CN1248603C - Virus infection resisting multifunctional beverage - Google Patents
Virus infection resisting multifunctional beverage Download PDFInfo
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- CN1248603C CN1248603C CN 03116921 CN03116921A CN1248603C CN 1248603 C CN1248603 C CN 1248603C CN 03116921 CN03116921 CN 03116921 CN 03116921 A CN03116921 A CN 03116921A CN 1248603 C CN1248603 C CN 1248603C
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Abstract
The present invention relates to the technical field of a functional beverage. The multifunctional beverage for resisting virus infection contains an edible sweetening agent frequently used by a common beverage, an edible sour agent and water. The present invention is characterized in that the beverage contains 0.01m% to 1m% of food grade sialic acid or sialic acid derivatives, 0.2 to 6m% of protein with bioactivity, a polypeptide mixture, ginseng, ginger, salvia, mushroom, astragalus root, honeysuckle flower, garlic, american ginseng or an extractive of tea. The extractive and swift's nest acid have synergistic action, and genetic substances of a cold virus and other viruses can be effectively prevented from entering host cells and being duplicated. The beverage can perform the action of preventing cold by drinking for a long time, enhance the absorption capacity of an intestinal tract for vitamin and mineral substances and enhance the learning capacity of a brain. The functional beverage is helpful for enhancing physical quality and intelligence development level.
Description
Technical field
The present invention relates to a kind of multifunctional beverage technical field.
Background technology
Flu belongs to common disease, is the disease that influences each consumer's daily life.The human immune system every day will be in the face of the infringement of various virus, and modal is exactly common cold virus.Various common cold virus is up to 200 kinds more than.The serious disease though flu is nothing, but, flu is easy to cause other diseases owing to descending body disease-resistant power, as diseases such as concurrent otitis media acuta, acute sinusitis, purulent rhinitis, acute myocarditis and rheumatic fever, ephritis, the chronic then can sb.'s illness took a turn for the worse because of flu makes, children and old man are easier to catch a cold and certain danger is arranged owing to health is tender or weak.According to statistics, the whole world has 500,000 to 1,000,000 people to die from flu every year, and millions of people are in hospital because of flu.
Usually said flu has common cold and influenza (being called for short " influenza ").Common cold and influenza are all caused by the virus infections respiratory tract.Common cold is a kind of respiratory tract common disease that is caused by multiple virus, and wherein 30%-50% is that rhinovirus by certain serotype causes.Though common cold is mainly in early winter, in any season, as all can taking place in spring, summer, and the Causative virus of the flu of Various Seasonal is also different.The distribution of common cold case is sporadic, does not cause popular.Common cold and influenza all are the inflammation of full respiratory tract, can cause nose, pharynx, the larynx of the upper respiratory tract, the inflammation of paranasal sinus, can cause the acute bronchitis of lower respiratory tract again.Common cold and influenza also can secondary (merging) bacterial infections, cause suppurative tonsillitis, suppurative paranasal sinusitis, bacillary bronchitis, bacterial pneumonia etc.Some original chronic bronchitis, bronchial astehma, ephritis, rheumatismal patient also often cause the outbreak of these original diseases later on or increase the weight of suffering from severe cold or influenza.
Influenza is a kind of acute respiratory infectious disease that is caused by influenza virus, and the main characteristics of influenza are popular, can cause regionality, national, even global being very popular.The influenza that is caused by " spanish influenza virus " of wreaking havoc in the whole world in 1918 to 1919 causes more than 50 ten thousand American's death, the whole world because of the dead number of this virus between 2000-5000 ten thousand.WHO (World Health Organization) prediction, the whole world have 1/3rd old man and 1/10th children can infect influenza every year.Influenza popular often betides late fall or early winter, and grippal popular among the crowd is by interpersonal close contact, and through air droplet infection, propagation.The elderly, immunocompetence is lower and some crowd in, influenza can cause severe complications.
Because the quick propagation of influenza and the tremendous influence that various countries' public health is brought, it has become the infectious disease of connection to global networks monitoring and report.Set up global anti-flu from the World Health Organization in 1948 and be organized into the present specially, set up 111 flu monitoring research centers, the flu patient of the annual about 6-12 hundred million in the whole world has been sampled common cold virus is identified and develops cold vaccine 83 countries and regions.According to these datas, the World Health Organization predicts and develops corresponding vaccine to the common cold virus that may occur.After the countries concerned that produce anti-cold vaccine verified predicting the outcome of the World Health Organization, the unit that produces anti-cold vaccine approximately need go to amplify, produces and its product is sent through 6 months.After about three months, relevant medical department can be injected the anti-cold vaccine of about 200,000,000 dosage units the individual to needs.Although the World Health Organization predicts the outcome accuracy well, it produces effects also very limited.In fact, since very consuming time and costly to the evaluation fully of common cold virus, have only very limited common cold virus to be carried out fully and identify.The more important thing is, the common cold virus that may occur is predicted very unreliable.Many animal common cold virus can cross over animal kind circle and infect humanly, come from birds as H5N1 Hong Kong common cold virus of outburst in 1997, and 6 people's death are arranged in 18 the infecteds.Therefore, the anti-flu tissue in the world generally believes: cross over animal kind circle and infect the infection of human unpredictable common cold virus to the titanic peril of human health tool.
Influenza is included " national disease prevention and control work 10th Five-Year Plan outline " in as one of infectious disease of China's keypoint control.Since calendar year 2001, the Ministry of Public Health cooperates The World Health Organization (WHO) to carry out influenza monitoring collaborative project, has set up the influenza monitoring point in 23 provinces and regions, the whole nation, for China prevents to provide scientific basis with the decision-making of control influenza.
The single strand RNA virus (Orthomyxoviridae) of influenza virus Shi Yi Seed band protein coat mainly is divided into A, B, C three types.A type common cold virus can infect the mankind and other animal, and 8 segments among its inhereditary material RNA contain the sequence information of 10 protein.The Type B common cold virus only infects the mankind and does not infect other animal, and 8 segments among its inhereditary material RNA contain the sequence information of 11 protein.C type common cold virus also only infects human, and 7 segments among its inhereditary material RNA contain the sequence information of 8 protein.Wherein the A type the easiest cause the whole world be very popular.The genetic mutation rate of influenza virus is very high, so the Strain of the influenza of each year generation, or virus serotype is different often.Regular meeting is along with the time changes its antigenicity during as A type influenza virus; or or even one season number become; new variant antigens virus can appear at set intervals; make most people to just all having effect antibody at present, take place thereby have superinfection (whole not More of flu beginning) popular common cold virus.British Wales university general type flu research center is the no specific drug of flu by the conclusion that expensive 5,000,000 pounds of researchs in 10 years draw, and most of antiviral agent all has certain side effect.
Two kinds of important antigens (Antigen) of influenza virus are hemagglutinin (Hemagglutinin, be called for short HA) and sialidase (Nauraminidase, also claim neural amino acid enzyme, be called for short NA), hemagglutinin and sialidase be two kinds on common cold virus surface to absorption with enter the necessary material of host cell, also be the key substance that body immune system is discerned external infectious agent.Because the inhereditary material of influenza virus is RNA, its mutation rate is very high, and the annual point mutation of being accumulated causes its protein of arranging to produce antigenic variation (being called antigenic little change, Antigenic drift) with regard to being enough to.Antigenic little change is the accumulation of point mutation, so the variability of its antigen is less, therefore caused popular scale is also less.When the common cold virus of different genotype exists simultaneously, the inhereditary material RNA of virus very easily produces whole section exchange and (is called genetic make up, Re-assortment.)。When this gene reorganization occurs in the antigen gene (as HA or NA) relevant with the human immunity reaction, can cause antigenic great change (Antigenic shift) and produce new prsa gene type (hypotype).So the hereditary variation of various influenza virus particle surface antigen HA and NA is the standard of virus being carried out the hypotype classification.Because most of people do not have immunocompetence to new hypotype antigen, this just may cause global popular comprehensively (Pandemic).
Therefore, two kinds of antigen proteins (HA and NA) of influenza virus particle surface are directly relevant with the human immunity reaction, and the structure of dissimilar its surface antigen proteins of common cold virus is all different.Due to illness the poison function that itself do not have inhereditary material to duplicate, thus it must enter in the body cell and integrate with host cell after just can breed.The whole process of poisoning intrusion can be divided into: 1) virion is adsorbed on cell surface; 2) viral genetic is injected host cell; 3) the how new virion of assembling is duplicated and made to viral genetic in host cell; 4) host cell breaks and discharges a large amount of new virion in body fluid.So but the virus that is not can be invaded the cell of all kinds.Whether the structures shape virion of virus surface proteins matter, particularly HA and NA can be adsorbed on specific cell surface.The immunocompetence of specific cells is according to the outermost structure that contains sialic polysaccharide material in its surface and fixed, the antigen tool immune response of the structure of these polysaccharide materials to being familiar with, thus can stop the absorption of virion at cell surface.
According to the mechanism of common cold virus invasion, scientist studies and has developed anti-cold medicine based on sialic acid derivative to stoping the common cold virus particle in the absorption of cell surface since the eighties in 20th century.One of the major antigen albumen of influenza virus HA is an ARBs, is a kind of primary structure protein on influenza virus particles surface, and the mediation virion combines with the sialic acid oligosaccharide of host cell surface glycoprotein receptor, makes virion enter host cell.The sialic acid oligosaccharide of host cell surface acceptor is that virus infections is necessary, and the analog that designs the sialic acid oligosaccharide thus is as the influenza virus ARBs.Designed at present and synthesized two valency sialic acid glucosides, sialic acid glucosides polymer and sialic acid glucosides liposome, wherein representative sialic acid glucosides analog has: the glucosides substituent of glycine ammonia benzyl-alpha-glucosides-N-n acetylneuraminic acid n, Neu5Ac and 4-O-hydroxyl substituent, benzoyl-α-glucosides-5N-sulphur n acetylneuraminic acid n and polymer thereof.With sialic acid and be that the anti-cold medicine of parent has been applied to abroad that clinical (wherein two kinds of medicines of Amantadine and Rimantadin are only effective to A type common cold virus with the sialic acid; Zanamivir and Oseltamivir are effective to A type and Type B common cold virus), its dominant mechanism is to suppress the sialidase that the common cold virus particle plays a crucial role in the cell surface adsorption process and the activity of hemagglutinin.But because the mechanism of these medicines is to stop the common cold virus particle to enter cell, so must just can make convalescence shorten about one day (because these medicines can not kill virus) in the early stage use of infection.Because these medicines are sialic derivatives, in human body, there is not natural existence again, so can cause certain side effect after using.When new influenza virus sub-strain produced, immune vaccine must be prepared again, and in fact new influenza virus sub-strain is in continuous generation.Therefore, the product of development of new anti-cold medicine or preventing cold is significant to outburst that prevents/prevent and treat sudden influenza and the health that ensures the people of the world.
Improving constantly along with living standards of the people on the other hand, beverage is come into the people's life family in large quantities, the beverage of traditional sense mainly is to be used for quenching one's thirst or relieving summer heat, though it is that 02139660.4 " relieving summer heat, arrange stone beverage ", number of patent application are 01124084.9 " six-medicine sugar-reducing tea " that producer has also developed some functional beverages such as number of patent application, their weak points are that function ratio is more single, the row's of being mainly used to stone or hypoglycemic, has significant limitation, consumer objects is fewer, and market is narrow.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of viral infection resisting multifunctional beverage at prior art, the stoped virion that this product offers the baby from the female colostrum of design principle simulation enters the mechanism of cell and develops, contain distinctive biological polyoses of female colostrum such as sialic acid or derivatives thereof and multiple bioactive protein and polypeptide, this drink of long-term drinking not only can play the effect of the anti-flu of pre-preventing virus infection, particularly influenza emits, also can improve the absorbability of enteron aisle for vitamin and mineral matter, improve the brain learning ability, help to improve fitness and intelligence development level for this drink of student's long-term drinking especially.
The present invention solves the problems of the technologies described above the technical scheme that is adopted: a kind of viral infection resisting multifunctional beverage, it removes and includes general beverage edible sweetener commonly used, outside edible acidic flavoring agent and the water, it is characterized in that beverage packets contains the protein and the mixtures of polypeptides of the biologically active of the food-grade sialic acid of mass percent 0.06%-1% or sialic acid derivative and mass percent 0.2-6%, wherein said sialic acid is the sialic acid of following general structural formula (1) and general formula (2), and described sialic acid derivative is its R4 of sialic acid of following general structural formula (1), R5, R7, R8, R9 is by material that other group replaced, wherein R can be :-H,-CH3,-COOH,-CNH,-SH and other any group comprise glycosyl, and the protein of described biologically active and mixtures of polypeptides are for comprising lactotransferrin, immunoglobulin (Ig), and the mixture of protein hydrolysising fragment;
Sialic general formula of molecular structure (1) is
Sialic general formula of molecular structure (2) is
Above-mentioned food-grade sialic acid or sialic acid derivative preferred content are mass percent 0.06%-0.3%, discover, be lower than 0.06% o'clock product at the content of sialic acid or sialic acid derivative and will do not have and stop the function of virion, and cost is too high above 0.3% the time there is no need when its content in cell surface absorption.
Importance in the foregoing invention is the sialic acid that the sialic acid of indication comprises the various versions of neuraminic acid.The sialic acid of use in this invention comprises the food-grade sialic acid that extracts from yolk or whey, comprise free form or be connected in the sialic acid of the different structure that the form of the end of protein, glycolipid exists.The sialic mensuration of free form can carry out according to the spectral photometry method of Hayakawa etc. (Hayakawa K, et al.J Chromatogr.1993,620:25-31).Free form and total sialic mensuration also can be carried out (the Ningbo name is Bioisystech Co., Ltd's sialic acid probation report carefully, in January, 2002) according to the oxidation spectral photometry method of our company (the Ningbo name is Bioisystech Co., Ltd carefully).
Importance in the foregoing invention is that the sialic acid of indication is made a general reference the general formula of molecular structure shown in the formula cited below-1, comprises the neuraminic acid shown in the formula-2 (NANA).The sialic acid derivative of indication is that R4, R5, R7, R8, R9 are by the material that other group replaced in the general formula of molecular structure shown in the formula-1 among the present invention, and wherein R can be :-H ,-CH3 ,-COOH ,-CNH ,-SH and other any group comprise glycosyl.Can the dissociate form of type and mating type of these sialic acids exists, and the sialic acid of mating type refers to and protein, fat, and the sialic acid compound that exists of other carbohydrate covalent bond form.
Importance in the foregoing invention is to include bioactive protein of multiple tool and the peptide material of mass percent 0.2%-6% simultaneously in the prescription, comprises lactotransferrin, immunoglobulin (Ig), and the mixture of proteolysis segment.The main effect of biological activity protein and peptide material is to improve body immunity, optimization content is 0.5-5%, its content is lower than 0.5% o'clock product will not have the effect of tangible raising body immunity, and not only cost is too high when its content surpasses 5%, and makes the viscosity of product exceed the scope of beverage.
Above-mentioned beverage contains the plant extracts of mass percent 0.2-3%, this plant includes genseng, ginger, Salvia japonica, mushroom, the Radix Astragali, honeysuckle, garlic, American Ginseng or tealeaves, they can use separately also can choose wherein several uses wantonly, it makes full use of the marrow of the traditional Chinese medical science, utilize the elite of natural plants, make blending the east and the westly, control foster combination, reach the diagnosis and treatment based on an overall analysis of the illness and the patient's condition effect, so anti-flu better effects if.The main effect of plant extracts is to improve body immunity, and wherein discrete component has the effect that suppresses common cold virus simultaneously.
Above-mentioned plant extracts content is preferably mass percent 0.2-1.6%, content is lower than 0.2% o'clock product will not have the effect that improves body immunity, not only cost is too high and when its content surpasses 1.6%, and the aesthetic quality of product had negative effect, but can be used as anti-cold oral liquid.The above-mentioned scope of carrying is plant extracts solid or the molten juice that contracts.
Above-mentioned beverage control acidity is in the pH3-7 value, and acidity preferably between pH3.6-6.6, makes sialic acid more stable in beverage, is not easy to destroy, and beverage mouthfeel is quenched one's thirst more relieve summer heat, and absorption helps digest.
Above-mentioned adjusting acidity can be used general edible acidic flavoring agent, preferred food product level phosphate or phosphoric acid or nicotinic acid or citric acid or citric acid or tartaric acid or malic acid.Phosphate preferably phosphoric acid hydrogen calcium or calcium dihydrogen phosphate, it provides human body that phosphorus matter is not only arranged, and helps the growth of brain, improves memory and comprehension, and provides human body a kind of calcareous, helps skeleton development and growing height.Can certainly select for use sodium hydrogen phosphate or sodium dihydrogen phosphate to make buffer, acidity adjustment directly realizes by the content of the edible acidic flavoring agent in the prescription, generally need not regulate and control in production process.
Compared with prior art, the invention has the advantages that: sialic acid (Sialic acid) also claim bird's nest acid, generally with free form or be connected in epicyte protein and the form of the end of glycolipid exists.Sialic acid is a neuraminic acid, participates in the cell surface different physiological roles, has antiviral, opposing bacterial infection, improves functions such as immunity of organisms, is playing important effect aspect Human Physiology, the biochemical function regulating.Bird's nest acid is the Main Ingredients and Appearance of Chinese traditional cuisines elaboration bird's nest, and also being provides one of early growth and the necessary important component of brain development (Wang B, et al.Am J Clin Nutr 74:510-5,2001) to the baby in the breast milk.Sialic acid in the breast milk is connected on the specified protein, for baby's early growth provides immunity, improves the absorbability of enteron aisle for vitamin and mineral matter.Zelanian scientists is once tried children to 1025 and is carried out finding that from being born to the senior middle school's follow-up study in 18 years by a definite date sialic acid also can improve children's early intelligence development level.For this reason, many scientists suggestion should be added sialic acid (Martin A.et al., Biochimie 1998,80:75-86) in the milk of feeding infant.Because its important function in biological study and field of biological pharmacy, sialic acid has become the popular research topic of current biology in the world and field of biological pharmacy.Sialic acid is found in 1936 the earliest, is a kind of acyl groupization nine carbon sugar that contain carboxyl, also claims saccharic acid, and its general formula of molecular structure is not suc as formula-1.According to R4, R5, R7, R8, and the various combination of R9 after being replaced by different substituting groups, at present known total about 40 kinds of the sialic acid that is distributed in the various cells.
The sialic general formula of molecular structure of formula-1
In normal human's serum, sialic total soluble matters (free type and convolution) is 2-3 mM/liter (being about 600-900mg/ml), wherein the solubility of the free sialic acid 0.5-1 micromoles per liter of only having an appointment.Discover, contain sialic acid (Sugiyama, N.et al.Life Science 1989, the 44:1247-1250 of quite high solubility in the animal brain; Brunngraber EG., et al.Neurobiology 1975,18:2086-2092).The sialic acid that content is the highest in human body is neuraminic acid (N-acetylneuraminic acid also claims NANA), and its R5 substituting group is CH3, and R4, R7, R8, R9 substituting group are H, and its molecular structural formula is suc as formula shown in-2.
The molecular structural formula of formula-2 sialic acid (N-acetylneuraminic acid, neuraminic acid)
The present invention finds by the back that studies for a long period of time to sialic acid and derivative thereof, naturally occurring sialic acid and derivative thereof in the human body are carried out the Multifunction beverage that scientific formula is made into the key composition of the female colostrum of simulation, can effectively prevent the influenza virus particle and enter human body cell.The present invention naturally occurring sialic acid and derivative thereof (free type and mating type) in to human body calculate the solubility of finding naturally occurring sialic acid in the increases/raising human body and derivative thereof in the back can be suppressed (or prevention) common cold virus particle effectively and enter cell.Because ewborn infant is relevant with its high-load sialic acid of drawing from breast milk at the antiviral infection ability of lactation, the influenza that the present invention makes emits beverage to simulate the antiviral mechanism that infects of breast milk to a certain extent.Combine the marrow of the traditional Chinese medical science in addition, adopted the natural elite of plant to carry out scientifically prescription, the human body self resistance is treated and cultivated to flu carry out combination, improved curative effect.Acidity adjustment is reasonable, improved the stability of sialic acid in the beverage products and derivative thereof, also make final products have good local flavor simultaneously to be suitable for the consumer of all age groups, also provide phosphorus matter and calcareous for human body, be particularly suitable for teen-age growth demand, bound sialic acid itself has the absorbability of raising enteron aisle for vitamin and mineral matter, so help to improve fitness and intelligence development level has profound significance for this drink of student's long-term drinking, be worth of widely use.
Comprehensively above-mentioned, advantage of the present invention has: 1) the viral infection resisting product of bright a kind of long-term drinking but the key composition of the female colostrum of simulation and the comprehensive present anti-machine for treating common cold of anti-cold medicine are in the world got a haircut; 2) but this product contains the food-grade sialic acid of industrial large-scale production, and natural existence in human body does not have any negative interaction, and blocks the absorption of common cold virus at cell surface by the sialic acid dynamic equilibrium of regulating body fluid; 3) this product contains bioactive protein of multiple tool and peptide material, comprises lactotransferrin, immunoglobulin (Ig), and the mixture of proteolysis segment, can improve body immunity; 4) this product contains the plant extracts that can improve body immunity.
Description of drawings
The production technology figure of Fig. 1 viral infection resisting multifunctional beverage of the present invention.
The specific embodiment
Embodiment describes in further detail the present invention below in conjunction with accompanying drawing.
Embodiment 1:
This example has been set forth the prescription design and the manufacturing process of " bird's nest acid viral infection resisting multifunctional beverage ":
(1) be to add 1 kilogram of food-grade bird's nest acid (WPI-SA100) in 8.6 kilograms of hot water of 45-85 ℃ to mix in temperature, its bird's nest acid content is mass percent 10%, wherein 80% for bioactive protein of tool and peptide material, comprise lactotransferrin, immunoglobulin (Ig), and the mixture of proteolysis segment, WPI-SA100 acid of food-grade bird's nest and the activated protein mixture that company and the U.S. one cartel is carefully produced of running after fame.
(2) the bird's nest acid viral infection resisting multifunctional beverage concentrate that mixes is packaged, under the chamber, be put in 4 ℃ of refrigerators after the cooling and store.
(3) 9.6 kilograms of granulated sugars are dissolved in 88 kilograms of hot water, its temperature is 65-100 ℃, mix, and filter, mix with material concentrate in the step 2 then, add 0.6 kilogram of mixed phosphate again, here to select calcium dihydrogen phosphate for use be good to phosphate, can certainly select for use sodium dihydrogen phosphate or sodium hydrogen phosphate to do buffer, 1.6 kilograms of the food-grade bird's nest of mass percent 1% content acid, 0.2 kilogram of plant American ginseng extract, 0.3 kilogram of acid citric acid, 0.12 kilogram of flavor enhancement flavoring essence, stabilizing agent edible glue 0.06-0.4 kilogram, mix.
(4) with the beverage in the step (3) by a high-temperature short-time sterilization device, generally control its temperature and be 121 ℃ of following 3-20 seconds, be cooled to the can finished product under aseptic condition of back below 20 degrees centigrade.
Embodiment 2:
Present embodiment has been set forth the manufacturing process of " bird's nest acid viral infection resisting multifunctional beverage ":
(1) 8.9 kilograms of granulated sugars are dissolved in 90 kilograms of hot water, temperature is 65-100 ℃, after mixing, filter, add 0.67 kilogram of mixed phosphate, phosphate is selected calcium monohydrogen phosphate for use, can certainly select for use sodium dihydrogen phosphate or sodium hydrogen phosphate to do buffer, 1.8 kilograms of the food-grade bird's nest acid of mass percent 1% content, 0.2 kilogram of Shitake Mushroom P.E, 0.1 kilogram of tea extract, 0.5 kilogram of acid citric acid, 0.14 kilogram of flavor enhancement flavoring essence, 0.2 kilogram of stabilizing agent edible glue mixes.
(2) bird's nest acid viral infection resisting multifunctional beverage concentrate and the above-mentioned mixing of materials with preparation among the embodiment 1 is even.
(3) beverage in the step (2) is passed through a high-temperature short-time sterilization device, generally control 121 ℃ of 3-20 of its temperature second, be cooled to the can finished product under aseptic condition of back below 20 degrees centigrade then.
Embodiment 3:
Present embodiment has been set forth " bird's nest acid viral infection resisting multifunctional beverage " manufacturing process according to another prescription:
(1) 4 kilograms of granulated sugars and 7 kg corn syrup (DE 42) are dissolved in 90 kilograms of hot water, temperature is 65-100 ℃, mix, add 0.6 kilogram of mixed phosphate after the filtration, select potassium phosphate for use, sodium phosphate, the mixture of calcium dihydrogen phosphate, proportioning between them can suitably be adjusted as required, can certainly select for use sodium dihydrogen phosphate or sodium hydrogen phosphate to do buffer, 1.6 kilograms of the food-grade bird's nest acid of percentage 1% content, 0.2 kilogram of garlic P.E, 0.2 kilogram of American ginseng extract, 0.6 kilogram of acid citric acid, 0.15 kilogram of flavor enhancement flavoring essence, 0.2 kilogram of stabilizing agent edible glue mixes.
(2) bird's nest acid viral infection resisting multifunctional beverage concentrate and the above-mentioned mixing of materials with preparation among the embodiment 1 is even.
(3) with the beverage in the step (2) by a high-temperature short-time sterilization device, generally control the following sterilization 3-20 of 121 ℃ of its temperature second, be cooled to below 20 degrees centigrade can finished product under aseptic condition then.
Embodiment 4:
This example has been set forth the prescription design and the manufacturing process of " bird's nest acid viral infection resisting multifunctional beverage ":
(1) be to add 1 kilogram of food-grade bird's nest acid (WPI-SA100) in 8.6 kilograms of hot water of 45-85 ℃ in temperature, its bird's nest acid content is mass percent 10%, mixes.
(2) the bird's nest acid viral infection resisting multifunctional beverage concentrate that mixes is packaged, under the chamber, be put in 4 ℃ of refrigerators after the cooling and store.
(3) 9.8 kilograms of granulated sugars are dissolved in 90 kilograms of hot water, its temperature is 65-100 ℃, mix, and filter, mix with material concentrate in the step 2 then, add 0.6 kilogram of mixed phosphate again, here to select calcium dihydrogen phosphate for use be good to phosphate, can certainly select for use sodium dihydrogen phosphate or sodium hydrogen phosphate to do buffer, 3 kilograms of the food-grade bird's nest acid of mass percent 1% content, 0.2 kilogram of tea plant leaf extract, 0.1 kilogram of honeysuckle, 0.5 kilogram of acid citric acid, 0.2 kilogram of flavor enhancement flavoring essence, 0.2 kilogram of stabilizing agent edible glue, mix.
(4) with the beverage in the step (3) by a high-temperature short-time sterilization device, generally control its temperature and be 121 ℃ of following 3-20 seconds, be cooled to the can finished product under aseptic condition of back below 20 degrees centigrade.
Embodiment 5:
This example has been set forth the prescription design and the manufacturing process of " bird's nest acid viral infection resisting multifunctional beverage ":
(1) be to add 2 kilograms of food-grade bird's nests acid (WPI-SA100) in 17.2 kilograms of hot water of 45-85 ℃ in temperature, its bird's nest acid content is mass percent 10%, mixes.
(2) the bird's nest acid viral infection resisting multifunctional beverage concentrate that mixes is packaged, under the chamber, be put in 4 ℃ of refrigerators after the cooling and store.
(3) 9.8 kilograms of granulated sugars are dissolved in 81.4 kilograms of hot water, its temperature is 65-100 ℃, mix, and filter, mix with material concentrate in the step 2 then, add 0.6 kilogram of mixed phosphate again, here to select calcium dihydrogen phosphate for use be good to phosphate, can certainly select for use sodium dihydrogen phosphate or sodium hydrogen phosphate to do buffer, 1 kilogram of the food-grade bird's nest acid of mass percent 1% content, 0.1 kilogram of tea plant leaf extract, 0.05 kilogram of garlic P.E, 0.3 kilogram of acid citric acid or malic acid, 0.2 kilogram of flavor enhancement flavoring essence, 0.2 kilogram of stabilizing agent edible glue, mix.
(4) with the beverage in the step (3) by a high-temperature short-time sterilization device, generally control its temperature and be 121 ℃ of following 3-20 seconds, be cooled to the can finished product under aseptic condition of back below 20 degrees centigrade.
Embodiment 6:
This example has been set forth the prescription design and the manufacturing process of " bird's nest acid viral infection resisting multifunctional beverage ":
(1) be to add 3 kilograms of food-grade bird's nests acid (WPI-SA100) in 25.8 kilograms of hot water of 45-85 ℃ in temperature, its bird's nest acid content is mass percent 10%, mixes.
(2) the bird's nest acid viral infection resisting multifunctional beverage concentrate that mixes is packaged, under the chamber, be put in 4 ℃ of refrigerators after the cooling and store.
(3) 9.8 kilograms of granulated sugars are dissolved in 72.8 kilograms of hot water, its temperature is 65-100 ℃, mix, and filter, mix with material concentrate in the step 2 then, add 0.6 kilogram of mixed phosphate again, here to select calcium dihydrogen phosphate for use be good to phosphate, can certainly select for use sodium dihydrogen phosphate or sodium hydrogen phosphate to do buffer, 1 kilogram of the food-grade bird's nest acid of mass percent 1% content, 0.5 kilogram of tea plant leaf extract, 0.25 kilogram of Shitake Mushroom P.E, 0.3 kilogram in acid citric acid or tartaric acid, 0.2 kilogram of flavor enhancement flavoring essence, 0.2 kilogram of stabilizing agent edible glue, mix.
(4) with the beverage in the step (3) by a high-temperature short-time sterilization device, generally control its temperature and be 121 ℃ of following 3-20 seconds, be cooled to the can finished product under aseptic condition of back below 20 degrees centigrade.
Embodiment 7:
This example has been set forth the prescription design and the manufacturing process of " bird's nest acid viral infection resisting multifunctional beverage ":
(1) be to add 9 kilograms of food-grade bird's nests acid (WPI-SA100) in 75 kilograms of hot water of 45-85 ℃ in temperature, its bird's nest acid content is mass percent 10%, mixes.
(2) the bird's nest acid viral infection resisting multifunctional beverage concentrate that mixes is packaged, under the chamber, be put in 4 ℃ of refrigerators after the cooling and store.
(3) 9.8 kilograms of granulated sugars are dissolved in 25 kilograms of hot water, its temperature is 65-100 ℃, mix, and filter, mix with material concentrate in the step 2 then, add 0.8 kilogram of mixed phosphate again, here to select calcium dihydrogen phosphate for use be good to phosphate, can certainly select for use sodium dihydrogen phosphate or sodium hydrogen phosphate to do buffer, 2 kilograms of tea plant leaf extracts, 1 kilogram of Shitake Mushroom P.E, mix at 0.3 kilogram of acid citric acid or malic acid, 0.2 kilogram of flavor enhancement flavoring essence, 0.2 kilogram of stabilizing agent edible glue.
(4) with the beverage in the step (3) by a high-temperature short-time sterilization device, generally control its temperature and be 121 ℃ of following 3-20 seconds, be cooled to the can finished product under aseptic condition of back below 20 degrees centigrade.
Embodiment 8:
This example has been set forth the prescription design and the manufacturing process of " bird's nest acid viral infection resisting multifunctional beverage ":
(1) be to add 0.3 kilogram of food-grade bird's nest acid (WPI-SA100) in 2.58 kilograms of hot water of 45-85 ℃ in temperature, its bird's nest acid content is mass percent 10%, mixes.
(2) the bird's nest acid viral infection resisting multifunctional beverage concentrate that mixes is packaged, under the chamber, be put in 4 ℃ of refrigerators after the cooling and store.
(3) 9 kilograms of granulated sugars are dissolved in 95 kilograms of hot water, its temperature is 65-100 ℃, mix, and filter, mix with material concentrate in the step 2 then, add 0.4 kilogram of mixed phosphate again, here to select calcium dihydrogen phosphate for use be good to phosphate, can certainly select for use sodium dihydrogen phosphate or sodium hydrogen phosphate to do buffer, 0.1 kilogram of tea plant leaf extract, 0.05 kilogram of Honegsukle flower P.E are as 0.3 kilogram of 0.3 kilogram of 0.6 kilogram of citric acid, flavor enhancement flavoring essence, the stabilizing agent edible glue of acid, mix.
(4) with the beverage in the step (3) by a high-temperature short-time sterilization device, generally control its temperature and be 121 ℃ of following 3-20 seconds, be cooled to the can finished product under aseptic condition of back below 20 degrees centigrade.
Claims (10)
1, a kind of viral infection resisting multifunctional beverage, it removes and includes general beverage edible sweetener commonly used, outside edible acidic flavoring agent and the water, it is characterized in that beverage packets contains the protein and the mixtures of polypeptides of the biologically active of the food-grade sialic acid of mass percent 0.06%-1% or sialic acid derivative and mass percent 0.2-6%, wherein said sialic acid is the sialic acid of following general structural formula (1) and general formula (2), and described sialic acid derivative is its R4 of sialic acid of following general structural formula (1), R5, R7, R8, R9 is by material that other group replaced, wherein R can be :-H,-CH3,-COOH,-CNH,-SH and other any group comprise glycosyl, and the protein of described biologically active and mixtures of polypeptides are for comprising lactotransferrin, immunoglobulin (Ig), and the mixture of protein hydrolysising fragment;
Sialic general formula of molecular structure (1) is
Sialic general formula of molecular structure (2) is
2, multifunctional beverage according to claim 1 is characterized in that described food-grade sialic acid or sialic acid derivative preferred content are mass percent 0.06%-0.3%.
3, multifunctional beverage according to claim 1 and 2 is characterized in that described food-grade sialic acid extracts from natural bird's nest, also can extract from whey or yolk raw material.
4, multifunctional beverage according to claim 1 and 2, it is characterized in that described food-grade sialic acid comprises the free type sialic acid or with other polysaccharide or/and the sialic acid that protein exists with state-set prices combining form.
5, multifunctional beverage according to claim 1 and 2, it is characterized in that described beverage contains the plant extracts of mass percent 0.2-3%, this plant includes genseng, ginger, Salvia japonica, mushroom, the Radix Astragali, honeysuckle, garlic, American Ginseng or tealeaves, and they can use separately and also can select several compatibilities to use arbitrarily.
6, multifunctional beverage according to claim 5 is characterized in that described plant extracts content is preferably mass percent 0.2-1.6%.
7, multifunctional beverage according to claim 1 and 2 is characterized in that described beverage adjusting acidity is at pH value 3-7.
8, multifunctional beverage according to claim 7 is characterized in that described adjusting acidity is preferably between pH value 3.6-6.6.
9, multifunctional beverage according to claim 7 is characterized in that described adjusting acidity selects food-grade phosphate or phosphoric acid or nicotinic acid or citric acid or citric acid or tartaric acid or malic acid for use, and phosphate is selected calcium monohydrogen phosphate or calcium dihydrogen phosphate for use.
10, multifunctional beverage according to claim 1 and 2, the protein and the mixtures of polypeptides content that it is characterized in that described biologically active are percentage 0.5-5%, and it comprises lactotransferrin, immunoglobulin (Ig), reaches the mixture of protein hydrolysising fragment.
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| CN 03116921 CN1248603C (en) | 2003-05-14 | 2003-05-14 | Virus infection resisting multifunctional beverage |
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|---|---|---|---|
| CN 03116921 CN1248603C (en) | 2003-05-14 | 2003-05-14 | Virus infection resisting multifunctional beverage |
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| CN1248603C true CN1248603C (en) | 2006-04-05 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019046426A1 (en) | 2017-08-30 | 2019-03-07 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899593B (en) * | 2006-07-17 | 2012-07-11 | 刘树平 | Powder for treating common cold and its preparing method |
| EP2116140A1 (en) * | 2008-05-08 | 2009-11-11 | Nestec S.A. | Sialic acid to support the immune system in the elderly |
| EP2116139A1 (en) * | 2008-05-08 | 2009-11-11 | Nestec S.A. | Sialic acid to support brain health in the elderly |
| CN110354262A (en) * | 2018-04-23 | 2019-10-22 | 杭州索契健康科技有限公司 | A kind of N-acetyl-neuraminate antiviral composition of tablet form |
| CN111248373A (en) * | 2019-10-31 | 2020-06-09 | 成都图径生物科技有限公司 | Edible bird's nest acid beverage and preparation method thereof |
| CN112568341A (en) * | 2019-12-30 | 2021-03-30 | 河北华朗生物科技有限公司 | Agaricus bisporus bird's nest prebiotics compound beverage formula and production process thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019046426A1 (en) | 2017-08-30 | 2019-03-07 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
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