CN1257740C - Preparation of pure Chinese traditional medicine for curing acute nephritis and chronic nephritis - Google Patents
Preparation of pure Chinese traditional medicine for curing acute nephritis and chronic nephritis Download PDFInfo
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Abstract
The present invention relates to a preparation of pure Chinese traditional medicine for curing acute nephritis and chronic nephritis, which mainly comprises 2% to 80% of motherwort, 1.5% to 75% of red sage root, 1.5% to 80% of astragalus root, 0.5% to 75% of solomonseal rhizome, 0.9% to 75% of tuckahoe, 1% to 70% of dodder, 0.9% to 65% of scutellaria root, 0.9% to 80% of barbat skullcap, 0.5% to 60% of kaladana and 0.9% to 80% reed rhizome. The present invention has the advantages of little side effect and good therapeutic effect, has the functions of activating blood circulation to dissipate blood stasis and inducing diuresis to remove edema and has favorable effect on treating acute chronic nephritis and edema, hematuria and albuminuria caused by damp-heat stagnation.
Description
Technical field: a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis that the invention relates to treatment nephritis.
Background technology: acute and chronic glomerulonephritis (being called for short acute and chronic nephritis) is because after infecting (especially hemolytic streptococcal infection), cause immunoreation, antigen antibody complex deposits in glomerule, and acute diffusivity and immune inflammation pathological changes take place the glomerule that causes the both sides kidney.Mainly show for it with edema, albuminuria, hematuria, hypertension and all renal function injury.This is commonly encountered diseases, frequently-occurring disease in the population of China, its sickness rate height, and the patient is wide, is the health problem that we can not be ignored.Therefore seek effective medicine, be the target that domestic nephropathy circle is made joint efforts always.The medicine of existing treatment nephritis, side effect is big, and curative effect is not remarkable.
Summary of the invention: the purpose of this invention is to provide a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis, its side effect is little, and therapeutic effect is good, has the effect of " blood circulation promoting and blood stasis dispelling; inducing diuresis to remove edema ", and acute and chronic oedema due to nephritis, hematuria, albuminuria due to the treatment damp-heat accumulation are had good effect.
Technical scheme of the present invention is: design a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis, it is characterized in that: it mainly comprises Herba Leonuri 2%-80%, Radix Salviae Miltiorrhizae 1.5%-75%, Radix Astragali 1.5%-80%, Rhizoma Polygonati 0.5%-75%, Poria 0.9%-75%, Semen Cuscutae 1%-70%, Radix Scutellariae 0.9%-65%, Herba Scutellariae Barbatae 0.9%-80%.
Described proportioning includes Herba Leonuri 2%-80%, Radix Salviae Miltiorrhizae 1.5%-75%, Radix Astragali 1.5%-80%, Rhizoma Polygonati 0.5%-75%, Poria 0.9%-75%, Semen Cuscutae 1%-70%, Radix Scutellariae 0.9%-65%, Herba Scutellariae Barbatae 0.9%-80%, Semen Pharbitidis 0.5%-60%, Rhizoma Phragmitis 0.9%-80%.
Described proportioning includes Herba Leonuri 2%-80%, Radix Salviae Miltiorrhizae 1.5%-75%, Radix Astragali 1.5%-80%, Rhizoma Polygonati 0.5%-75%, Poria 0.9%-75%, Semen Cuscutae 1%-70%, Radix Scutellariae 0.9%-65%, Herba Scutellariae Barbatae 0.9%-80%, Semen Plantaginis 1%-75%, Fructus Jujubae 1%-75%, Poria 0.9%-75%, Pollen Typhae 0.5%-65%, Radix Rubiae 0.5%-65%, Fructus Crataegi 1.5%-70%, Rhizoma Imperatae 1%-80%.
Described proportioning is Herba Leonuri 2%-80%, Radix Astragali 1.5%-80%, Rhizoma Polygonati 0.5%-75%, Herba Scutellariae Barbatae 0.9%-80%, Semen Cuscutae 1%-70%, Semen Pharbitidis 0.5%-60%, Rhizoma Phragmitis 0.9%-80%, Radix Salviae Miltiorrhizae 1.5%-75%, Poria 0.9%-75%, Radix Scutellariae 0.9%-65%, Semen Plantaginis 1%-75%, Fructus Jujubae 1%-75%, Pollen Typhae 0.5%-65%, Radix Rubiae 0.5%-65%, Fructus Crataegi 1.5%-70%, Rhizoma Imperatae 1%-80%, Radix Glycyrrhizae 0.1%-65%.
Described proportioning is Radix Salviae Miltiorrhizae 10%, Radix Scutellariae 6%, Pollen Typhae 3%, Semen Pharbitidis 3%, Herba Leonuri 13%, the Radix Astragali 10%, Rhizoma Polygonati 3%, Poria 6%, Herba Scutellariae Barbatae 6%, Semen Cuscutae 7%, Radix Rubiae 3%, Fructus Crataegi 10%, Rhizoma Phragmitis 6%, Rhizoma Imperatae 7%, Semen Plantaginis 7%.
The described technological process of production is: get Radix Salviae Miltiorrhizae, Radix Scutellariae, Pollen Typhae, Semen Pharbitidis and be ground into fine powder and sieve; Again 13 flavor medicines such as Herba Leonuri, the Radix Astragali are decocted with water secondary, each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.35-1.39 (60 ℃), adds above-mentioned fine powder, mixing, 60 ℃ of oven dry are ground into fine powder, add dextrin, make granule with 85% ethanol, 60 ℃ of oven dry, add magnesium stearate, mixing, tabletting, sugar coating, promptly.
Characteristics of the present invention are: because acute and chronic nephritis relates to the edema, hematuria, lumbago, asthenia of the traditional Chinese medical science etc.Acute nephritis is that ailment said due to cold or exposure is violated lung, due to the impairment of purifying and descending function of the lung, disturbance in water passage.And chronic nephritis is because lung loses logical the accent, dysfunction of the spleen in transportation, and kidney loses folding, haves no right and rises to functioning of bladder eventually, has 10% to be to come for acute nephritis develops clinically approximately.A kind of its prescription of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis is started with from detoxifcation, blood stasis dispelling, diuretic, kidney tonifying, spleen invigorating, has caught pathological factor, has cut the influence of pathological product to body again.The effect of Radix Salviae Miltiorrhizae, Herba Leonuri blood circulation promoting and blood stasis dispelling, pain relieving regulating menstruation, inducing diuresis to remove edema is strong in the side, is monarch drug.The Radix Astragali, Semen Cuscutae, Rhizoma Polygonati, Poria have the effect of invigorating QI to consolidate the body surface resistance, diuresis poison holding, tonifying speen and tonifying kidney, eliminating dampness by diuresis mind calming, are ministerial drug.Radix Scutellariae, Herba Scutellariae Barbatae, Pollen Typhae, Radix Rubiae, Semen Pharbitidis, Fructus Crataegi, Semen Plantaginis seven flavor medicine are played the effect of clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, inducing diuresis to remove edema altogether and are adjuvant drug.Rhizoma Imperatae, Rhizoma Phragmitis clearing away heat and promoting diuresis, the relieving restlessness of promoting the production of body fluid are messenger drug.The present invention is combined together different medicines, and compatibility is proper, monarch, minister, helps, makes and match and usefulness toxicity restriction or checking relation in five elements, the effect of playing blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema altogether.
Below in conjunction with embodiment the present invention is done specific description.
The specific embodiment:
Embodiment 1 gets Radix Salviae Miltiorrhizae 20%, Radix Scutellariae 15% is ground into fine powder and sieves; The medicine of Herba Leonuri 20%, the Radix Astragali 10%, Rhizoma Polygonati 5%, Poria 10%, Semen Cuscutae 5%, Herba Scutellariae Barbatae 15% is decocted with water secondary, each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.35-1.39 (60 ℃), adds above-mentioned fine powder, mixing, 60 ℃ of oven dry are ground into fine powder, add dextrin, make granule with 85% ethanol, 60 ℃ of oven dry, add magnesium stearate, mixing, tabletting, sugar coating, promptly.
Embodiment 2 gets Radix Salviae Miltiorrhizae 10%, Radix Scutellariae 5%, Semen Pharbitidis 10% mixed powder and is broken into fine powder, crosses 100 mesh sieves; The medicine of getting Herba Leonuri 30%, the Radix Astragali 10%, Rhizoma Polygonati 15%, Poria 5%, Semen Cuscutae 5%, Herba Scutellariae Barbatae 5%, Rhizoma Phragmitis 5% decocts with water secondary, and each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.35-1.39 (60 ℃), adds above-mentioned fine powder, mixing, 60 ℃ of oven dry are ground into fine powder, add dextrin, make granule with 85% ethanol, 60 ℃ of oven dry, add magnesium stearate, mixing, tabletting, sugar coating, promptly.
Embodiment 3 gets Radix Salviae Miltiorrhizae 10%, Radix Scutellariae 7%, Pollen Typhae 5% mixed powder and is broken into fine powder, crosses 100 mesh sieves; The medicine of getting Rhizoma Polygonati 5%, Herba Leonuri 20%, Poria 5%, Semen Cuscutae 5%, the Radix Astragali 10%, Herba Scutellariae Barbatae 6%, Semen Plantaginis 3%, Fructus Jujubae 4%, Radix Rubiae 5%, Fructus Crataegi 5%, Rhizoma Imperatae 10% decocts with water secondary, each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.35-1.39 (60 ℃), add above-mentioned fine powder, mixing, 60 ℃ of oven dry, be ground into fine powder, add dextrin, make granule with 85% ethanol, 60 ℃ of oven dry, add magnesium stearate, mixing, tabletting, sugar coating, promptly.
Embodiment 4 gets Radix Salviae Miltiorrhizae 4%, Radix Scutellariae 5%, Pollen Typhae 5%, Semen Pharbitidis 5% mixed powder and is broken into fine powder, crosses 100 mesh sieves; Get Herba Leonuri 20%, the Radix Astragali 5%, Rhizoma Polygonati 5%, Poria 5%, Semen Cuscutae 5%, Rhizoma Phragmitis 10%, Herba Scutellariae Barbatae 6%, Semen Plantaginis 4%, Fructus Jujubae 3%, Poria 5%,, the medicine of Radix Rubiae 5%, Fructus Crataegi 5%, Rhizoma Imperatae 5%, Radix Glycyrrhizae 3% decocts with water secondary, each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.35-1.39 (60 ℃), add above-mentioned fine powder, mixing, 60 ℃ of oven dry, be ground into fine powder, add dextrin, make granule with 85% ethanol, 60 ℃ of oven dry, add magnesium stearate, mixing, tabletting, sugar coating, promptly.
Embodiment 5 gets Radix Salviae Miltiorrhizae 150g, Radix Scutellariae 90g, Pollen Typhae 50g, Semen Pharbitidis 50g, and mixed powder is broken into fine powder, crosses 100 mesh sieves; Get Herba Leonuri 200g, Radix Astragali 150g, Rhizoma Polygonati 50g, Poria 90g, Herba Scutellariae Barbatae 90g, Semen Cuscutae 100g, Radix Rubiae 50g, Fructus Crataegi 150g, Rhizoma Phragmitis 90g, Rhizoma Imperatae 100g, Semen Plantaginis 100g, mixing and water adding decocts secondary, add for the first time 10 times of water gagings, decocted 2 hours, and added 8 times of water gagings for the second time, decocted 2 hours, collecting decoction, filter, filtrate decompression is concentrated into relative density and is the thick paste of 1.35-1.39 60 ℃ of intermittent fever surveys, adds above-mentioned fine powder, mixing, at vacuum 0.06～0.08MPa, vacuum drying becomes dried cream under temperature 60-65 ℃ the condition, is ground into fine powder, cross 100 mesh sieves, add dextrin, make granule with 85% ethanol, 60 ℃ of oven dry, add magnesium stearate, mixing, tabletting, sugar coating is made 1000.
Pharmacological research:
1. test method: 150 of ICR kind white mice are divided into 6 groups at random, 25 every group, sub-cage rearing.First group is matched group, give distilled water 10ml/kg every day, second group is the moulding group, give distilled water 10ml/kg every day, the 3rd group of positive medicine matched group, give SHENYAN SIWEI PIAN 4.8g/kg (be clinical people's consumption 40 times) every day, fourth, fifth, six group is a kind of pure Chinese medicinal preparation dosage group for the treatment of acute and chronic nephritis, respectively to a kind of pure Chinese medicinal preparation 6.75g/kg, 3.375g/kg, 0.84g/kg that treats acute and chronic nephritis.From test first day every group begin gastric infusion, simultaneously except that first group, other each treated animal is from administration the 1st day, 7 days and 10 days, the equal lumbar injection polydextran geies of all animals (G200) 1mg/ only, each is once.Since the equal intravenous injection glucosan saline solution 3 times weekly of the 3rd week all animals except that first group, each 1mg/ only.The 5th weekend, each group was all put to death 5 animals, got kidney and carried out histological examination, prove that kidney obviously suffers damage after, detect in respectively getting 10 animals the 6th week, survey urine protein with test paper method, and convert score value to, comparison between organizing.Measure total protein content with biuret method.Measure urea nitrogen content with the DAM method.Survey serum creatinine content with picric acid method.And the title the weight of animals, after with sacrifice of animal, win kidney, claim the kidney weight in wet base, calculate the organ weight ratio value.Again kidney is fixed with formalin solution and cut into slices.Carry out HE dyeing, Masson three former dyeing are observed the renal tissue gross morphology respectively and are changed, and glomerular mesangium changes and the immune complex deposit situation.Each is organized all the other animals and stops to inject the glucosan saline solution, continues to give medicine, and once a day, successive administration 30 days is to observe recovery and the therapeutical effect of medicine to the animal kidney damage.
2. result of the test: (first) a kind of pure Chinese medicinal preparation 6.75g/kg and 3.375g/kg two treated animal urine protein for the treatment of acute and chronic nephritis all are starkly lower than moulding group (P＜0.05); The animal urea nitrogen content, a kind of pure Chinese medicinal preparation 6.75g/kg group for the treatment of acute and chronic nephritis descends not obvious, and the 3.375g/kg group obviously reduces (P＜0.05), and a kind of pure Chinese medicinal preparation 0.84g/kg group for the treatment of acute and chronic nephritis then descends very obvious; Each treated animal is not obvious to the influence of animal serum total protein; The animal serum creatinine content, a kind of pure Chinese medicinal preparation 6.75g/kg group for the treatment of acute and chronic nephritis is starkly lower than the moulding group, and other two groups all are lower than the moulding group.The histological examination result: a kind of pure Chinese medicinal preparation 6.75g/kg group for the treatment of acute and chronic nephritis has 7 routine glomerular capsule intracavity to still have deposit, and cyst wall thickens, the mesentery hypertrophy, and the mesangial region cell number is starkly lower than the moulding group.Two routine glomerule chambeies enlarge in a kind of pure Chinese medicinal preparation 3.375g/kg group for the treatment of acute and chronic nephritis, four routine part glomerule blister cavities as seen, the mesangial region cell number is starkly lower than the moulding group.Nine routine glomerule blister cavities enlarged during a kind of pure Chinese medicinal preparation 0.84g/kg that treats acute and chronic nephritis organized, and the mesentery hypertrophy is light, and the mesangial region cell number is starkly lower than the moulding group.Illustrate that a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis has therapeutical effect to tentative glomerule infringement, shows that renal damage lightens.
(second batch) stops moulding and continue the curative effect of treatment and the situation that nephritis is recovered naturally, and the result shows: animal urine albumen, a kind of each group of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis all is starkly lower than the moulding group.Urea nitrogen content, a kind of pure Chinese medicinal preparation 3.375g/kg group for the treatment of acute and chronic nephritis is starkly lower than the moulding group.Serum creatinine, a kind of pure Chinese medicinal preparation 0.84g/kg group and the apparent in view reduction of moulding group for the treatment of acute and chronic nephritis.The histological examination result: a kind of three groups of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis, the glomerule blister cavities enlarges, and deposit disappears on the mesentery, and deposit reduces or disappearance in the blister cavities.A kind of pure Chinese medicinal preparation 0.84g/kg group for the treatment of acute and chronic nephritis is better than 6.75g/kg group and 3.375g/kg group, and the messangial cell number returns to than moulding group and obviously reduces and compare no significant difference with matched group.A kind of pure Chinese medicinal preparation 3.375g/kg group for the treatment of acute and chronic nephritis, the outer mesangial region cell number of glomerule return to matched group than zero difference, the mesentery hypertrophy alleviates in a kind of three groups of pure Chinese medicinal preparation glomerule for the treatment of acute and chronic nephritis, mesentery is thin, the mesentery morphological Edge is smooth, and it is light to dye.
Two batches of result of the test explanations: a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis has the obvious treatment effect to experimental glomerule infringement, shows that the renal damage pathological changes is light, recovers fast, particularly immune complex deposit is had obvious scavenging action.
In addition, a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis also has refrigeration function, analgesic activity, diuresis, and experimental kidney animal hypertension is had obvious hypotensive effect, can also promote microcirculation.
Model case:
1, Zhang, the woman, 31 years old, first visit on March 2 in 2000, two weeks once caught a cold, the slight edema of facial area in morning before 3 days, lower limb are stranded heavy, edema again in the afternoon, companion's dizziness, oliguria, tired, lumbago, idol has the sense of feeling sick.Blood pressure 146/86, lab testing urine protein (++), leukocyte 5-8/HP, erythrocyte (+++), granular cast 0-3/HP, specific gravity of urine 1.012, endogenous creatinine clearance rate 2mg%, BUNllmmol/L, two floating and rapid pulse are string slightly, and body of the tongue is light red, and yellow and thin fur is moist.Control the method for reinforcing the kidney, take a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis, every day 3 times, each 3 with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, strengthening the spleen.Above-mentioned all symptoms obviously alleviate after 5 days, and face and edema of lower limbs subtract greatly.Routine urinalysis: albumen (+), leukocyte 4-6, erythrocyte (+), granular cast (±), blood pressure 140/80.Continue to take a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis after 5 days, above-mentioned all diseases and edema disappear.It is normal that routine urianlysis recovers, specific gravity of urine 1.020, endogenous creatinine clearance rate 1.5mg%, BUN5.6mmol/L, blood pressure 106/80.Take medicine 10 days again to consolidate curative effect.Follow up a case by regular visits to half a year continuously, do not see recurrence.
2, Chen, woman, 39 years old.Go to a doctor May 13 calendar year 2001, the patient suffered from nephritis before 2 years, once used medicines such as " penicillins ", and effect is not remarkable, and day by day becomes thin, and is weak, giddy, edema of lower limbs repeatedly, oliguria.The patient is the anemia looks, and blood pressure 120/70, two lower limb pitting edemas (++), tongue fur are slightly thick in vain, deep-rolling pulse.Lab testing: Hb8 gram, RBC260 ten thousand, WBC4800, urine protein (+++), erythrocyte 12-15, leukocyte 3-5, granular cast 3-5, blood BUNl7mmol/L.Card belongs to humidity not to the greatest extent, checks the sun of spleen kidney, causes the deficiency of spleen-YANG and kidneyYANG blood stasis of holding concurrently, and controls suitable blood circulation promoting and blood stasis dispelling, detoxifcation removing dampness.Take a kind of pure Chinese medicinal preparation for the treatment of acute and chronic nephritis, every day 3 times, each 3, obeyed 20 days.June 4 examined again, and in high spirits, dizziness alleviates, hydrouria, and edema disappears, thin white fur of tongue, thready pulse.Laboratory is checked every index and is all taken a favorable turn.Continued to take medicine 20 days, check urine protein (-), erythrocyte (-), leukocyte (-) is not seen cast.The Hbll gram, RBC320 ten thousand, BUN6.7mmol/L.For consolidating curative effect, to continue to take medicine, check once every day, and continuous 5 inspection many indexs are normal, follow up a case by regular visits to 1 year, do not see recurrence.
In sum, the pure Chinese medicinal preparation blood circulation promoting and blood stasis dispelling of the acute and chronic nephritis of this treatment, the effect of inducing diuresis to remove edema are worth certainly, and it is used for the treatment of acute and chronic oedema due to nephritis, hematuria, albuminuria due to the damp-heat accumulation, and this is that other medicines institute is incomparable.
Claims (2)
1, a kind of Chinese medicine preparation for the treatment of acute and chronic nephritis is characterized in that: its proportioning is Radix Salviae Miltiorrhizae 10%, Radix Scutellariae 6%, Pollen Typhae 3%, Semen Pharbitidis 3%, Herba Leonuri 13%, the Radix Astragali 10%, Rhizoma Polygonati 3%, Poria 6%, Herba Scutellariae Barbatae 6%, Semen Cuscutae 7%, Radix Rubiae 3%, Fructus Crataegi 10%, Rhizoma Phragmitis 6%, Rhizoma Imperatae 7%, Semen Plantaginis 7%.
2, a kind of Chinese medicine preparation for the treatment of acute and chronic nephritis according to claim 1, its technological process of production is: get Radix Salviae Miltiorrhizae 10%, Radix Scutellariae 6%, Pollen Typhae 3%, Semen Pharbitidis 3% and be ground into fine powder and sieve; Medicine mixing and water adding with Herba Leonuri 13%, the Radix Astragali 10%, Rhizoma Polygonati 3%, Poria 6%, Herba Scutellariae Barbatae 6%, Semen Cuscutae 7%, Radix Rubiae 3%, Fructus Crataegi 10%, Rhizoma Phragmitis 6%, Rhizoma Imperatae 7%, Semen Plantaginis 7% decocts secondary again, each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into relative density and is the thick paste of 1.35-1.39 60 ℃ of intermittent fever surveys, add above-mentioned fine powder, mixing, 60 ℃ of oven dry, be ground into fine powder, add dextrin, make granule with 85% ethanol, 60 ℃ of oven dry, add magnesium stearate, mixing, tabletting, sugar coating, promptly.
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| CN100457165C (en) * | 2006-03-16 | 2009-02-04 | 上海巨洲医药科技有限公司 | Hematuria treating Chinese medicine and its preparing method and use |
| CN101693090B (en) * | 2009-06-02 | 2011-03-23 | 陈仁德 | Technology for preparing compound kidney inflammation tablets |
| CN101979058B (en) * | 2010-10-22 | 2011-12-07 | 姜秀芹 | Chinese medicament for treating chronic nephritis |
| CN102716330A (en) * | 2012-06-25 | 2012-10-10 | 李良 | Astragalus root traditional Chinese medicine decoction for treating edema and preparation method thereof |
| CN103800736B (en) * | 2014-02-18 | 2016-12-07 | 栾世波 | A kind of pharmaceutical composition treating hypertensive nephropathy and application thereof |
| CN106943545A (en) * | 2017-05-10 | 2017-07-14 | 西安恒生堂制药有限公司 | A kind of Chinese herbal granules and its preparation technology for being used to treat children's ephritis |
| CN109106812A (en) * | 2018-09-25 | 2019-01-01 | 湖北吉登丰生物技术有限公司 | One kind is relieved oedema or abdominal distension through diuresis or purgation mixture |
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