en) | 2000-08-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00102995 Pending CN1263146A (en) | 2000-03-14 | 2000-03-14 | Mosquito-expelling bactericidal propolis medicated soap |
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| Country | Link |
|---|---|
| CN (1) | CN1263146A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101215495B (en) * | 2008-01-21 | 2011-01-12 | 福建省神蜂科技开发有限公司 | Bee biological scented soap |
| CN103361211A (en) * | 2013-05-22 | 2013-10-23 | 上海巴方精细化工有限公司 | Mint cool and refreshing compound perfumed soap |
| CN104367529A (en) * | 2014-11-19 | 2015-02-25 | 苏州佑君环境科技有限公司 | Mosquito repellent floral water for purifying air and preparation method of mosquito repellent floral water |
| CN105802774A (en) * | 2016-04-07 | 2016-07-27 | 苏州市天灵中药饮片有限公司 | Antibacterial facial soap and preparation method thereof |
| CN106172472A (en) * | 2016-07-07 | 2016-12-07 | 平阳县小鸽工艺品厂 | A kind of environmental protection mosquito eradication formula and the mosquito killing liquid being prepared as thereof and mosquito eradication bag |
| CN106350323A (en) * | 2016-08-24 | 2017-01-25 | 上海制皂(集团)如皋有限公司 | Perfumed soap grain production formula capable of improving bar output speed in perfumed soap grain forming process |
-
2000
- 2000-03-14 CN CN 00102995 patent/CN1263146A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101215495B (en) * | 2008-01-21 | 2011-01-12 | 福建省神蜂科技开发有限公司 | Bee biological scented soap |
| CN103361211A (en) * | 2013-05-22 | 2013-10-23 | 上海巴方精细化工有限公司 | Mint cool and refreshing compound perfumed soap |
| CN104367529A (en) * | 2014-11-19 | 2015-02-25 | 苏州佑君环境科技有限公司 | Mosquito repellent floral water for purifying air and preparation method of mosquito repellent floral water |
| CN105802774A (en) * | 2016-04-07 | 2016-07-27 | 苏州市天灵中药饮片有限公司 | Antibacterial facial soap and preparation method thereof |
| CN106172472A (en) * | 2016-07-07 | 2016-12-07 | 平阳县小鸽工艺品厂 | A kind of environmental protection mosquito eradication formula and the mosquito killing liquid being prepared as thereof and mosquito eradication bag |
| CN106172472B (en) * | 2016-07-07 | 2019-03-26 | 平阳县小鸽工艺品厂 | A kind of environmental protection mosquitocide composition and its mosquito killing liquid and mosquito eradication packet that are prepared into |
| CN106350323A (en) * | 2016-08-24 | 2017-01-25 | 上海制皂(集团)如皋有限公司 | Perfumed soap grain production formula capable of improving bar output speed in perfumed soap grain forming process |
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