CN1255140C - Granuless for treating psoriasis and preparing process thereof - Google Patents
Granuless for treating psoriasis and preparing process thereof Download PDFInfo
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- CN1255140C CN1255140C CN 200310105836 CN200310105836A CN1255140C CN 1255140 C CN1255140 C CN 1255140C CN 200310105836 CN200310105836 CN 200310105836 CN 200310105836 A CN200310105836 A CN 200310105836A CN 1255140 C CN1255140 C CN 1255140C
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Abstract
The present invention relates to granules for treating psoriasis and a preparing technology thereof. The granules comprises rehmannia root, safflower, figwort root, honeysuckle flower, great burdock achene, cicada slough, ledebouriella root, red peony root, dittany bark, angelica, flavescent sophora root, tree peony bark and dyer woad leaf. The present invention overcomes the defects caused by the lag of the form of tablets for treating psoriasis. The granules for treating psoriasis have the advantages of high absorption speed, direct dissolution in the stomach without disintegration, and simple preparation technology.
Description
Technical field
The present invention relates to dermopathic Chinese patent medicine of a kind of treatment and preparation technology thereof, especially relate to a kind of psoriasis Chinese medicinal granule and preparation technology thereof identical for the treatment of with the XIAOYIN PIAN material medicine.
Background technology
Psoriasis is the dermatosis common disease, and motherland's medical literature has the record of similar disease, is called " psoriasis "." surgery great achievement " cloud: " Se Bai and itching has scratched Rhizoma Euonymus, is a kind of chronic and refractory dermatosis for psoriasis, skin such as rash scabies ".The psoriatic medicine of treatment is a lot of both at home and abroad at present, but curative effect is not ideal enough, and relapse rate is very high, and some medicine has serious adverse.XIAOYIN PIAN is the psoriatic medicine commonly used of treatment, and is slow but this medicine absorbs, and needs disintegrate in human body, and complex process has limited the production and the extensive use of this medicine.
Summary of the invention
The objective of the invention is for overcoming disadvantages of background technology, and a kind of psoriasis Chinese medicinal granule and preparation technology thereof identical with the XIAOYIN PIAN material medicine for the treatment of is provided.
The present invention realizes by the following technical solutions.The present invention is the improvement dosage form of XIAOYIN PIAN, and it is to be made by the material medicine of following weight ratio:
Radix Rehmanniae 10-20% Flos Carthami 2-6% Radix Scrophulariae 6-10% Flos Lonicerae 6-10%
Fructus Arctii 6-10% Periostracum Cicadae 2-6% Radix Saposhnikoviae 2-6% Radix Paeoniae Rubra 6-10%
Cortex Dictamni 6-10% Radix Angelicae Sinensis 6-10% Radix Sophorae Flavescentis 6-10% Cortex Moutan 6-10%
Folium Isatidis 6-10%.
The preparation technology of this medicine may further comprise the steps:
(1) Flos Carthami, Flos Lonicerae are chosen clean impurity, 50 ℃ of cold drying by the weighing of inventory regulation, check, are ground into 60 order fine powders, the double-layer polyethylene pack, and numbering, to be checked, the reserve extract dry operation that is up to the standards is used;
(2) with Radix Rehmanniae, Radix Scrophulariae, Radix Paeoniae Rubra, Fructus Arctii, Radix Sophorae Flavescentis, Periostracum Cicadae, Cortex Moutan, Radix Saposhnikoviae, Radix Angelicae Sinensis, Cortex Dictamni, Folium Isatidis respectively by the pharmacopeia requirement in 2000 of Chinese medicine pharmacopeia choose clean impurity, concoct qualified, flowing water is cleaned, run through section, oven dry, be ground into 8 order coarse powder, measure weighing in accordance with regulations, double-layer polyethylene pack, numbering, to be checked, the reserve that is up to the standards is extracted and is used;
(3) with ten Herba indigoferae Pseudotinctoriae coarse grain such as Radix Rehmanniae, Radix Scrophulariae, Radix Paeoniae Rubra, Fructus Arctii, Radix Sophorae Flavescentis, Cortex Moutan, Radix Saposhnikoviae, Radix Angelicae Sinensis, dittany, Periostracum Cicadae, Folium Isatidiss, by the weighing of inventory regulation, check the back and drop in the multi-function extractor, add 7 times of amount 70% alcohol dipping 12 hours, add 6 times of amount 70% reflux, extract, 12 hours again, extracting solution merges, reclaim ethanol, be condensed into cream;
(4) the condensed cream powder adds the crude drug powder, and vacuum drying is ground into 80 order fine powders;
(5) the cream powder is added dextrin, the protein sugar of ormal weight, mix, be up to the standards, prepare grain to use through assay etc.;
(6) with the material pelletization that mixes, drying, granulate, is checked at weighing, and total mixing is up to the standards, and bag is used in being equipped with;
(7) press the packed amount standard of 3.5g/, carry out packing, granule is crossed the composite membrane heat-sealing,, be equipped with outer package and use through being up to the standards;
(8) finish by packing specification packing after, packing is through warehouse-in after the assay was approved.
Radix Rehmanniae is a goatweed in the above-mentioned prescription, contains catalpol, several amino acids and sugar, mannitol, cupreol and campesterol etc.Radix Rehmanniae is cold in nature, sweet in the mouth, hardship.Radix Rehmanniae is cold in nature, sweet in the mouth.The Radix Rehmanniae clearing away heat and promoting production of body fluid, after the cold, hemostasis; Be used for hot blast impairment of YIN, the whole excessive thirst of tongue, send out speckle dermexanthesis, haematemesis, epistaxis, laryngopharynx swelling and pain.The Radix Rehmanniae clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid; Be used for the calentura excessive thirst, send out speckle dermexanthesis, interior-heat caused by deficiency of YIN, haematemesis, epistaxis, diabetes, infectious hepatitis.Flos Carthami is feverfew, and is warm in nature, acrid in the mouth.Invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.Radix Scrophulariae is a goatweed, cold nature, sweet in the mouth, hardship, one-tenth.The removing heat from blood YIN nourishing, eliminating fire and detoxication.Flos Lonicerae is caprifoliaceae plant, and is cold in nature, sweet in the mouth.Heat-clearing and toxic substances removing, wind-heat dissipating.Be used for carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease heating.Fructus Arctii is feverfew, and is cold in nature, acrid in the mouth, hardship.Dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.Be used for anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, Zha rib erysipelas, carbuncle sore tumefacting virus.Periostracum Cicadae, sweet in the mouth becomes, cold.Go into lung, Liver Channel.Diffusing wind heat, lung qi dispersing is decided convulsion.Control affection due to external wind and heat, the cough hoarseness, measles is sent out not smooth thoroughly, rubella pruritus, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.Radix Saposhnikoviae is a samphire, contains volatile oil and mannitol.Warm in nature, hide sweet, hot.Inducing diaphoresis to dispel wind wins and wets, relieving convulsion.Be used for headache due to common cold, rheumatic arthralgia, spasm of the limbs, rheumatism pruritus, tetanus.Radix Paeoniae Rubra is a cohosh, contains paeoniflorin, and other contains a spot of hydroxypaeoniflorin, peony lactone glycoside and benzoic acid.Cold nature, bitter in the mouth.Clearing away heat and cooling blood, eliminating stasis to stop pain; Be used for hematemesis and epistaxis, amenorrhea stomachache and angina pectoris.Cortex Dictamni is rutaceae, and is cold in nature, bitter in the mouth.Heat clearing and damp drying, the detoxifcation of dispeling the wind.Be used for that damp and hot sore, yellow fluid are dripping, eczema, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, jaundice dark coloured urine.When being classified as samphire, contain basic lactone, n-butene acyl lactone, ferulic acid, nicotinic acid, sucrose and several amino acids, and sesquiterpenoids etc.Warm in nature, hide sweet, hot.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Sophorae Flavescentis is a leguminous plant, and nature and flavor are cold in nature, bitter in the mouth.Heat clearing and damp drying, the parasite killing diuresis.Be used for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Cortex Moutan is cohosh, and is cold in nature, bitter in the mouth, suffering.Clearing away heat and cooling blood, blood circulation promoting competent silt.Be used for maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, the amenorrhea dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury.Radix Scrophulariae is a goatweed, cold nature, sweet in the mouth, hardship, one-tenth.The removing heat from blood YIN nourishing, eliminating fire and detoxication.Cortex Moutan is cohosh, and is cold in nature, bitter in the mouth, suffering.Clearing away heat and cooling blood, blood circulation promoting competent silt.Be used for maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, the amenorrhea dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury.Folium Isatidis is a crucifer, and bitter in the mouth is cold.Go into liver, the heart, stomach three warps.Attainment is separated in heat clearing away, removing heat from blood, hemostasis.
Advantage of the present invention is: the present invention has the effect of clearing away heat and cooling blood, blood enriching and dryness moistening, dispelling wind for relieving itching, heat in blood and blood-deficiency and wind-dry psoriasis pustulosa there is better curative effect, its is applicable to simultaneously eczema, urticaria again, and also can play certain control and therapeutical effect to other because of itching skin disease that heat in blood, blood deficiency cause.This medicine absorbs fast, without disintegrate, directly dissolves in stomach, and preparation technology is simple.
The specific embodiment
Embodiment 1
Present embodiment is to be made by the material medicine of following weight ratio:
Radix Rehmanniae 15.9% Flos Carthami 3.7% Radix Scrophulariae 8.04% Flos Lonicerae 8.04%
Fructus Arctii 8.04% Periostracum Cicadae 4.02% Radix Saposhnikoviae 4.02% Radix Paeoniae Rubra 8.04%
Cortex Dictamni 8.04% Radix Angelicae Sinensis 8.04% Radix Sophorae Flavescentis 8.04% Cortex Moutan 8.04%
Folium Isatidis 8.04%.
The preparation technology of present embodiment may further comprise the steps:
(1) Flos Carthami, Flos Lonicerae are chosen clean impurity, 50 ℃ of cold drying by the weighing of inventory regulation, check, are ground into 60 order fine powders, the double-layer polyethylene pack, and numbering, to be checked, the reserve extract dry operation that is up to the standards is used;
(2) with Radix Rehmanniae, Radix Scrophulariae, Radix Paeoniae Rubra, Fructus Arctii, Radix Sophorae Flavescentis, Periostracum Cicadae, Cortex Moutan, Radix Saposhnikoviae, Radix Angelicae Sinensis, Cortex Dictamni, Folium Isatidis respectively by the pharmacopeia requirement in 2000 of Chinese medicine pharmacopeia choose clean impurity, concoct qualified, flowing water is cleaned, run through section, oven dry, be ground into 8 order coarse powder, measure weighing in accordance with regulations, double-layer polyethylene pack, numbering, to be checked, the reserve that is up to the standards is extracted and is used;
(3) with ten Herba indigoferae Pseudotinctoriae coarse grain such as Radix Rehmanniae, Radix Scrophulariae, Radix Paeoniae Rubra, Fructus Arctii, Radix Sophorae Flavescentis, Cortex Moutan, Radix Saposhnikoviae, Radix Angelicae Sinensis, dittany, Periostracum Cicadae, Folium Isatidiss, by the weighing of inventory regulation, check the back and drop in the multi-function extractor, add 7 times of amount 70% alcohol dipping 12 hours, add 6 times of amount 70% reflux, extract, 12 hours again, extracting solution merges, reclaim ethanol, be condensed into cream;
(4) the condensed cream powder adds the crude drug powder, and vacuum drying is ground into 80 order fine powders;
(5) the cream powder is added dextrin, the protein sugar of ormal weight, mix, be up to the standards, prepare grain to use through assay etc.;
(6) with the material pelletization that mixes, drying, granulate, is checked at weighing, and total mixing is up to the standards, and bag is used in being equipped with;
(7) press the packed amount standard of 3.5g/, carry out packing, granule is crossed the composite membrane heat-sealing,, be equipped with outer package and use through being up to the standards;
(8) finish by packing specification packing after, packing is through warehouse-in after the assay was approved.
Embodiment 2
Present embodiment is to be made by the material medicine of following weight ratio:
Radix Rehmanniae 10% Flos Carthami 3% Radix Scrophulariae 6% Flos Lonicerae 6% Fructus Arctii 6%
Periostracum Cicadae 6% Radix Saposhnikoviae 3% Radix Paeoniae Rubra 10% Cortex Dictamni 10% Radix Angelicae Sinensis 10%
Radix Sophorae Flavescentis 10% Cortex Moutan 10% Folium Isatidis 10%.
Its preparation technology is with embodiment 1.
Embodiment 3
Present embodiment is to be made by the material medicine of following weight ratio:
Radix Rehmanniae 20% Flos Carthami 6% Radix Scrophulariae 6% Flos Lonicerae 10% Fructus Arctii 6%
Periostracum Cicadae 6% Radix Saposhnikoviae 6% Radix Paeoniae Rubra 10% Cortex Dictamni 6% Radix Angelicae Sinensis 6%
Radix Sophorae Flavescentis 6% Cortex Moutan 6% Folium Isatidis 6%.
Its preparation technology is with embodiment 1.
Pharmacodynamic study is the result show: high dose has remarkable inhibitory action to mouse vagina epithelial cell mitosis, and mouse tail scale epidermis is had significant particle layer facilitation, improves mouse blood T lymphocyte percentage ratio.Suppress the wide swelling of dimethylbenzene induced mice, obviously prolong the incubation period of Cavia porcellus asthma reaction due to the histamine, postpone the death time of allergy latent time, test shows that the present invention has the effect of antiinflammatory, antiallergic, enhancing cellular immune function and promotion hyperplasia.
Clinical experiment: this laboratory observation case 487 examples, 334 examples are organized in treatment, matched group 153 examples, clinic case 382 examples, inpatient's 105 examples, male's 295 examples, women's 192 examples, psoriasis 197 examples, eczema 146 examples, papular urticaria 144 examples.Treatment group medicine of the present invention, matched group clinical Dermatological Agents FUFANG QINGDAI WAN commonly used at present.The analysis of comparable result shows between group, treatment group and matched group are except that the course of disease, all the other are every to comprise the difference of age, sex, sick kind, syndrome, the state of an illness etc. there are no significant meaning, good comparability between group, the difference of the course of disease has the significance meaning between two groups, the treatment group course of disease is long, the unnecessary matched group of the ratio of case.Efficacy analysis is the result show, treatment group total effective rate is 91.32%, and the matched group total effective rate is 79.74%, and learning by statistics to handle has significant difference, explanation is compared with FUFANG QINGDAI WAN, and the present invention obviously is better than the former to the curative effect of psoriasis and other common dermatosis.
The present invention has overcome the shortcoming that XIAOYIN PIAN dosage form backwardness is brought, and this medicine absorbs fast, without disintegrate, directly dissolves in stomach, and preparation technology is simple, is worth applying clinically.
Claims (1)
1, the psoriatic particulate preparation technology of a kind of treatment, raw material that adopts in this technology and percetage by weight thereof are Radix Rehmanniae 10～20%, Flos Carthami 2～6%, Radix Scrophulariae 6～10%, Flos Lonicerae 6～10%, Fructus Arctii 6～10%, Periostracum Cicadae 2～6%, Radix Saposhnikoviae 2～6%, Radix Paeoniae Rubra 6～10%, Cortex Dictamni 6～10%, Radix Angelicae Sinensis 6～10%, Radix Sophorae Flavescentis 6～10%, Cortex Moutan 6～10% and Folium Isatidis 6～10%, it is characterized in that this preparation technology may further comprise the steps:
(1) above-mentioned Flos Carthami, Flos Lonicerae are chosen clean impurity, 50 ℃ of cold drying by the weighing of inventory regulation, check, are ground into 60 order fine powders, the double-layer polyethylene pack, and numbering, to be checked, the reserve extract dry operation that is up to the standards is used;
(2) with above-mentioned Radix Rehmanniae, Radix Scrophulariae, Radix Paeoniae Rubra, Fructus Arctii, Radix Sophorae Flavescentis, Periostracum Cicadae, Cortex Moutan, Radix Saposhnikoviae, Radix Angelicae Sinensis, Cortex Dictamni, Folium Isatidis respectively by the pharmacopeia requirement in 2000 of Chinese medicine pharmacopeia choose clean impurity, concoct qualified, flowing water is cleaned, run through section, oven dry, be ground into 8 order coarse powder, measure weighing in accordance with regulations, double-layer polyethylene pack, numbering, to be checked, the reserve that is up to the standards is extracted and is used;
(3) with the Radix Rehmanniae in the step 2, Radix Scrophulariae, Radix Paeoniae Rubra, Fructus Arctii, Radix Sophorae Flavescentis, Cortex Moutan, Radix Saposhnikoviae, Radix Angelicae Sinensis, dittany, Periostracum Cicadae and Folium Isatidis ten Herba indigoferae Pseudotinctoriae coarse grain, by the weighing of inventory regulation, check the back and drop in the multi-function extractor, add 7 times of amount 70% alcohol dipping 12 hours, add 6 times of amount 70% reflux, extract, 12 hours again, extracting solution merges, reclaim ethanol, be condensed into cream;
(4) the condensed cream powder adds the crude drug powder, and vacuum drying is ground into 80 order fine powders;
(5) the cream powder is added dextrin, the protein sugar of ormal weight, mix, be up to the standards, prepare grain to use through assay etc.;
(6) with the material pelletization that mixes, drying, granulate, is checked at weighing, and total mixing is up to the standards, and bag is used in being equipped with;
(7) press the packed amount standard of 3.5g/, carry out packing, granule is crossed the composite membrane heat-sealing,, be equipped with outer package and use through being up to the standards;
(8) finish by packing specification packing after, packing is through warehouse-in after the assay was approved.
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| CN 200310105836 CN1255140C (en) | 2003-10-17 | 2003-10-17 | Granuless for treating psoriasis and preparing process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1301124C (en) * | 2004-11-17 | 2007-02-21 | 汤铁强 | Chinese traditional medicine liquor for treating chronic dermatopathy |
| CN101199663B (en) * | 2006-12-14 | 2011-07-20 | 黑龙江福和华星制药集团股份有限公司 | Chinese medicine for treating psoriasis and preparing method thereof |
| CN101647903B (en) * | 2008-08-13 | 2011-07-20 | 黑龙江福和华星制药集团股份有限公司 | Detection method of traditional Chinese medicine for treating psoriasis |
| CN102240336B (en) * | 2011-07-05 | 2015-09-09 | 张丽敏 | Treat psoriasic Chinese medicine composition |
| CN103356803B (en) * | 2013-07-26 | 2015-03-18 | 张佳奇 | Medicament for treating urticaria, and preparation method thereof |
| CN105617322A (en) * | 2016-01-18 | 2016-06-01 | 南阳理工学院 | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
| CN106361884A (en) * | 2016-11-28 | 2017-02-01 | 陕西康惠制药股份有限公司 | Sucrose-free psoriasis relieving granules and quality detection method thereof |
| CN114984115B (en) * | 2022-07-11 | 2023-05-26 | 陕西康惠制药股份有限公司 | Preparation method of traditional Chinese medicine composition of silver-eliminating particles |
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