CN1261407C - Azo structure contained fluorine-aromatic diamine and preparation process and use thereof - Google Patents
Azo structure contained fluorine-aromatic diamine and preparation process and use thereof Download PDFInfo
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- CN1261407C CN1261407C CN 02102543 CN02102543A CN1261407C CN 1261407 C CN1261407 C CN 1261407C CN 02102543 CN02102543 CN 02102543 CN 02102543 A CN02102543 A CN 02102543A CN 1261407 C CN1261407 C CN 1261407C
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Abstract
The present invention relates to fluorine-aromatic diamine containing an azo structure, which is prepared by the following steps: (1), 1 to 80 parts by weight of trifluoromethyl substituted aniline, 1 to 160 parts by weight of HCl/H2O mixed solutions, and 1 to 40 parts by weight of sodium nitrite aqueous solutions are made into a diazonium salt solution; (2), 1 to 80 parts by weight of lentine, and 1 to 160 parts by weight of HCl/H2O mixed solutions are slowly dropped into the diazonium salt solution, and the fluorine-aromatic diamine containing an azo structure can be obtained after filtration, water washing, baking and recrystallization. The fluorine-aromatic diamine containing an azo structure is used for synthesizing a polyimide liquid crystal orientation agent.
Description
Technical field
The present invention relates to the azo structure contained fluorinated aromatic diamines of a class and method for making and purposes.
Background technology
Aromatic diamine is widely used in the synthetic of polyimide.In recent years, along with developing rapidly of microelectronics industry, more and more widely for the demand of functional polyimide material.The standard type polyimide material is because its inflexible skeleton structure, therefore indissoluble infusible normally.Therefore, many in actual applications with its precursor, promptly the form of polyamic acid is used (Ding Mengxian, what day write polyimide type material, Science Press, 1998,1 in vain).Polyamic acid can be converted into polyimide after the high-temperature sub amination, the imidization temperature is usually at 250-300 ℃, and so high temperature is unaffordable for many thermally sensitive fields in the microelectronics industry.Given this, people have carried out modification work widely to the standard type polyimide material.Wherein, by the synthesizing new monomer prepare the much-talked-about topic that the organic soluble polyimide is research at present (Huang S.J., Hoyt A.E., The synthesis of soluble polyimides, TRIP, 1995,3 (8), 262-271).
The diamine monomer that is used for synthesizing soluble polyimide is of a great variety, introduce in diamines wherein that to contain fluoro substituents be the most effectively one of means (Ghosh M.K. of synthesizing soluble polyimide, Mittal K.L., Polyimide:fundamentals and applications, Marcel Dekker, 1996, p71).A lot of in the document about the monomeric report of fluorinated diamine.For example, people such as Ichino reported the fluorinated diamine monomer that has long fluoroalkyl side chain (Ichino T., Sasaki S., Matsuura T.and Nishi S., J.Polym.Sci., Part A:Polym.Chem., 1990,28, p323).People such as Auman synthesized side chain have two substituent fluorinated diamine monomers of (trifluoromethyl) Sevoflurane base (Auman B.C., Higley D.P., Scherer K.V, Polym.Prepr., 1993,34 (1), p389).People such as Yusa studied the polymerization behavior that side chain has the diamine monomer of perfluorinated nonene base ether (Yusa M., Takeda S., and Miyadera Y, Polym.Prepr.Japan, 1990,39, p897) or the like.
Though above-mentioned fluorochemical monomer is used for the synthetic of polyimide, but the synthetic route of these fluorinated diamines is comparatively complicated, and raw material is not easy to obtain, and particularly monomeric purification is difficulty comparatively, the purpose that is difficult to obtain the high product of purity and reaches batch process, this has limited application to a great extent.
Summary of the invention
The invention provides a kind of novel fluorine diamine monomer and method for making and purposes.This monomeric synthetic route is succinct, and raw material is easy to get, and is easy to purify, and can produce in enormous quantities.
Fluorinated aromatic diamines of the present invention has the structure shown in the general formula (1):
Wherein, R
1For:
Or
Wherein, R
fFor :-CF
3Or-(CF
3)
2
Fluorine-containing aromatic diamine shown in the general formula (1) is particularly including the diamine monomer of following structure:
Azo structure contained fluorinated aromatic diamines of the present invention is by following step synthetic:
(1) by weight, 1-80 part trifluoromethyl substituted aniline is dissolved in 1-160 part HCl/H
2In the O mixing solutions, 0-5 ℃ drips 1-40 part sodium nitrite in aqueous solution down, stirs after 0.5-3 hour, makes diazonium salt solution A;
(2) by weight, 1-80 part mphenylenediamine is dissolved in 1-160 part HCl/H
2Make solution B in the O mixing solutions;
(3) solution B slowly is added drop-wise in the solution A under 0-5 ℃, after dropwising, mixture was stirred 1-3 hour down at 0-5 ℃, be warming up to 25 ℃.In system, drip 1-60 part (weight part) ammonia soln, adjust about pH value to 7.Mixed system is filtered, washing repeatedly, vacuum-drying obtains crude product.Crude product is obtained described azo structure contained fluorinated aromatic diamines with ethyl alcohol recrystallization.
Azo structure contained fluorinated aromatic diamines of the present invention is tested through analysis means such as Fourier infrared spectrum (FT-IR), nucleus magnetic resonance (NMR), mass spectrum (MS), ultimate analysis, application of gas chromatorgraphy/mass, confirmed the structure of diamines of the present invention, its purity can reach 99.5%, through the ion analysis test shows, the monomeric ion content of this structure is as follows: Na
+＜1-2ppm, Cl
-＜1-2ppm, K
+＜1ppm.In addition, the monomeric raw material of the type is easy to get, and productive rate is suitable for scale operation up to 80-85%.
Azo structure contained fluorinated aromatic diamines of the present invention is used to prepare orientation agent of polyimide liquid crystal.
Embodiment
Embodiment 1 is dissolved in 52.5ml37%HCl and 20mlH with 33.52g (0.208mol) m-trifluoromethyl aniline in the there-necked flask of being furnished with agitator, thermometer
2Among the O.System is cooled to 0-5 ℃ with frozen water, drips 14.1gNaNO
2/ 30mlH
2O solution.Dropwise the back and continue to stir 1hr.21.8g (0.202mol) mphenylenediamine is dissolved in 18.0ml37%HCl and 150mlH
2Among the O, this drips of solution is added in the above-mentioned system.After dropwising, mixture was stirred 2 hours, add the 46g sodium acetate.The frozen water cooling was warming up to room temperature after 1 hour.In system, drip 20%NaOH solution, adjust about pH value to 7.With the red powder sedimentation and filtration that generates, washing repeatedly, vacuum-drying.Crude product is obtained crystal 2 with ethyl alcohol recrystallization, 4-diamino-3 '-trifluoromethyl nitrogen benzide, output 39.8g (84%), its structure is as the formula (2).FT-IR (KBr, cm
-1): 3501.7,3439.4,3362.7,1632.8,1576.1;
1H-NMR (300MHz, DMSO-d
6, ppm): 5.93 (s; 1H); 6.08-6.11 (d; 1H); 6.17 (s; 2H); 7.37 (s; 2H); 7.42-7.47 (d; 1H); 7.57-7.62 (m; 1H); 7.65-7.67 (m; 1H); 7.97-8.00 (d; 1H); 8.02 (s; 1H).
13C-NMR (300MHz, DMSO-d
6, ppm): 96.5,106.8; 117.3; 119.3,122.9,126.5,131.0; 123.5; 125.1; 129.9; 130.5; 148.0; 154.0; 154.4. mass spectrum: 280 (M+, 36.6). ultimate analysis: C
13H
11F
3N
4: calculated value: C, 55.71%; H, 3.96%; N, 19.99%. measured value: C, 55.54%; H, 3.95%; N, 19.95%.
Embodiment 2 is dissolved in 52.5ml37%HCl and 20mlH with 33.52g (0.208mol) p-trifluoromethylaniline in the there-necked flask of being furnished with agitator, thermometer
2Among the O.System is cooled to 0-5 ℃ with frozen water, drips 14.1gNaNO
2/ 30mlH
2O solution.Dropwise the back and continue to stir 1hr.21.8g (0.202mol) mphenylenediamine is dissolved in 18.0ml37%HCl and 150mlH
2Among the O, this drips of solution is added in the above-mentioned system.After dropwising, mixture is stirred 2hr, add the 46g sodium acetate.Behind the frozen water cooling 1hr, be warming up to room temperature.In system, drip 20%NaOH solution, adjust about pH value to 7.With the red powder sedimentation and filtration that generates, washing repeatedly, vacuum-drying.Crude product is obtained crystal 2 with ethyl alcohol recrystallization, 4-diamino-4 '-trifluoromethyl nitrogen benzide, output 40.7g (86%).Its structure as the formula (3).FT-IR (KBr, cm
-1): 3496.7,3432.4,3369.7,1630.8,1570.1;
1H-NMR (300MHz, DMSO-d
6, ppm): 5.96 (s; 1H); 6.06-6.11 (d; 1H); 6.20 (s, 2H), 7.44 (s; 2H); 7.67-7.70 (m; 2H); 7.87-7.92 (d; 2H); 8.05 (s; 2H). mass spectrum: 280 (M+, 36.6). ultimate analysis: C
13H
11F
3N
4: calculated value: C, 55.71%; H, 3.96%; N, 19.99%. measured value: C, 55.54%; H, 3.95%; N, 19.95%.
Embodiment 3 is dissolved in 52.5ml37%HCl and 50mlH with 52.60g (0.208mol) 4-(4 '-trifluoromethyl) phenoxybenzamine in the there-necked flask of being furnished with agitator, thermometer
2Among the O.System is cooled to 0-5 ℃ with frozen water, drips 14.1g NaNO
2/ 50mlH
2O solution.Dropwise the back and continue to stir 1.5hr.21.8g (0.202mol) mphenylenediamine is dissolved in 18.0ml37%HCl and 150mlH
2Among the O, this drips of solution is added in the above-mentioned system.After dropwising, mixture is stirred 1hr, add the 46g sodium acetate.Behind the frozen water cooling 1hr, be warming up to room temperature.In system, drip 20%NaOH solution, adjust about pH value to 7.With the red powder sedimentation and filtration that generates, washing repeatedly, vacuum-drying.Crude product is obtained crystal 2 with ethyl alcohol recrystallization, 4-diamino-4 '-[4 "-(trifluoromethyl) phenoxy group] nitrogen benzide, output 63.93g (85%), its structure is as the formula (4).FT-IR (KBr, cm
-1): 3442.4,3369.2,1630.8,1570.1;
1H-NMR (300MHz, DMSO-d
6, ppm): 5.92 (s; 1H); 6.07-6.10 (d; 1H); 6.19 (s; 2H); 6.92-6.96 (d, 2H), 7.20-7.25 (d, 2H), 7.37 (s; 2H); 7.42-7.47 (d; 1H); 7.57-7.62 (m; 2H); 7.97-8.00 (d; 2H). mass spectrum: 372 (M+, 36.6). ultimate analysis: C
19H
15F
3N
4O: calculated value: C, 61.29%; H, 4.06%; N, 15.05%. measured value: C, 61.24%; H, 4.05%; N, 15.02%.
Embodiment 4 is dissolved in 52.5ml37%HCl and 60mlH with 66.81g (0.208mol) 4-(3 ', 5 '-bis trifluoromethyl) phenoxybenzamine in the there-necked flask of being furnished with agitator, thermometer
2Among the O.System is cooled to 0-5 ℃ with frozen water, drips 14.1g NaNO
2/ 60mlH
2O solution.Dropwising the back continues to stir 1.5 hours.21.8g (0.202mol) mphenylenediamine is dissolved in 18.0ml37%HCl and 150mlH
2Among the O, this drips of solution is added in the above-mentioned system.After dropwising, mixture was stirred 2.5 hours, add the 46g sodium acetate.Behind the frozen water cooling 1hr, be warming up to room temperature.In system, drip 20%NaOH solution, adjust about pH value to 7.With the red powder sedimentation and filtration that generates, washing repeatedly, vacuum-drying.Crude product is obtained crystal 2 with ethyl alcohol recrystallization, 4-diamino-4 '-[3 ", 5 "-two (trifluoromethyl) phenoxy group] nitrogen benzide, output 71.16g (80%), its structure is as the formula (5).FT-IR (KBr, cm
-1): 3440.6,3354.2,1640.8,1572.7;
1H-NMR (300MHz, DMSO-d
6, pprr): 5.94 (s; 1H); 6.07-6.10 (d; 1H); 6.19 (s; 2H); 7.23-7.26 (m, 2H), 7.27-7.31 (m; 2H); 7.40 (s; 1H); 7.96-8.03 (d; 2H). mass spectrum: 440 (M+, 36.6). ultimate analysis: C
20H
14F
6N
4O: calculated value: C, 54.55%; H, 3.20%; N, 12.72%. measured value: C, 54.52%; H, 3.22%; N, 12.69%.
Claims (4)
1. azo structure contained fluorinated aromatic diamines is characterized in that described azo structure contained fluorinated aromatic diamines general formula is as follows:
Wherein, R
1For
Or
Wherein, R
fFor :-CF
3Or-(CF
3)
2
2. azo structure contained fluorinated aromatic diamines according to claim 1 is characterized in that described azo structure contained fluorinated aromatic diamines is:
3. the method for making of azo structure contained fluorinated aromatic diamines according to claim 1 is characterized in that step is carried out in the following order:
(1) by weight, 1-80 part trifluoromethyl substituted aniline is dissolved in 1-160 part HCl/H
2In the O mixing solutions, 0-5 ℃ drips 1-40 part sodium nitrite in aqueous solution down, stirs after 0.5-3 hour, makes diazonium salt solution;
(2) under 0-5 ℃, in above-mentioned solution, slowly drip by 1-80 part mphenylenediamine and 1-160 part HCl/H
2The solution that the O mixed solution is made into obtains mixture;
(3) said mixture is warming up to 25 ℃ in stirring under 0-5 ℃ after 1-3 hour.Drip 1-60 part ammonia soln again, adjust about pH value to 7, with the suspension filtered that obtains, filter cake is washed repeatedly, vacuum-drying and recrystallization obtain described azo structure contained fluorinated aromatic diamines.
4. the purposes of azo structure contained fluorinated aromatic diamines according to claim 1 is characterized in that being used to prepare orientation agent of polyimide liquid crystal.
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|---|---|---|---|
| CN 02102543 CN1261407C (en) | 2002-01-25 | 2002-01-25 | Azo structure contained fluorine-aromatic diamine and preparation process and use thereof |
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| CN1261407C true CN1261407C (en) | 2006-06-28 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10347932A1 (en) * | 2003-10-15 | 2005-05-19 | Bayer Chemicals Ag | Process for the preparation of fluorine-containing anilines |
| CN100412160C (en) * | 2006-09-21 | 2008-08-20 | 青岛科技大学 | Liquid crystal compound 4'-n-decyloxy-4-phenylazobenzoic acid-3-fluoro-4-cyanobenzene ester and preparation method thereof |
| CN100410347C (en) * | 2006-09-21 | 2008-08-13 | 青岛科技大学 | Liquid crystal compound 4'-allyloxy-4-phenylazobenzoic acid-3-fluoro-4-cyanobenzene ester and preparation method thereof |
| CN114456084B (en) * | 2022-02-09 | 2023-06-30 | 中国科学院化学研究所 | Synthesis method of aromatic azo compound |
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Granted publication date: 20060628 Termination date: 20100225 |